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Cited by 170Iron Metabolism and DisordersExercise and Physiological ResponsesErythropoietin and Anemia Treatment

Iron deficiency in sports-definition, influence on performance and therapy

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Clénin, German, Cordes, Mareike, Huber, Andreas, Schumacher, Yorck Olaf, Noack, Patrick, Scales, John, Kriemler, Susi·2015·Swiss Medical Weekly
DOI 10.4414/smw.2015.14196
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Abstract

Iron deficiency is frequent among athletes. All types of iron deficiency may affect physical performance and should be treated. The main mechanisms by which sport leads to iron deficiency are increased iron demand, elevated iron loss and blockage of iron absorption due to hepcidin bursts. As a baseline set of blood tests, haemoglobin, haematocrit, mean cellular volume, mean cellular haemoglobin and serum ferritin levels help monitor iron deficiency. In healthy male and female athletes >15 years, ferritin values <15 mcg are equivalent to empty, values from 15 to 30 mcg/l to low iron stores. Therefore a cut-off of 30 mcg/l is appropriate. For children aged from 6-12 years and younger adolescents from 12-15 years, cut-offs of 15 and 20 mcg/l, respectively, are recommended. As an exception in adult elite sports, a ferritin value of 50 mcg/l should be attained in athletes prior to altitude training, as iron demands in these situations are increased. Treatment of iron deficiency consists of nutritional counselling, oral iron supplementation or, in specific cases, by intravenous injection. Athletes with repeatedly low ferritin values benefit from intermittent oral substitution. It is important to follow up the athletes on an individual basis, repeating the baseline blood tests listed above twice a year. A long-term daily oral iron intake or i.v. supplementation in the presence of normal or even high ferritin values does not make sense and may be harmful.

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  • Serum ferritin concentrations are highly correlated with total body iron stores, and serum ferritin is used as a biomarker to estimate bodily iron stores.

    “As serum ferritin concentrations are highly correlated with total body iron stores, serum ferritin is used as a biomarker to estimate bodily iron stores [242].”

    From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [242]

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Research works printed but not linked: 11

  1. 1 Proposed nutrient and energy intakes for the European community: a report of the Scientific Committee for Food of the European community. Nutr Rev. 1993;51:209-12.
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Authors
Clénin, G., Cordes, M., Huber, A., Schumacher, Y. O., Noack, P., Scales, J., & Kriemler, S.
Affiliations
  • Kantonsspital Aarau (CH)
  • Qatar Orthopaedic and Sports Medicine Hospital (QA)
  • University of Zurich (CH)
ORCID
Venue
Swiss Medical Weekly
Publisher
SMW Supporting Association
Published
2015-10-18
Volume
145
Issue
4344
Pages
w14196
ISSN
  • 0036-7672 (ISSN-L)
  • 1424-3997
DOI
10.4414/smw.2015.14196
OpenAlex
W1883754188
Cited by
170
References
96
Citations by year
2026: 12 · 2025: 24 · 2024: 16 · 2023: 31 · 2022: 18 · 2021: 13 · 2020: 15 · 2019: 15 · 2018: 17 · 2017: 6 · 2016: 2 · 2015: 1
FWCI
1.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Swiss Medical Weekly (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-nd)
  • Zurich Open Repository and Archive (University of Zurich)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Keywords
iron deficiency, athletes, physical performance, serum ferritin, hepcidin, iron absorption, iron supplementation, altitude training, iron deficiency anemia, nutrition counseling, children and adolescents
MeSH terms
Adolescent, Adult, Child, Female, Ferritins, Hematocrit, Hemoglobins, Humans, Iron, Male, Anemia, Iron-Deficiency, Iron, Dietary, Dietary Supplements, Athletic Performance, Young Adult, Athletes

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