Apathy correlates with prefrontal amyloid deposition in Alzheimer's disease
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OBJECTIVE: Neuropsychiatric symptoms affect many patients with Alzheimer's disease (AD). ((11)C)Pittsburgh Compound-B (PIB) positron emission tomography (PET) has enabled the in vivo visualisation of brain amyloid-β (Aβ) deposition. This study exploratively investigated the correlation between brain Aβ deposition measured by ((11)C)PIB PET and neuropsychiatric symptoms in AD. METHODS: Participants were 28 patients (15 women, 13 men) with PIB-positive AD. Clinical assessments included Mini-Mental State Examination, Clinical Dementia Rating scale, neuropsychiatry inventory (NPI) and frontal assessment battery. All patients underwent three-dimensional T1-weighted MRI and ((11)C)PIB PET. The distribution volume ratio (DVR), an index of ((11)C)PIB retention and, thus, Aβ deposition, was estimated voxel by voxel from ((11)C)PIB PET data with partial volume correction. Voxel-based correlation analysis was performed to assess the relationships between DVR and each NPI subscale. Additionally, voxel-based analysis of covariance (ANCOVA) of the DVR images was performed between Patients with AD with and without each neuropsychiatric symptom. Voxel-based morphometry analysis of MRI was also performed. RESULTS: Apathy subscale was correlated with ((11)C)PIB retention in the bilateral frontal and right anterior cingulate. ((11)C)PIB retention was greater in the bilateral frontal cortex of patients with AD with apathy than those of without apathy. Overlapping areas between the two analyses were the bilateral orbitofrontal gyrus and left superior frontal gyrus. Other NPI subscales were not correlated with ((11)C)PIB retention. Voxel-based morphometry analysis of MRI showed no significant cluster of correlation between grey matter volume and NPI subscales. CONCLUSIONS: This study revealed that prefrontal Aβ deposition correlates with apathy.
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Apathy in Alzheimer's disease is associated with greater amyloid burden in bilateral frontal cortex, reduced orbitofrontal metabolism on the left or right, and reduced connectivity in left-sided functional connectivity with frontal cortex.
“Apathy is further associated with greater amyloid burden in bilateral frontal cortex (Mori et al., 2014), reduced orbitofrontal metabolism on the left (Holthoff et al., 2005) or right (Lanctôt et al., 2007), and reduced connectivity in left-sided functional connectivity with frontal cortex (Baggio et al., 2015).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Mori et al., 2014
Apathy in Alzheimer's disease is associated with increased amyloid burden in right anterior cingulate cortex.
“Similarly apathy is associated with decreased perfusion in ACC (Benoit et al., 2004; Lanctôt et al., 2007; Robert et al., 2006), decreased ACC white matter integrity by DTI (Hahn et al., 2013; Kim et al., 2011; Ota et al., 2012) and increased amyloid burden in right ACC (Mori et al., 2014).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Mori et al., 2014
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Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
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- Authors
- Mori, T., Shimada, H., Shinotoh, H., Hirano, S., Eguchi, Y., Yamada, M., Fukuhara, R., Tanimukai, S., Zhang, M.-R., Kuwabara, S., Ueno, S.-I., & Suhara, T.
- Affiliations
- Ehime University (JP)
- Chiba University (JP)
- National Institute of Radiological Sciences (JP)
- Corresponding author
- Suhara, T.
- ORCID
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2013-10-16
- Volume
- 85
- Issue
- 4
- Pages
- 449-455
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W1966601502
- Cited by
- 122
- References
- 40
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 15 · 2023: 12 · 2022: 16 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 8 · 2014: 5
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- green
- repo.qst.go.jp
- Licence
- cc-by-nc-nd
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (25861015)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- apathy, Alzheimer's disease, amyloid-beta deposition, distribution volume ratio, neuropsychiatric symptoms, prefrontal cortex, anterior cingulate cortex, gray matter volume
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Radionuclide Imaging, Amyloid beta-Peptides, Prefrontal Cortex, Apathy, Functional Neuroimaging
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