Frontotemporal dementia
Open accessAbstract
Frontotemporal dementia refers to a diverse group of conditions that collectively are a major cause of young onset dementia Frontotemporal dementia produces selective brain atrophy involving the frontal and temporal lobes, requiring brain magnetic resonance imaging for accurate diagnosis Clinically, these diseases present chiefly as progressive aphasia or as disintegration of personality and behaviour that may be misdiagnosed as a psychiatric disorder Up to around a quarter of cases arise from dominant mutations in one of three major causative genes Frontotemporal dementia is commonly associated with other neurological impairment, in particular parkinsonism or motor neurone disease Treatment remains supportive, but patients and families need extensive counselling, future planning, and involvement of social and mental health services Sources and selection criteriaWe examined recent literature on frontotemporal dementia, targeting full text English language studies published since 1990.We selected articles on the basis of our personal knowledge and searches of the Medline database using the terms "frontotemporal dementia," "frontotemporal lobar degeneration," "progressive nonfluent aphasia," "semantic dementia," and "logopenic aphasia," and each of these terms in conjunction with "diagnosis," "treatment," and "therapy."The final selection of references was based on our judgment of relevance, completeness, and compatibility with recent clinical, pathological, and genetic criteria.
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The differential diagnosis of frontotemporal dementia (FTD) remains challenging due to clinical and pathological heterogeneity and symptomatic overlap with other neurodegenerative and psychiatric disorders.
“Due to its clinical and pathological heterogeneity and symptomatic overlap with other neurodegenerative diseases, such as Alzheimer’s disease (AD), and other non-neurodegenerative psychiatric disorders, the differential diagnosis of FTD remains challenging [2, 7–9].”
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- Authors
- Warren, J. D., Rohrer, J. D., & Rossor, M. N.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Warren, J. D.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2013-08-06
- Volume
- 347
- Issue
- aug12 3
- Pages
- f4827-f4827
- ISSN
- 1756-1833 (ISSN-L)
- PMC
- PMC3735339
- OpenAlex
- W349712691
- Cited by
- 292
- References
- 37
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 15 · 2023: 20 · 2022: 32 · 2021: 27 · 2020: 21 · 2019: 30 · 2018: 27 · 2017: 19 · 2016: 31 · 2015: 24 · 2014: 17
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (091673)
- National Institute for Health and Care Research (NF-SI-0512-10033, NF-SI-0508-10123)
- Medical Research Council (MR/J009482/1)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- frontotemporal dementia, frontotemporal lobar degeneration, progressive nonfluent aphasia, semantic dementia, logopenic aphasia, early-onset dementia, brain atrophy, frontal and temporal lobes, genetic mutations, parkinsonism, motor neuron disease, diagnosis, treatment, supportive care, family counseling
- MeSH terms
- Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Disease Management, Frontotemporal Dementia
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