Cited by 62Adipose Tissue and MetabolismGut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning via Activating the AC3/PKA/HSL Pathway

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Zheng, Xifen, Huang, Wenting, Li, Qianbei, Chen, Yun, Wu, Linyan, Dong, Yifan, Huang, Xinyue, He, Xiaojing +2 more·2023·Microbiology Spectrum

Abstract

An important intestinal bacterial strain Akkermansia muciniphila contributes to improving carbohydrate and lipid metabolism, thus alleviating obesity symptoms. Here, we find that the Akk membrane protein Amuc_1100 regulates lipid metabolism in 3T3-L1 preadipocytes.

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Authors
Zheng, X., Huang, W., Li, Q., Chen, Y., Wu, L., Dong, Y., Huang, X., He, X., Ou, Z., & Peng, Y.
Affiliations
  • Zhujiang Hospital (CN)
  • Nanfang Hospital (CN)
Corresponding author
  • He, Xiaojing
  • Ou, Zihao
  • Peng, Yongzheng
Venue
Microbiology Spectrum
Published
2023-04-13
Volume
11
Issue
2
Pages
e0432322-e0432322
ISSN
2165-0497 (ISSN-L)
OpenAlex
W4322494072
Cited by
62
References
36
Citations by year
2026: 22 · 2025: 22 · 2024: 10 · 2023: 8
FWCI
11.01
Type
journal article
Language
en
Open access
Locations
  • Microbiology Spectrum (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Department of Agriculture of Guangdong Province (2021A1515011639)
  • Foundation for Innovative Research Groups of the National Natural Science Foundation of China (82002245)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
Akkermansia muciniphila, Amuc_1100, membrane proteins, lipolysis, brown adipose tissue browning, cyclic AMP, protein kinase A, histone deacetylase, obesity, metabolic disorders

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