The incidence of cancer in schizophrenic patients.
Open accessAbstract
A cohort of 6168 schizophrenic patients was followed from 1957 to 1984 to determine the incidence of cancer in these patients. In the male schizophrenic patients the incidence of cancer was found to be significantly reduced in comparison with the general Danish population. This reduction was especially marked for cancer in the respiratory system, cancer of the prostate and cancer of the bladder. In the female patients the overall incidence of cancer did not differ from that of the general Danish population, but there was an increased risk of cancer of the digestive tract, especially cancer of the pancreas and a slight increase of the risk of breast cancer. In the female patients the risk of respiratory cancers and cancer of the female genital organs, especially cancer of the uterine cervix, was reduced. These alterations of the incidence of cancer in schizophrenic patients cannot be ascribed to differences in diagnostic accuracy. As a possible explanation of these findings a reduced exposure to well known carcinogens such as cigarette smoke may be relevant. We speculate that exposure to neuroleptics such as phenothiazines and reserpine may also be part of the explanation for the findings.
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Some studies have demonstrated a decreased cancer risk in schizophrenia.
“Some studies have demonstrated a decreased cancer risk in schizophrenia (440-448).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [440]
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Cites
Rotkin, I. D. (1973) · PubMed · Cited by 355 · see citing works
Physical Illness Presenting as Psychiatric Disease
Hall, R. C. W. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770350041003 · Cited by 350 · see citing works
Hematoporphyrin derivative for detection and management of cancer
Lipson, R. L., Baldes, E. J., & Gray, M. J. (1967) · Cancer · doi:10.1002/1097-0142(196712)20:12 · Cited by 237 · see citing works
Unrecognized physical illness prompting psychiatric admission: a prospective study
Hall, R. C. W., Gardner, E. R., Popkin, M. K., et al. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.5.629 · Cited by 229 · see citing works
RESERPINE USE IN RELATION TO BREAST CANCER
Heinonen, O. P., Shapiro, S., Tuominen, L., et al. (1974) · The Lancet · doi:10.1016/s0140-6736(74)93259-0 · Cited by 206 · see citing works
Armstrong, B. K., Stevens, N., & Doll, R. (1974) · The Lancet · doi:10.1016/s0140-6736(74)93258-9 · Cited by 200 · see citing works
Statistical studies in the aetiology of malignant neoplasms.
Clemmesen, J. (1969) · PubMed · Cited by 187 · see citing works
Cancer morbidity and causes of death among danish brewery workers
Jensen, O. M. (1979) · International Journal of Cancer · doi:10.1002/ijc.2910230404 · Cited by 181 · see citing works
Smoking and Malignancy in Schizophrenia
Masterson, E. L., & O’Shea, B. (1984) · The British Journal of Psychiatry · doi:10.1192/bjp.145.4.429 · Cited by 155 · see citing works
Schizophrenia and physical disease
Baldwin, J. A. (1979) · Psychological Medicine · doi:10.1017/s0033291700033948 · Cited by 133 · see citing works
Reserpine and Breast Cancer in a Retirement Community
Mack, T. M., Henderson, B. E., Gerkins, V. R., et al. (1975) · New England Journal of Medicine · doi:10.1056/nejm197506262922603 · Cited by 112 · see citing works
PHYSICAL DISORDERS IN PSYCHIATRIC ILLNESS
Herridge, C. F. (1960) · The Lancet · doi:10.1016/s0140-6736(60)92025-0 · Cited by 101 · see citing works
Neuroleptic-induced Prolactin Level Elevation and Breast Cancer
Schyve, P. M. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770350017001 · Cited by 97 · see citing works
Mortality in psychiatric hospitals in Norway 1950–74
Saustad, L. F., & Ødegård, Ø. (1979) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1979.tb04485.x · Cited by 86 · see citing works
RAUWOLFIA DERIVATIVES AND BREAST CANCER
O’Fallon, W. M., Labarthe, D., & Kurland, L. T. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92730-0 · Cited by 86 · see citing works
Herrman, H., Baldwin, J. A., & Christie, D. G. S. (1983) · Psychological Medicine · doi:10.1017/s0033291700048005 · Cited by 77 · see citing works
Neuroleptic treatment and other factors modifying cancer risk in schizophrenic patients
Mortensen, P. B. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02839.x · Cited by 75 · see citing works
Self-citationMATCHED-PAIRS STUDY OF RESERPINE USE AND BREAST CANCER
LASKA, E. M., Meisner, M., Siegel, C., et al. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92731-2 · Cited by 66 · see citing works
Psychotropic drugs as potential antitumor agents: a selective screening study.
Js, D., Melnick, N. R., Fr, Q., Lomax, N., Jp, D., Ing, R., Bj, A., Congleton, G., & Dudeck, L. (1978) · PubMed · Cited by 51 · see citing works
The evaluation of routine physical examination in psychiatric cases.
Johnson, D. A. (1968) · PubMed · Cited by 48 · see citing works
PROGRAM, B. C. D. S. (1974) · The Lancet · doi:10.1016/s0140-6736(74)93257-7 · Cited by 47 · see citing works
Østerlind, A., & Om, J. (1985) · PubMed · Cited by 45 · see citing works
RAUWOLFIA DERIVATIVES AND BREAST CANCER
O’Fallon, W. M., & Larbarthe, D. R. (1975) · The Lancet · doi:10.1016/s0140-6736(75)90760-6 · Cited by 40 · see citing works
The Medical Care of Psychiatric Patients
Hall, R. C. W., Beresford, T. P., Gardner, E. R., et al. (1982) · Psychiatric Services · doi:10.1176/ps.33.1.25 · Cited by 34 · see citing works
Phenothiazine Inhibition of Intestinal and Urinary Bladder Tumors Induced in Rats by Bracken Fern 2
Pamukcu, A. M., Wattenberg, L. W., Price, J. M., et al. (1971) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/47.1.155 · Cited by 29 · see citing works
RAUWOLFIA DERIVATIVES AND BREAST CANCER
Lilienfeld, A. M., Chang, L., Thomas, D. B., et al. (1974) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1974.tb71124.x · Cited by 29 · see citing works
Statistical studies in the aetiology of malignant neoplasms.
Clemmesen, J. (1974) · Cited by 27 · see citing works
Phenothiazines and breast cancer.
Kanhouwa, S., Gowdy, J. M., & Solomon, J. D. (1984) · PubMed · Cited by 26 · see citing works
Ciompi, L., & Müller, C. A. (1976) · Springer eBooks · Cited by 20 · see citing works
Cancer Morbidity and Causes of Death among Danish Brewery Workers
Alderson, M. (1981) · British Journal of Cancer · doi:10.1038/bjc.1981.138 · Cited by 15 · see citing works
[Cancer mortality in patients of psychiatric hospitals].
PAN, R. M. D., & Müller, C. (1977) · PubMed · Cited by 13 · see citing works
Clemmesen, J. (1969) · Apmis · Cited by 11 · see citing works
[Diagnosis of cancer and autopsy rate in schizophrenic patients].
Mortensen, P. B. (1987) · PubMed · Cited by 8 · see citing works
Self-citationControversies in Breast Cancer 2008
Miller, W. R. (2008) · Breast Cancer Research · doi:10.1186/bcr2161 · Cited by 8 · see citing works
[Re-use of historical data. Experience with re-identification of a 30-year material].
Andersen, T. F. (1980) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- 2du Pan RM, Muller C. La mortalite par cancer chez les patients psychiatriques hospitalis&es. Schweiz Med Wochenschr 1977; 107: 597-604.
- Katz J, Kunofsky S, Patton RE, Allaway NC. Cancer mortality among patients in New York Mental Hospitals. Cancer 1967; 20: 2194-9.
- Ciompi L, Muller C. Lebensweg und Alter der Schizophrenen, Eine katamnestische Langzeitstudie bis ins Senium. Berlin, Heidelberg, New York: Springer-Verlag, 1976.
- 7Dupont A, Jensen OM, Stromgren E, Jablensky A. Incidence of cancer in patients diagnosed as schizophrenic in Denmark. In: ten Horn GHMM, Giel R, Gulbinat WH, Henderson JH, eds. Psychiatric case registers in public health. A worldwide inventory 1960- 1985. Amsterdam, New York, Oxford: Elsevier, 1986: 229-39. Protected by copyright. on August 7, 2023 by guest. http://jech.bmj.com/ J Epidemiol Community Health: first published as 10.1136/jech.43.1.43 on 1 March 1989. Downloaded from The incidence of cancer in schizophrenic patients 8 Nakane Y, Ohta Y. The example of linkage with a cancer register. In: ten Horn GHMM, Giel R, Gulbinat WH, Henderson JH, eds. Psychiatric case registers in public health. A worldwide inventory 1960-1985. Amsterdam, New York, Oxford: Elsevier, 1986: 240-5.
- 10Arentsen K, Str6mgren E. Patients in Danish psychiatric hospitals. Acta Jutlandica 1959; 31, Medicinsk serie 9. l Andersen TF. Genanvendelse afhistoriske datamaterialer. Ugeskr Laeger 1980; 142: 1054-8.
- 190sterlind A, Jensen OM. Evaluering af cancer- registreringen i Danmark. En prmliminwr evaluering af cancerregistrering og landspatientregisterets registrering af cancertilfaelde. Ugeskr Laeger 1985; 147: 2483-8.
- 25Mortensen PB. Cancerdiagnostik og autopsifrekvens blandt skizofrene patienter. Ugeskr Laeger 1987; 149: 1973-5.
Cited by
Sorted by citations
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Excess mortality of schizophrenia: A meta-analysis
Brown, S. (1997) · British Journal of Psychiatry · doi:10.1192/bjp.171.6.502 · Cited by 869 · see citing works
Physical illness and schizophrenia: a review of the literature
Leucht, S., Burkard, T., Henderson, J., Maj, M., & Sartorius, N. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01095.x · Cited by 633 · see citing works
Callaghan, R. C., Veldhuizen, S., Jeysingh, T., Orlan, C., Graham, C., Kakouris, G., Remington, G., & Gatley, J. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.09.014 · Cited by 255 · see citing works
Cancer incidence in patients with schizophrenia and their first‐degree relatives – a meta‐analysis
Catts, V. S., Catts, S. V., O’Toole, B. I., & Frost, A. D. J. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01163.x · Cited by 209 · see citing works
Cancer mortality in patients with schizophrenia: An 11‐year prospective cohort study
Tran, E., Rouillon, F., Loze, J., Casadebaig, F., Philippe, A., Vitry, F., & Limosin, F. (2009) · Cancer · doi:10.1002/cncr.24383 · Cited by 173 · see citing works
The occurence of cancer in first admitted schizophrenic patients
Mortensen, P. B. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90028-0 · Cited by 142 · see citing works
Self-citationRisk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969–1993
Dalton, S. O., Mellemkjær, L., Thomassen, L., Mortensen, P. B., & Johansen, C. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.11.009 · Cited by 142 · see citing works
Self-citationMortality and causes of death in schizophrenic patients in Denmark
Mortensen, P. B., & Juel, K. (1990) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1990.tb05466.x · Cited by 138 · see citing works
Self-citationCancer risk among users of neuroleptic medication: a population-based cohort study
Dalton, S. O., Johansen, C., Poulsen, A. H., Nørgaard, M., Sørensen, H. T., McLaughlin, J. K., Mortensen, P. B., & Friis, S. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603259 · Cited by 123 · see citing works
Self-citationSchizophrenia and cancer: an epidemiological study
Goldacre, M. J., Kurina, L. M., Wotton, C. J., Yeates, D., & Seagroatt, V. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.187.4.334 · Cited by 123 · see citing works
The association between schizophrenia and cancer: a population-based mortality study
Cohen, M. E., Dembling, B., & Schorling, J. B. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00308-5 · Cited by 114 · see citing works
Cancer incidence of schizophrenic patients. Results of record linkage studies in three countries
Gulbinat, W., Dupont, A., Jablensky, A., Jensen, O. M., Marsella, A., Nakane, Y., & Sartorius, N. (1992) · British Journal of Psychiatry · doi:10.1192/s0007125000297080 · Cited by 110 · see citing works
- Authors
- Mortensen, P. B.
- Affiliations
- Aarhus University Hospital (DK)
- Corresponding author
- Mortensen, P B
- ORCID
- Mortensen, P B
- Venue
- Journal of Epidemiology and Community Health
- Publisher
- BMJ
- Published
- 1989-03
- Volume
- 43
- Issue
- 1
- Pages
- 43-47
- ISSN
- 0141-7681 (ISSN-L)
- 0143-005X
- 1470-2738
- PMC
- PMC1052789
- OpenAlex
- W2149986615
- Cited by
- 175
- References
- 35
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 5
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Epidemiology & Community Health (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- schizophrenia, cancer incidence, respiratory cancer, prostate cancer, bladder cancer, digestive tract cancer, pancreatic cancer, breast cancer, uterine cervix cancer, sex differences, cigarette smoking, antipsychotic drugs, phenothiazines, reserpine, carcinogen exposure
- MeSH terms
- Denmark, Female, Humans, Male, Neoplasms, Risk Factors, Schizophrenia
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