The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Evidence for two distinct perceptual alterations in irritable bowel syndrome
Open accessAbstract
Background and aims —Visceral hyperalgesia has been implicated as a factor contributing to symptom generation in irritable bowel syndrome (IBS). However, previous studies using intestinal balloon distension have used psychophysical procedures which do not provide adequate and unbiased measures of visceral sensitivity. Methods —Three psychophysical tasks were examined in 45 patients with IBS (positive Rome criteria) and 14 controls using rectal balloon distension with a computerised distension device. Discomfort threshold and tolerance were assessed during an ascending series of phasic pressure stimuli and during an interactive threshold tracking procedure. In addition, stimulus response functions were generated from intensity and unpleasantness ratings of the rectal distensions. Results —Discomfort threshold and tolerance for the ascending stimuli were significantly lower for the patients with IBS compared with the controls. In contrast, discomfort thresholds during the tracking procedure and stimulus response curves for the ascending series were not different between the groups. A factor analysis of the psychophysical data was consistent with the presence of two distinct and unrelated perceptual alterations related to rectal distension: hypervigilance for visceral stimuli, manifested as lowered response criteria for using the descriptor “discomfort”; and rectal hypersensitivity, manifested as a lower discomfort threshold and left shift of the stimulus response curves. Conclusions —Patients with IBS as a group have a greater propensity to label visceral sensations negatively and show a lower tolerance for rectal balloon distension. A subgroup of patients also have baseline rectal hypersensitivity, assessed by unbiased measures of discomfort threshold and stimulus intensity judgements.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Experimental Design: Procedures for the Behavioral Sciences
Kirk, R. (2013) · doi:10.4135/9781483384733 · Cited by 8,539
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757
Cited by
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384
Self-citationGuidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818
Fibromyalgia and overlapping disorders: The unifying concept of central sensitivity syndromes
Yunus, M. B. (2007) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2006.12.009 · Cited by 780
Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome
Zhou, Q., Zhang, B., & Verne, N. G. (2009) · Pain · doi:10.1016/j.pain.2009.06.017 · Cited by 373
Gender differences in irritable bowel syndrome
Chang, L., & Heitkemper, M. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.36603 · Cited by 351
WHITEHEAD, W., & PALSSON, O. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70099-x · Cited by 314
Pain and inflammatory bowel disease.
Bielefeldt, K., Davis, B., & Binion, D. G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20848 · Cited by 304
Craske, M. G., Wolitzky-Taylor, K. B., Labus, J., Wu, S., Frese, M., Mayer, E. A., & Naliboff, B. D. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.04.001 · Cited by 243
Self-citationAltered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity
Posserud, I., Syrous, A., Lindström, L., Tack, J., Abrahamsson, H., & Simrén, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.024 · Cited by 248
Comorbidity in Irritable Bowel Syndrome
Whitehead, W. E., Palsson, O. S., Levy, R. R., Feld, A. D., Turner, M., & Von Korff, M. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01540.x · Cited by 210
PTSD and stress sensitisation: A tale of brain and body
Stam, R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.11.010 · Cited by 211
Symptoms and Visceral Perception in Patients With Pain-Predominant Irritable Bowel Syndrome
Lembo, T., Naliboff, B., Munakata, J., Fullerton, S., Saba, L., Tung, S., Schmulson, M., & Mayer, E. A. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01009.x · Cited by 202
Self-citationPalsson, O. S., Turner, M. J., Johnson, D. A., Burnett, C. K., & Whitehead, W. E. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020545017390 · Cited by 195
Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome
Kennedy, P. J., Clarke, G., Quigley, E. M. M., Groeger, J. A., Dinan, T. G., & Cryan, J. F. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.001 · Cited by 193
Sex specific alterations in autonomic function among patients with irritable bowel syndrome
Tillisch, K., Mayer, E. A., Labus, J. S., Stains, J., Chang, L., & Naliboff, B. D. (2005) · Gut · doi:10.1136/gut.2004.058685 · Cited by 156
Self-citationBrain and gut CRF signaling: biological actions and role in the gastrointestinal tract
Tache, Y., Larauche, M., Yuan, P.-Q., & Million, M. (2018) · Current Molecular Pharmacology · doi:10.2174/1874467210666170224095741 · Cited by 147
Choi, C. H., Jo, S. Y., Park, H. J., Chang, S. K., Byeon, J.-S., & Myung, S.-J. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318204593e · Cited by 144
Chang, L., Berman, S., Mayer, E. A., Suyenobu, B., Derbyshire, S., Naliboff, B., Vogt, B., FitzGerald, L., & Mandelkern, M. A. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07478.x · Cited by 122
Self-citationAdding to the Burden: Gastrointestinal Symptoms and Syndromes in Multiple Sclerosis
Levinthal, D. J., Rahman, A., Nusrat, S., O’Leary, M., Heyman, R., & Bielefeldt, K. (2013) · Multiple Sclerosis International · doi:10.1155/2013/319201 · Cited by 93
Visceral sensation and emotion: a study using hypnosis
Houghton, L. A., Calvert, E. L., Jackson, N. A., Cooper, P., & Whorwell, P. J. (2002) · Gut · doi:10.1136/gut.51.5.701 · Cited by 88
Functional findings in irritable bowel syndrome
Posserud, I. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i18.2830 · Cited by 83
Autonomic cardiovascular responses are impaired in women with irritable bowel syndrome
Waring, W. S., Chui, M., Japp, A., Nicol, E. F., & Ford, M. J. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000135362.35665.49 · Cited by 83
Heymen, S., Maixner, W., Whitehead, W. E., Klatzkin, R. R., Mechlin, B., & Light, K. C. (2010) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181bff800 · Cited by 82
Tillisch, K., Labus, J., Nam, B., Bueller, J., Smith, S., Suyenobu, B., Siffert, J., McKelvy, J., Naliboff, B., & Mayer, E. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04958.x · Cited by 60
Self-citationPeripheral factors in the pathophysiology of irritable bowel syndrome
Gunnarsson, J., & Simrén, M. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.006 · Cited by 57
Complementary and alternative medicine for IBS in adults: mind-body interventions.
Kearney, D. J., & Brown-Chang, J. (2008) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep1257 · Cited by 57
Increased Acoustic Startle Responses in IBS Patients During Abdominal and Nonabdominal Threat
Naliboff, B. D., Waters, A. M., Labus, J. S., Kilpatrick, L., Craske, M. G., Chang, L., Negoro, H., Ibrahimovic, H., Mayer, E. A., & Ornitz, E. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318186d858 · Cited by 45
Self-citationCentral sensitivity syndromes: An overview
Yunus, M. B. (2009) · Journal of Musculoskeletal Pain · doi:10.3109/10582450903284752 · Cited by 29
Gender differences and hormonal modulation in visceral pain
Heitkemper, M. M., & Jarrett, M. (2001) · Current Pain and Headache Reports · doi:10.1007/s11916-001-0008-z · Cited by 23
Heart Rate Variability as a Measure of Disease State in Irritable Bowel Syndrome
Park, H.-J. (2008) · Asian Nursing Research · doi:10.1016/s1976-1317(08)60024-9 · Cited by 8
Metadata
- Authors
- Naliboff, B. D., Munakata, J., Fullerton, S., Gracely, R. H., Kodner, A., Harraf, F., & Mayer, E. A.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1997-10-01
- Volume
- 41
- Issue
- 4
- Pages
- 505-512
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2096884223
- Cited by
- 371
- References
- 3
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
