Conceptualising fairness: three pillars for medical algorithms and health equity
Open accessAbstract
Objectives: Fairness is a core concept meant to grapple with different forms of discrimination and bias that emerge with advances in Artificial Intelligence (eg, machine learning, ML). Yet, claims to fairness in ML discourses are often vague and contradictory. The response to these issues within the scientific community has been technocratic. Studies either measure (mathematically) competing definitions of fairness, and/or recommend a range of governance tools (eg, fairness checklists or guiding principles). To advance efforts to operationalise fairness in medicine, we synthesised a broad range of literature. Methods: We conducted an environmental scan of English language literature on fairness from 1960-July 31, 2021. Electronic databases Medline, PubMed and Google Scholar were searched, supplemented by additional hand searches. Data from 213 selected publications were analysed using rapid framework analysis. Search and analysis were completed in two rounds: to explore previously identified issues (a priori), as well as those emerging from the analysis (de novo). Results: Our synthesis identified ‘Three Pillars for Fairness’: transparency, impartiality and inclusion. We draw on these insights to propose a multidimensional conceptual framework to guide empirical research on the operationalisation of fairness in healthcare. Discussion: We apply the conceptual framework generated by our synthesis to risk assessment in psychiatry as a case study. We argue that any claim to fairness must reflect critical assessment and ongoing social and political deliberation around these three pillars with a range of stakeholders, including patients. Conclusion: We conclude by outlining areas for further research that would bolster ongoing commitments to fairness and health equity in healthcare.
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Cognitive bias is introduced during data annotation or input processes and often reflects subjective judgments of healthcare providers, such as manual data entry errors or inconsistent diagnoses.
“Cognitive bias also poses a major challenge (n = 5), introduced during data annotation or input processes. Kudina et al. and Sikstrom et al., [49,51] acknowledge that this bias often reflects the subjective judgments of healthcare providers, such as manual data entry errors or inconsistent diagnoses.”
From Frameworks encompassing intersectional perspective of artificial intelligence in healthcare. Scoping review (2026) · cites this paper as [51]
The Results > Impartiality section says medical practices can reflect arbitrary assumptions about patients and that human actors help gather and curate datasets. The Discussion also gives misdiagnosis of schizophrenia as an example of a feature that could bias a model. The paper does not specifically describe cognitive bias arising during annotation or input, manual data-entry errors, or inconsistent diagnoses as a general mechanism; page numbers were not available in our copy. (LLM, conf=0.83)
Experimental — accuracy not yet measuredModels validated on biased datasets frequently exhibit reduced accuracy for underserved populations, such as rural communities or individuals with unique healthcare needs.
“For instance, Sikstrom et al. and Haseeb et al., [46,51] reveal that models validated on biased datasets frequently exhibit reduced accuracy for underserved populations, such as rural communities or individuals with unique healthcare needs.”
From Frameworks encompassing intersectional perspective of artificial intelligence in healthcare. Scoping review (2026) · cites this paper as [51]
The Introduction says models trained on biased datasets can amplify inequities, and Results > Inclusion says small samples of marginalised groups can bias outputs toward the majority group. Those passages support the general concern, but they do not establish that models validated on biased datasets frequently have reduced accuracy for rural communities or people with unique healthcare needs. No page numbers are available in our copy. (LLM, conf=0.84)
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Artificial intelligence bias in medical system designs: a systematic review
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- Authors
- Sikstrom, L., Maslej, M. M., Hui, K., Findlay, Z., Buchman, D. Z., & Hill, S. L.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Corresponding author
- Sikstrom, Laura
- Venue
- BMJ Health & Care Informatics
- Publisher
- BMJ
- Published
- 2022-01
- Volume
- 29
- Issue
- 1
- Pages
- e100459
- ISSN
- 2632-1009 (ISSN-L)
- PMC
- PMC8753410
- OpenAlex
- W4206398356
- Cited by
- 76
- References
- 25
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 13 · 2023: 20 · 2022: 3
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMJ Health & Care Informatics (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Social Sciences and Humanities Research Council of Canada (430-2021-0116)
- Dalla Lana School of Public Health Interdisciplinary Data Science Seed Funding
- Canadian Institutes of Health Research
- AMS Fellowship in Compassion and Artificial Intelligence
- Topics
- Social Sciences › Safety Research › Ethics and Social Impacts of AI
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Artificial Intelligence › Explainable Artificial Intelligence (XAI)
- Keywords
- fairness, algorithmic fairness, health equity, clinical algorithms, artificial intelligence in healthcare, transparency, impartiality, inclusion, conceptual framework, risk assessment, algorithmic discrimination, stakeholder engagement
- MeSH terms
- Machine Learning, Health Equity, Artificial Intelligence, Delivery of Health Care, Humans, Risk Assessment
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