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Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model.
Open accessAbstract
BACKGROUND: Helicobacter pylori is a bacterium which causes gastric inflammatory diseases. Oral inoculation of H pylori usually results in only a temporary colonisation without a successful infection in the stomach of conventional mice in which lactobacilli are the predominant indigenous bacteria. AIM: To determine whether lactobacilli exert an inhibitory effect on colonisation by H pylori in the stomach. METHODS: The effects of H pylori on attachment to murine and human gastric epithelial cells and the H pylori mediated release of interleukin-8 (IL-8) by these cells were examined in vitro. Lactobacillus salivarius infected gnotobiotic BALB/c mice and control germ free mice were inoculated orally with H pylori to examine whether L salivarius can inhibit colonisation by H pylori. RESULTS: L salivarius inhibited both the attachment and IL-8 release in vitro. H pylori could not colonise the stomach of L salivarius infected gnotobiotic BALB/c mice, but colonised in large numbers and subsequently caused active gastritis in germ free mice. In addition, L salivarius given after H pylori implantation could eliminate colonisation by H pylori. CONCLUSION: These findings suggest the possibility of lactobacilli being used as probiotic agents against H pylori.
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Metadata
- Authors
- Kabir, A. M., Aiba, Y., Takagi, A., Kamiya, S., Miwa, T., & Koga, Y.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1997-07
- Volume
- 41
- Issue
- 1
- Pages
- 49-55
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2119190752
- Cited by
- 308
- References
- 0
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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