Function of Akkermansia muciniphila in obesity: interactions with lipid metabolism, immune response and gut systems

Obesity alters gut microbial ecology

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity

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Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

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Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

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Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

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Diet–microbiota interactions as moderators of human metabolism

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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

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Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

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<i>Akkermansia muciniphila</i> and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

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Dysbiosis of the gut microbiota in disease

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An increase in the <i>Akkermansia</i> spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

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Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

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Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

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Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women

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Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

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Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women

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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

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The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

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Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

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<i>Akkermansia Muciniphila</i> Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in <i>Apoe</i> ^−/− Mice

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The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism

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Microbes inside—from diversity to function: the case of Akkermansia

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<i>Akkermansia muciniphila</i> is a promising probiotic

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Intestinal Integrity and <i>Akkermansia muciniphila</i> , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

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Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading <i>Akkermansia muciniphila</i> and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

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Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health

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Dietary Polyphenols Promote Growth of the Gut Bacterium <i>Akkermansia muciniphila</i> and Attenuate High-Fat Diet–Induced Metabolic Syndrome

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Recovery of ethanol-induced <i>Akkermansia muciniphila</i> depletion ameliorates alcoholic liver disease

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Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila

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Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis

Kang, C.-S., Ban, M., Choi, E.-J., Moon, H.-G., Jeon, J.-S., Kim, D.-K., Park, S.-K., Jeon, S. G., Roh, T.-Y., Myung, S.-J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076520 · Cited by 543 · see citing works

Commensal Akkermansia muciniphila Exacerbates Gut Inflammation in Salmonella Typhimurium-Infected Gnotobiotic Mice

Ganesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074963 · Cited by 522 · see citing works

Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

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Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer

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Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse

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Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

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Aberrant intestinal microbiota in individuals with prediabetes

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Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

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Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

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Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

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Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum / necrophorum

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Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts

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A next generation probiotic, Akkermansia muciniphila

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Low Relative Abundances of the Mucolytic Bacterium Akkermansia muciniphila and Bifidobacterium spp. in Feces of Children with Autism

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Metagenome-wide association studies: fine-mining the microbiome

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NLRP6 Protects Il10 Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

Seregin, S. S., Golovchenko, N., Schaf, B., Chen, J., Pudlo, N. A., Mitchell, J., Baxter, N. T., Zhao, L., Schloss, P. D., Martens, E. C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.080 · Cited by 386 · see citing works

Effect of mother’s weight on infant’s microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy

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<i>Akkermansia muciniphila</i> induces gut microbiota remodelling and controls islet autoimmunity in NOD mice

Hänninen, A., Toivonen, R., Pöysti, S., Belzer, C., Plovier, H., Ouwerkerk, J. P., Emani, R., Cani, P. D., & De Vos, W. M. (2018) · Gut · doi:10.1136/gutjnl-2017-314508 · Cited by 359 · see citing works

Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

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Specific gut microbiota features and metabolic markers in postmenopausal women with obesity

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Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice

Zhao, S., Liu, W., Wang, J., Shi, J., Sun, Y., Wang, W., Ning, G., Liu, R., & Hong, J. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0054 · Cited by 298 · see citing works

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease

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Action and function of Akkermansia muciniphila in microbiome ecology, health and disease

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Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes

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Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Greer, R. L., Dong, X., de Moraes, A. C. F., Zielke, R. A., Fernandes, G. D. R., Peremyslova, E., Vasquez‐Perez, S., Schoenborn, A. A., Gomes, E. P., Pereira, A. C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13329 · Cited by 277 · see citing works

Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk

Collado, M. C., Laitinen, K., Salminen, S., & Isolauri, E. (2012) · Pediatric Research · doi:10.1038/pr.2012.42 · Cited by 270 · see citing works

Genome-Scale Model and Omics Analysis of Metabolic Capacities of <i>Akkermansia muciniphila</i> Reveal a Preferential Mucin-Degrading Lifestyle

Ottman, N., Davids, M., Suarez-Diez, M., Boeren, S., Schaap, P. J., Martins dos Santos, V. A. P., Smidt, H., Belzer, C., & de Vos, W. M. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01014-17 · Cited by 269 · see citing works

HLA-B27 and Human β2-Microglobulin Affect the Gut Microbiota of Transgenic Rats

Lin, P., Bach, M., Asquith, M. J., Lee, A., Akileswaran, L., Stauffer, P., Davin, S., Pan, Y., Cambronne, E. D., Dorris, M. L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105684 · Cited by 253 · see citing works

Gut microbiota and non-alcoholic fatty liver disease: new insights

Aron‐Wisnewsky, J., Gaborit, B., Dutour, A., & Clément, K. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12140 · Cited by 249 · see citing works

Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model

Wu, W., Lv, L., Shi, D., Ye, J., Fang, D., Guo, F., Li, Y., He, X., & Li, L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01804 · Cited by 247 · see citing works

The role of gut microbiota in obesity, diabetes mellitus, and effect of metformin: new insights into old diseases

Pascale, A., Marchesi, N., Govoni, S. M., Coppola, A., & Gazzaruso, C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.03.011 · Cited by 240 · see citing works

Host adaptive immunity alters gut microbiota

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Alterations in the Abundance and Co-occurrence of Akkermansia muciniphila and Faecalibacterium prausnitzii in the Colonic Mucosa of Inflammatory Bowel Disease Subjects

López‐Siles, M., Enrich-Capó, N., Aldeguer, X., Sàbat, M., Duncan, S. H., Garcia-Gil, L. J., & Martínez-Medina, M. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00281 · Cited by 212 · see citing works

Dietary Factors and Modulation of Bacteria Strains of Akkermansia muciniphila and Faecalibacterium prausnitzii: A Systematic Review

Verhoog, S., Taneri, P. E., Roa‐Díaz, Z. M., Marques-Vidal, P. M., Troup, J. P., Bally, L., Franco, O. H., Glišić, M., & Muka, T. (2019) · Nutrients · doi:10.3390/nu11071565 · Cited by 205 · see citing works

Safety of Novel Microbes for Human Consumption: Practical Examples of Assessment in the European Union

Brodmann, T., Endo, A., Gueimonde, M., Vinderola, G., Kneifel, W., de Vos, W. M., Salminen, S., & Gómez-Gallego, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01725 · Cited by 191 · see citing works

A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes

Vera, I., Sánchez‐Tapia, M., Noriega, L. G., Granados‐Portillo, O., Guevara‐Cruz, M., Flores‐López, A., Ávila-Nava, A., Fernández, M. L., Tovar, A. R., & Torres, N. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.09.004 · Cited by 185 · see citing works

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism

Duparc, T., Plovier, H., Marrachelli, V. G., Hul, M. V., Essaghir, A., Ståhlman, M., Matamoros, S., Geurts, L., Pardo-Tendero, M., Druart, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310904 · Cited by 177 · see citing works

Altered Gut Microbiota Composition Associated with Eczema in Infants

Zheng, H., Liang, H., Wang, Y., Miao, M., Shi, T., Yang, F., Liu, E., Yuan, W., Ji, Z., & Li, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166026 · Cited by 167 · see citing works

Alterations in Gut Microbiota by Statin Therapy and Possible Intermediate Effects on Hyperglycemia and Hyperlipidemia

Kim, J., Lee, H., An, J., Song, Y., Lee, C., Kim, K., & Kong, H. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01947 · Cited by 163 · see citing works

Anti-obesity Effect of Capsaicin in Mice Fed with High-Fat Diet Is Associated with an Increase in Population of the Gut Bacterium Akkermansia muciniphila

Shen, W., Shen, M., Zhao, X., Zhu, H., Yang, Y., Lu, S., Tan, Y., Li, G., Li, M., Wang, J., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00272 · Cited by 159 · see citing works

Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa

de Vos, W. M. (2017) · Microbiology · doi:10.1099/mic.0.000444 · Cited by 158 · see citing works

Adaptation of Akkermansia muciniphila to the Oxic-Anoxic Interface of the Mucus Layer

Ouwerkerk, J. P., van der Ark, K. C. H., Davids, M., Claassens, N. J., Robert-Finestra, T., de Vos, W. M., & Belzer, C. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.01641-16 · Cited by 155 · see citing works

Triggering Akkermansia with dietary polyphenols: A new weapon to combat the metabolic syndrome?

Anhê, F. F., Pilon, G., Roy, D., Desjardins, Y., Levy, E. H., & Marette, A. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1142036 · Cited by 149 · see citing works

Gut Microbiota of Obese, Type 2 Diabetic Individuals is Enriched in Faecalibacterium prausnitzii, Akkermansia muciniphila and Peptostreptococcus anaerobius after Weight Loss

Remely, M., Hippe, B., Zanner, J., Aumueller, E., Brath, H., & Haslberger, A. G. (2016) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530316666160831093813 · Cited by 143 · see citing works

Obesity and microbiota: an example of an intricate relationship

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Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach

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Akkermansia muciniphila: a novel functional microbe with probiotic properties

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Characterization of Outer Membrane Proteome of Akkermansia muciniphila Reveals Sets of Novel Proteins Exposed to the Human Intestine

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Akkermansia muciniphilaandHelicobacter typhloniusmodulate intestinal tumor development in mice

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Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

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Atorvastatin Treatment Modulates the Gut Microbiota of the Hypercholesterolemic Patients

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Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice

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The effects of sodium butyrate and inulin supplementation on angiotensin signaling pathway via promotion of Akkermansia muciniphila abundance in type 2 diabetes; A randomized, double-blind, placebo-controlled trial

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Aguamiel concentrate from Agave salmiana and its extracted saponins attenuated obesity and hepatic steatosis and increased Akkermansia muciniphila in C57BL6 mice

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Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health

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Pomegranate ellagitannins stimulate the growth of Akkermansia muciniphila in vivo

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Biochemical characterisation of the neuraminidase pool of the human gut symbiont Akkermansia muciniphila

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Cranberry Proanthocyanidins Improve the Gut Mucous Layer Morphology and Function in Mice Receiving Elemental Enteral Nutrition

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Mucin degradation niche as a driver of microbiome composition and Akkermansia muciniphila abundance in a dynamic gut model is donor independent

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Low-Density Lipoprotein Receptor Signaling Mediates the Triglyceride-Lowering Action of Akkermansia muciniphila in Genetic-Induced Hyperlipidemia

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Model‐driven design of a minimal medium for Akkermansia muciniphila confirms mucus adaptation

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Establishing a causal link between gut microbes, body weight gain and glucose metabolism in humans – towards treatment with probiotics

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Gut Microbiota: Modulation of Host Physiology in Obesity

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A Preliminary Study Examining the Binding Capacity of Akkermansia muciniphila and Desulfovibrio spp., to Colonic Mucin in Health and Ulcerative Colitis

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Different subtype strains of Akkermansia muciniphila abundantly colonize in southern China

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Gut Microbiota and Host Reaction in Liver Diseases

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The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: A pilot randomized, placebo-controlled clinical trial

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Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actin Related Cytoskeletal Reorganization

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Dysbiosis of urinary microbiota is positively correlated with Type 2 diabetes mellitus

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NMMHC IIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3β-NF-κB signalling pathways in the endothelium

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Determination of certain bacterial groups in gut microbiota and endotoxin levels in patients with nonalcoholic steatohepatitis

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Myosin IIA-related Actomyosin Contractility Mediates Oxidative Stress-induced Neuronal Apoptosis

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The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation

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Shifts in intestinal microbiota after duodenal exclusion favor glycemic control and weight loss: a randomized controlled trial

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Preparation and preservation of viable Akkermansia muciniphila cells for therapeutic interventions

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The Stem Cell Factor Sox2 Is a Positive Timer of Oligodendrocyte Development in the Postnatal Murine Spinal Cord

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Pathophysiology and Treatment of Canavan Disease

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Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model

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Bacteria to alleviate metabolic syndrome

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Commentary: Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome

Anonye, B. O. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00850 · Cited by 22 · see citing works

The Gut Microbiome, Aging, and Longevity: A Systematic Review

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Probiotic: conceptualization from a new approach

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Integrity of the Intestinal Barrier: The Involvement of Epithelial Cells and Microbiota—A Mutual Relationship

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Obesity and gut–microbiota–brain axis: A narrative review

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From correlation to causality: the case of Subdoligranulum

Hul, M. V., Roy, T. L., Prifti, E., Dao, M. C., Paquot, A., Zucker, J., Delzenne, N. M., Muccioli, G. G., Clément, K., & Cani, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1849998 · Cited by 221 · see citing works

Aging, Frailty, and the Microbiome—How Dysbiosis Influences Human Aging and Disease

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Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia <i>via</i> Regulating Bile Acid Metabolism and Gut Microbiota in Mice

Duan, R., Guan, X., Huang, K., Zhang, Y., Li, S., Xia, J., & Shen, M. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c01813 · Cited by 198 · see citing works

The Related Metabolic Diseases and Treatments of Obesity

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Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?

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Polyphenols: Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits: A review

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Effects of Fecal Microbiome Transfer in Adolescents With Obesity

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Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia muciniphila as a Key Gut Bacterium

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Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis

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Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota

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The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis

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Akkermansia muciniphila : A promising probiotic against inflammation and metabolic disorders

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Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia

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Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

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The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesity

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Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate

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The Interplay of Dietary Fibers and Intestinal Microbiota Affects Type 2 Diabetes by Generating Short-Chain Fatty Acids

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Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease

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Benchmark of 16S rRNA gene amplicon sequencing using Japanese gut microbiome data from the V1–V2 and V3–V4 primer sets

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Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

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Gut Microbiota and Host Metabolism: From Proof of Concept to Therapeutic Intervention

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Fostering next-generation probiotics in human gut by targeted dietary modulation: An emerging perspective

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The Ability of Resveratrol to Attenuate Ovalbumin-Mediated Allergic Asthma Is Associated With Changes in Microbiota Involving the Gut-Lung Axis, Enhanced Barrier Function and Decreased Inflammation in the Lungs

Alharris, E. S., Mohammed, A. K., Alghetaa, H., Zhou, J., Nagarkatti, M., & Nagarkatti, P. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.805770 · Cited by 104 · see citing works

The metabolic, protective, and immune functions of Akkermansia muciniphila

Ghotaslou, R., Nabizadeh, E., Memar, M. Y., Law, W. M. H., Ozma, M. A., Abdi, M., Yekani, M., Kadkhoda, H., Hosseinpour, R., Bafadam, S., et al. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127245 · Cited by 104 · see citing works

Adjuvant Probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus

Wang, C., Yen, H., Lu, W., Ho, H.-H., Lin, W., Kuo, Y., Huang, Y.-Y., Tsai, S., & Lin, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.754401 · Cited by 108 · see citing works

Akkermansia muciniphila: A key player in gut microbiota-based disease modulation

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Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases

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The Gut–CNS Axis in Multiple Sclerosis

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Gut health benefit and application of postbiotics in animal production

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Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine

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Lactobacillus acidophilus LA5 improves saturated fat-induced obesity mouse model through the enhanced intestinal Akkermansia muciniphila

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A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

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Hydroxycinnamic acids on gut microbiota and health

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Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs

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Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study

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The Link between Obesity, Microbiota Dysbiosis, and Neurodegenerative Pathogenesis

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