Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages

Wu, Ting; Li, Hongru; Su, Cong; Xu, Fangming; Yang, Guangwei; Sun, Kaili; Xu, Mengran; Lv, Na; Meng, Bao; Liu, Yanyan; Hu, Lifen; Liu, Yan; Gao, Yufeng; Wang, Heng; Lan, Yanhu; Xu, Dexiang; Li, Jiabin

doi:10.1128/msystems.00587-20

Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages

These observations highlight that SCFAs promote macrophage elimination of K. pneumoniae via a LAMTOR2-dependent signal pathway and suggest that it is possible to intervene in K. pneumoniae pneumonia by targeting the gut microbiota.