The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Genetically Engineered Phages: a Review of Advances over the Last Decade
Open accessAbstract
SUMMARY: Soon after their discovery in the early 20th century, bacteriophages were recognized to have great potential as antimicrobial agents, a potential that has yet to be fully realized. The nascent field of phage therapy was adversely affected by inadequately controlled trials and the discovery of antibiotics. Although the study of phages as anti-infective agents slowed, phages played an important role in the development of molecular biology. In recent years, the increase in multidrug-resistant bacteria has renewed interest in the use of phages as antimicrobial agents. With the wide array of possibilities offered by genetic engineering, these bacterial viruses are being modified to precisely control and detect bacteria and to serve as new sources of antibacterials. In applications that go beyond their antimicrobial activity, phages are also being developed as vehicles for drug delivery and vaccines, as well as for the assembly of new materials. This review highlights advances in techniques used to engineer phages for all of these purposes and discusses existing challenges and opportunities for future work.
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Cites
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Cited by
Phage therapy: From biological mechanisms to future directions
Strathdee, S. A., Hatfull, G. F., Mutalik, V. K., & Schooley, R. T. (2023) · Cell · doi:10.1016/j.cell.2022.11.017 · Cited by 817
Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808
Mutuku, C., Gazdag, Z., & Melegh, S. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03334-0 · Cited by 280
High-throughput mapping of the phage resistance landscape in E. coli
Mutalik, V. K., Adler, B. A., Rishi, H. S., Piya, D., Zhong, C., Koskella, B., Kutter, E. M., Calendar, R., Novichkov, P. S., Price, M. N., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000877 · Cited by 171
The power of phages: revolutionizing cancer treatment
Islam, M. S., Fan, J., & Pan, F. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1290296 · Cited by 50
Metadata
- Authors
- Pires, D. P., Cleto, S., Sillankorva, S., Azeredo, J., & Lu, T. K.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2016-09
- Volume
- 80
- Issue
- 3
- Pages
- 523-543
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2409985107
- Cited by
- 427
- References
- 9
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pires, D. P., Cleto, S., Sillankorva, S., Azeredo, J., & Lu, T. K. (2016). Genetically Engineered Phages: a Review of Advances over the Last Decade. Microbiology and Molecular Biology Reviews. https://doi.org/10.1128/mmbr.00069-15
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
