Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site
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FMT treatment shows a profound impact on the microenvironment that involves microcirculation, blood-spinal cord-barrier, activation of immune cells, and secretion of neurotrophic factors. Analysis of metabolic profiles reveals around 22 differentially detected metabolites between the groups, and β-alanine was further chosen for functional validation experiments.
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FMT from control mice enhanced pericyte coverage in a spinal cord injury mouse model.
“FMT from control mice enhanced pericyte coverage in a spinal cord injury mouse model [77]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [77]
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- Authors
- Jing, Y., Bai, F., Wang, L., Yang, D., Yan, Y., Wang, Q., Zhu, Y., Yu, Y., & Chen, Z.
- Affiliations
- Capital Medical University (CN)
- Corresponding author
- Yu, Yan
- Chen, Zhiguo
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2022-06-29
- Volume
- 10
- Issue
- 3
- Pages
- e0017722-e0017722
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC9241636
- OpenAlex
- W4224816966
- Cited by
- 37
- References
- 64
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 2 · 2023: 16 · 2022: 3
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81901272)
- special fund for basic scientific research of central public research institutes (2016cz-1, 2018cz-11)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- fecal microbiota transplantation, spinal cord injury, neuroprotection, beta-alanine, blood-spinal cord barrier, lesion microenvironment, metabolomics, neurotrophic factors, immune cell activation, neuronal survival, functional recovery
- MeSH terms
- Fecal Microbiota Transplantation, Animals, Disease Models, Animal, Inflammation, Nerve Growth Factors, Spinal Cord Injuries, beta-Alanine, Rats, Sprague-Dawley, Neuroprotective Agents, Mice, Rats
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