Waning of vaccine effectiveness against moderate and severe covid-19 among adults in the US from the VISION network: test negative, case-control study
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Objective: To estimate the effectiveness of mRNA vaccines against moderate and severe covid-19 in adults by time since second, third, or fourth doses, and by age and immunocompromised status. Design: Test negative case-control study. Setting: Hospitals, emergency departments, and urgent care clinics in 10 US states, 17 January 2021 to 12 July 2022. Participants: 893 461 adults (≥18 years) admitted to one of 261 hospitals or to one of 272 emergency department or 119 urgent care centers for covid-like illness tested for SARS-CoV-2. Main outcome measures: The main outcome was waning of vaccine effectiveness with BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) vaccine during the omicron and delta periods, and the period before delta was dominant using logistic regression conditioned on calendar week and geographic area while adjusting for age, race, ethnicity, local virus circulation, immunocompromised status, and likelihood of being vaccinated. Results: 45 903 people admitted to hospital with covid-19 (cases) were compared with 213 103 people with covid-like illness who tested negative for SARS-CoV-2 (controls), and 103 287 people admitted to emergency department or urgent care with covid-19 (cases) were compared with 531 168 people with covid-like illness who tested negative for SARS-CoV-2. In the omicron period, vaccine effectiveness against covid-19 requiring admission to hospital was 89% (95% confidence interval 88% to 90%) within two months after dose 3 but waned to 66% (63% to 68%) by four to five months. Vaccine effectiveness of three doses against emergency department or urgent care visits was 83% (82% to 84%) initially but waned to 46% (44% to 49%) by four to five months. Waning was evident in all subgroups, including young adults and individuals who were not immunocompromised; although waning was morein people who were immunocompromised. Vaccine effectiveness increased among most groups after a fourth dose in whom this booster was recommended. Conclusions: Effectiveness of mRNA vaccines against moderate and severe covid-19 waned with time after vaccination. The findings support recommendations for a booster dose after a primary series and consideration of additional booster doses.
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Boosting by BNT162b2 or CoronaVac restores strong protection against hospitalization and death, but the incremental effectiveness of BNT162b2 boosters against such outcomes waned over 4-6 months for adults and the elderly.
“Further, although boosting by BNT162b2 or CoronaVac restores strong protection against hospitalization and death33–35, the incremental effectiveness of BNT162b2 boosters against such outcomes waned over the course of 4–6 months34 for both adults and the elderly36.”
From Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population (2023) · cites this paper as [36]
The Results (Vaccine effectiveness; Vaccine effectiveness in subgroups, page not provided) report that protection against hospital admission rose after a third mRNA dose and waned by four to five months, including in adults aged 65 or older. The paper includes BNT162b2, but it does not establish waning protection against death or evaluate CoronaVac; its reported vaccine effectiveness is not specifically the incremental effectiveness of a booster relative to two doses. (LLM, conf=0.88)
Experimental — accuracy not yet measuredVaccine effectiveness declines over time, as shown in several observational studies.
“This led to a decline in vaccine effectiveness (VE) over time, as shown in several observational studies [2, 3].”
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Cites
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592 · see citing works
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Baden, L. R., El Sahly, H. M., Essink, B., Kotloff, K., Frey, S., Novak, R., Diemert, D., Spector, S. A., Rouphael, N., Creech, C. B., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2035389 · Cited by 10,119 · see citing works
Negative Controls: A Tool for Detecting Confounding and Bias in Observational Studies
Lipsitch, M., Tchetgen Tchetgen, E., & Cohen, T. (2010) · Epidemiology · doi:10.1097/ede.0b013e3181d61eeb · Cited by 1,583 · see citing works
Feikin, D. R., Higdon, M. M., Abu-Raddad, L. J., Andrews, N., Araos, R., Goldberg, Y., Groome, M. J., Huppert, A., O'Brien, K. L., Smith, P. G., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00152-0 · Cited by 1,237 · see citing works
Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel
Bar-On, Y. M., Goldberg, Y., Mandel, M., Bodenheimer, O., Freedman, L., Kalkstein, N., Mizrahi, B., Alroy-Preis, S., Ash, N., Milo, R., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2114255 · Cited by 1,169 · see citing works
Tartof, S. Y., Slezak, J. M., Fischer, H., Hong, V., Ackerson, B. K., Ranasinghe, O. N., Frankland, T. B., Ogun, O. A., Zamparo, J. M., Gray, S., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)02183-8 · Cited by 1,167 · see citing works
Waning Immunity after the BNT162b2 Vaccine in Israel
Goldberg, Y., Mandel, M., Bar-On, Y. M., Bodenheimer, O., Freedman, L., Haas, E. J., Milo, R., Alroy-Preis, S., Ash, N., & Huppert, A. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2114228 · Cited by 1,034 · see citing works
Barda, N., Dagan, N., Cohen, C., Hernán, M. A., Lipsitch, M., Kohane, I. S., Reis, B. Y., & Balicer, R. D. (2021) · The Lancet · doi:10.1016/s0140-6736(21)02249-2 · Cited by 860 · see citing works
Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar
Chemaitelly, H., Tang, P., Hasan, M. R., AlMukdad, S., Yassine, H. M., Benslimane, F. M., Al Khatib, H. A., Coyle, P., Ayoub, H. H., Al Kanaani, Z., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2114114 · Cited by 831 · see citing works
Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines
Andrews, N., Tessier, E., Stowe, J., Gower, C., Kirsebom, F., Simmons, R., Gallagher, E., Thelwall, S., Groves, N., Dabrera, G., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2115481 · Cited by 807 · see citing works
Homologous and Heterologous Covid-19 Booster Vaccinations
Atmar, R. L., Lyke, K. E., Deming, M. E., Jackson, L. A., Branche, A. R., Sahly, H. M. E., Rostad, C. A., Martin, J. M., Johnston, C., Rupp, R. E., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2116414 · Cited by 629 · see citing works
Maximum likelihood estimation of the attributable fraction from logistic models.
Greenland, S., & Drescher, K. (1993) · Biometrics · doi:10.2307/2532206 · Cited by 565 · see citing works
Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings
Thompson, M. G., Stenehjem, E. A., Grannis, S. J., Ball, S. W., Naleway, A. L., Ong, T. C., DeSilva, M. B., Natarajan, K., Bozio, C. H., Lewis, N., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2110362 · Cited by 459 · see citing works
Self-citationFerdinands, J. M., Rao, S., Dixon, B. E., Mitchell, P. K., DeSilva, M. B., Irving, S. A., Lewis, N., Natarajan, K., Stenehjem, E., Grannis, S. J., et al. (2022) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7107e2 · Cited by 435 · see citing works
Self-citationThird BNT162b2 Vaccination Neutralization of SARS-CoV-2 Omicron Infection
Nemet, I., Kliker, L., Lustig, Y., Zuckerman, N. S., Erster, O., Cohen, C., Kreiss, Y., Alroy‐Preis, S., Regev‐Yochay, G., Mendelson, E., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmc2119358 · Cited by 418 · see citing works
Thompson, M. G., Natarajan, K., Irving, S. A., Rowley, E. A., Griggs, E. P., Gaglani, M., Klein, N. P., Grannis, S. J., DeSilva, M. B., Stenehjem, E., et al. (2022) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7104e3 · Cited by 398 · see citing works
Self-citationChoi, A., Koch, M., Wu, K., Chu, L., Ma, L., Hill, A., Nunna, N., Huang, W., Oestreicher, J., Colpitts, T., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01527-y · Cited by 396 · see citing works
Bruxvoort, K. J., Sy, L. S., Qian, L., Ackerson, B. K., Luo, Y., Lee, G. S., Tian, Y., Florea, A., Aragones, M., Tubert, J. E., et al. (2021) · BMJ · doi:10.1136/bmj-2021-068848 · Cited by 230 · see citing works
Embí, P. J., Levy, M. E., Naleway, A. L., Patel, P. Y., Gaglani, M., Natarajan, K., Dascomb, K. K., Ong, T. C., Klein, N. P., Liao, I., et al. (2021) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7044e3 · Cited by 174 · see citing works
Self-citationGram, M. A., Emborg, H.-D., Schelde, A. B., Friis, N. U., Nielsen, K. F., Moustsen-Helms, I. R., Legarth, R., Lam, J. U. H., Chaine, M., Malik, A. Z., et al. (2022) · PLOS Medicine · doi:10.1371/journal.pmed.1003992 · Cited by 146 · see citing works
Tartof, S. Y., Slezak, J. M., Puzniak, L., Hong, V. X., Frankland, T. B., Ackerson, B. K., Takhar, H. S., Ogun, O. A., Simmons, S. R., Zamparo, J. M., et al. (2021) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2022.100198 · Cited by 106 · see citing works
Plumb, I. D., Feldstein, L. R., Barkley, E., Posner, A. B., Bregman, H. S., Hagen, M. B., & Gerhart, J. L. (2022) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7115e2 · Cited by 99 · see citing works
Feikin, D. R., Abu-Raddad, L. J., Andrews, N., Davies, M.-A., Higdon, M. M., Orenstein, W. A., & Patel, M. K. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.04.069 · Cited by 83 · see citing works
Šmíd, M., Berec, L., Přibylová, L., Májek, O., Pavlík, T., Jarkovský, J., Weiner, J., Barusová, T., & Trnka, J. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac161 · Cited by 67 · see citing works
Nordström, P., Ballin, M., & Nordström, A. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3949410 · Cited by 58 · see citing works
Kwon, J. H., Tenforde, M. W., Gaglani, M., Talbot, H. K., Ginde, A. A., McNeal, T., Ghamande, S. A., Douin, D. J., Casey, J. D., Mohr, N. M., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac118 · Cited by 37 · see citing works
Self-citationHitchings, M. D. T., Lewnard, J. A., Dean, N. E., Ko, A. I., Ranzani, O., Andrews, J. R., & Cummings, D. A. T. (2022) · Epidemiology · doi:10.1097/ede.0000000000001484 · Cited by 28 · see citing works
Hansen, C. H., Schelde, A. B., Moustsen‐Helms, I. R., Emborg, H., Eriksen, R. S., Stegger, M., Krause, T. G., Mølbak, K., & Valentiner‐Branth, P. (2022) · Research Square · doi:10.21203/rs.3.rs-1486018/v1 · Cited by 9 · see citing works
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Lau, J. J., Cheng, S. M. S., Leung, K., Lee, C. K., Hachim, A., Tsang, L. C. H., Yam, K. W. H., Chaothai, S., Kwan, K. K. H., Chai, Z. Y. H., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02219-5 · Cited by 198 · see citing works
Evans, R. A., Dube, S., Lu, Y., Yates, M., Arnetorp, S., Barnes, E. J., Bell, S., Carty, L., Evans, K., Graham, S., et al. (2023) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2023.100747 · Cited by 206 · see citing works
Tartof, S. Y., Slezak, J. M., Puzniak, L., Hong, V. X., Frankland, T. B., Ackerson, B. K., Xie, F., Takhar, H. S., Ogun, O. A., Simmons, S. R., et al. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00306-5 · Cited by 70 · see citing works
Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines
Fraser, R., Resendiz, A. O., Mazein, A., & Dockrell, D. H. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.01.003 · Cited by 61 · see citing works
Mozaffari, E., Chandak, A. N., Gottlieb, R., Chima-Melton, C., Read, S. H., Jiang, H., Chiang, M., Lee, E., Gupta, R. S., Berry, M. C., et al. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad460 · Cited by 62 · see citing works
Klaassen, F., Chitwood, M. H., Cohen, T., Pitzer, V. E., Russi, M., Swartwood, N. A., Salomon, J. A., & Menzies, N. A. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad210 · Cited by 59 · see citing works
Klein, N. P., Bartlett, J., FIREMAN, B. H., Marks, M. A., Hansen, J. R., Lewis, E. M., Aukes, L. L., & Saddier, P. (2023) · BMJ · doi:10.1136/bmj-2023-076321 · Cited by 45 · see citing works
Self-citationPalmer, C. D., Scallan, C. D., Kraemer Tardif, L. D., Kachura, M. A., Rappaport, A. R., Koralek, D. O., Uriel, A., Gitlin, L., Klein, J., Davis, M. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39053-9 · Cited by 42 · see citing works
DeCuir, J., Surie, D., Zhu, Y., Gaglani, M., Ginde, A. A., Douin, D. J., Talbot, H. K., Casey, J. D., Mohr, N. M., McNeal, T., et al. (2023) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7217a3 · Cited by 41 · see citing works
Self-citationPark, H. J., Gonsalves, G., Tan, S. T., Kelly, J. D., Rutherford, G. W., Wachter, R. M., Schechter, R., Paltiel, A. D., & Lo, N. C. (2024) · Nature Communications · doi:10.1038/s41467-024-45549-9 · Cited by 41 · see citing works
Wee, L. E., Pang, D., Chiew, C. J., Tan, J. S. H., Lee, V., Ong, B., Lye, D. C., & Tan, K. B. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad345 · Cited by 38 · see citing works
Zhou, G., Dael, N., Verweij, S., Balafas, S., Mubarik, S., Oude Rengerink, K., Pasmooij, A. M. G., van Baarle, D., Mol, P. G. M., de Bock, G. H., et al. (2025) · European Respiratory Review · doi:10.1183/16000617.0222-2024 · Cited by 34 · see citing works
mRNA vaccines against respiratory viruses
Whitaker, J. A., Sahly, H. M. E., & Healy, C. M. (2023) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000948 · Cited by 38 · see citing works
Song, S., Madewell, Z. J., Liu, M., Longini, I. M., & Yang, Y. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1195908 · Cited by 34 · see citing works
Antonelli, M., Penfold, R., Canas, L. S., Sudre, C. H., Rjoob, K. W. Y., Murray, B., Molteni, E., Kerfoot, E., Cheetham, N. J., Pujol, J. C., et al. (2023) · Journal of Infection · doi:10.1016/j.jinf.2023.08.009 · Cited by 33 · see citing works
Vaccination against rapidly evolving pathogens and the entanglements of memory
Cobey, S. E. (2024) · Nature Immunology · doi:10.1038/s41590-024-01970-2 · Cited by 35 · see citing works
Comparative Effectiveness of Bivalent (Original/Omicron BA.4/BA.5) COVID-19 Vaccines in Adults
Kopel, H., Nguyễn, V. H., Boileau, C., Bogdanov, A., Winer, I. H., Ducruet, T., Zeng, N., Bonafede, M., Esposito, D. B., Martin, D., et al. (2023) · Vaccines · doi:10.3390/vaccines11111711 · Cited by 30 · see citing works
Andersson, N. W., Thiesson, E. M., Baum, U., Pihlström, N., Starrfelt, J., Faksová, K., Poukka, E., Lund, L. C., Hansen, C. H., Aakjær, M., et al. (2023) · BMJ · doi:10.1136/bmj-2022-074325 · Cited by 27 · see citing works
Understanding low COVID-19 booster uptake among US adults
Jacobs, E. T., Cordova-Marks, F. M., Farland, L. V., Ernst, K. C., Andrews, J., Vu, S., Heslin, K. M., Catalfamo, C. J., Chen, Z., & Pogreba-Brown, K. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.08.080 · Cited by 27 · see citing works
Dallan, B., Proietto, D., Laurentis, M. D., Gallerani, E., Martino, M., Ghisellini, S., Zurlo, A., Volpato, S., Govoni, B., Borghesi, M., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00644-w · Cited by 25 · see citing works
Canaday, D. H., Oyebanji, O. A., White, E. M., Bosch, J., Nugent, C., Vishnepolskiy, I., Abul, Y., Didion, E. M., Paxitzis, A., Sundheimer, N., et al. (2023) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7204a4 · Cited by 24 · see citing works
Mesenchymal Stem Cells in the Treatment of COVID-19
Guo, B.-C., Wu, K., Chen, C., Lin, W.-Y., Chang, Y., Lee, T.-A., Lin, M.-J., & Wu, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914800 · Cited by 22 · see citing works
Development of COVID-19 vaccine policy — United States, 2020–2023
Oliver, S. E., Wallace, M. M., Twentyman, E., Moulia, D., Godfrey, M., Link‐Gelles, R., Meyer, S. A., Fleming-Dutra, K. E., Hall, E., Wolicki, J., et al. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.12.022 · Cited by 23 · see citing works
Self-citationLuck, A. N., Elo, I. T., Preston, S. H., Paglino, E., Hempstead, K., & Stokes, A. C. (2023) · Population Research and Policy Review · doi:10.1007/s11113-023-09817-8 · Cited by 21 · see citing works
Effectiveness of BNT162b2 COVID-19 Vaccination in Children and Adolescents
Klein, N. P., Demarco, M., Fleming-Dutra, K. E., Stockwell, M. S., Kharbanda, A. B., Gaglani, M., Rao, S., Lewis, N., Irving, S. A., Hartmann, E., et al. (2023) · PEDIATRICS · doi:10.1542/peds.2022-060894 · Cited by 20 · see citing works
Self-citationMarks, K., & Gulick, R. M. (2023) · Annals of Internal Medicine · doi:10.7326/aitc202310170 · Cited by 21 · see citing works
Mozaffari, E., Chandak, A. N., Chima-Melton, C., Kalil, A. C., Jiang, H., Lee, E., Der-Torossian, C., Thrun, M. W., Berry, M. C., Haubrich, R., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae202 · Cited by 18 · see citing works
Giannouchos, T. V., Li, Z., Hung, P., Li, X., & Olatosi, B. (2023) · Journal of Community Health · doi:10.1007/s10900-023-01216-6 · Cited by 17 · see citing works
Immune Response following BNT162b2 mRNA COVID-19 Vaccination in Pediatric Cancer Patients
Schmidt, K. L. J., Dautzenberg, N. M. M., Hoogerbrugge, P. M., Lindemans, C. A., Nierkens, S., Smits, G. P., van Binnendijk, R. S., Bont, L., & Tissing, W. J. E. (2023) · Cancers · doi:10.3390/cancers15092562 · Cited by 17 · see citing works
Rose, A. M., Nicolay, N., Martín, V. S., Mazagatos, C., Petrović, G., Baruch, J., Denayer, S., Seyler, L., Domegan, L. M., Launay, O., et al. (2023) · Eurosurveillance · doi:10.2807/1560-7917.es.2023.28.47.2300187 · Cited by 17 · see citing works
Maltezou, H. C., Basoulis, D., Bonelis, K., Gamaletsou, M. N., Giannouchos, T. V., Karantoni, E., Karapanou, Α., Kounouklas, K., Livanou, M. E., Zotou, M., et al. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.01.067 · Cited by 16 · see citing works
Lunt, R., Quinot, C., Kirsebom, F. C. M., Andrews, N. J., Skarnes, C., Letley, L. H., Haskins, D., Angel, C., Firminger, S., Ratcliffe, K., et al. (2023) · Journal of Infection · doi:10.1016/j.jinf.2023.10.016 · Cited by 16 · see citing works
Adams, K., Riddles, J. J., Rowley, E. A. K., Grannis, S. J., Gaglani, M., FIREMAN, B. H., Hartmann, E., Naleway, A. L., Stenehjem, E. A., Hughes, A., et al. (2023) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2023.100530 · Cited by 15 · see citing works
Self-citationBraeye, T., van Loenhout, J. A. F., Brondeel, R., Stouten, V., Hubin, P., Billuart, M., Chung, P. Y. J., Vandromme, M., Wyndham-Thomas, C., Blot, K. Y., et al. (2023) · Eurosurveillance · doi:10.2807/1560-7917.es.2023.28.26.2200768 · Cited by 16 · see citing works
Taus, E., Hofmann, C., Ibarrondo, F. J., Gong, L. S., Hausner, M. A., Fulcher, J. A., Krogstad, P. A., Kitchen, S. G., Ferbas, K. G., Tobin, N. H., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1100594 · Cited by 14 · see citing works
Petrie, J. G., King, J. P., McClure, D. L., Rolfes, M. A. R., Meece, J. K., Pattinson, D., Neumann, G., Kawaoka, Y., Belongia, E. A., & McLean, H. Q. (2023) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.13104 · Cited by 13 · see citing works
Bohnert, A. S. B., Kumbier, K. E., Rowneki, M., Gupta, A. B., Bajema, K. L., Hynes, D. M., Viglianti, E. M., O’Hare, A. M., Osborne, T. F., Boyko, E. J., et al. (2023) · BMJ · doi:10.1136/bmj-2022-074521 · Cited by 15 · see citing works
From COVID-19 Vaccine Hesitancy to Vaccine Acceptance: Results of a Longitudinal Survey
Fisher, K. A., Nguyen, N. T. T., Fouayzi, H., Crawford, S. L., Singh, S., Dong, M., Wittenberg, R., & Mazor, K. M. (2023) · Public Health Reports · doi:10.1177/00333549231176006 · Cited by 14 · see citing works
Peng, K. K., Renouf, E. M., Dean, C. B., Hu, X. J., Delatolla, R., & Manuel, D. G. (2023) · Infectious Disease Modelling · doi:10.1016/j.idm.2023.05.011 · Cited by 14 · see citing works
COVID Vaccination as a Strategy for Cardiovascular Disease Prevention
Fundora, M. P., Kamidani, S., & Oster, M. E. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01950-2 · Cited by 14 · see citing works
Xiang, Y., Feng, Y., Qiu, J., Zhang, R., & So, H. (2024) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2024.107080 · Cited by 13 · see citing works
Naylor, K. L., Knoll, G. A., Smith, G. H. R., McArthur, E., Kwong, J. C., Dixon, S. N., Treleaven, D. J., & Kim, S. J. (2023) · Transplantation · doi:10.1097/tp.0000000000004766 · Cited by 12 · see citing works
Moser, M. J., Hill-Batorski, L., Bowen, R. A., Matejka, S. M., Marshall, D. C., Kawaoka, Y., Neumann, G., & Bilsel, P. (2023) · Vaccines · doi:10.3390/vaccines11061063 · Cited by 11 · see citing works
Søndergaard, M. H., Thavarajah, J. J., Henson, H. C., & Wejse, C. M. (2023) · HIV Medicine · doi:10.1111/hiv.13537 · Cited by 11 · see citing works
Halford, F., Yates, K., Clare, T., Bernal, J. L., Kall, M. M., & Allen, H. (2023) · Journal of the Royal Society of Medicine · doi:10.1177/01410768231216332 · Cited by 11 · see citing works
Protecting the vulnerable: addressing the COVID-19 care needs of people with compromised immunity
Razonable, R. R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1397040 · Cited by 11 · see citing works
Andersen, K. M., Allen, K. E., Nepal, R. M., Mateus, J. S., Yu, T., Zhou, A., Porter, T. M., Lopez, S. M. C., Puzniak, L., McLaughlin, J. M., et al. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.126881 · Cited by 11 · see citing works
Stecher, M., Kristoffersen, A. B., Lie, K., Andersen, S. R., Meijerink, H., & Starrfelt, J. (2023) · International Journal of Epidemiology · doi:10.1093/ije/dyad114 · Cited by 11 · see citing works
Bieńkowski, C., Skrzat‐Klapaczyńska, A., Firląg‐Burkacka, E., Horban, A., & Kowalska, J. D. (2023) · Vaccines · doi:10.3390/vaccines11030514 · Cited by 11 · see citing works
Kopel, H., Nguyễn, V. H., Boileau, C., Bogdanov, A., Winer, I. H., Ducruet, T., Zeng, N., Bonafede, M., Esposito, D. B., Martin, D., et al. (2023) · medRxiv · doi:10.1101/2023.07.12.23292576 · Cited by 11 · see citing works
Waning effectiveness of mRNA COVID-19 vaccines against inpatient and emergency department encounters
Giannouchos, T. V., Hair, N. L., Olatosi, B., & Li, X. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300198 · Cited by 10 · see citing works
DeCuir, J., Surie, D., Zhu, Y., Lauring, A. S., Gaglani, M., McNeal, T., Ghamande, S. A., Peltan, I. D., Brown, S. M., Ginde, A. A., et al. (2024) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.70027 · Cited by 10 · see citing works
Self-citationBonanni, P., Heo, J. Y., Honda, H., Lee, P., Mouliom, A., Leong, H. N., Matos, M. D. P. M., & Dawson, R. S. (2025) · Infectious Diseases and Therapy · doi:10.1007/s40121-025-01135-0 · Cited by 10 · see citing works
Yan, V. K. C., Wan, E. Y. F., Ye, X., Mok, A. H. Y., Lai, F. T. T., Chui, C. S. L., Li, X., Wong, C. K. H., Li, P. H., Ma, T., et al. (2023) · Emerging Microbes & Infections · doi:10.1080/22221751.2023.2209201 · Cited by 10 · see citing works
Jorgensen, S. C. J., Brown, K. A., Clarke, A. E., Schwartz, K. L., Maxwell, C. J., Daneman, N., Kwong, J. C., & MacFadden, D. R. (2024) · Clinical Infectious Diseases · doi:10.1093/cid/ciae182 · Cited by 9 · see citing works
Zheng, Z., Yousefi, M., MacCormac, D., Radin, J. M., Sun, T., Wilson, A., Shah, R., Skornicki, M., Sheridan, P. E., Toyip, A., et al. (2025) · Vaccine X · doi:10.1016/j.jvacx.2025.100737 · Cited by 9 · see citing works
Humoral and cellular immunity against diverse SARS-CoV-2 variants
Chen, C., Wang, X., & Zhang, Z. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.10.003 · Cited by 9 · see citing works
Follmann, D. A., Wang, X., Baden, L. R., Sahly, H. M. E., Essink, B. J., Gilbert, P. B., Janes, H., Kelley, C. F., Berman, M. A., Frank, I., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae689 · Cited by 8 · see citing works
Waning vaccine response to severe COVID-19 outcomes during omicron predominance in Thailand
Intawong, K., Chariyalertsak, S., Chalom, K., Wonghirundecha, T., Kowatcharakul, W., Thongprachum, A., Chotirosniramit, N., Noppakun, K., Khwanngern, K., Teacharak, W., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284130 · Cited by 8 · see citing works
Yang, F., Tran, T. N.-A., Howerton, E., Boni, M. F., & Servadio, J. L. (2023) · BMC Medicine · doi:10.1186/s12916-023-03025-z · Cited by 10 · see citing works
Covid-19 mortality: the Proportionality Hypothesis
Cairns, A. J. G., Blake, D. P., Kessler, A. R., Kessler, M., & Mathur, R. (2024) · European Actuarial Journal · doi:10.1007/s13385-024-00400-9 · Cited by 7 · see citing works
Wang, C. Y., Kuo, B.-S., Lee, Y.-H., Ho, Y.-H., Pan, Y., Yang, Y.-T., Chang, H.-C., Lin-fang, F., & Peng, W. (2024) · iScience · doi:10.1016/j.isci.2024.108887 · Cited by 7 · see citing works
Cherneha, M., Zydek, I., Braß, P., Korth, J., Jansen, S., Eßer, S., Karsten, C. B., Meyer, F., Kraiselburd, I., Dittmer, U., et al. (2024) · Vaccines · doi:10.3390/vaccines12070785 · Cited by 7 · see citing works
Bellavite, P., Donzelli, A., & Isidoro, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13237291 · Cited by 7 · see citing works
Nationwide analysis of COVID-19 death rate throughout the pandemic in Italy
Mattiuzzi, C., & Lippi, G. (2023) · Journal of Laboratory and Precision Medicine · doi:10.21037/jlpm-22-75 · Cited by 7 · see citing works
Li, H., Ping, F., Li, X., Wang, Z., Xiao, J., Jiang, H., Xue, Y., Quan, J., Yao, H., Zheng, X., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1172089 · Cited by 7 · see citing works
Semenzato, L., Botton, J., Vu, S. L., Jabagi, M.-J., Cuenot, F., Drouin, J., Dray‐Spira, R., Weill, A., & Zureik, M. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad460 · Cited by 7 · see citing works
Dari, A., Jacqmin, P., Iwaki, Y., Neyens, M., Gars, M. L., SADOFF, J. C., Hardt, K., Ruiz‐Guiñazú, J., & Ruixo, J. J. P. (2023) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.13025 · Cited by 6 · see citing works
Marron, L., Mateo‐Urdiales, A., O’Donnell, J., Robinson, E., & Domegan, L. M. (2024) · Eurosurveillance · doi:10.2807/1560-7917.es.2024.29.28.2300697 · Cited by 9 · see citing works
COVID‐19 vaccine effectiveness in children by age groups. A population‐based study in Galicia, Spain
Mallah, N., Pardo‐Seco, J., Ares‐Gómez, S., López‐Pérez, L., González‐Pérez, J., Rosón, B., Otero‐Barrós, M., Durán‐Parrondo, C., Nartallo‐Penas, V., Mirás‐Carballal, S., et al. (2023) · Pediatric Allergy and Immunology · doi:10.1111/pai.14037 · Cited by 6 · see citing works
Kumar, P., Parveen, P., Raj, N., Kumar, M., Fakhri, K. U., Kumar, S., Khan, A. A., Alanazi, A. M., Solanki, R., Harsha, H., et al. (2024) · Archives of Microbiology · doi:10.1007/s00203-023-03820-5 · Cited by 6 · see citing works
Shachor‐Meyouhas, Y., Dabaja‐Younis, H., Magid, A., Leiba, R., Szwarcwort‐Cohen, M., Almog, R., Mekel, M., Weissman, A., Hyams, G., Gepstein, V., et al. (2023) · Vaccines · doi:10.3390/vaccines11020283 · Cited by 6 · see citing works
Gui, Y., Cao, Y., He, J., Zhao, C., Zheng, W., Qian, L., Cheng, J., Yu, C., Chen, Y., Lou, K., et al. (2023) · Life Metabolism · doi:10.1093/lifemeta/load019 · Cited by 6 · see citing works
Rhodes, S., Demou, E., Wilkinson, J., Cherrie, M. P. C., Edge, R., Gittins, M., Katikireddi, S. V., Kromydas, T., Mueller, W., Pearce, N. E., et al. (2023) · Occupational and Environmental Medicine · doi:10.1136/oemed-2023-108931 · Cited by 6 · see citing works
Wang, L., Swayze, S., Bodner, K., Calzavara, A., Harrigan, S. P., Siddiqi, A., Baral, S. D., Austin, P. C., Smylie, J., Koh, M., et al. (2026) · American Journal of Epidemiology · doi:10.1093/aje/kwaf051 · Cited by 5 · see citing works
Pandemic Open Data: Blessing or Curse?
Rinner, C. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1001594 · Cited by 5 · see citing works
Mostafavi, F., Bahardoust, M., Sera, F., Amirabadizadeh, A., Allahyari, S., Ssentongod, P., Karami, M., & Nazari, S. S. H. (2024) · Journal of Research in Health Sciences · doi:10.34172/jrhs.2024.161 · Cited by 5 · see citing works
Zak, A. J., Hoang, T., Yee, C. M., Rizvi, S. M., Prabhu, P., & Wen, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914622 · Cited by 5 · see citing works
Prior COVID-19 Diagnosis, Severe Outcomes, and Long COVID among U.S. Adults, 2022
Nguyen, K. H., Bao, Y., Chen, S., Bednarczyk, R. A., Vasudevan, L., & Corlin, L. (2024) · Vaccines · doi:10.3390/vaccines12060669 · Cited by 5 · see citing works
Uemura, K., Ono, S., Michihata, N., Yamana, H., & Yasunaga, H. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-09488-6 · Cited by 5 · see citing works
Airway and Systemic Immune Responses Following the Third COVID-19 Vaccination in COPD Patients
Southworth, T. W., Jackson, N. A., & Singh, D. (2023) · International Journal of COPD · doi:10.2147/copd.s433269 · Cited by 5 · see citing works
Jones, R., & Ponomarenko, A. (2023) · Preprints.org · doi:10.20944/preprints202304.0248.v1 · Cited by 4 · see citing works
DeCuir, J., Surie, D., Zhu, Y., Lauring, A. S., Gaglani, M., McNeal, T., Ghamande, S. A., Peltan, I. D., Brown, S. M., Ginde, A. A., et al. (2024) · medRxiv · doi:10.1101/2024.01.07.24300910 · Cited by 5 · see citing works
Self-citationTsang, T. K., Sullivan, S. G., Meng, Y., Lai, F. T. T., Fan, M., Huang, X., Lin, Y., Peng, L., Zhang, C., Yang, B., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03597-4 · Cited by 4 · see citing works
Stoll, S. S., Desai, S., & Levit, E. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104574 · Cited by 4 · see citing works
Vaccine-induced or hybrid immunity and COVID-19-associated mortality during the Omicron wave
Weigert, M., Beyerlein, A., Katz, K., Schulte, R., Hartl, W. H., & Küchenhoff, H. (2023) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2023.0051 · Cited by 4 · see citing works
Exploring the potential benefits of mucosal COVID-19 vaccines: opportunities and challenges
Croda, J. (2023) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(23)00363-8 · Cited by 4 · see citing works
Paret, K., Beyhaghi, H., Herring, W. L., Mauskopf, J., Shane, L. G., & Rousculp, M. D. (2024) · Vaccines · doi:10.3390/vaccines12010074 · Cited by 4 · see citing works
Wu, S., Li, Y., Baral, S., Mishra, S., Koh, M., Golding, H., Kwong, J. C., & Wei, X. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299304 · Cited by 4 · see citing works
Assessing the dynamics and impact of COVID-19 vaccination on disease spread: A data-driven approach
Waseel, F., Streftaris, G., Rudrusamy, B., & Dass, S. C. (2024) · Infectious Disease Modelling · doi:10.1016/j.idm.2024.02.010 · Cited by 4 · see citing works
Harrigan, S. P., Fibke, C. D., García, H. A. V., Mak, S., Wilton, J., Prystajecky, N., Tyson, J. R., Wang, L., Sander, B., Baral, S., et al. (2024) · American Journal of Epidemiology · doi:10.1093/aje/kwae266 · Cited by 3 · see citing works
Alsaeed, A. A., Alkhalaf, A. M., Alomran, A. A., Alsfyani, W., Alhaddad, F., & Alhaddad, M. J. (2023) · Cureus · doi:10.7759/cureus.39234 · Cited by 4 · see citing works
Souan, L., Abdel‐Razeq, H., Zughbieh, M. A., Badr, S. A., & Sughayer, M. A. (2023) · Viruses · doi:10.3390/v15071439 · Cited by 3 · see citing works
Adly, H. M., Saleh, S. A. K., Garout, M. A., Abdulkhaliq, A. A., Khafagy, A. A., Saati, A. A., AlJahdali, I. A., Alandiyjany, M. N., & Al‐Tawfiq, J. A. (2023) · Journal of Epidemiology and Global Health · doi:10.1007/s44197-023-00146-9 · Cited by 4 · see citing works
A multi-country analysis of COVID-19 hospitalizations by vaccination status
Gonçalves, B. P., Jassat, W., Baruch, J., Hashmi, M., Rojek, A. M., Dasgupta, A., Martín‐Loeches, I., Reyes, L. F., Piubelli, C., Citarella, B. W., et al. (2023) · Med · doi:10.1016/j.medj.2023.08.005 · Cited by 4 · see citing works
van den Berg, J. M., Blom, M. T., Overbeek, J. A., Remmelzwaal, S., Herings, R. M. C., & Elders, P. J. M. (2025) · Vaccines · doi:10.3390/vaccines13060564 · Cited by 3 · see citing works
Wolff, M. J., Charpentier, P., Canals, A., Vial, C., Hormazábal, J., Cortés, J., & Silva, M. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.12.035 · Cited by 3 · see citing works
Manley, H. J., Li, N. C., Hsu, C. M., Weiner, D. E., Miskulin, D. C., Harford, A., Johnson, D. S., & Lacson, E. K., Jr. (2024) · Kidney360 · doi:10.34067/kid.0000000000000373 · Cited by 3 · see citing works
Nassoro, A. A., Millanzi, W. C., & Herman, P. Z. (2024) · Nursing Open · doi:10.1002/nop2.2171 · Cited by 3 · see citing works
Kale, D., Shoesmith, E., Herbeć, A., & Shahab, L. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-080778 · Cited by 3 · see citing works
- Authors
- Ferdinands, J. M., Rao, S., Dixon, B. E., Mitchell, P. K., DeSilva, M. B., Irving, S. A., Lewis, N., Natarajan, K., Stenehjem, E., Grannis, S. J., Han, J., McEvoy, C., Ong, T. C., Naleway, A. L., Reese, S. E., Embi, P. J., Dascomb, K., Klein, N. P., Griggs, E. P., Liao, I.-C., Yang, D.-H., Fadel, W. F., Grisel, N., Goddard, K., Patel, P., Murthy, K., Birch, R., Valvi, N. R., Arndorfer, J., Zerbo, O., Dickerson, M., Raiyani, C., Williams, J., Bozio, C. H., Blanton, L., Link-Gelles, R., Barron, M. A., Gaglani, M., Thompson, M. G., & Fireman, B.
- Affiliations
- Centers for Disease Control and Prevention (US)
- University of Colorado Anschutz (US)
- Regenstrief Institute (US)
- Westat (United States) (US)
- HealthPartners (US)
- Kaiser Permanente (US)
- NewYork–Presbyterian Hospital (US)
- Intermountain Healthcare (US)
- Columbia University Irving Medical Center (US)
- Baylor Scott & White Medical Center - Temple (US)
- Corresponding author
- Ferdinands, Jill M
- ORCID
- Ferdinands, Jill M
- Rao, Suchitra
- Dixon, Brian E
- Mitchell, Patrick K
- DeSilva, Malini B
- Irving, Stephanie A
- Lewis, Ned
- Natarajan, Karthik
- Stenehjem, Edward
- Grannis, Shaun J
- McEvoy, Charlene
- Ong, Toan C
- Naleway, Allison L
- Reese, Sarah E
- Dascomb, Kristin
- Klein, Nicola P
- Griggs, Eric P
- Liao, I-Chia
- Yang, Duck-Hye
- Fadel, William F
- Goddard, Kristin
- Patel, Palak
- Murthy, Kempapura
- Valvi, Nimish R
- Zerbo, Ousseny
- Dickerson, Monica
- Raiyani, Chandni
- Bozio, Catherine H
- Blanton, Lenee
- Barron, Michelle A
- Gaglani, Manjusha
- Thompson, Mark G
- Fireman, Bruce
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2022-10-03
- Volume
- 379
- Pages
- e072141
- ISSN
- 1756-1833 (ISSN-L)
- PMC
- PMC9527398
- OpenAlex
- W4300863078
- Cited by
- 185
- References
- 30
- Citations by year
- 2026: 5 · 2025: 23 · 2024: 63 · 2023: 88 · 2022: 5
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- BMJ (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by-nc)
- Funders
- National Center for Immunization and Respiratory Diseases
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- waning vaccine effectiveness, COVID-19 pandemic, SARS-CoV-2, mRNA vaccines, BNT162b2, mRNA-1273, booster vaccination, immunocompromised patients, hospitalization, emergency department visits, Omicron variant, Delta variant, adults, test-negative case-control, COVID-19 vaccination
- MeSH terms
- COVID-19, SARS-CoV-2, Vaccine Efficacy, BNT162 Vaccine, Humans, Case-Control Studies, Young Adult
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