Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning via Activating the AC3/PKA/HSL Pathway
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An important intestinal bacterial strain Akkermansia muciniphila contributes to improving carbohydrate and lipid metabolism, thus alleviating obesity symptoms. Here, we find that the Akk membrane protein Amuc_1100 regulates lipid metabolism in 3T3-L1 preadipocytes.
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Amuc_1100, a membrane protein derived from A. muciniphila, can activate the AC3/PKA/HSL pathway, leading to activation of lipolysis and browning.
“Amuc_1100, a membrane protein derived from A. muciniphila, has been found to be able to activate the AC3/PKA/HSL pathway, which can lead to the activation of lipolysis and browning (Zheng et al., 2023).”
From <i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Zheng et al., 2023
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Jiang, Y.-T., Li, G., Zhou, Y., Jiang, Z.-D., Zhao, Y., Zhang, Y., Yin, X.-M., Li, S., Tong, H., Feng, L.-S., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.09.014
- Authors
- Zheng, X., Huang, W., Li, Q., Chen, Y., Wu, L., Dong, Y., Huang, X., He, X., Ou, Z., & Peng, Y.
- Affiliations
- Zhujiang Hospital (CN)
- Nanfang Hospital (CN)
- Corresponding author
- He, Xiaojing
- Ou, Zihao
- Peng, Yongzheng
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2023-04-13
- Volume
- 11
- Issue
- 2
- Pages
- e0432322-e0432322
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC10100790
- OpenAlex
- W4322494072
- Cited by
- 62
- References
- 36
- Citations by year
- 2026: 22 · 2025: 22 · 2024: 10 · 2023: 8
- FWCI
- 11.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Department of Agriculture of Guangdong Province (2021A1515011639)
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China (82002245)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Akkermansia muciniphila, Amuc_1100, membrane proteins, lipolysis, brown adipose tissue browning, cyclic AMP, protein kinase A, histone deacetylase, obesity, metabolic disorders
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