Rationale and Design of TransplantLines: A Prospective Cohort Study and Biobank of Solid Organ Transplant Recipients
Open accessAbstract
INTRODUCTION: In the past decades, short-term results after solid organ transplantation have markedly improved. Disappointingly, this has not been accompanied by parallel improvements in long-term outcomes after transplantation. To improve graft and recipient outcomes, identification of potentially modifiable risk factors and development of biomarkers are required. We provide the rationale and design of a large prospective cohort study of solid organ transplant recipients (TransplantLines). METHODS AND ANALYSIS: TransplantLines is designed as a single-centre, prospective cohort study and biobank including all different types of solid organ transplant recipients as well as living organ donors. Data will be collected from transplant candidates before transplantation, during transplantation, at 3 months, 6 months, 1 year, 2 years and 5 years, and subsequently every 5 years after transplantation. Data from living organ donors will be collected before donation, during donation, at 3 months, 1 year and 5 years after donation, and subsequently every 5 years. The primary outcomes are mortality and graft failure. The secondary outcomes will be cause-specific mortality, cause-specific graft failure and rejection. The tertiary outcomes will be other health problems, including diabetes, obesity, hypertension, hypercholesterolaemia and cardiovascular disease, and disturbances that relate to quality of life, that is, physical and psychological functioning, including quality of sleep, and neurological problems such as tremor and polyneuropathy. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the relevant local ethics committee. The TransplantLines cohort study is designed to deliver pioneering insights into transplantation and donation outcomes. The study design allows comprehensive data collection on perioperative care, nutrition, social and psychological functioning, and biochemical parameters. This may provide a rationale for future intervention strategies to more individualised, patient-centred transplant care and individualisation of treatment. TRIAL REGISTRATION NUMBER: NCT03272841.
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The underlying clinical study was approved by the Institutional Review Board of the UMCG and collected informed consent from all participants.
“was approved by the Institutional Review Board of the University Medical Center Groningen (UMCG; decision METc 2014/077 on 25 August 2014), adhered to the UMCG Biobank Regulation, the Declaration of Helsinki, and the Declaration of Istanbul, and collected informed consent from all the participants.”
From Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion (2025) · cites this paper as [25]
The Abstract’s Ethics and dissemination section says the TransplantLines study obtained approval from the relevant local ethics committee, and Methods/Design > Study design and setting says all participants will give written informed consent on enrolment. Our copy does not identify the committee as the UMCG Institutional Review Board or substantiate the stated decision and date; it describes consent prospectively rather than confirming it had been collected from all participants. (LLM, conf=0.83)
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Protein Intake, Fatigue and Quality of Life in Stable Outpatient Kidney Transplant Recipients
Neto, A. W. G., Boslooper‐Meulenbelt, K., Geelink, M., van Vliet, I. M. Y., Post, A., Joustra, M. L., Knoop, H., Berger, S. P., Navis, G. J., & Bakker, S. J. L. (2020) · Nutrients · doi:10.3390/nu12082451 · Cited by 34 · see citing works
Knobbe, T. J., Kremer, D., Eisenga, M. F., van Londen, M., Annema, C., Bültmann, U., Kema, I. P., Navis, G. J., Berger, S. P., Bakker, S. J. L., et al. (2023) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfad148 · Cited by 27 · see citing works
Using a novel concept to measure outcomes in solid organ recipients provided promising results
Parizi, A. S., Vermeulen, K. M., Neto, A. W. G., van der Bij, W., Blokzijl, H., Buskens, E., Bakker, S. J. L., & Krabbe, P. F. M. (2021) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2021.07.005 · Cited by 26 · see citing works
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Eelderink, C., Kremer, D., Riphagen, I. J., Knobbe, T. J., Schurgers, L. J., Pasch, A., Mulder, D. J., Corpeleijn, E., Navis, G. J., Bakker, S. J. L., et al. (2023) · American Journal of Transplantation · doi:10.1016/j.ajt.2022.12.015 · Cited by 25 · see citing works
Ziengs, A. L., Buunk, A. M., van Sonderen, L., Eisenga, M. F., Neto, A. W. G., Annema, C., Vlagsma, T. T., Navis, G. J., Berger, S. P., Bakker, S. J. L., et al. (2022) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfac035 · Cited by 24 · see citing works
Calciprotein particle counts associate with vascular remodelling in chronic kidney disease
Feenstra, L., Reijrink, M., Pasch, A., Smith, E. R., Visser, L. M., Bulthuis, M. L. C., Lodewijk, M. E., Mastik, M. F., Greuter, M. J. W., Slart, R. H. J. A., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae164 · Cited by 22 · see citing works
Vinke, J. S. J., Wouters, H. J. C. M., Stam, S. P., Douwes, R. M., Post, A., Neto, A. W. G., van der Klauw, M. M., Berger, S. P., Bakker, S. J. L., TransplantLines Investigators, et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12999 · Cited by 22 · see citing works
van Vliet, I. M. Y., Post, A., Kremer, D., Boslooper‐Meulenbelt, K., van der Veen, Y., de Jong, M. F. C., Pol, R. A., TransplantLines Investigators, Jager‐Wittenaar, H., Navis, G. J., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13070 · Cited by 22 · see citing works
The clinical relevance of novel biomarkers as outcome parameter in adults with phenylketonuria
van Wegberg, A. M. J., van der Weerd, J. C., Engelke, U. F. H., Coene, K. L. M., Jahja, R., Bakker, S. J. L., Huijbregts, S. C. J., Wevers, R. A., Heiner-Fokkema, M. R., & van Spronsen, F. J. (2024) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12732 · Cited by 22 · see citing works
Boslooper-Meulenbelt, K., van Vliet, I. V., Gomes-Neto, A., de Jong, M. D., Bakker, S., Jager-Wittenaar, H., & Navis, G. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.11.034 · Cited by 18 · see citing works
Employment Status and Work Functioning among Kidney Transplant Recipients
Knobbe, T. J., Kremer, D., Abma, F. I., Annema, C., Berger, S. P., Navis, G. J., van der Mei, S. F., Bültmann, U., Visser, A., & Bakker, S. J. L. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05560522 · Cited by 21 · see citing works
Health-related quality of life is linked to the gut microbiome in kidney transplant recipients
Swarte, J. C., Knobbe, T. J., Björk, J. R., Gaćeša, R., Nieuwenhuis, L. M., Zhang, S., Vila, A. V., Kremer, D., Douwes, R. M., Post, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43431-8 · Cited by 20 · see citing works
Airflow Limitation, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients
Knobbe, T. J., Kremer, D., Eisenga, M. F., van Londen, M., Neto, A. W. G., Douwes, R. M., Gan, C. T., Corpeleijn, E., Annema, C., Navis, G. J., et al. (2021) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06600521 · Cited by 19 · see citing works
van der Plas, W. Y., Neto, A. W. G., Berger, S. P., Pol, R. A., Kruijff, S., Bakker, S. J. L., & de Borst, M. H. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16457 · Cited by 19 · see citing works
Pretransplant endotrophin predicts delayed graft function after kidney transplantation
Tepel, M., Alkaff, F. F., Kremer, D., Bakker, S. J. L., Thaunat, O., Nagarajah, S., Saleh, Q. W., Berger, S. P., van den Born, J., Krogstrup, N. V., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-07645-y · Cited by 18 · see citing works
Swarte, J. C., Zhang, S., Nieuwenhuis, L. M., Gaćeša, R., Knobbe, T. J., TransplantLines Investigators, de Meijer, V. E., Damman, K., Verschuuren, E. A. M., Gan, T. C., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-331441 · Cited by 19 · see citing works
Koomen, J. V., Knobbe, T. J., Zijp, T. R., Kremer, D., Gan, C. T., Verschuuren, E. A. M., Bakker, S. J. L., Touw, D. J., Colin, P. J., & TransplantLines Investigators (2023) · Clinical Pharmacokinetics · doi:10.1007/s40262-023-01259-x · Cited by 17 · see citing works
Sotomayor, C. G., Groothof, D., Vodegel, J. J., Gacitúa, T. A., Neto, A. W. G., Osté, M. C. J., Pol, R. A., Catterina Ferreccio, R., Berger, S. P., Guillermo Chong, M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020417 · Cited by 17 · see citing works
Sotomayor, C. G., Giubergia, F., Groothof, D., Catterina Ferreccio, R., Nolte, I. M., Navis, G. J., Neto, A. W. G., Kremer, D., Knobbe, T. J., Eisenga, M. F., et al. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2021.10.009 · Cited by 16 · see citing works
Vinke, J. S. J., Ziengs, A. L., Buunk, A. M., van Sonderen, L., Neto, A. W. G., TransplantLines Investigators, Berger, S. P., Bakker, S. J. L., Eisenga, M. F., Spikman, J. M., et al. (2023) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfad013 · Cited by 16 · see citing works
Westenberg, L. B., Zorgdrager, M., Swaab, T. D. A., van Londen, M., Bakker, S. J. L., Leuvenink, H. G. D., Viddeleer, A. R., & Pol, R. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-33041-1 · Cited by 16 · see citing works
TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors
Posthumus, A. M., Knobbe, T. J., Kremer, D., Neto, A. W. G., Dielwart, I. J. C., Jonker, J., Doorenbos, C. S. E., Eisenga, M. F., van Londen, M., Douwes, R. M., et al. (2025) · European Journal of Epidemiology · doi:10.1007/s10654-025-01258-1 · Cited by 15 · see citing works
Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients
Kremer, D., Knobbe, T. J., Vinke, J. S. J., Groothof, D., Post, A., Annema, C., Abrahams, A. C., van Jaarsveld, B. C., de Borst, M. H., Berger, S. P., et al. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.03.017 · Cited by 15 · see citing works
Sotomayor, C. G., Velde‐Keyzer, C. A. T., de Borst, M. H., Navis, G. J., & Bakker, S. J. L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061911 · Cited by 15 · see citing works
Kremer, D., Groothof, D., Velde‐Keyzer, C. A. T., Eelderink, C., Knobbe, T. J., Post, A., van Londen, M., Eisenga, M. F., TransplantLines Investigators, Schurgers, L. J., et al. (2021) · Nutrients · doi:10.3390/nu13093069 · Cited by 15 · see citing works
Böhler, M., van den Berg, E. H., Almanza, M. C. T., Connelly, M. A., Bakker, S. J. L., de Meijer, V. E., Dullaart, R. P. F., Blokzijl, H., Hak, E., Hepkema, B. G., et al. (2022) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2022.01.009 · Cited by 15 · see citing works
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Tremor, Daily Functioning, and Health-Related Quality of Life in Solid Organ Transplant Recipients
Riemersma, N. L., Kremer, D., Knobbe, T., Gan, C., Nolte, S., Gomes-Neto, A., Blokzijl, H., de Meijer, V. D., Damman, K., Eisenga, M., et al. (2023) · Transplant International · doi:10.3389/ti.2023.10951 · Cited by 13 · see citing works
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Zijp, T. R., Knobbe, T. J., van Hateren, K., Roggeveld, J., Blokzijl, H., Gan, C. T., Bakker, S. J. L., Jongedijk, E. M., TransplantLines Investigators, & Touw, D. J. (2023) · Journal of Chromatography B · doi:10.1016/j.jchromb.2023.123709 · Cited by 13 · see citing works
Post, A., Groothof, D., Kremer, D., Knobbe, T. J., Abma, W., Koops, C. A., Tsikas, D., Wallimann, T., Dullaart, R. P. F., Franssen, C. F. M., et al. (2024) · Amino Acids · doi:10.1007/s00726-024-03401-w · Cited by 13 · see citing works
Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney
Tiller, G., Lammerts, R. G. M., Karijosemito, J. J., Alkaff, F. F., Diepstra, A., Pol, R. A., Meter-Arkema, A. H., Seelen, M. A., van den Heuvel, M. C., Hepkema, B. G., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.845301 · Cited by 13 · see citing works
van den Berg, E. H., Flores-Guerrero, J. L., Garcia, E., Connelly, M. A., de Meijer, V. E., TransplantLines Investigators, Bakker, S. J. L., Blokzijl, H., & Dullaart, R. P. F. (2022) · Liver International · doi:10.1111/liv.15310 · Cited by 13 · see citing works
Knobbe, T. J., Douwes, R. M., Kremer, D., Swarte, J. C., Eisenga, M. F., Neto, A. W. G., van Londen, M., Peters, F. T., Blokzijl, H., Nolte, I. M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020518 · Cited by 12 · see citing works
Quint, E. E., Haanstra, A. J., van der Veen, Y., Maring, H., Berger, S. P., Ranchor, A. V., Bakker, S. J. L., Finnema, E., Pol, R. A., & Annema, C. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-072805 · Cited by 12 · see citing works
Urinary Oxalate Excretion and Long-Term Outcomes in Kidney Transplant Recipients
Tubben, A., Sotomayor, C. G., Post, A., Minović, I., Frelink, T., de Borst, M. H., Said, M. Y., Douwes, R. M., van den Berg, E., Rodrigo, R., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122104 · Cited by 12 · see citing works
Klont, F., Sosnowski, P., Kremer, D., Knobbe, T. J., Bonner, R. F., Blokzijl, H., Weersma, R. K., Bakker, S. J. L., TransplantLines Investigators, Hak, E., et al. (2022) · Metabolites · doi:10.3390/metabo12100942 · Cited by 11 · see citing works
Central Body Fat Distribution and Kidney Function after Living Kidney Donation
Westenberg, L. B., Pol, R. A., van der Weijden, J., de Borst, M. H., Bakker, S. J. L., van Londen, M., & on behalf of the Transplant Lines Investigators (2024) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000000000403 · Cited by 11 · see citing works
Visser, K., van der Horn, H. J., Bourgonje, A. R., Jacobs, B., de Borst, M. H., Vos, P. E., Bulthuis, M. L. C., van Goor, H., & van der Naalt, J. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11240-6 · Cited by 11 · see citing works
Knobbe, T. J., Kremer, D., Douwes, R. M., Eisenga, M. F., Neto, A. W. G., Annema, C., Swarte, J. C., Klont, F., Navis, G. J., Berger, S. P., et al. (2023) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2022.12.012 · Cited by 11 · see citing works
Smoking, Alcohol Intake and Torque Teno Virus in Stable Kidney Transplant Recipients
Doorenbos, C. S. E., Jonker, J., Hao, J., Gore, E. J., Kremer, D., Knobbe, T. J., de Joode, A. A. E., Sanders, J., Thaunat, O., Niesters, H. G. M., et al. (2023) · Viruses · doi:10.3390/v15122387 · Cited by 11 · see citing works
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van den Berg, E. H., Flores-Guerrero, J. L., Gruppen, E. G., Garcia, E., Connelly, M. A., de Meijer, V. E., Bakker, S. J. L., Blokzijl, H., & Dullaart, R. P. F. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11051223 · Cited by 10 · see citing works
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Post, A., Garcia, E., SHALAUROVA, I. Y., Matyus, S. P., González-Delgado, J. M., Doorenbos, C. S. E., van der Veen, Y., Shah, S. H., Kraus, W. E., Kremer, D., et al. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117517 · Cited by 9 · see citing works
van der Weerd, J. C., van Wegberg, A. M. J., Boer, T. S., Engelke, U. F. H., Coene, K. L. M., Wevers, R. A., Bakker, S. J. L., de Blaauw, P., Groen, J., van Spronsen, F. J., et al. (2024) · Metabolites · doi:10.3390/metabo14090479 · Cited by 9 · see citing works
Ayerdem, G., van Hassel, G., Vinke, J. S. J., Kremer, D., Gaillard, S., de Borst, M. H., Bakker, S. J. L., & Eisenga, M. F. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab173 · Cited by 9 · see citing works
Hand dexterity, daily functioning and health-related quality of life in kidney transplant recipients
Knobbe, T. J., Kremer, D., Eisenga, M. F., Corpeleijn, E., Annema, C., Spikman, J. M., Transplantlines Investigators, Annema, C., Bakker, S. J. L., Berger, S. P., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-19952-5 · Cited by 9 · see citing works
Vibration threshold in non-diabetic subjects
Nolte, S., van Londen, M., Elting, J. W. J., de Greef, B. T. A., Kuks, J. B. M., Faber, C. G., Nolte, I. M., Groen, R. J. M., Bakker, S. J. L., Groothof, D., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237733 · Cited by 9 · see citing works
Prolonged Dual Hypothermic Oxygenated Machine Perfusion for Daytime Liver Transplant
Bodewes, S. B., Woltjes, L. C., Thorne, A. M., Eden, J., Lantinga, V. A., Lascaris, B., Blokzijl, H., Fouraschen, S. M. G., Hartog, H., Vos, J. J., et al. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.5039 · Cited by 8 · see citing works
Kremer, D., Alkaff, F. F., Post, A., Knobbe, T. J., Tepel, M., Thaunat, O., Berger, S. P., van den Born, J., Genovese, F., Karsdal, M. A., et al. (2022) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfac332 · Cited by 8 · see citing works
Plasma Vitamin C and Cancer Mortality in Kidney Transplant Recipients
Gacitúa, T. A., Sotomayor, C. G., Groothof, D., Eisenga, M. F., Pol, R. A., de Borst, M. H., Gans, R. O. B., Berger, S. P., Rodrigo, R., Navis, G., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122064 · Cited by 8 · see citing works
Urinary Copper Excretion Is Associated with Long-Term Graft Failure in Kidney Transplant Recipients
Yepes-Calderón, M., Kremer, D., Post, A., Sotomayor, C. G., Seidel, U., Huebbe, P., Knobbe, T. J., Lüersen, K., Eisenga, M. F., Corpeleijn, E., et al. (2023) · American Journal of Nephrology · doi:10.1159/000531147 · Cited by 7 · see citing works
The gut microbiome in end-stage lung disease and lung transplantation
Zhang, S., Swarte, J. C., Gaćeša, R., Knobbe, T. J., Kremer, D., Jansen, B. H., de Borst, M. H., TransplantLines Investigators, Harmsen, H. J. M., Erasmus, M. E., et al. (2024) · mSystems · doi:10.1128/msystems.01312-23 · Cited by 7 · see citing works
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Almanza, M. C. T., Wessel, H., Martínez-Aguilar, M., van den Berg, E. H., Douwes, R. M., Moshage, H. J., Connelly, M. A., Bakker, S. J. L., de Meijer, V. E., Dullaart, R. P. F., et al. (2023) · Biomolecules · doi:10.3390/biom13050824 · Cited by 7 · see citing works
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Frie, M., Annema, C., Knijff, E. S. X., Bakker, S. J. L., Ranchor, A. V., Eisenga, M. F., & Rácz, E. (2020) · JAMA Dermatology · doi:10.1001/jamadermatol.2019.4541 · Cited by 6 · see citing works
Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment
Wang, S., Said, M. A., Groot, H. E., van der Most, P. J., Thio, C. H. L., van de Vegte, Y. J., Verweij, N., Snieder, H., & van der Harst, P. (2021) · Genes · doi:10.3390/genes12081174 · Cited by 6 · see citing works
Jonker, J., Doorenbos, C. S. E., Gore, E. J., Gomes-Neto, A. W., de Meijer, V. E., Blokzijl, H., Verschuuren, E. A. M., Gan, C. T., Sanders, J., Linssen, J., et al. (2025) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2025.108217 · Cited by 5 · see citing works
Yepes-Calderón, M., van der Veen, Y., Fernando Martín del Campo, S., Kremer, D., Sotomayor, C. G., Knobbe, T. J., Vos, M. J., Corpeleijn, E., de Borst, M. H., Bakker, S. J. L., et al. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03426-7 · Cited by 5 · see citing works
Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant Recipients
Almanza, M. C. T., Chvatal‐Medina, M., Connelly, M. A., Moshage, H. J., TransplantLines Investigators, Bakker, S. J. L., de Meijer, V. E., Blokzijl, H., & Dullaart, R. P. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116031 · Cited by 5 · see citing works
Li, Y., Chvatal‐Medina, M., Almanza, M. C. T., Connelly, M. A., Moshage, H. J., Bakker, S. J. L., de Meijer, V. E., Blokzijl, H., & Dullaart, R. P. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020459 · Cited by 5 · see citing works
Pharmacometabolomics Enables Real-World Drug Metabolism Sciences
Nijdam, F. B., Hof, M. A. J., Blokzijl, H., Bakker, S. J. L., Hak, E., Gérard Hopfgartner, D., Klont, F., & on behalf of the TransplantLines Investigators (2025) · Metabolites · doi:10.3390/metabo15010039 · Cited by 6 · see citing works
Plasma trimethylamine N-oxide concentration and all-cause mortality in kidney transplant recipients
Yepes-Calderón, M., Sanchez, F. M. D. C., Kremer, D., Knobbe, T. J., Neto, A. W. G., Connelley, M. A., Dullaart, R. P. F., Corpeleijn, E., de Borst, M. H., Bakker, S. J. L., et al. (2025) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaf071 · Cited by 5 · see citing works
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Rodrigues, F. G., Swarte, J. C., Douwes, R. M., Knobbe, T. J., Sotomayor, C. G., Blokzijl, H., Weersma, R. K., Heilberg, I. P., Bakker, S. J. L., de Borst, M. H., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132854 · Cited by 5 · see citing works
Swaab, T. D. A., Quint, E. E., Westenberg, L. B., Zorgdrager, M., Segev, D. L., McAdams‐DeMarco, M., Bakker, S. J. L., Viddeleer, A. R., & Pol, R. A. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13316 · Cited by 5 · see citing works
Pre-Transplant Hyperparathyroidism and Graft or Patient Outcomes After Kidney Transplantation
Rodrigues, F. G., van der Plas, W. Y., Sotomayor, C. G., van der Vaart, A., Kremer, D., Pol, R. A., Kruijff, S., Heilberg, I. P., Bakker, S. J. L., TransplantLines Investigators, et al. (2024) · Transplant International · doi:10.3389/ti.2024.11916 · Cited by 5 · see citing works
van der Weijden, J., Kremer, D., Westenberg, L. B., Sanders, J., Pol, R. A., Nolte, I. M., de Borst, M. H., Berger, S. P., Bakker, S. J. L., & van Londen, M. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae065 · Cited by 5 · see citing works
Douwes, R. M., Swarte, J. C., Post, A., Annema, C., Harmsen, H. J. M., & Bakker, S. J. L. (2021) · Clinical Transplantation · doi:10.1111/ctr.14321 · Cited by 5 · see citing works
Sotomayor, C. G., Rodrigo, R., Neto, A. W. G., Gormaz, J. G., Pol, R. A., Minović, I., Eggersdorfer, M. L., Vos, M. J., Riphagen, I. J., de Borst, M. H., et al. (2019) · Nutrients · doi:10.3390/nu11112821 · Cited by 5 · see citing works
Eden, J., Stimmeder, S., Thorne, A. M., Woltjes, L. C., Veenma, V., de Bree, M., Binnekamp, C. W., Kuiper, W. N., Dutkowski, P., & de Meijer, V. E. (2026) · Liver Transplantation · doi:10.1097/lvt.0000000000000894 · Cited by 4 · see citing works
Lockwood, M. B., Sung, C., Alvernaz, S. A., Lee, J. R., Chin, J. L., Nayebpour, M., Bernabé, B. P., Tussing-Humphreys, L. M., Li, H., Spaggiari, M., et al. (2024) · Biological Research For Nursing · doi:10.1177/10998004241256031 · Cited by 4 · see citing works
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Klont, F., Nijdam, F. B., Bakker, S. J. L., Keski‐Rahkonen, P., Gérard Hopfgartner, D., & TransplantLines Investigators (2024) · The Analyst · doi:10.1039/d3an01874a · Cited by 4 · see citing works
Nieuwenhuis, L. M., Li, Y., Loza, B., Lambeck, A. J. A., Hu, S., Gaćeša, R., Voskuil, M. D., Hepkema, B. G., Jansen, B. H., Blokzijl, H., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000601 · Cited by 4 · see citing works
Wijma, A. G., Bongers, B. C., Annema, C., Dekker, R., Blokzijl, H., van der Palen, J. A. M., de Meijer, V. E., Cuperus, F. J. C., & Klaase, J. M. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-080430 · Cited by 4 · see citing works
Tremor after solid organ transplantation: Results from the TransplantLines Biobank and Cohort Study
van der Stouwe, A. M. M., Riemersma³, N. L., Knobbe, T. J., Kremer, D., Nolte, S., Plasmeijer, D. B., Neto, A. W. G., Bakker, S. J. L., Drost, G., Elting, J. W. J., et al. (2024) · European Journal of Neurology · doi:10.1111/ene.16412 · Cited by 4 · see citing works
Riemersma³, N. L., Knobbe, T. J., Kremer, D., Nolte, S., Bültmann, U., Annema, C., Shehab, N. B. N., Eisenga, M. F., Berger, S. P., Bakker, S. J. L., et al. (2025) · Kidney Medicine · doi:10.1016/j.xkme.2025.101168 · Cited by 3 · see citing works
Analyzing body composition in living kidney donors: impact on post-transplant kidney function
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Rationale and design of the CORE (COrticosteroids REvised) study: protocol
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Polyneuropathy in Kidney Transplant Recipients: Accuracy of a New Clinical Diagnostic Scoring System
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- Authors
- Eisenga, M. F., Gomes-Neto, A. W., van Londen, M., Ziengs, A. L., Douwes, R. M., Stam, S. P., Osté, M. C. J., Knobbe, T. J., Hessels, N. R., Buunk, A. M., Annema, C., Siebelink, M. J., Racz, E., Spikman, J. M., Bodewes, F. A. J. A., Pol, R. A., Berger, S. P., Drost, G., Porte, R. J., Leuvenink, H. G. D., Damman, K., Verschuuren, E. A. M., de Meijer, V. E., Blokzijl, H., & Bakker, S. J. L.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Eisenga, Michele F
- ORCID
- Eisenga, Michele F
- Douwes, Rianne M
- Stam, Suzanne P
- Osté, Maryse C J
- Knobbe, Tim J
- Hessels, Niek R
- Buunk, Anne M
- Annema, Coby
- Siebelink, Marion J
- Spikman, Jacoba M
- Bodewes, Frank A J A
- Pol, Robert A
- Berger, Stefan P
- Drost, Gea
- Porte, Robert J
- Leuvenink, Henri G D
- Damman, Kevin
- Verschuuren, Erik A M
- Blokzijl, Hans
- Bakker, Stephan J L
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2018-12
- Volume
- 8
- Issue
- 12
- Pages
- e024502
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC6318532
- OpenAlex
- W2908082263
- Cited by
- 141
- References
- 77
- Citations by year
- 2026: 20 · 2025: 23 · 2024: 30 · 2023: 17 · 2022: 18 · 2021: 17 · 2020: 11 · 2019: 5
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Open (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Astellas BV
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Keywords
- solid organ transplantation, living donor, transplant recipients, biobanks, graft failure, mortality, graft rejection, long-term outcomes, risk factors, biomarkers, post-transplant complications, diabetes mellitus, cardiovascular disease, quality of life, sleep disorders, neurological complications
- MeSH terms
- Graft Survival, Humans, Netherlands, Tissue and Organ Procurement, Prospective Studies, Research Design, Time Factors, Tissue Banks, Organ Transplantation, Living Donors, Observational Studies as Topic, Transplant Recipients
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