Review on obesity management: diet, exercise and pharmacotherapy
Open accessAbstract
Currently, obesity is one of the largest risk factors for cardiometabolic disease in North American adults. Over the past few years, the prevalence of this disease has been steadily increasing. This article is the second article in a three-part series of reviews exploring current clinical guidelines and management strategies used in practice to mitigate the spread of obesity. Guidelines to help physicians manage patients with obesity have been released in Canada and Europe. They outline proper management and treatment for overweight and obese patients. Examples include changes in diet and exercise, behavioural therapy and the administration of antiobesity medications as first-line and second-line treatments. Management of obesity takes on a tiered approach, where first-line therapies include lifestyle changes such as diet and exercise and second-line therapies include the use of antiobesity medications.
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Physical activity aids preservation of muscle mass and function in patients undergoing significant weight reduction and offers health benefits independent of weight.
“In addition to aiding the preservation of muscle mass and function in patients undergoing significant weight reduction, physical activity also offers health benefits independent of weight [113].”
From Application of nutrition interventions with GLP-1 based therapies: A narrative review of the challenges and solutions (2025) · cites this paper as [113]
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Cites
Tirzepatide Once Weekly for the Treatment of Obesity
Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., Kiyosue, A., Zhang, S., Liu, B., Bunck, M. C., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2206038 · Cited by 3,838 · cited 1× · see citing works
“58 In this study, 2539 adults with a BMI of >30 or >27 with one weight-related comorbidity were administered weekly injections of Mounjaro for a period of 72 weeks.”
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
Pi-Sunyer, X., Astrup, A., Fujioka, K., Greenway, F., Halpern, A., Krempf, M., Lau, D. C. W., le Roux, C. W., Violante Ortiz, R., Jensen, C. B., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411892 · Cited by 2,724 · see citing works
DONNELLY, J. E., BLAIR, S. N., JAKICIC, J. M., MANORE, M. M., RANKIN, J. W., & SMITH, B. K. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181949333 · Cited by 2,658 · see citing works
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · see citing works
Obesity in adults: a clinical practice guideline
Wharton, S., Lau, D. C. W., Vallis, M., Sharma, A. M., Biertho, L., Campbell-Scherer, D., Adamo, K., Alberga, A., Bell, R., Boulé, N., et al. (2020) · Canadian Medical Association Journal · doi:10.1503/cmaj.191707 · Cited by 1,506 · see citing works
Rubino, D., Abrahamsson, N., Davies, M., Hesse, D., Greenway, F. L., Jensen, C., Lingvay, I., Mosenzon, O., Rosenstock, J., Rubio, M. A., et al. (2021) · JAMA · doi:10.1001/jama.2021.3224 · Cited by 1,444 · see citing works
Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Jastreboff, A. M., Kaplan, L. M., Frías, J. P., Wu, Q., Du, Y., Gurbuz, S., Coskun, T., Haupt, A., Milicevic, Z., & Hartman, M. L. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2301972 · Cited by 1,174 · cited 2× · see citing works
“61 This weight reduction exceeds that of orforglipron, semaglutide and tirzepatide.”
InfluentialGreenway, F. L., Fujioka, K., Plodkowski, R. A., Mudaliar, S., Guttadauria, M., Erickson, J., Kim, D. D., & Dunayevich, E. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60888-4 · Cited by 1,036 · see citing works
Anti-obesity drug discovery: advances and challenges
Müller, T. D., Blüher, M., Tschöp, M. H., & DiMarchi, R. D. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00337-8 · Cited by 1,021 · see citing works
O’Brien, P. E., Hindle, A., Brennan, L., Skinner, S., Burton, P., Smith, A., Crosthwaite, G., & Brown, W. (2019) · Obesity Surgery · doi:10.1007/s11695-018-3525-0 · Cited by 815 · see citing works
Church, T. S., Earnest, C. P., Skinner, J. S., & Blair, S. N. (2007) · JAMA · doi:10.1001/jama.297.19.2081 · Cited by 756 · see citing works
Garvey, W. T., Ryan, D. H., Look, M., Gadde, K. M., Allison, D. B., Peterson, C. A., Schwiers, M., Day, W. W., & Bowden, C. H. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.024927 · Cited by 716 · see citing works
Ruegsegger, G. N., & Booth, F. W. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029694 · Cited by 690 · see citing works
SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications
Brown, E., Heerspink, H. J. L., Cuthbertson, D. J., & Wilding, J. P. H. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00536-5 · Cited by 581 · see citing works
Development and Validation of the Mindful Eating Questionnaire
Framson, C., Kristal, A. R., Schenk, J. M., Littman, A. J., Zeliadt, S., & Benitez, D. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2009.05.006 · Cited by 574 · see citing works
Mindfulness‐based interventions for obesity‐related eating behaviours: a literature review
O'Reilly, G. A., Cook, L., Spruijt‐Metz, D., & Black, D. S. (2014) · Obesity Reviews · doi:10.1111/obr.12156 · Cited by 547 · see citing works
The Effects of Exercise and Physical Activity on Weight Loss and Maintenance
Swift, D. L., McGee, J. E., Earnest, C. P., Carlisle, E., Nygard, M., & Johannsen, N. M. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.014 · Cited by 536 · see citing works
Increased food energy supply is more than sufficient to explain the US epidemic of obesity
Swinburn, B., Sacks, G., & Ravussin, E. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28595 · Cited by 526 · see citing works
An update on sodium-glucose co-transporter-2 inhibitors for the treatment of diabetes mellitus
Hsia, D. S., Grove, O., & Cefalu, W. T. (2017) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000311 · Cited by 508 · see citing works
European Practical and Patient-Centred Guidelines for Adult Obesity Management in Primary Care
Durrer Schutz, D., Busetto, L., Dicker, D., Farpour-Lambert, N., Pryke, R., Toplak, H., Widmer, D., Yumuk, V., & Schutz, Y. (2019) · Obesity Facts · doi:10.1159/000496183 · Cited by 492 · see citing works
Clément, K., van den Akker, E., Argente, J., Bahm, A., Chung, W. K., Connors, H., De Waele, K., Farooqi, I. S., Gonneau-Lejeune, J., Gordon, G., et al. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30364-8 · Cited by 492 · see citing works
Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
Wharton, S., Blevins, T., Connery, L., Rosenstock, J., Raha, S., Liu, R., Ma, X., Mather, K. J., Haupt, A., Robins, D., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2302392 · Cited by 478 · see citing works
2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death
Grundlingh, J., Dargan, P. I., El-Zanfaly, M., & Wood, D. M. (2011) · Journal of Medical Toxicology · doi:10.1007/s13181-011-0162-6 · Cited by 470 · see citing works
Foster‐Schubert, K. E., Alfano, C. M., Duggan, C. R., Xiao, L., Campbell, K. L., Kong, A., Bain, C. E., Wang, C., Blackburn, G. L., & McTiernan, A. (2011) · Obesity · doi:10.1038/oby.2011.76 · Cited by 452 · see citing works
Hypothalamic POMC neurons promote cannabinoid-induced feeding
Koch, M., Varela, L., Kim, J. G., Kim, J. D., Hernández-Nuño, F., Simonds, S. E., Castorena, C. M., Vianna, C. R., Elmquist, J. K., Morozov, Y. M., et al. (2015) · Nature · doi:10.1038/nature14260 · Cited by 436 · see citing works
Häring, H., Merker, L., Seewaldt-Becker, E., Weimer, M. S., Meinicke, T. W., Broedl, U. C., Woerle, H. J., & on behalf of the EMPA-REG MET Trial Investigators (2014) · Diabetes Care · doi:10.2337/dc13-2105 · Cited by 401 · see citing works
Alberts, H. J. E. M., Thewissen, R., & Raes, L. (2012) · Appetite · doi:10.1016/j.appet.2012.01.009 · Cited by 395 · see citing works
Dietary interventions for obesity: clinical and mechanistic findings.
Chao, A. M., Quigley, K. M., & Wadden, T. A. (2021) · Journal of Clinical Investigation · doi:10.1172/jci140065 · Cited by 257 · see citing works
Thorogood, A., Mottillo, S., Shimony, A., Filion, K. B., Joseph, L., Genest, J., Pilote, L., Poirier, P., Schiffrin, E. L., & Eisenberg, M. J. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.02.037 · Cited by 255 · see citing works
Self-citationSystematic Review of the Mediterranean Diet for Long-Term Weight Loss
Mancini, J. G., Filion, K. B., Atallah, R., & Eisenberg, M. J. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.11.028 · Cited by 248 · see citing works
Self-citationWeight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity
Ghusn, W., De la Rosa, A., Sacoto, D., Cifuentes, L., Campos, A., Feris, F., Hurtado, M. D., & Acosta, A. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.31982 · Cited by 238 · see citing works
Caixàs, A., Albert, L., Capel, I., & Rigla, M. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s55587 · Cited by 236 · see citing works
Guideline Recommendations for Obesity Management
Ryan, D. H., & Kahan, S. (2018) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.08.006 · Cited by 221 · see citing works
Insulin Regulates Glucagon-Like Peptide-1 Secretion from the Enteroendocrine L Cell
Lim, G. E., Huang, G. J., Flora, N., LeRoith, D., Rhodes, C. J., & Brubaker, P. L. (2009) · Endocrinology · doi:10.1210/en.2008-0726 · Cited by 200 · see citing works
Frias, J. P., Bonora, E., Nevarez Ruiz, L., Li, Y. G., Yu, Z., Milicevic, Z., Malik, R., Bethel, M. A., & Cox, D. A. (2021) · Diabetes Care · doi:10.2337/dc20-1473 · Cited by 199 · see citing works
Markham, A. (2021) · Drugs · doi:10.1007/s40265-021-01470-9 · Cited by 193 · see citing works
Forman, E. M., Butryn, M. L., Juarascio, A. S., Bradley, L. E., Lowe, M. R., Herbert, J. D., & Shaw, J. A. (2013) · Obesity · doi:10.1002/oby.20169 · Cited by 182 · see citing works
Canagliflozin: effects in overweight and obese subjects without diabetes mellitus
Bays, H. E., Weinstein, R., Law, G., & Canovatchel, W. (2014) · Obesity · doi:10.1002/oby.20663 · Cited by 166 · see citing works
Adverse effects and safety of SGLT-2 inhibitors
Halimi, S., & Vergès, B. L. (2014) · Diabetes & Metabolism · doi:10.1016/s1262-3636(14)72693-x · Cited by 161 · see citing works
The effect of a mindful restaurant eating intervention on weight management in women
Timmerman, G. M., & Brown, A. (2012) · Journal of Nutrition Education and Behavior · doi:10.1016/j.jneb.2011.03.143 · Cited by 149 · see citing works
Comprehensive Review of Current and Upcoming Anti-Obesity Drugs
Son, J. W., & Kim, S. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0258 · Cited by 147 · see citing works
Adverse drug reactions of GLP-1 agonists: A systematic review of case reports
Shetty, R., Basheer, F. T., Poojari, P. G., Thunga, G., Chandran, V. P., & Acharya, L. D. (2022) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2022.102427 · Cited by 145 · see citing works
Booth, H. P., Prevost, T. A., Wright, A. J., & Gulliford, M. C. (2014) · Family Practice · doi:10.1093/fampra/cmu064 · Cited by 144 · see citing works
Efficacy and tolerability of orlistat in the treatment of obesity: a 6-month dose-ranging study
van Gaal, L. V., Broom, J., Enzi, G., & Toplak, H. (1998) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050433 · Cited by 142 · see citing works
Rosenstock, J., Guerci, B., Hanefeld, M., Gentile, S., Aronson, R., Tinahones, F. J., Roy-Duval, C., Souhami, E., Wardęcki, M., Ye, J., et al. (2016) · Diabetes Care · doi:10.2337/dc16-0014 · Cited by 134 · see citing works
Thyroid Hormone Therapy for Obesity and Nonthyroidal Illnesses: A Systematic Review
Kaptein, E. M., Beale, E., & Chan, L. S. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0899 · Cited by 110 · see citing works
Lesses, M. F., & Myerson, A. (1938) · New England Journal of Medicine · doi:10.1056/nejm193801202180307 · Cited by 82 · see citing works
Atallah, R., Filion, K. B., Wakil, S. M., Genest, J., Joseph, L., Poirier, P., Rinfret, S., Schiffrin, E. L., & Eisenberg, M. J. (2014) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.113.000723 · Cited by 81 · see citing works
Self-citationWeight Loss Medications in the Treatment of Obesity and Hypertension
Cohen, J. B., & Gadde, K. M. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0915-1 · Cited by 80 · see citing works
Weight-Reducing Side Effects of the Antiepileptic Agents Topiramate and Zonisamide
Antel, J., & Hebebrand, J. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-24716-3_20 · Cited by 79 · see citing works
Goodwin, C. L., Forman, E. M., Herbert, J. D., Butryn, M. L., & Ledley, G. S. (2012) · Behavior Modification · doi:10.1177/0145445511427770 · Cited by 69 · see citing works
Ryan, D. H. (2021) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes21033 · Cited by 67 · cited 1× · see citing works
“47 Setmelanotide is administered as a daily 3 mg subcutaneous injection.”
β-Endorphin Antagonizes the Effects of α-MSH on Food Intake and Body Weight
Dutia, R., Meece, K., Dighe, S. V., Kim, A. J., & Wardlaw, S. L. (2012) · Endocrinology · doi:10.1210/en.2012-1166 · Cited by 61 · see citing works
Influence Of Body Fat Percentage On Agility, Strength, And Endurance Performance
Bouley, K. J., Pieklo, M. C., Matthews, T., & Paolone, V. J. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000355949.56770.cf · Cited by 58 · see citing works
Pharmacological and Neurotoxicological Actions Mediated By Bupropion and Diethylpropion
Arias, H. R., Santamarı́a, A., & Ali, S. F. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)88009-4 · Cited by 41 · see citing works
Yazawa, R., Ishida, M., Balavarca, Y., & Hennige, A. M. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15064 · Cited by 26 · see citing works
Heymsfield, S. B., Raji, A., Gallo, S., Liu, J., Pong, A., Hannachi, H., & Terra, S. G. (2020) · Obesity · doi:10.1002/oby.22748 · Cited by 21 · see citing works
SGLT2 Inhibitors for Type 2 Diabetes Mellitus Treatment.
Plodkowski, R. A., McGarvey, M. E., Huribal, H. M., Reisinger‐Kindle, K., Kramer, B., Solomon, M., & Nguyen, Q. T. (2015) · Europe PMC (PubMed Central) · Cited by 16 · see citing works
The design of the liraglutide clinical trial programme
Nauck, M. A. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01573.x · Cited by 13 · see citing works
Huh, Y., & Kim, Y. S. (2022) · BMC Family Practice · doi:10.1186/s12875-022-01748-1 · Cited by 13 · see citing works
Farah, D., & Fonseca, M. C. M. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.06.005 · Cited by 10 · see citing works
Oliveira, J. P. T., do Carmo, S. G., Aragão, B. D. A., Cunha, J., & Botelho, P. B. (2023) · Nutrition · doi:10.1016/j.nut.2023.111972 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [1]Bray GA Purnell JQ An historical review of steps and missteps in the discovery of anti-obesity drugs Endotext South Dartmouth (MA) MDText.com, Inc 2000-2024 Available https://www.ncbi.nlm.nih.gov/books/NBK581942/ 35834619
- [12]Donnelly JE Blair SN Jakicic JM et al American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults Med Sci Sports Exerc 2009 41 459 71 10.1249/MSS.0b013e3181949333 19127177 · DOI · Paper page
- [26]National Institute of Diabetes and Digestive and Kidney Diseases "Diethylpropion," in LiverTox: Clinical and Research Information on Drug-Induced Liver Injury Bethesda (MD) 2012 31643176
- [29]National Institute of Diabetes and Digestive and Kidney Diseases LiverTox: Clinical and Research Information on Drug-Induced Liver Injury Bethesda (MD) 2012 31643176
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Fitch, A., Gigliotti, L., & Bays, H. E. (2025) · Obesity Pillars · doi:10.1016/j.obpill.2025.100205 · Cited by 14 · see citing works
2026 ESC Guidelines on cardiac rehabilitation
Bäck, M., Wilhelm, M., Marcin, T., Machado, F. V. C., Sandberg, A., Buccheri, S., Conde, A. C., Czapla, M., Rosa, S. D., Gibson, I., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag099 · Cited by 18 · see citing works
Setayesh, A., Arzhang, P., Baniasadi, M. M., Lahouti, M., & Azadbakht, L. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01994-0 · Cited by 3 · see citing works
Habib, H. B., Omi, F. R., Biswas, S., Mita, M. A., Suhi, S., Zaman, S., Akhtar‐E‐Ekram, M., Saleh, M. A., & Uddin, M. S. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10639-7 · Cited by 2 · see citing works
Metwally, E., Burton, L. C., Mirza, I., Morsy, M., Scichilone, G., Mostafa, A., Shimotake, L. Y., Lighter, M., Bianco, F. M., Hassan, C., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf586 · Cited by 2 · see citing works
The Global Obesity Epidemic: Epidemiology, Health Burden and Policy Priorities
Henney, A. E., & Wilding, J. P. H. (2026) · European Cardiology Review · doi:10.15420/ecr.2025.84 · Cited by 3 · see citing works
Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review
de Paula, G. L. A. D. S., Garcia, E. C., Beserra, B. T. S., & Amato, A. A. (2025) · Cells · doi:10.3390/cells14231907 · Cited by 1 · see citing works
Kang, M. H., Han, M. H., Hwang, Y. S., Oh, J. H., Lee, J. H., & Kim, J. W. (2025) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-025-00224-8
Lipoeto, N. I., Sari, N. V., Febri, D. S., & Mirnawati, M. (2026) · Precision Nutrition · doi:10.1097/pn9.0000000000000139
Intermittent fasting for adults with overweight or obesity: Summary of a Cochrane review
Boopalan, D., Ravi, P., Vijayakumar, V., & Kuppuswamy, M. (2026) · EXPLORE · doi:10.1016/j.explore.2026.103492
2026 ESC Guidelines on cardiac rehabilitation
Bäck, M., Wilhelm, M., Marcin, T., Machado, F. V. C., Sandberg, A., Buccheri, S., Conde, A. C., Czapla, M., Rosa, S. D., Gibson, I., et al. (2026) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwag417
Zhu, L.-N., Yuan, W., Gu, Q.-Z., Yang, Q.-L., Yi, C.-J., & Wang, Z. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1869229
Yang, B., Wang, J., Pan, W., Liang, H., & Zhao, H. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1913436
- Authors
- Peri, K., & Eisenberg, M.
- Affiliations
- McGill University (CA)
- Jewish General Hospital (CA)
- Corresponding author
- Eisenberg, Mark
- Venue
- BMJ Public Health
- Publisher
- BMJ
- Published
- 2024-11
- Volume
- 2
- Issue
- 2
- Pages
- e000246
- ISSN
- 2753-4294 (ISSN-L)
- PMC
- PMC12581000
- OpenAlex
- W4405445084
- Cited by
- 13
- References
- 62
- Citations by year
- 2026: 7 · 2025: 6
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- BMJ Public Health (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
- Keywords
- obesity treatment, anti-obesity drugs, pharmacotherapy, diet, physical activity, behavior therapy, lifestyle modification, cardiometabolic disease, obesity prevalence, clinical guidelines
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