GRADE approach to drawing conclusions from a network meta-analysis using a minimally contextualised framework
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This article describes GRADE (grading of recommendations assessment, development and evaluation) guidance on how to draw conclusions from a network meta-analysis of interventions that includes individual randomised controlled trials addressing a single outcome. The guidance uses a minimally contextualised approach that avoids value judgments regarding the magnitude of intervention effects. The framework is based on two principles: interventions should be grouped in categories, from the most to the least effective or harmful; and the judgments that place interventions in such categories should simultaneously consider the estimates of effect, the certainty of the evidence, and the rankings. The framework includes five steps, which we describe and illustrate using an example. The framework is simple, methodologically sound, and flexible, allowing for modifications to resolve situations in which additional complexity or value judgments might be appropriate.
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Confidence in the evidence for the primary outcomes was evaluated using CINeMA, and conclusions were drawn using a minimally contextualised framework of the GRADE approach.
“We evaluated confidence in the evidence for the primary outcomes using CINeMA (Confidence-In-Network-Meta-Analysis), 14 and conclusions were drawn using a minimally contextualised framework of the GRADE approach.15”
From Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis (2023) · cites this paper as [15]
The GRADE framework was used to assess the overall quality of evidence and main findings were presented according to GRADE guidance for network meta-analysis.
“We used the GRADE framework to assess the overall quality of evidence and presented our main findings according to GRADE guidance for NMA. 42 , 46”
From Exercise for sarcopenia in older people: A systematic review and network meta‐analysis (2023) · cites this paper as [42]
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Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Puhan, M. A., Schunemann, H. J., Murad, M. H., Li, T., Brignardello-Petersen, R., Singh, J. A., Kessels, A. G., Guyatt, G. H., & for the GRADE Working Group (2014) · BMJ · doi:10.1136/bmj.g5630 · Cited by 1,812 · see citing works
Self-citationAndrews, J. C., Schünemann, H. J., Oxman, A. D., Pottie, K. C., Meerpohl, J. J., Alonso‐Coello, P., Rind, D. M., Montori, V. M., Brito, J. P., Norris, S. L., et al. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2013.02.003 · Cited by 1,332 · see citing works
Self-citationAlonso-Coello, P., Schünemann, H. J., Moberg, J., Brignardello-Petersen, R., Akl, E. A., Davoli, M., Treweek, S., Mustafa, R. A., Rada, G., Rosenbaum, S., et al. (2016) · BMJ · doi:10.1136/bmj.i2016 · Cited by 1,317 · see citing works
Self-citationSantesso, N., Glenton, C., Dahm, P., Garner, P., Akl, E. A., Alper, B., Brignardello-Petersen, R., Carrasco-Labra, A., De Beer, H., Hultcrantz, M., et al. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2019.10.014 · Cited by 1,198 · see citing works
Self-citationThe GRADE Working Group clarifies the construct of certainty of evidence
Hultcrantz, M., Rind, D., Akl, E. A., Treweek, S., Mustafa, R. A., Iorio, A., Alper, B. S., Meerpohl, J. J., Murad, M. H., Ansari, M. T., et al. (2017) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2017.05.006 · Cited by 853 · see citing works
Self-citationAlonso-Coello, P., Oxman, A. D., Moberg, J., Brignardello-Petersen, R., Akl, E. A., Davoli, M., Treweek, S., Mustafa, R. A., Vandvik, P. O., Meerpohl, J., et al. (2016) · BMJ · doi:10.1136/bmj.i2089 · Cited by 814 · see citing works
Self-citationAdvances in the GRADE approach to rate the certainty in estimates from a network meta-analysis
Brignardello-Petersen, R., Bonner, A., Alexander, P. E., Siemieniuk, R. A., Furukawa, T. A., Rochwerg, B., Hazlewood, G. S., Alhazzani, W., Mustafa, R. A., Murad, M. H., et al. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2017.10.005 · Cited by 753 · see citing works
Self-citationCompleting ‘Summary of findings’ tables and grading the certainty of the evidence
Schünemann, H. J., Higgins, J. P., Vist, G. E., Glasziou, P., Akl, E. A., Skoetz, N., Guyatt, G. H., & on behalf of the Cochrane GRADEing Methods Group (formerly Applicability and Recommendations Methods Group) and the Cochrane Statistical Methods Group (2019) · Cochrane Handbook for Systematic Reviews of Interventions · doi:10.1002/9781119536604.ch14 · Cited by 669 · see citing works
Self-citationSchünemann, H. J., Wiercioch, W., Brożek, J., Etxeandia‐Ikobaltzeta, I., Mustafa, R. A., Manja, V., Brignardello‐Petersen, R., Neumann, I., Falavigna, M., Alhazzani, W. A., et al. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.09.009 · Cited by 652 · see citing works
Self-citationSchünemann, H. J., Mustafa, R., Brozek, J., Santesso, N., Alonso-Coello, P., Guyatt, G., Scholten, R., Langendam, M., Leeflang, M. M., Akl, E. A., et al. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.01.032 · Cited by 350 · see citing works
Self-citationFluid Resuscitation in Sepsis: A Systematic Review and Network Meta-analysis
Rochwerg, B., Alhazzani, W., Sindi, A., Heels-Ansdell, D., Thabane, L., Fox-Robichaud, A., Mbuagbaw, L., Szczeklik, W., Alshamsi, F., Altayyar, S., et al. (2014) · Annals of Internal Medicine · doi:10.7326/m14-0178 · Cited by 309 · see citing works
Self-citationZhang, Y., Alonso‐Coello, P., Guyatt, G. H., Yepes-Núñez, J. J., Akl, E. A., Hazlewood, G. S., Hernandez, H. P., Etxeandia‐Ikobaltzeta, I., Qaseem, A., Williams, J. W., et al. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.05.011 · Cited by 287 · see citing works
Self-citationZhang, Y., Alonso‐Coello, P., Guyatt, G. H., Yepes-Núñez, J. J., Akl, E. A., Hazlewood, G. S., Hernandez, H. P., Etxeandia‐Ikobaltzeta, I., Qaseem, A., Williams, J. W., et al. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.01.013 · Cited by 281 · see citing works
Self-citationMorgan, R. L., Preidis, G. A., Kashyap, P. C., Weizman, A. V., Sadeghirad, B., Chang, Y., Florez, I. D., Foroutan, F., Shahid, S., & Zeraatkar, D. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.096 · Cited by 246 · see citing works
Development of the summary of findings table for network meta-analysis
Yepes-Nuñez, J. J., Li, S.-A., Guyatt, G., Jack, S. M., Brozek, J. L., Beyene, J., Murad, M. H., Rochwerg, B., Mbuagbaw, L., Zhang, Y., et al. (2019) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2019.04.018 · Cited by 218 · see citing works
Self-citationUncertainty in Treatment Rankings: Reanalysis of Network Meta-analyses of Randomized Trials
Trinquart, L., Attiche, N., Bafeta, A., Porcher, R., & Ravaud, P. (2016) · Annals of Internal Medicine · doi:10.7326/m15-2521 · Cited by 202 · see citing works
GRADE approach to rate the certainty from a network meta-analysis: addressing incoherence
Brignardello‐Petersen, R., Mustafa, R. A., Siemieniuk, R. A. C., Murad, M. H., Agoritsas, T., Izcovich, A., Schünemann, H. J., & Guyatt, G. H. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.11.025 · Cited by 202 · see citing works
Self-citationHazlewood, G. S., Barnabe, C. C. M., TOMLINSON, G. A., Marshall, D. A., Devoe, D. J. A., & Bombardier, C. (2016) · BMJ · doi:10.1136/bmj.i1777 · Cited by 193 · see citing works
Self-citationBrignardello‐Petersen, R., Murad, M. H., Walter, S. D., McLeod, S. L., Carrasco‐Labra, A., Rochwerg, B. N., Schünemann, H. J., TOMLINSON, G. A., & Guyatt, G. H. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.08.022 · Cited by 174 · see citing works
Self-citationAlhazzani, W. A., Alshamsi, F. E., Belley‐Côté, E. P., Heels‐Ansdell, D., Brignardello‐Petersen, R., Alquraini, M., Perner, A., Møller, M. H., Krag, M., Almenawer, S. A., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-5005-8 · Cited by 165 · see citing works
Self-citationBrignardello‐Petersen, R., Izcovich, A., Rochwerg, B. N., Flórez, I. D., Hazlewood, G. S., Alhazanni, W., Yepes-Núñez, J. J., Santesso, N. A., Guyatt, G. H., & Schünemann, H. J. (2020) · BMJ · doi:10.1136/bmj.m3907 · Cited by 152 · see citing works
Self-citationHazlewood, G. S., Barnabe, C. C. M., TOMLINSON, G. A., Marshall, D. A., Devoe, D. J. A., & Bombardier, C. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010227.pub2 · Cited by 145 · see citing works
Self-citationTreatment of idiopathic pulmonary fibrosis: a network meta-analysis
Rochwerg, B., Neupane, B., Zhang, Y., Garcia, C. C., Raghu, G., Richeldi, L., Brozek, J., Beyene, J., & Schünemann, H. (2016) · BMC Medicine · doi:10.1186/s12916-016-0558-x · Cited by 101 · see citing works
Self-citationFlorez, I. D., Veroniki, A.-A., Al Khalifah, R., Yepes-Nuñez, J. J., Sierra, J. M., Vernooij, R. W. M., Acosta-Reyes, J., Granados, C. M., Pérez-Gaxiola, G., Cuello-Garcia, C., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0207701 · Cited by 87 · see citing works
Self-citationSchünemann, H. J. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.03.018 · Cited by 76 · see citing works
Self-citationAntiemetics in Children With Acute Gastroenteritis: A Meta-analysis
Niño-Serna, L. F., Acosta-Reyes, J. L., Veroniki, A. A., & Flórez, I. D. (2020) · PEDIATRICS · doi:10.1542/peds.2019-3260 · Cited by 61 · see citing works
Methods for Development of the European Commission Initiative on Breast Cancer Guidelines
Schünemann, H. J., Donata, L., Dimitrova, N., Alonso‐Coello, P., Gräwingholt, A., Quinn, C., Follmann, M., Mansel, R. E., Sardanelli, F., Rossi, P. G., et al. (2019) · Annals of Internal Medicine · doi:10.7326/m18-3445 · Cited by 58 · see citing works
Self-citationWhat is a network meta-analysis and how can we use it to inform clinical practice?
Brignardello‐Petersen, R., Rochwerg, B. N., & Guyatt, G. H. (2014) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.2546 · Cited by 20 · see citing works
Self-citationZeng, L., Qasim, A., Neogi, T., FitzGerald, J. D., Dalbeth, N., Mikuls, T. R., Guyatt, G. H., & Brignardello‐Petersen, R. (2020) · Arthritis Care & Research · doi:10.1002/acr.24402 · Cited by 18 · see citing works
Self-citationLytvyn, L., Zeraatkar, D., Anbari, A. B., Ginex, P., Zoratti, M. J., Niburski, K., Sadeghirad, B., Siedler, M. R., Thabane, L., & Morgan, R. L. (2020) · Oncology nursing forum · doi:10.1188/20.onf.e171-e189 · Cited by 13 · see citing works
Individual opioids, and long- versus short-acting opioids, for chronic noncancer pain
Noori, A., Busse, J. W., Sadeghirad, B., Siemieniuk, R. A. C., Wang, L., Couban, R., Juurlink, D. N., Thabane, L., & Guyatt, G. H. (2019) · Medicine · doi:10.1097/md.0000000000017647 · Cited by 6 · see citing works
Self-citationβ‑blockers in heart failure – are all created equal?
Brignardello‐Petersen, R., & Guyatt, G. H. (2013) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1720 · Cited by 4 · see citing works
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Neumann, I., Brignardello‐Petersen, R., & Guyatt, G. H. (2014) · Annals of Internal Medicine · doi:10.7326/0003-4819-160-4-201402180-02003 · Cited by 3 · see citing works
Self-citationSadeghirad, B., Flórez, I. D., Morgan, R. L., Foroutan, F., Chang, Y., Zeraatkar, D., Bała, M. M., Shahid, S., Lu, T., Ge, L., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3354688 · Cited by 3 · see citing works
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- Hutton B, Hersi M, Cheng W, et al. Comparison of the effects of natural health products, pharmacologics, physical activity, psychologic therapy and combination interventions on hot flash frequency and intensity in patients with a history of breast and prostate cancer: a systematic review with meta-analyses. J Oncol Nurs [forthcoming].
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Shen, Y., Shi, Q., Nong, K., Li, S., Yue, J., Huang, J., Dong, B., Beauchamp, M., & Hao, Q. (2023) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.13225 · Cited by 464 · see citing works
Shi, Q., Wang, Y., Hao, Q., Vandvik, P. O., Guyatt, G., Li, J., Chen, Z., Xu, S., Shen, Y., Ge, L., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)01640-8 · Cited by 279 · see citing works
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Pitre, T., Zeraatkar, D., Kachkovski, G. V., Leung, G., Shligold, E., Dowhanik, S., Angriman, F., Ferreyro, B. L., Scales, D. C., & Rochwerg, B. N. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.04.022 · Cited by 60 · see citing works
Balasubramanian, P., Abia‐Trujillo, D., Barrios-Ruiz, A., Garza-Salas, A., Koratala, A., Chandra, N. C., Lee‐Mateus, A. Y., Gonzalo Labarca, T., & Fernández-Bussy, S. (2024) · European Respiratory Review · doi:10.1183/16000617.0046-2024 · Cited by 59 · see citing works
Yao, L., Sadeghirad, B., Li, M., Li, J., Wang, Q., Crandon, H. N., Martin, G., Morgan, R., Florez, I. D., Hunskaar, B. S., et al. (2023) · BMJ · doi:10.1136/bmj-2023-076226 · Cited by 57 · see citing works
Self-citationPozuelo‐Carrascosa, D. P., Cobo‐Cuenca, A. I., Carmona‐Torres, J. M., Laredo‐Aguilera, J. A., Santacruz‐Salas, E., & Fernández-Rodríguez, R. (2022) · Journal of Intensive Care · doi:10.1186/s40560-022-00600-z · Cited by 62 · see citing works
Yang, Q., Lang, Y., Yang, W., Yang, F., Yang, J., Wu, Y., Xiao, X., Qin, C., Zou, Y., Zhao, Y., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110592 · Cited by 59 · see citing works
Wang, X., Martin, G., Sadeghirad, B., Chang, Y., Flórez, I. D., Couban, R., Mehrabi, F., Crandon, H. N., Esfahani, M. A., Sivananthan, L., et al. (2025) · BMJ · doi:10.1136/bmj-2024-079971 · Cited by 59 · see citing works
Self-citationMiroshnychenko, A., Ibrahim, S., Azab, M., Roldán, Y., Martinez, J. P. D., Tamilselvan, D., He, L., Little, J. W., Urquhart, O., Tampi, M. P., et al. (2023) · Journal of Dental Research · doi:10.1177/00220345221139230 · Cited by 57 · see citing works
Self-citationMastrantoni, L., Chiaravalli, M., Spring, A., Beccia, V., Bello, A. D., Bagalá, C., Bensi, M., Barone, D., Trovato, G., Caira, G., et al. (2024) · The Lancet Oncology · doi:10.1016/s1470-2045(24)00511-4 · Cited by 56 · see citing works
Ye, Z., Wang, Y., Ge, L., Guyatt, G. H., Collister, D., Alhazzani, W. A., Bagshaw, S. M., Belley‐Côté, E. P., Fang, F., Hou, L., et al. (2021) · Critical Care Explorations · doi:10.1097/cce.0000000000000399 · Cited by 55 · see citing works
Self-citationSharif, S., Kang, J., Sadeghirad, B., Rizvi, F., Forestell, B., Greer, A., Hewitt, M. K., Fernando, S. M., Mehta, S., Eltorki, M., et al. (2024) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.11.050 · Cited by 57 · see citing works
Moncion, K., Rodrigues, L., Wiley, E., Noguchi, K. S., Negm, A. M., Richardson, J. A., MacDonald, M. J., Roig, M., & Tang, A. (2024) · British Journal of Sports Medicine · doi:10.1136/bjsports-2023-107956 · Cited by 52 · see citing works
Chen, R., Guo, Y., Kuang, Y., & Zhang, Q. (2024) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2024.104698 · Cited by 50 · see citing works
Marcucci, M., Etxeandia‐Ikobaltzeta, I., Yang, S. S., Germini, F., Gupta, S., Agarwal, A., Ventresca, M., Tang, S., Morgano, G. P., Wang, M., et al. (2022) · BMJ · doi:10.1136/bmj-2021-066785 · Cited by 48 · see citing works
Self-citationMedications for adults with type 2 diabetes: a living systematic review and network meta-analysis
Nong, K., Jeppesen, B. T., Shi, Q., Agoritsas, T., Guyatt, G. H., White, H., Gao, Y., Agarwal, A., Macdonald, H., Zou, X., et al. (2025) · BMJ · doi:10.1136/bmj-2024-083039 · Cited by 48 · see citing works
Self-citationLü, Y., Zhu, H., Wang, Q., Tian, C., Lai, H., Hou, L., Liu, Y., Gao, Y., Liu, M., Yang, F., et al. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.03.012 · Cited by 42 · see citing works
Pan, B., Ge, L., Lai, H., Hou, L., Tian, C., Wang, Q., Yang, K., Lü, Y., Zhu, H., Li, M., et al. (2023) · Drugs · doi:10.1007/s40265-023-01859-8 · Cited by 44 · see citing works
Gu, Y., Sun, L., Zhang, W., Kong, T., Zhou, R., He, Y., Deng, C., Yang, L., Kong, J., Chen, Y., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1102792 · Cited by 46 · see citing works
Low, C. J. W., Ling, R. R., Lau, M. P. X. L., Liu, N. S. H., Tan, M., Tan, C. S., Lim, S. L., Rochwerg, B. N., Combes, A., Brodie, D., et al. (2024) · Intensive Care Medicine · doi:10.1007/s00134-023-07278-3 · Cited by 42 · see citing works
Noninvasive respiratory support after extubation: a systematic review and network meta-analysis
Boscolo, A., Pettenuzzo, T., Sella, N., Zatta, M., Salvagno, M., Tassone, M., Pretto, C., Peralta, A., Muraro, L., Zarantonello, F., et al. (2023) · European Respiratory Review · doi:10.1183/16000617.0196-2022 · Cited by 39 · see citing works
Nochaiwong, S., Chuamanochan, M., Ruengorn, C., Awiphan, R., Tovanabutra, N., & Chiewchanvit, S. (2021) · JAMA Dermatology · doi:10.1001/jamadermatol.2021.3237 · Cited by 40 · see citing works
Pitre, T., Kiflen, M., Helmeczi, W., Dionne, J. C., Rewa, O. G., Bagshaw, S. M., Needham-Nethercott, N., Alhazzani, W. A., Zeraatkar, D., & Rochwerg, B. N. (2022) · Critical Care Medicine · doi:10.1097/ccm.0000000000005595 · Cited by 39 · see citing works
A clinician’s guide to network meta-analysis
Phillips, M., STEEL, D. H., Wykoff, C. C., Busse, J. W., Bannuru, R. R., Thabane, L., Bhandari, M., Chaudhary, V., for the Retina Evidence Trials InterNational Alliance (R.E.T.I.N.A.) Study Group, Sivaprasad, S., et al. (2022) · Eye · doi:10.1038/s41433-022-01943-5 · Cited by 39 · see citing works
A comparison of the effectiveness of biologic therapies for asthma
Pitre, T., Jassal, T., Angjeli, A., Jarabana, V., Nannapaneni, S., Umair, A., Hussain, M., Leung, G., Kirsh, S., Su, J. S., et al. (2022) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2022.12.018 · Cited by 44 · see citing works
Deng, M., Wen, Y., Yan, J., Fan, Y., Wang, Z., Zhang, R., Ren, L., Ba, Y., Wang, H., Lü, Q., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03129-6 · Cited by 40 · see citing works
Brignardello‐Petersen, R., & Guyatt, G. H. (2024) · American Journal of Epidemiology · doi:10.1093/aje/kwae260 · Cited by 41 · see citing works
Self-citationKhera, R., Schuemie, M. J., Lu, Y., Ostropolets, A., Chen, R., Hripcsak, G., Ryan, P. B., Krumholz, H. M., & Suchard, M. A. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-057977 · Cited by 37 · see citing works
Phillips, M., Sadeghirad, B., Busse, J. W., Brignardello‐Petersen, R., Cuello‐García, C. A., Nampo, F. K., Guo, Y. J., Bzovsky, S., Bannuru, R. R., Thabane, L., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-056400 · Cited by 36 · see citing works
Self-citationTopical anti-inflammatory treatments for eczema: network meta-analysis
Lax, S. J., Vogt, E. V., Candy, B., Steele, L., Reynolds, C. M., Stuart, B. L., Parker, R., Axon, E., Roberts, A., Doyle, M., et al. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015064.pub2 · Cited by 36 · see citing works
Epinephrine in Out-of-Hospital Cardiac Arrest
Fernando, S. M., Mathew, R., Sadeghirad, B., Rochwerg, B. N., Hibbert, B. M., Munshi, L., Fan, E., Brodie, D., Santo, P. D., Tran, A., et al. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.01.033 · Cited by 34 · see citing works
Fernando, S. M., Mathew, R., Sadeghirad, B., Brodie, D., Belley‐Côté, E. P., Thiele, H., van Diepen, S., Fan, E., Santo, P. D., Simard, T., et al. (2022) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-022-02337-7 · Cited by 33 · see citing works
Bognanni, A., Chu, D. K., Rank, M. A., Bernstein, J., Ellis, A. K., Golden, D. B. K., Greenhawt, M., Hagan, J. B., Horner, C. C., Ledford, D. K., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.07.023 · Cited by 32 · see citing works
Pettenuzzo, T., Boscolo, A., Pistollato, E., Pretto, C., Giacon, T. A., Frasson, S., Carbotti, F. M., Medici, F., Pettenon, G., Carofiglio, G., et al. (2024) · Critical Care · doi:10.1186/s13054-024-04924-0 · Cited by 32 · see citing works
Stahl‐Pehe, A., Mashhadi, N. S., Wirth, M., Schlesinger, S., Kuß, O., Holl, R. W., Bächle, C., Warz, K.-D., Bürger-Büsing, J., Spörkel, O., et al. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103190 · Cited by 36 · see citing works
Xu, Z., Sun, W. J., Zhang, D., Chung, V. C., Sit, R. W. S., & Wong, S. Y. S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.653340 · Cited by 32 · see citing works
Chu, A. W. L., Oykhman, P., Chu, X., Rayner, D. G., Bhangal, S., Dam, A., Xu, J. H., Sheikh, J. K., Trayes, K. P., Frazier, W. T., et al. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.06.004 · Cited by 32 · see citing works
Using GRADE evidence to decision frameworks to choose from multiple interventions
Piggott, T., Brożek, J., Nowak, A. J., Dietl, H., Dietl, B., Saz‐Parkinson, Z., Mirzayev, F., González-Angulo, L., Yepes-Núñez, J. J., Mustafa, R. A., et al. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2020.10.016 · Cited by 31 · see citing works
Self-citationdeSouza, I. S., Thode, H. C., Shrestha, P., Allen, R. W., Koos, J. A., & Singer, A. J. (2021) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2021.11.011 · Cited by 30 · see citing works
Progress and challenges of network meta‐analysis
Tian, J., Gao, Y., Zhang, J., Yang, Z., Dong, S., Zhang, T., Sun, F., Wu, S., Wu, J., Wang, J., et al. (2021) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12443 · Cited by 28 · see citing works
Pitre, T., Su, J. S., Cui, S., Scanlan, R., Chiang, C., Husnudinov, R., Khalid, M. F., Khan, N., Leung, G., Mikhail, D., et al. (2022) · European Respiratory Review · doi:10.1183/16000617.0036-2022 · Cited by 30 · see citing works
Pitre, T., Mah, J. C., Roberts, S., Desai, K., Gu, Y., Ryan, C. M., Busse, J. W., & Zeraatkar, D. (2023) · Annals of Internal Medicine · doi:10.7326/m22-3473 · Cited by 27 · see citing works
Yu, X., Li, X., Du, Z.-R., Zhang, Y., Fei, Y., Tang, W.-P., Li, X., & Zhao, Q. S. (2024) · BMC Medicine · doi:10.1186/s12916-024-03491-z · Cited by 25 · see citing works
Ho, L. T. F., Zhong, C. C., Wong, C. H. L., Wu, J. C., Chan, K. K., Wu, X., Leung, T. H., & Chung, V. C. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00556-6 · Cited by 26 · see citing works
Xie, C.-R., Tang, B., Shi, Y., Peng, W.-Y., Ye, K., Tao, Q., Yu, S., Zheng, H., & Chen, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.853011 · Cited by 26 · see citing works
How to Promote Gerotranscendence in Older Adults? A Scoping Review of Interventions
Abreu, T., Araújo, L., & Ribeiro, Ó. M. (2023) · Journal of Applied Gerontology · doi:10.1177/07334648231169082 · Cited by 23 · see citing works
Zhou, H., Liao, Y., Zhou, X., Peng, Z., Xu, S., Shi, S., Liu, L., Hao, L., & Yang, W. Q. (2023) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2023-0118 · Cited by 24 · see citing works
Sud, S., Fan, E., Adhikari, N. K. J., Friedrich, J. O., Ferguson, N. D., Combes, A., Guérin, C., & Guyatt, G. H. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07492-7 · Cited by 24 · see citing works
Self-citationDifferent doses of dual orexin receptor antagonists in primary insomnia: a Bayesian network analysis
Xue, T., Wu, X., Li, J., Chen, S., Wang, Z., Tan, X., Wang, Z., & Zhang, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1175372 · Cited by 22 · see citing works
Huang, S., Xu, J., Wang, H., Li, Z., Song, R., Zhang, Y., Lu, M., Han, X., Ma, T., Wang, Y., et al. (2024) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0012405 · Cited by 26 · see citing works
Pharmacologic Management of Acute Pain in Children
Olejnik, L. J., Lima, J. P., Sadeghirad, B., Busse, J. W., Flórez, I. D., Ali, S., Bunker, J., Jomaa, D., Bleik, A., & Eltorki, M. (2025) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2024.5920 · Cited by 23 · see citing works
Guo, J., Liu, K., Liao, Y., Qin, Y., & Yue, W. (2024) · Schizophrenia · doi:10.1038/s41537-023-00426-0 · Cited by 26 · see citing works
Shahinfar, H., Jayedi, A., Torabynasab, K., Payandeh, N., Martami, F., Moosavi, H., Bazshahi, E., & Shab‐Bidar, S. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106944 · Cited by 22 · see citing works
Noori, A., Sadeghirad, B., Wang, L., Siemieniuk, R. A. C., Shokoohi, M., Kum, E., Jeddi, M., Montoya, L., Hong, P. J., Zhou, E., et al. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.05.031 · Cited by 19 · see citing works
Self-citationHerbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-analysis
Hoang, M. P., Seresirikachorn, K., Chitsuthipakorn, W., & Snidvongs, K. (2023) · Current Allergy and Asthma Reports · doi:10.1007/s11882-022-01060-z · Cited by 20 · see citing works
Assessment of optimal combinations of therapeutic probiotics for depression, anxiety, and stress
Yang, Y., Yang, L., Wan, M., Pan, D., Sun, G., & Yang, C. (2024) · Psychological Medicine · doi:10.1017/s0033291724000679 · Cited by 20 · see citing works
Zang, W., Zhu, J., Xiao, N., Fang, M., Li, D., Li, H., Yan, J. H., Jing, H., & Wang, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28633 · Cited by 23 · see citing works
Queiroz, I., Barbosa, L., Ruelas, M. G., Araújo, B., Defante, M. L. R., Tavares, A. H., de Mesquita, C. F., Pimentel, T., Mendes, B. X., Félix, I. F., et al. (2025) · Anaesthesia · doi:10.1111/anae.16757 · Cited by 19 · see citing works
Chitsuthipakorn, W., Hoang, M. P., Kanjanawasee, D., Seresirikachorn, K., & Snidvongs, K. (2023) · Current Allergy and Asthma Reports · doi:10.1007/s11882-023-01116-8 · Cited by 19 · see citing works
Leg Cycle Ergometry in Critically Ill Patients — An Updated Systematic Review and Meta-Analysis
O’Grady, H. K., Hasan, H., Rochwerg, B. N., Cook, D. J., Takaoka, A., Utgikar, R., Reid, J. C., & Kho, M. E. (2024) · NEJM Evidence · doi:10.1056/evidoa2400194 · Cited by 19 · see citing works
Liu, H., Wang, X., Gong, T., Xu, S., Zhang, J., Li, Y., Zeng, Y., Yi, M., & Qian, Y. (2024) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2024.102912 · Cited by 19 · see citing works
Antiseizure Medications in Poststroke Seizures
Misra, S., Wang, S., Quinn, T. J., Dawson, J., Zelano, J., Tanaka, T., Grotta, J. C., Khan, E. I., Beriwal, N., Funaro, M. C., et al. (2025) · Neurology · doi:10.1212/wnl.0000000000210231 · Cited by 18 · see citing works
GRADE Certainty Ratings: Thresholds Rather Than Categories of Contextualization (GRADE Guidance 41)
Hultcrantz, M., Schünemann, H. J., Mustafa, R. A., Rind, D. M., Murad, M. H., Mayer, M. G., Tovey, D. I., Alper, B. S., Akl, E. A., Saif‐Ur‐Rahman, K., et al. (2025) · Annals of Internal Medicine · doi:10.7326/annals-25-00548 · Cited by 19 · see citing works
Self-citationMunyayi, F. K., van Wyk, B. E., & Mayman, Y. R. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19073940 · Cited by 18 · see citing works
Xu, X., Liang, Z., Lin, Y., Rao, J., Lin, F., Yang, Z., Wang, R., & Chen, C. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.860131 · Cited by 18 · see citing works
Nunes, G. S., de Oliveira, J., Iacob, G. S., Signori, L. U., Diel, A. P., Schreiner, R. A., & Solner, M. W. (2023) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2023.11956 · Cited by 19 · see citing works
- Authors
- Brignardello-Petersen, R., Florez, I. D., Izcovich, A., Santesso, N., Hazlewood, G., Alhazanni, W., Yepes-Nuñez, J. J., Tomlinson, G., Schünemann, H. J., & Guyatt, G. H.
- Affiliations
- Hospital Alemán (AR)
- McMaster University (CA)
- University of Calgary (CA)
- University Health Network (CA)
- ORCID
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2020-11-11
- Volume
- 371
- Pages
- m3900
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W3099906708
- Cited by
- 320
- References
- 35
- Citations by year
- 2026: 42 · 2025: 62 · 2024: 77 · 2023: 60 · 2022: 52 · 2021: 23 · 2020: 4
- FWCI
- 21.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Social Sciences › Sociology and Political Science › Delphi Technique in Research
- Keywords
- GRADE, network meta-analysis, evidence synthesis, intervention ranking, quality of evidence, value judgments, evidence-based recommendations
- MeSH terms
- Network Meta-Analysis as Topic, Network Meta-Analysis, GRADE Approach, Humans, Randomized Controlled Trials as Topic
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