Fecal transplant prevents gut dysbiosis and anxiety-like behaviour after spinal cord injury in rats
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Secondary manifestations of spinal cord injury beyond motor and sensory dysfunction can negatively affect a person's quality of life. Spinal cord injury is associated with an increased incidence of depression and anxiety; however, the mechanisms of this relationship are currently not well understood. Human and animal studies suggest that changes in the composition of the intestinal microbiota (dysbiosis) are associated with mood disorders. The objective of the current study is to establish a model of anxiety following a cervical contusion spinal cord injury in rats and to determine whether the microbiota play a role in the observed behavioural changes. We found that spinal cord injury caused dysbiosis and increased symptoms of anxiety-like behaviour. Treatment with a fecal transplant prevented both spinal cord injury-induced dysbiosis as well as the development of anxiety-like behaviour. These results indicate that an incomplete unilateral cervical spinal cord injury can cause affective disorders and intestinal dysbiosis, and that both can be prevented by treatment with fecal transplant therapy.
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FMT was reported to decrease antibiotic, chemotherapy, and injury-induced gut permeability and increased the prevalence of specific microbiota strains exhibiting anti-inflammatory properties.
“FMT was reported to decrease antibiotic, chemotherapy, and injury-induced gut permeability and increased the prevalence of specific microbiota strains exhibiting anti-inflammatory properties.195,196”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [196]
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- Authors
- Schmidt, E. K. A., Torres-Espin, A., Raposo, P. J. F., Madsen, K. L., Kigerl, K. A., Popovich, P. G., Fenrich, K. K., & Fouad, K.
- Affiliations
- University of Alberta (CA)
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Fouad, Karim
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-01-15
- Volume
- 15
- Issue
- 1
- Pages
- e0226128
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6961833
- OpenAlex
- W2998874562
- Cited by
- 119
- References
- 73
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 12 · 2023: 24 · 2022: 17 · 2021: 31 · 2020: 15
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Craig H. Neilsen Foundation (542589)
- Canadian Institutes of Health Research (119281)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fecal microbiota transplantation, spinal cord injury, gut dysbiosis, anxiety-like behavior, gut microbiota, mood disorders, depression
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Anxiety, Behavior, Animal, Spinal Cord Injuries, Maze Learning, Recovery of Function, Rats, Dysbiosis
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