Pain and inflammatory bowel disease.
Open accessAbstract
Abdominal pain is a common symptom of inflammatory bowel disease (IBD: Crohn's disease, ulcerative colitis). Pain may arise from different mechanisms, which can include partial blockage and gut distention as well as severe intestinal inflammation. A majority of patients suffering from acute flares of IBD will experience pain, which will typically improve as disease activity decreases. However, a significant percentage of IBD patients continue experiencing symptoms of pain despite resolving inflammation and achieving what appears to be clinical remission. Current evidence suggests that sensory pathways sensitize during inflammation, leading to persistent changes in afferent neurons and central nervous system pain processing. Such persistent pain is not only a simple result of sensory input. Pain processing and even the activation of sensory pathways is modulated by arousal, emotion, and cognitive factors. Considering the high prevalence of iatrogenic as well as essential neuropsychiatric comorbidities including anxiety and depression in IBD patients, these central modulating factors may significantly contribute to the clinical manifestation of chronic pain. The improved understanding of peripheral and central pain mechanisms is leading to new treatment strategies that view pain as a biopsychosocial problem. Thus, improving the underlying inflammation, decreasing the excitability of sensitized afferent pathways, and altering emotional and/or cognitive functions may be required to more effectively address the difficult and disabling disease manifestations.
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Meta-analyses of controlled trials reported numbers-needed-to-treat of 3 to 4 for symptomatic benefit over placebo in irritable bowel syndrome patients.
“Meta-analyses combining controlled studies have reported numbers-needed-to-treat of 3 to 4 for symptomatic benefit over placebo in IBS patients.8,9”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [8]
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Cites
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284 · see citing works
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024 · see citing works
Serious Infections and Mortality in Association With Therapies for Crohn’s Disease: TREAT Registry
Lichtenstein, G. R., Feagan, B. G., Cohen, R. D., Salzberg, B. A., Diamond, R. H., Chen, D. M., Pritchard, M. L., & Sandborn, W. J. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.002 · Cited by 902 · see citing works
Al–Chaer, E. D., Kawasaki, M., & Pasricha, P. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.19576 · Cited by 727 · see citing works
Psychological stress in IBD: new insights into pathogenic and therapeutic implications
Mawdsley, J. E., & Rampton, D. S. (2005) · Gut · doi:10.1136/gut.2005.064261 · Cited by 622 · see citing works
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614 · see citing works
The lower limb flexion reflex in humans
Sandrini, G., Serrao, M., Rossi, P., Romaniello, A., Cruccu, G., & Willer, J. C. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.11.003 · Cited by 508 · see citing works
Coutinho, S. V., Plotsky, P. M., Sablad, M., Miller, J. C., Zhou, H., Bayati, A. I., McRoberts, J. A., & Mayer, E. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00240.2001 · Cited by 456 · see citing works
Jones, R. C. W., Xu, L., & Gebhart, G. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0703-05.2005 · Cited by 415 · see citing works
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E. (1998) · Gut · doi:10.1136/gut.43.2.256 · Cited by 405 · see citing works
Wilder‐Smith, C. H., Schindler, D., Lövblad, K., Redmond, S. M., & Nirkko, A. (2004) · Gut · doi:10.1136/gut.2003.028514 · Cited by 386 · see citing works
Evidence for two distinct perceptual alterations in irritable bowel syndrome
Naliboff, B. D., Munakata, J., Fullerton, S. C., Gracely, R. H., Kodner, A., Harraf, F., & Mayer, E. A. (1997) · Gut · doi:10.1136/gut.41.4.505 · Cited by 364 · see citing works
Vanilloid receptor 1 immunoreactivity in inflamed human bowel
Yiangou, Y., Facer, P., Dyer, N., Chan, C., Knowles, C. H., Williams, N. S., & Anand, P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04503-7 · Cited by 360 · see citing works
Spiller, R. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00324-x · Cited by 353 · see citing works
Depression and anxiety in people with inflammatory bowel disease
Kurina, L. M., Goldacre, M. J., Yeates, D., & Gill, L. E. (2001) · Journal of Epidemiology & Community Health · doi:10.1136/jech.55.10.716 · Cited by 347 · see citing works
Deletion of vanilloid receptor 1_expressing primary afferent neurons for pain control
Karai, L., Brown, D. C., Mannes, A. J., Connelly, S. T., Brown, J., Gandal, M., Wellisch, O. M., Neubert, J. K., Olah, Z., & Iadarola, M. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20449 · Cited by 340 · see citing works
TRPV1+ Sensory Neurons Control β Cell Stress and Islet Inflammation in Autoimmune Diabetes
Razavi, R., Chan, Y., Afifiyan, F. N., Liu, X. J., Wan, X., Yantha, J., Tsui, H., Tang, L. F., Tsai, S. J., Santamaría, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.038 · Cited by 338 · see citing works
Farrokhyar, F., Marshall, J. K., Easterbrook, B., & Irvine, J. E. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000195391.49762.89 · Cited by 310 · see citing works
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
Bradesi, S., Schwetz, I., Ennes, H. S., Lamy, C. M., Ohning, G., Fanselow, M. S., Pothoulakis, C., McRoberts, J. A., & Mayer, E. A. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00500.2004 · Cited by 307 · see citing works
Guthrie, E., Jackson, J., Shaffer, J., Thompson, D., Tomenson, B., & Creed, F. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05842.x · Cited by 306 · see citing works
Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis
Lackner, J. M., Mesmer, C., Morley, S., Dowzer, C., & Hamilton, S. (2004) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.72.6.1100 · Cited by 295 · see citing works
Takeuchi, K., Smale, S., Premchand, P., Maiden, L., Sherwood, R., Thjódleifsson, B., Björnsson, E., & Bjarnason, I. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00980-8 · Cited by 293 · see citing works
Graff, L. A., Walker, J. R., Lix, L., Clara, I., Rawsthorne, P., Rogala, L., Miller, N., Jakul, L., McPhail, C., Ediger, J., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.09.027 · Cited by 292 · see citing works
Fuller-Thomson, E., & Sulman, J. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200608000-00005 · Cited by 292 · see citing works
Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis
Linden, D. R., Chen, J.-X., Gershon, M. D., Sharkey, K. A., & Mawe, G. M. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00488.2002 · Cited by 291 · see citing works
Tack, J. F., Broekaert, D., Fischler, B., Oudenhove, L. V., Gevers, A. M., & Janssens, J. (2006) · Gut · doi:10.1136/gut.2005.077503 · Cited by 289 · see citing works
Bleakman, D., Alt, A. J., & Nisenbaum, E. S. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.10.008 · Cited by 284 · see citing works
Long term benefits of hypnotherapy for irritable bowel syndrome
Gonsalkorale, W. M., Miller, V, Afzal, A., & Whorwell, P. J. (2003) · Gut · doi:10.1136/gut.52.11.1623 · Cited by 283 · see citing works
Mayer, E. A., Berman, S. M., Suyenobu, B. Y., Labus, J. S., Mandelkern, M. A., Naliboff, B. D., & Chang, L. (2005) · Pain · doi:10.1016/j.pain.2005.03.023 · Cited by 275 · see citing works
Henriksen, M., Jahnsen, J., Lygren, I., Sauar, J., Kjellevold, Y., Schulz, T. B., Vatn, M. H., & Moum, B. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000225339.91484.fc · Cited by 267 · see citing works
Dunckley, P., Wise, R. G., Fairhurst, M. T., Hobden, P., Aziz, Q., Chang, L., & Tracey, I. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1100-05.2005 · Cited by 262 · see citing works
Malin, S. A., Molliver, D. C., Koerber, H. R., Cornuet, P. K., Frye, R., Albers, K. M., & Davis, B. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1726-06.2006 · Cited by 256 · see citing works
Self-citationMinderhoud, I. M., Oldenburg, B., Wismeijer, J. A., Henegouwen, G. P. V. B., & Smout, A. J. P. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020506.84248.f9 · Cited by 243 · see citing works
Lix, L. M., Graff, L. A., Walker, J. R., Clara, I., Rawsthorne, P., Rogala, L., Miller, N., Ediger, J., Pretorius, T., & Bernstein, C. N. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20511 · Cited by 238 · see citing works
A psychophysiological study in humans using phasic colonic distension as a noxious visceral stimulus
Ness, T. J., Metcalf, A., & Gebhart, G. F. (1990) · Pain · doi:10.1016/0304-3959(90)90035-c · Cited by 224 · see citing works
IV. Modulation of intestinal inflammation by stress: basic mechanisms and clinical relevance
Collins, S. M. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.3.g315 · Cited by 224 · see citing works
Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70039-1 · Cited by 206 · see citing works
Verne, N. G., Robinson, M. E., Vase, L., & Price, D. D. (2003) · Pain · doi:10.1016/s0304-3959(03)00210-0 · Cited by 205 · see citing works
Robinson, D. R., McNaughton, P. A., Evans, M. L., & Hicks, G. A. (2004) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00456.x · Cited by 204 · see citing works
Maunder, R., & Levenstein, S. (2008) · Current Molecular Medicine · doi:10.2174/156652408784533832 · Cited by 198 · see citing works
Tabas, G., Beaves, M., Wang, J., Friday, P., Mardini, H. E., & Arnold, G. L. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04127.x · Cited by 192 · see citing works
Simrén, M. (2002) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(01)04037-0 · Cited by 186 · see citing works
Murray, C. D. R., Flynn, J., Ratcliffe, L., Jacyna, M. R., Kamm, M. A., & Emmanuel, A. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.057 · Cited by 185 · see citing works
Perceptual responses in patients with inflammatory and functional bowel disease
Chang, L., Munakata, J., Mayer, E. A., Schmulson, M. J., Johnson, T. D., Bernstein, C. N., Saba, L., Naliboff, B., Anton, P. A., & Matin, K. (2000) · Gut · doi:10.1136/gut.47.4.497 · Cited by 185 · see citing works
SZIGETHY, E., KENNEY, E., CARPENTER, J., HARDY, D. M., FAIRCLOUGH, D., BOUSVAROS, A., KELJO, D., WEISZ, J., BEARDSLEE, W. R., NOLL, R., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180f6341f · Cited by 183 · see citing works
Nicholl, B. I., Halder, S. L. S., Macfarlane, G. J., Thompson, D. G., O’Brien, S. J., Musleh, M., & McBeth, J. (2007) · Pain · doi:10.1016/j.pain.2007.08.029 · Cited by 182 · see citing works
Ness, T. J., & Gebhart, G. F. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.57.6.1867 · Cited by 181 · see citing works
Jones, M. P., Wessinger, S. B., & Crowell, M. D. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2005.12.012 · Cited by 180 · see citing works
Rectal afferent function in patients with inflammatory and functional intestinal disorders
Bernstein, C. N., Niazi, N., Robert, M. E., Mertz, H., Kodner, A., Munakata, J., Naliboff, B. D., & Mayer, E. A. (1996) · Pain · doi:10.1016/0304-3959(96)03062-x · Cited by 179 · see citing works
Mikocka-Walus, A. A., Turnbull, D. A., Moulding, N. T., Wilson, I. G., Andrews, J. M., & Holtmann, G. J. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20062 · Cited by 178 · see citing works
Lackner, J. M., Jaccard, J., Krasner, S. S., Katz, L. A., Gudleski, G. D., & Holroyd, K. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.03.004 · Cited by 176 · see citing works
Song, G. H., Venkatraman, V., Ho, K. Y., Chee, M. W. L., Yeoh, K. G., & Wilder‐Smith, C. H. (2006) · Pain · doi:10.1016/j.pain.2006.06.017 · Cited by 175 · see citing works
Lea, R., Houghton, L. A., Calvert, E. L., Larder, S., Gonsalkorale, W. M., Whelan, V., Randles, J., Cooper, P., Cruickshanks, P., Miller, V., et al. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01486.x · Cited by 172 · see citing works
Antidepressant Agents for the Treatment of Chronic Pain and Depression
Jann, M. W., & Slade, J. H. (2007) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.27.11.1571 · Cited by 172 · see citing works
Peripheral neuropathy in patients with inflammatory bowel disease
Gondim, F. D. A. A. (2005) · Brain · doi:10.1093/brain/awh429 · Cited by 168 · see citing works
Nerve Growth Factor and Its High-Affinity Receptor in Chronic Pancreatitis
Frieß, H., Zhu, Z., di Mola, F. F., Kulli, C., Graber, H. U., Andrén‐Sandberg, Å., Zimmermann, A., Korc, M., Reinshagen, M., & Büchler, M. W. (1999) · Annals of Surgery · doi:10.1097/00000658-199911000-00002 · Cited by 166 · see citing works
Inflammatory bowel disease in Iran: A review of 457 cases
Aghazadeh, R., Zali, M. R., Bahari, A., Amin, K., Ghahghaie, F., & Firouzi, F. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.03905.x · Cited by 155 · see citing works
di Mola, F. F. (2000) · Gut · doi:10.1136/gut.46.5.670 · Cited by 152 · see citing works
Miranda, A., Nordstrom, E. M., Mannem, A., Smith, C. R., Banerjee, B., & Sengupta, J. N. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.034 · Cited by 151 · see citing works
Beyak, M. J., Ramji, N., Krol, K. M., Kawaja, M. D., & Vanner, S. J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2004 · Cited by 150 · see citing works
Previous inflammation alters the response of the rat colon to stress
Collins, S. M., McHugh, K., Jacobson, K., Khan, I., Riddell, R. H., Murase, K., & Weingarten, H. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70012-4 · Cited by 148 · see citing works
Sipe, W. E. B., Brierley, S. M., Martin, C. M., Phillis, B. D., Cruz, F. B., Grady, E. F., Liedtke, W., Cohen, D., Vanner, S. J., Blackshaw, L. A., et al. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00002.2008 · Cited by 146 · see citing works
Walker, E. A., Gelfand, M. D., Gelfand, A. N., Creed, F., & Katon, W. J. (1996) · General Hospital Psychiatry · doi:10.1016/0163-8343(96)00036-9 · Cited by 144 · see citing works
Ileitis modulates potassium and sodium currents in guinea pig dorsal root ganglia sensory neurons
Stewart, T., Beyak, M. J., & Vanner, S. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.046409 · Cited by 140 · see citing works
Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis
O'Hara, J. R., Ho, W., Linden, D. R., Mawe, G. M., & Sharkey, K. A. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00090.2004 · Cited by 139 · see citing works
Veenema, A. H., Reber, S. O., Selch, S., Obermeier, F., & Neumann, I. D. (2008) · Endocrinology · doi:10.1210/en.2007-1469 · Cited by 138 · see citing works
Sengupta, J., Su, X., & Gebhart, G. F. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70064-1 · Cited by 137 · see citing works
Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome
Mangel, A. W., Bornstein, J. D., Hamm, L. R., Buda, J. J., Wang, J., Irish, W. D., & Urso, D. M. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03730.x · Cited by 136 · see citing works
Jones, R. C. W., Otsuka, E., Wagstrom, E. A., Jensen, C. S., Price, M. P., & Gebhart, G. F. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.042 · Cited by 134 · see citing works
Moss-Morris, R. E., & Spence, M. J. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000221384.07521.05 · Cited by 128 · see citing works
ATP‐gated ion channel P2X3 is increased in human inflammatory bowel disease
Yiangou, Y., Facer, P., Baecker, P. A., Ford, A. P. D. W., Knowles, C. H., Chan, C., Williams, N. S., & Anand, P. (2001) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2001.00276.x · Cited by 126 · see citing works
Imbe, H., Murakami, S., Okamoto, K., IWAI-LIAO, Y., & Senba, E. (2004) · Pain · doi:10.1016/j.pain.2004.09.015 · Cited by 125 · see citing works
Stereotaxic delivery of corticosterone to the amygdala modulates colonic sensitivity in rats
Meerveld, B. G., Gibson, M. S., Gunter, W., Shepard, J. D., Foreman, R. D., & Myers, D. A. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03305-9 · Cited by 125 · see citing works
A controlled evaluation of group cognitive therapy in the treatment of irritable bowel syndrome
Blanchard, E. B., Lackner, J. M., Sanders, K., Krasner, S., Keefer, L., Payne, A., Gudleski, G. D., Katz, L., Rowell, D., Sykes, M., et al. (2007) · Behaviour Research and Therapy · doi:10.1016/j.brat.2006.07.003 · Cited by 121 · see citing works
Differences in spinal distribution and neurochemical phenotype of colonic afferents in mouse and rat
Christianson, J. A., Traub, R. J., & Davis, B. M. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20816 · Cited by 120 · see citing works
Self-citationLackner, J. M., Lou Coad, M., Mertz, H. R., Wack, D. S., Katz, L. A., Krasner, S. S., Firth, R., Mahl, T. C., & Lockwood, A. H. (2006) · Behaviour Research and Therapy · doi:10.1016/j.brat.2005.05.002 · Cited by 120 · see citing works
Crohn's Disease in the Elderly
Wagtmans, M. J., Verspaget, H. W., Lamers, C. B. H. W., & van Hogezand, R. A. (1998) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199809000-00005 · Cited by 117 · see citing works
Increased acid-sensing ion channel ASIC-3 in inflamed human intestine
Yiangou, Y., Facer, P., Smith, J. A. M., Sangameswaran, L., Eglen, R. M., Birch, R., Knowles, C. H., Williams, N. S., & Anand, P. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200108000-00003 · Cited by 117 · see citing works
Delafoy, L., Gelot, A., Ardid, D., Eschalier, A., Bertrand, C., Doherty, A. M., & Diop, L. (2006) · Gut · doi:10.1136/gut.2005.064063 · Cited by 113 · see citing works
Purinergic component of mechanosensory transduction is increased in a rat model of colitis
Wynn, G., Ma, B., Ruan, H. Z., & Burnstock, G. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00020.2004 · Cited by 113 · see citing works
Wick, E. C., Hoge, S. G., Grahn, S. W., Kim, E. J., Divino, L., Grady, E. F., Bunnett, N. W., & Kirkwood, K. S. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2005 · Cited by 110 · see citing works
Psychophysical analysis of visceral and cutaneous pain in human subjects
Strigo, I. A., Bushnell, C. M., Boivin, M., & Duncan, G. H. (2002) · Pain · doi:10.1016/s0304-3959(02)00023-4 · Cited by 109 · see citing works
Matuk, R., Crawford, J., Abreu, M. T., et al. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200407000-00005 · Cited by 108 · see citing works
Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways
Lamb, K. R., Zhong, F., Gebhart, G. F., & Bielefeldt, K. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00353.2005 · Cited by 107 · see citing works
Self-citationPsychotherapy with chronic inflammatory bowel disease patients: A Review
von Wietersheim, J., & Kessler, H. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000236925.87502.e0 · Cited by 103 · see citing works
Lackner, J. M., & Quigley, B. M. (2004) · Behaviour Research and Therapy · doi:10.1016/j.brat.2004.06.018 · Cited by 102 · see citing works
The effect of hypnosis on systemic and rectal mucosal measures of inflammation in ulcerative colitis
Mawdsley, J. E., Jenkins, D. G., Macey, M. G., Langmead, L., & Rampton, D. S. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01845.x · Cited by 102 · see citing works
Distribution and neurochemical identification of pancreatic afferents in the mouse
Fasanella, K. E., Christianson, J. A., Chanthaphavong, R. S., et al. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21736 · Cited by 96 · see citing works
Chronic narcotic use in inflammatory bowel disease patients: Prevalence and clinical characteristics
Edwards, J. T., Radford‐Smith, G. L., & Florin, T. H. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02468.x · Cited by 96 · see citing works
Irritable bowel syndrome patients show altered sensitivity to exogenous opioids
Lembo, T., Naliboff, B. D., Matin, K., Munakata, J., Parker, R. A., Gracely, R. H., & Mayer, E. A. (2000) · Pain · doi:10.1016/s0304-3959(00)00282-7 · Cited by 94 · see citing works
Zhuo, M., & Gebhart, G. F. (2002) · Gastroenterology · doi:10.1053/gast.2002.32389 · Cited by 94 · see citing works
SZIGETHY, E., WHITTON, S. W., LEVY-WARREN, A., DeMaso, D. R., WEISZ, J., & BEARDSLEE, W. R. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000142284.10574.1f · Cited by 92 · see citing works
Jantschek, G. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850172386 · Cited by 92 · see citing works
Role of nerve growth factor in the trinitrobenzene sulfonic acid-induced colonic hypersensitivity
Delafoy, L., Raymond, F., Doherty, A. M., Eschalier, A., & Diop, L. (2003) · Pain · doi:10.1016/s0304-3959(03)00266-5 · Cited by 91 · see citing works
Eijkelkamp, N., Kavelaars, A., Elsenbruch, S., et al. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00114.2007 · Cited by 91 · see citing works
Ruigómez, A., Rodríguez, L. A. G., & Panés, J. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.02.008 · Cited by 84 · see citing works
Palm, Ø., Bernklev, T., Moum, B. A., & Gran, J. T. (2005) · PubMed · Cited by 79 · see citing works
Szarka, L. A., Camilleri, M., Burton, D. D., Fox, J. C., McKinzie, S., Stanislav, T., Simonson, J., Sullivan, N., & Zinsmeister, A. R. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.07.011 · Cited by 78 · see citing works
Altered visceral sensation in response to somatic pain in the rat☆
Miranda, A., Peles, S., Rudolph, C., Shaker, R., & Sengupta, J. N. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.003 · Cited by 77 · see citing works
Fibromyalgia in inflammatory bowel disease.
Buskila, D., Odes, L., Neumann, L., & Odes, H. S. (1999) · PubMed · Cited by 76 · see citing works
Verne, G. N., Sen, A., & Price, D. D. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.02.009 · Cited by 74 · see citing works
Expression of Nerve Growth Factors in Pancreatic Neural Tissue and Pancreatic Cancer
Schneider, M. B., Standop, J., Ulrich, A. B., et al. (2001) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540104901002 · Cited by 74 · see citing works
Halpert, A. D., Dalton, C. B., Diamant, N. E., Toner, B. B., Hu, Y., Morris, C. B., Bangdiwala, S. I., Whitehead, W. E., & Drossman, D. A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.30375.x · Cited by 73 · see citing works
Basic and clinical aspects of visceral sensation: transmission in the CNS
Bielefeldt, K., Christianson, J. A., & Davis, B. M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00671.x · Cited by 72 · see citing works
Self-citationIncreased responsiveness of rat colonic splanchnic afferents to 5‐HT after inflammation and recovery
Coldwell, J. R., Phillis, B. D., Sutherland, K., Howarth, G. S., & Blackshaw, L. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123158 · Cited by 70 · see citing works
Straub, R. H., Antoniou, E., Zeuner, M., Groß, V., Schölmerich, J., & Andus, T. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00150-1 · Cited by 67 · see citing works
Supportive-Expressive Group Psychotherapy for Persons with Inflammatory Bowel Disease
Maunder, R., & Esplen, M. J. (2001) · The Canadian Journal of Psychiatry · doi:10.1177/070674370104600706 · Cited by 65 · see citing works
Pain and mechanical properties of the rectum in patients with active ulcerative colitis
Drewes, A. M., Frkjær, J. B., Larsen, E., et al. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000209365.09189.04 · Cited by 62 · see citing works
Barada, K. A., Mourad, F. H., Sawah, S. I., Khoury, C. I., Safieh‐Garabedian, B., Nassar, C. F., Tawil, A. N., Jurjus, A. R., & Saadé, N. E. (2007) · Cytokine · doi:10.1016/j.cyto.2007.04.005 · Cited by 60 · see citing works
κ-Opioid Receptor Agonists Modulate Visceral Nociception at a Novel, Peripheral Site of Action
Joshi, S. K., Su, X., Porreca, F., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05874.2000 · Cited by 59 · see citing works
Treatment of Inflammatory Bowel Disease:A Role for Hypnotherapy?
Miller, V., & Whorwell, P. J. (2008) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207140802041884 · Cited by 56 · see citing works
Palm, Ø., Moum, B. A., Jahnsen, J., & Gran, J. T. (2001) · PubMed · Cited by 55 · see citing works
Dichotomizing Axons in Spinal and Vagal Afferents of the Mouse Stomach
Zhong, F., Christianson, J. A., Davis, B. M., & Bielefeldt, K. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9843-z · Cited by 55 · see citing works
Self-citationA Systematic Review of Psychological Therapies for Nonulcer Dyspepsia
Soo, S., Forman, D., Delaney, B. C., & Moayyedi, P. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30086.x · Cited by 54 · see citing works
Narcotic Use in Patients with Crohn's Disease
Cross, R., Wilson, K., & Binion, D. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00256.x · Cited by 53 · see citing works
Self-citationImportance of anti- and pro-nociceptive mechanisms in human disease
Tracey, I., & Dunckley, P. (2004) · Gut · doi:10.1136/gut.2004.046110 · Cited by 52 · see citing works
Narcotic Dependence in Inflammatory Bowel Disease
Kaplan, M. A., & Korelitz, B. I. (1988) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-198806000-00010 · Cited by 48 · see citing works
Peles, S., Miranda, A., Shaker, R., & Sengupta, J. N. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.069070 · Cited by 47 · see citing works
Keefer, L., & Keshavarzian, A. (2007) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207140701506565 · Cited by 43 · see citing works
Qin, C., Meerveld, B. G., Myers, D. A., & Foreman, R. D. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00834.2002 · Cited by 41 · see citing works
Mikocka‐Walus, A. A., Turnbull, D. A., Moulding, N., Wilson, I. G., Andrews, J. M., & Holtmann, G. (2007) · BMC Gastroenterology · doi:10.1186/1471-230x-7-38 · Cited by 40 · see citing works
Pethö, G., Izydorczyk, I., & Reeh, P. W. (2004) · Pain · doi:10.1016/j.pain.2004.01.038 · Cited by 38 · see citing works
Peripheral neuropathy associated with Crohn's disease
Nemni, R., Fazio, R., Corbo, M., et al. (1987) · Neurology · doi:10.1212/wnl.37.8.1414 · Cited by 35 · see citing works
Case study: Longitudinal treatment of adolescents with depression and inflammatory bowel disease
SZIGETHY, E., CARPENTER, J., BAUM, E., KENNEY, E., BAPTISTA-NETO, L., BEARDSLEE, W. R., & DeMASO, D. R. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000198591.45949.a4 · Cited by 33 · see citing works
Subclinical sympathetic neuropathy appears early in the course of Crohn's disease
Ohlsson, B., Sundkvist, G., & Lindgren, S. C. (2007) · BMC Gastroenterology · doi:10.1186/1471-230x-7-33 · Cited by 31 · see citing works
Investigating placebo effects in irritable bowel syndrome: A novel research design
Conboy, L. A., Wasserman, R. H., Jacobson, E., Davis, R. B., Legedza, A., Park, M., Rivers, A. L., Morey, E. B., Nam, B. H., Lasagna, L. C., et al. (2006) · Contemporary Clinical Trials · doi:10.1016/j.cct.2005.11.012 · Cited by 26 · see citing works
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Systematic review: psychosocial factors associated with pain in inflammatory bowel disease
Sweeney, L., Moss‐Morris, R., Czuber‐Dochan, W., Meade, L., Chumbley, G., & Norton, C. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14493 · Cited by 112 · see citing works
Pain management in patients with inflammatory bowel disease: insights for the clinician
Srinath, A. I., Walter, C., Newara, M. C., & Szigethy, E. M. (2012) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12446158 · Cited by 111 · see citing works
Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease
Iskandar, H. N., Cassell, B., Kanuri, N., Gyawali, C. P., Gutierrez, A., Dassopoulos, T., Ciorba, M. A., & Sayuk, G. S. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000049 · Cited by 96 · see citing works
Benson, S., Kattoor, J., Wegner, A., Hammes, F., Reidick, D., Grigoleit, J.-S., Engler, H., Oberbeck, R., Schedlowski, M., & Elsenbruch, S. (2012) · Pain · doi:10.1016/j.pain.2011.12.001 · Cited by 89 · see citing works
Visceral Inflammation and Immune Activation Stress the Brain
Holzer, P., Farzi, A., Hassan, A. M., Zenz, G., Jačan, A., & Reichmann, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01613 · Cited by 84 · see citing works
Pain and opioid use in chronic pancreatitis
Nusrat, S., Yadav, D., & Bielefeldt, K. (2012) · Pancreas · doi:10.1097/mpa.0b013e318224056f · Cited by 67 · see citing works
McGing, J. J., Radford, S. J., Francis, S. T., Serres, S., Greenhaff, P. L., & Moran, G. W. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16465 · Cited by 60 · see citing works
Reed-Knight, B., van Tilburg, M. A. L., Levy, R. L., Langer, S. L., Romano, J. M., Murphy, T. B., DuPen, M. M., & Feld, A. D. (2018) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsx082 · Cited by 30 · see citing works
Sweeney, L., Moss-Morris, R., Czuber-Dochan, W., Belotti, L., Kabeli, Z., & Norton, C. (2019) · British Journal of Pain · doi:10.1177/2049463719844539 · Cited by 29 · see citing works
Palus, K., & Całka, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010015 · Cited by 22 · see citing works
Murphy, L. K., Rights, J. D., Ricciuto, A., Church, P. C., & Ahola Kohut, S. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00559 · Cited by 11 · see citing works
“Disease-related processes that contribute to pain include acute inflammation, strictures, bowel obstruction, and dysmotility, as well as visceral hypersensitization (1, 6).”
Background
- Authors
- Bielefeldt, K., Davis, B., & Binion, D. G.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05
- Volume
- 15
- Issue
- 5
- Pages
- 778-788
- ISSN
- 1078-0998 (ISSN-L)
- PMC
- PMC3180862
- OpenAlex
- W2006195533
- Cited by
- 304
- References
- 126
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 25 · 2023: 24 · 2022: 30 · 2021: 34 · 2020: 33 · 2019: 28 · 2018: 18 · 2017: 16 · 2016: 10 · 2015: 6 · 2014: 11 · 2013: 13 · 2012: 6
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS050758)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- inflammatory bowel disease, abdominal pain
- MeSH terms
- Humans, Pain, Inflammatory Bowel Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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