The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Helicobacter pylori outer membrane proteins and gastroduodenal disease
Open accessAbstract
Background and aims: A number of Helicobacter pylori outer membrane proteins (OMPs) undergo phase variations. This study examined the relation between OMP phase variations and clinical outcome. Methods: Expression of H pylori BabA, BabB, SabA, and OipA proteins was determined by immunoblot. Multiple regression analysis was performed to determine the relation among OMP expression, clinical outcome, and mucosal histology. Results: H pylori were cultured from 200 patients (80 with gastritis, 80 with duodenal ulcer (DU), and 40 with gastric cancer). The most reliable results were obtained using cultures from single colonies of low passage number. Stability of expression with passage varied with OipA > BabA > BabB > SabA. OipA positive status was significantly associated with the presence of DU and gastric cancer, high H pylori density, and severe neutrophil infiltration. SabA positive status was associated with gastric cancer, intestinal metaplasia, and corpus atrophy, and negatively associated with DU and neutrophil infiltration. The Sydney system underestimated the prevalence of intestinal metaplasia/atrophy compared with systems using proximal and distal corpus biopsies. SabA expression dramatically decreased following exposure of H pylori to pH 5.0 for two hours. Conclusions: SabA expression frequently switched on or off, suggesting that SabA expression can rapidly respond to changing conditions in the stomach or in different regions of the stomach. SabA positive status was inversely related to the ability of the stomach to secrete acid, suggesting that its expression may be regulated by changes in acid secretion and/or in antigens expressed by the atrophic mucosa.
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The complete genome sequence of the gastric pathogen Helicobacter pylori
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Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
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Self-citationAttachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens
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Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation
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Self-citationClinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin
Gerhard, M., Lehn, N., Neumayer, N., Borén, T., Rad, R., Schepp, W., Miehlke, S., Classen, M., & Prinz, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12778 · Cited by 610
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Self-citationFunctional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin
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Self-citationA M r 34,000 proinflammatory outer membrane protein ( oipA ) of Helicobacter pylori
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Self-citationYamaoka, Y., Kikuchi, S., El–Zimaity, H. M. T., Gutierrez, O., Osato, M. S., & Graham, D. Y. (2002) · Gastroenterology · doi:10.1053/gast.2002.34781 · Cited by 351
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Cited by
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
Wroblewski, L. E., Peek, R. M., & Wilson, K. T. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00011-10 · Cited by 1,442
Mechanisms of disease: Helicobacter pylori virulence factors
Yamaoka, Y. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.154 · Cited by 666
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Metadata
- Authors
- Yamaoka, Y., Ojo, O., Fujimoto, S., Odenbreit, S., Haas, R., Gutierrez, O., El-Zimaity, H. M. T., Reddy, R., Arnqvist, A., & Graham, D. Y.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2005-12-01
- Volume
- 55
- Issue
- 6
- Pages
- 775-781
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2121426096
- Cited by
- 256
- References
- 33
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- green
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