Engagement and outcomes in a digital Diabetes Prevention Program: 3-year update
Open accessAbstract
Objective: Translations of the Diabetes Prevention Program (DPP) have proliferated in recent years, with increasing expansion to digital formats. Although these DPP translations have consistently shown favorable clinical outcomes, long-term data for digital formats are limited. This study’s objective was to examine clinical outcomes up to 3 years post-baseline and the relationship between program engagement and clinical outcomes in a digital DPP. Research design and methods: In a single-arm, non-randomized trial, 220 patients previously diagnosed with prediabetes were enrolled in the Omada Health Program, a commercially available, 16-week DPP-based weight loss intervention followed by an ongoing weight maintenance intervention. Changes in body weight and A1c were assessed annually. Relationships between program engagement during the first year and clinical outcomes across 3 years were examined. Results: Participants were socioeconomically diverse (62% women, 50.2% non-Hispanic white, 51.7% college educated or higher). From baseline to 3 years, those participants who completed four or more lessons and nine or more lessons achieved significant sustained weight loss (–3.0% and –2.9%, respectively) and an absolute reduction in A1c (–0.31 and –0.33, respectively) with an average remission from the prediabetes range to the normal glycemic range. Factor analysis of engagement metrics during the first year revealed two underlying dimensions, one comprising lesson completion and health behavior tracking consistency, and the other comprising website logins and group participation. When these two factors were used to predict weight loss, only the logins and group participation factor was a significant predictor of weight loss at 16 weeks and 1 year. Conclusions: This study demonstrates significant long-term reductions in body weight and A1c in a digital DPP and identifies patterns of program engagement that predict weight loss.
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Omada Health's outcomes are more centered on diabetes prevention, focusing on weight reduction and lowering the risk of developing T2D.
“Omada Health’s outcomes are more centered on diabetes prevention, focusing on weight reduction and lowering the risk of developing T2D (30).”
From Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control (2024) · cites this paper as [30]
The Program section describes Omada Health as a digital Diabetes Prevention Program, and the Abstract Results report sustained weight loss and improved A1c in participants with prediabetes. The study did not measure whether participants’ risk of developing type 2 diabetes fell, so it does not establish that as an outcome of this program. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe DT technology offers a unique and comprehensive approach to diabetes management, setting itself apart from other digital tools such as Livongo, Omada Health, One Drop, and mySugr.
“The DT technology offers a unique and comprehensive approach to diabetes management, setting itself apart from other digital tools such as Livongo (29), Omada Health (30), One Drop (31), and mySugr (32).”
From Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control (2024) · cites this paper as [30]
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- Authors
- Sepah, S. C., Jiang, L., Ellis, R. J., McDermott, K., & Peters, A. L.
- Affiliations
- University of California, San Francisco (US)
- University of California, Irvine (US)
- Medical Affairs, Omada Health, San Francisco, California, USA
- Dominican University of California (US)
- University of Southern California (US)
- Corresponding author
- Sepah, S Cameron
- Venue
- BMJ Open Diabetes Research & Care
- Publisher
- BMJ
- Published
- 2017-09
- Volume
- 5
- Issue
- 1
- Pages
- e000422
- ISSN
- 2052-4897 (ISSN-L)
- PMC
- PMC5595194
- OpenAlex
- W2752742138
- Cited by
- 122
- References
- 47
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 23 · 2023: 14 · 2022: 17 · 2021: 22 · 2020: 10 · 2019: 12 · 2018: 6
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Open Diabetes Research & Care (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dominican Scholar (Dominican University of California) (submittedVersion, cc-by-nc)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Center for Complementary and Integrative Health (T32AT003997)
- Topics
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Diabetes Prevention Program, digital health interventions, prediabetes, weight loss, weight maintenance, glycemic control, HbA1c, program engagement, long-term outcomes, group participation
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