The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Genetics of Mosquito Vector Competence
Open accessAbstract
SUMMARY: Mosquito-borne diseases are responsible for significant human morbidity and mortality throughout the world. Efforts to control mosquito-borne diseases have been impeded, in part, by the development of drug-resistant parasites, insecticide-resistant mosquitoes, and environmental concerns over the application of insecticides. Therefore, there is a need to develop novel disease control strategies that can complement or replace existing control methods. One such strategy is to generate pathogen-resistant mosquitoes from those that are susceptible. To this end, efforts have focused on isolating and characterizing genes that influence mosquito vector competence. It has been known for over 70 years that there is a genetic basis for the susceptibility of mosquitoes to parasites, but until the advent of powerful molecular biological tools and protocols, it was difficult to assess the interactions of pathogens with their host tissues within the mosquito at a molecular level. Moreover, it has been only recently that the molecular mechanisms responsible for pathogen destruction, such as melanotic encapsulation and immune peptide production, have been investigated. The molecular characterization of genes that influence vector competence is becoming routine, and with the development of the Sindbis virus transducing system, potential antipathogen genes now can be introduced into the mosquito and their effect on parasite development can be assessed in vivo. With the recent successes in the field of mosquito germ line transformation, it seems likely that the generation of a pathogen-resistant mosquito population from a susceptible population soon will become a reality.
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Cites
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Background
Cited by
Vazeille, M., Moutailler, S., Coudrier, D., Rousseaux, C., Khun, H., Huerre, M., Thiria, J., Dehecq, J.-S., Fontenille, D., Schuffenecker, I., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001168 · Cited by 687
Melanogenesis and associated cytotoxic reactions: Applications to insect innate immunity
Nappi, A. J., & Christensen, B. M. (2005) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2005.01.014 · Cited by 675
Self-citationTabachnick, W. J. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.037564 · Cited by 344
Effects of landscape anthropization on mosquito community composition and abundance
Ferraguti, M., Martínez-de la Puente, J., Roiz, D., Ruiz, S., Soriguer, R., & Figuerola, J. (2016) · Scientific Reports · doi:10.1038/srep29002 · Cited by 273
Montarsi, F., Ciocchetta, S., Devine, G., Ravagnan, S., Mutinelli, F., Frangipane di Regalbono, A., Otranto, D., & Capelli, G. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-0800-y · Cited by 101
Metadata
- Authors
- Beerntsen, B. T., James, A. A., & Christensen, B. M.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2000-03
- Volume
- 64
- Issue
- 1
- Pages
- 115-137
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2158091936
- Cited by
- 425
- References
- 118
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
