Probiotic lactic acid bacteria in the gastro-intestinal tract: health benefits, safety and mode of action

Dicks, L.; Botes, M.

doi:10.3920/bm2009.0012

Cited by 207Probiotics and Fermented FoodsReproductive tract infections researchGut microbiota and health

Probiotic lactic acid bacteria in the gastro-intestinal tract: health benefits, safety and mode of action

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Dicks, L., Botes, M.·2010·Beneficial Microbes

DOI 10.3920/bm2009.0012

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Abstract

Lactic acid bacteria (LAB) have received considerable attention as probiotics over the past few years. This concept has grown from traditional dairy products to a profitable market of probiotic health supplements and functional foods. Extensive research is done on novel potential probiotic strains, with specific emphasis on their health benefits and mode of action. Criteria for the selection of probiotic strains have only recently been formulated by the Food and Agriculture Organization of the United Nations and the World Health Organization (FAO/WHO). Several in vitro techniques have been developed to evaluate the probiotic properties of strains. In many cases, this is followed by in vivo tests. Safety studies are also obligatory, as a few cases of bacteremia caused by LAB have been reported. This review focuses on the health benefits and safety of LAB probiotics, the criteria used to select a probiotic, mode of action and the impact these organisms have on natural microbiota in the gastro-intestinal tract.

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Caco-2 cells resemble mature enterocyte cells in the small intestine of humans and form crypts, forming a homogeneous typical epithelial monolayer.
“These cells resemble mature enterocyte cells in the small intestine of humans and form crypts, forming a homogeneous typical epithelial monolayer [43-45].”
From Probiotic and Antifungal Attributes of Lactic Acid Bacteria Isolates from Naturally Fermented Brazilian Table Olives (2022) · cites this paper as [43]
The Introduction and Conclusions describe Caco-2 as a human cell line used to study adhesion to intestinal epithelial cells. The Adhesion to mucus and epithelial cells section does not say that Caco-2 cells resemble mature small-intestinal enterocytes, form crypts, or form a homogeneous epithelial monolayer; those specific features are unsupported by our copy. Page numbers are unavailable. (LLM, conf=0.82)
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Authors: Dicks, L., & Botes, M.
Affiliations: Stellenbosch University (ZA)
ORCID: Dicks, L.
Botes, M.
Venue: Beneficial Microbes
Publisher: Walter de Gruyter GmbH
Published: 2010-03-01
Volume: 1
Issue: 1
Pages: 11-29
ISSN: 1876-2883 (ISSN-L)
1876-2891
DOI: 10.3920/bm2009.0012
OpenAlex: W2146990030
Cited by: 207
References: 208
Citations by year: 2026: 2 · 2025: 12 · 2024: 9 · 2023: 14 · 2022: 20 · 2021: 20 · 2020: 20 · 2019: 10 · 2018: 19 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 14 · 2013: 13 · 2012: 12
FWCI: 11.05
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Beneficial Microbes (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: probiotics, lactic acid bacteria, gastrointestinal tract, health benefits, probiotic safety, mechanism of action, probiotic strain selection, functional foods, probiotic supplements, gut microbiota, bacteremia
MeSH terms: Bacteria, Humans, Insurance Benefits, Lactic Acid, Probiotics, Gastrointestinal Tract, Drug-Related Side Effects and Adverse Reactions

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Probiotic lactic acid bacteria in the gastro-intestinal tract: health benefits, safety and mode of action

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