Intermittent Fasting: A Promising Approach for Preventing Vascular Dementia
Open accessAbstract
Vascular dementia is the most common neuropsychiatric syndrome and is characterized by synaptic dysfunction, neuroinflammation, and cognitive dysfunction. Vascular dementia is associated with various environmental, genetic, and lifestyle risk factors. Recent research has focused on the association between vascular dementia and dietary patterns, suggesting that dietary regulation leads to better control of energy metabolism, improvements in brain insulin resistance, and the suppression of neuroinflammation. Intermittent fasting is a calorie-restriction method known to be more effective in promoting fat loss and regulating the impairment of glucose metabolism as compared with other dietary restriction regimens. Herein, the authors review the effects of intermittent fasting with regard to vascular dementia based on recent evidence and propose that intermittent fasting could be a therapeutic approach for ameliorating vascular dementia pathology and preventing its onset.
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Dietary approaches in terms of nutrition supplementation or nutritional guidance ameliorate both cognition and function of prodromal and mild AD patients.
“Finally, dietary approaches in terms of nutrition supplementation, such as combined formulation of specific active ingredients or probiotics, or nutritional guidance, such as fasting intermitting or Mediterranean diet, ameliorate both cognition and function of prodromal and mild AD patients [200,201,202].”
From Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies (2023) · cites this paper as [202]
The Conclusions (page not available) report evidence that intermittent fasting improves cognitive dysfunction and memory deficits in dementia. The paper presents fasting as a potential therapy, but does not establish that it improves both cognition and daily functioning in patients with prodromal or mild Alzheimer’s disease. (LLM, conf=0.85)
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Flavonoids and neurodegeneration: Structure-activity relationship and therapeutic insights
Paragas, D. S., Ortinero, C., Feliciano, M. A. M., Lazaro, S. E., Quitos, L. S., Gonzales, R. L., Hsieh, C.-Y., Chen, B.-Y., Hsueh, C., & Tsai, P. (2026) · Studies in natural products chemistry · doi:10.1016/b978-0-443-49142-9.00010-x
- Authors
- Yoon, G., & Song, J.
- Affiliations
- Chonnam National University (KR)
- Corresponding author
- Song, Juhyun
- Venue
- Journal of Lipid and Atherosclerosis
- Publisher
- XMLink
- Published
- 2019
- Volume
- 8
- Issue
- 1
- Pages
- 1
- ISSN
- 2287-2892 (ISSN-L)
- 2288-2561
- PMC
- PMC7379085
- OpenAlex
- W2945904746
- Cited by
- 20
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 2 · 2021: 2
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Lipid and Atherosclerosis (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2016R1D1A1B03930394)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- intermittent fasting, vascular dementia, caloric restriction, neuroinflammation, brain insulin resistance, glucose metabolism, dietary habits, synaptic dysfunction, cognitive impairment, dementia prevention
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