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Cited by 315

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial

Open access
Verdon, F, Burnand, B, Stubi, C-L Fallab, Bonard, C, Graff, M, Michaud, A, Bischoff, T, de Vevey, M, Studer, J-P, Herzig, L, Chapuis, C, Tissot, J, Pécoud, A, Favrat, B·2003·BMJ
DOI 10.1136/bmj.326.7399.1124
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Abstract

Objective To determine the subjective response to iron therapy in non-anaemic women with unexplained fatigue. Design Double blind randomised placebo controlled trial. Setting Academic primary care centre and eight general practices in western Switzerland. Participants 144 women aged 18 to 55, assigned to either oral ferrous sulphate (80 mg/day of elemental iron daily; n=75) or placebo (n=69) for four weeks. Main outcome measures Level of fatigue, measured by a 10 point visual analogue scale. Results 136 (94%) women completed the study. Most had a low serum ferritin concentration; ≤ 20 μg/l in 69 (51%) women. Mean age, haemoglobin concentration, serum ferritin concentration, level of fatigue, depression, and anxiety were similar in both groups at baseline. Both groups were also similar for compliance and dropout rates. The level of fatigue after one month decreased by −1.82/6.37 points (29%) in the iron group compared with −0.85/6.46 points (13%) in the placebo group (difference 0.95 points, 95% confidence interval 0.32 to 1.62; P=0.004). Subgroups analysis showed that only women with ferritin concentrations ≤ 50 μg/l improved with oral supplementation. Conclusion Non-anaemic women with unexplained fatigue may benefit from iron supplementation. The effect may be restricted to women with low or borderline serum ferritin concentrations.

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Metadata

Authors
Verdon, F., Burnand, B., Stubi, C.-L. F., Bonard, C., Graff, M., Michaud, A., Bischoff, T., de Vevey, M., Studer, J.-P., Herzig, L., Chapuis, C., Tissot, J., Pécoud, A., & Favrat, B.
Venue
BMJ
Publisher
BMJ
Published
2003-05-22
Volume
326
Issue
7399
Pages
1124
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.326.7399.1124
OpenAlex
W2149408824
Cited by
315
References
2
FWCI
3.15
Type
journal article
Language
en
Open access
bronze

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