Characteristics of ischaemic stroke associated with COVID-19
Open accessAbstract
Characteristics of ischaemic stroke associated with COVID-19Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with coagulopathy causing venous and arterial thrombosis. 1 2 Recent data from the pandemic epicentre in Wuhan, China, reported neurological complications in 36% of 214 patients with COVID-19; acute cerebrovascular disease (mainly ischaemic stroke) was more common among 88 patients with severe COVID-19 than those with nonsevere disease (5.7% vs 0.8%).3 However, the mechanisms, phenotype and optimal management of ischaemic stroke associated with COVID-19 remain uncertain.We describe the demographic, clinical, radiological and laboratory characteristics of six consecutive patients assessed between 1 st and 16 th April 2020 at the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK, with acute ischaemic stroke and COVID-19 (confirmed by reverse-transcriptase PCR (RT-PCR)) (table 1).All six patients had large vessel occlusion with markedly elevated D-dimer levels (≥1000μg/L).Three patients had multiterritory infarcts, two had concurrent venous thrombosis, and, in two, ischaemic strokes occurred despite therapeutic anticoagulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many neurological symptoms associated with CoV-2 infection, such as stroke or altered consciousness, are consistent with underlying vasculopathy.
“Multiple immunostaining studies reveal that ACE2 protein in the human brain is predominantly or exclusively expressed in vasculature (and specifically expressed within pericytes) (52, 53, 70), and many neurological symptoms associated with CoV-2 infection like stroke or altered consciousness are consistent with an underlying vasculopathy (71-76).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415 · see citing works
Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166 · see citing works
Tang, N., Li, D., Wang, X., & Sun, Z.-Y. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14768 · Cited by 5,527 · see citing works
Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
Zhang, Y., Xiao, M., Zhang, S., Xia, P., Cao, W., Jiang, W., Chen, H., Ding, X., Zhao, H., Zhang, H., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2007575 · Cited by 2,179 · see citing works
ISTH interim guidance on recognition and management of coagulopathy in COVID‐19
Thachil, J. V., Tang, N., Gando, S., Falanga, A., Cattaneo, M., Levi, M. M., Clark, C., & Iba, T. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14810 · Cited by 1,957 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neurological associations of COVID-19
Ellul, M. A., Benjamin, L., Singh, B., Lant, S., Michael, B. D., Easton, A., Kneen, R., Defres, S., Sejvar, J., & Solomon, T. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30221-0 · Cited by 2,156 · see citing works
Self-citationVaratharaj, A., Thomas, N., Ellul, M. A., Davies, N. W. S., Pollak, T. A., Tenorio, E. L., Sultan, M., Easton, A., Breen, G., Zandi, M., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30287-x · Cited by 1,246 · see citing works
Self-citationBrann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., Van den Berge, K., Gong, B., Chance, R., Macaulay, I. C., Chou, H.-J., Fletcher, R. B., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc5801 · Cited by 1,198 · see citing works
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings
Paterson, R. W., Brown, R. L., Benjamin, L. A., Nortley, R., Wiethoff, S., Bharucha, T., Jayaseelan, D. L., Kumar, G., Raftopoulos, R., Zambreanu, L., et al. (2020) · Brain · doi:10.1093/brain/awaa240 · Cited by 1,134 · see citing works
Self-citationPlatelet gene expression and function in patients with COVID-19
Manne, B. K., Denorme, F., Middleton, E. A., Portier, I., Rowley, J. W., Stubben, C., Petrey, A. C., Tolley, N. D., Guo, L., Cody, M. J., et al. (2020) · Blood · doi:10.1182/blood.2020007214 · Cited by 941 · see citing works
Cognitive deficits in people who have recovered from COVID-19
Hampshire, A., Trender, W. R., Chamberlain, S. R., Jolly, A., Grant, J. E., Patrick, F., Mazibuko, N., Williams, S., Barnby, J. M., Hellyer, P. J., et al. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.101044 · Cited by 704 · see citing works
Stroke in COVID-19: A systematic review and meta-analysis
Nannoni, S., de Groot, R., Bell, S., & Markus, H. S. (2020) · International Journal of Stroke · doi:10.1177/1747493020972922 · Cited by 588 · see citing works
Heneka, M. T., Golenbock, D., Latz, E., Morgan, D., & Brown, R. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00640-3 · Cited by 555 · see citing works
COVID ‐19: A Global Threat to the Nervous System
Koralnik, I. J., & Tyler, K. L. (2020) · Annals of Neurology · doi:10.1002/ana.25807 · Cited by 463 · see citing works
Lifting the mask on neurological manifestations of COVID-19
Pezzini, A., & Padovani, A. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0398-3 · Cited by 447 · see citing works
Evans, P. C., Rainger, G. E., Mason, J. C., Guzik, T. J., Osto, E., Stamataki, Z., Neil, D., Hoefer, I. E., Fragiadaki, M., Waltenberger, J. L., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa230 · Cited by 439 · see citing works
Chou, S., Beghi, E., Helbok, R., Moro, E., Sampson, J. N., Altamirano, V., Mainali, S., Bassetti, C. L., Suárez, J. I., McNett, M., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.12131 · Cited by 406 · see citing works
LaRovere, K. L., Riggs, B. J., Poussaint, T. Y., Young, C. C., Newhams, M. M., Maamari, M., Walker, T. C., Singh, A. R., Dapul, H. R., Hobbs, C. V., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.0504 · Cited by 396 · see citing works
COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital
Thakur, K. T., Miller, E. H., Glendinning, M. D., Al‐Dalahmah, O., Banu, M. A., Boehme, A. K., Boubour, A., Bruce, S. S., Chong, A. M., Claassen, J., et al. (2021) · Brain · doi:10.1093/brain/awab148 · Cited by 385 · see citing works
COVID-19 and the Chemical Senses: Supporting Players Take Center Stage
Cooper, K. W., Brann, D. H., Farruggia, M. C., Bhutani, S., Pellegrino, R., Tsukahara, T., Weinreb, C., Joseph, P. V., Larson, E. D., Parma, V., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.032 · Cited by 335 · see citing works
COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature
Tan, Y. K., Goh, C. M. J. L., Leow, A. S., Tambyah, P. A., Ang, A., Yap, E. S., Tu, T. M., Sharma, V. K., Yeo, L. L. L., Chan, B., et al. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02228-y · Cited by 318 · see citing works
Choudry, F., Hamshere, S. M., Rathod, K. S., Akhtar, M. M., Archbold, A., Guttmann, O. P., Woldman, S., Jain, A., Knight, C. J., Baumbach, A., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.07.022 · Cited by 295 · see citing works
Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke
Ntaios, G., Michel, P., Georgiopoulos, G. A., Guo, Y., Li, W., Xiong, J., Calleja, P., Ostos, F., González‐Ortega, G., Fuentes, B., et al. (2020) · Stroke · doi:10.1161/strokeaha.120.031208 · Cited by 285 · see citing works
Self-citationBody Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 283 · see citing works
Hernández-Fernández, F., Sandoval Valencia, H., Barbella-Aponte, R. A., Collado-Jiménez, R., Ayo-Martín, Ó., Barrena, C., Molina-Nuevo, J. D., García-García, J., Lozano-Setién, E., Alcahut-Rodriguez, C., et al. (2020) · Brain · doi:10.1093/brain/awaa239 · Cited by 280 · see citing works
COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies
Rawat, K., Kumari, P., & Saha, L. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173751 · Cited by 276 · see citing works
Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow’s triad
Ahmed, S., Zimba, O., & Gasparyan, A. Y. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05275-1 · Cited by 251 · see citing works
Mechanisms of Stroke in COVID-19
Spence, J. D., de Freitas, G. R., Pettigrew, L. C., Ay, H., Liebeskind, D. S., Kase, C. S., Brutto, Ó. H. D., Hankey, G. J., & Venketasubramanian, N. (2020) · Cerebrovascular Diseases · doi:10.1159/000509581 · Cited by 247 · see citing works
Maury, A., Lyoubi, A., Peiffer‐Smadja, N., de Broucker, T., & Meppiel, E. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.10.001 · Cited by 232 · see citing works
Sharifian, M., Huot, P., Osherov, M., Wen, D., Saveriano, A., Giacomini, P. S., Antel, J. P., & Mowla, A. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117085 · Cited by 224 · see citing works
Neurologic and neuroimaging findings in patients with COVID-19
Kremer, S., Lersy, F., Anheim, M., Merdji, H., Schenck, M., Oesterle, H., Bolognini, F., Messié, J., Khalil, A., Gaudemer, A., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000010112 · Cited by 216 · see citing works
Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions
Favas, T. T., Dev, P., Chaurasia, R. N., Chakravarty, K., Mishra, R., Joshi, D., Mishra, V. N., Kumar, A., Singh, V. K., Pandey, M., et al. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04801-y · Cited by 211 · see citing works
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines
Lee, S., Channappanavar, R., & Kanneganti, T. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.10.005 · Cited by 205 · see citing works
Borghi, M. O., Beltagy, A., Garrafa, E., Curreli, D., Cecchini, G., Bodio, C., Grossi, C., Blengino, S., Tincani, A., Franceschini, F., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584241 · Cited by 193 · see citing works
de Erausquin, G. A., Snyder, H. M., Carrillo, M. C., Hosseini, A. A., Brugha, T. S., & Seshadri, S. S. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12255 · Cited by 193 · see citing works
Neurological infection with SARS-CoV-2 — the story so far
Solomon, T. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00453-w · Cited by 187 · see citing works
Cardiovascular Implications of the COVID-19 Pandemic: A Global Perspective
Boukhris, M., Hillani, A., Moroni, F., Annabi, M., Addad, F., Ribeiro, M. H., Mansour, S., Zhao, X., Ybarra, L. F., Abbate, A., et al. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.05.018 · Cited by 176 · see citing works
COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside
Sulzer, D. L., Antonini, A., Leta, V., Nordvig, A. S., Smeyne, R. J., Goldman, J. E., Al‐Dalahmah, O., Zecca, L., Sette, A., Bubacco, L., et al. (2020) · npj Parkinson s Disease · doi:10.1038/s41531-020-00123-0 · Cited by 171 · see citing works
Achar, A., & Ghosh, C. (2020) · Cells · doi:10.3390/cells9112360 · Cited by 159 · see citing works
Neuropathobiology of COVID-19: The Role for Glia
Tremblay, M.-E., Madore, C., Bordeleau, M., Tian, L., & Verkhratsky, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592214 · Cited by 159 · see citing works
Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses
Gavriilaki, E., Anyfanti, P., Gavriilaki, M., Lazaridis, A. A., Δούμα, Σ., & Gkaliagkousi, Ε. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01078-6 · Cited by 158 · see citing works
Neurologic manifestations associated with COVID-19: a multicentre registry
Meppiel, E., Peiffer‐Smadja, N., Maury, A., Bekri, I., Delorme, C., Desestret, V., Gorza, L., Hautecloque-Raysz, G., Landre, S., Lannuzel, A., et al. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.11.005 · Cited by 155 · see citing works
Guo, P., Benito-Ballesteros, Á., Yeung, S. P., Liu, R., Saha, A., Curtis, L., Kaşer, M., Haggard, M. P., & Cheke, L. G. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.804937 · Cited by 155 · see citing works
Patanavanich, R., & Glantz, S. A. (2021) · BMC Public Health · doi:10.1186/s12889-021-11579-x · Cited by 149 · see citing works
Neurological complications in patients with SARS-CoV-2 infection: a systematic review
Munhoz, R. P., Pedroso, J. L., Nascimento, F. A., de Almeida, S. M., Barsottini, O. G. P., Cardoso, F., & Teive, H. A. G. (2020) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20200051 · Cited by 147 · see citing works
Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology
Deigendesch, N., Sironi, L., Kutza, M., Wischnewski, S., Fuchs, V., Hench, J., Frank, A., Nienhold, R., Mertz, K. D., Cathomas, G., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02213-y · Cited by 140 · see citing works
Stroke risk, phenotypes, and death in COVID-19
Fridman, S., Bullrich, M. B., Jiménez‐Ruiz, A., Costantini, P., Shah, P. A., Just, C., Vela‐Duarte, D., Linfante, I., Razavi, A. S., Karimi, N., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000010851 · Cited by 144 · see citing works
Cerebrovascular Complications of COVID-19
Katz, J. M., Libman, R., WANG, J. J., Sanelli, P. C., Filippi, C. G., Gribko, M., Pacia, S. V., Kuzniecky, R., Najjar, S., & Azhar, S. (2020) · Stroke · doi:10.1161/strokeaha.120.031265 · Cited by 140 · see citing works
Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage
Al‐Dalahmah, O., Thakur, K. T., Nordvig, A. S., Prust, M., Roth, W., Lignelli, A., Uhlemann, A., Miller, E. H., Kunnath-Velayudhan, S., Portillo, A. D., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01024-2 · Cited by 136 · see citing works
Stroke in patients with COVID-19: Clinical and neuroimaging characteristics
Vogrig, A., Gigli, G. L., Bnà, C., & Morassi, M. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135564 · Cited by 139 · see citing works
Neurological complications and infection mechanism of SARS-CoV-2
Wan, D., Du, T., Hong, W., Chen, L., Que, H., Lu, S., & Peng, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00818-7 · Cited by 132 · see citing works
Multiple Neuroinvasive Pathways in COVID-19
Bougakov, D., Podell, K., & Goldberg, E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02152-5 · Cited by 137 · see citing works
The Impact of SARS‐CoV ‐2 on Stroke Epidemiology and Care: A Meta‐Analysis
Katsanos, A. H., Palaiodimou, L., Zand, R., Yaghi, S. R., Kamel, H., Navi, B. B., Turc, G., Romoli, M., Sharma, V. K., Mavridis, D., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25967 · Cited by 138 · see citing works
The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients
He, X., Yao, F., Chen, J., Wang, Y., Fang, X., Lin, X., Long, H., Wang, Q., & Wu, Q. (2021) · Scientific Reports · doi:10.1038/s41598-021-81300-w · Cited by 135 · see citing works
SARS-CoV-2 and coagulation disorders in different organs
Vinayagam, S., & Kamaraj, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118431 · Cited by 135 · see citing works
Spectrum of Neurological Manifestations in Covid-19: A Review
Garg, R. K. (2020) · Neurology India · doi:10.4103/0028-3886.289000 · Cited by 133 · see citing works
Sex Disparities in COVID-19 Severity and Outcome: Are Men Weaker or Women Stronger?
Pivonello, R., Auriemma, R. S., Pivonello, C., Isidori, A. M., Corona, G., Colao, A. A. L., & Millar, R. P. (2020) · Neuroendocrinology · doi:10.1159/000513346 · Cited by 132 · see citing works
Neuropsychiatric aspects of COVID-19 pandemic: A selective review
Dinakaran, D., Manjunatha, N., Kumar, C. N., & Suresh, B. M. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102188 · Cited by 129 · see citing works
Cerebral ischemic and hemorrhagic complications of coronavirus disease 2019
Sweid, A., Hammoud, B., Bekelis, K., Missios, S., Tjoumakaris, S. I., Gooch, M. R., Herial, N. A., Zarzour, H. K., Romo, V. M., DePrince, M., et al. (2020) · International Journal of Stroke · doi:10.1177/1747493020937189 · Cited by 128 · see citing works
Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis
Wu, T., Zuo, Z., Kang, S., Jiang, L., Luo, X., Xia, Z., Liu, J., Xiao, X., Ye, M., & Deng, M. (2020) · Aging and Disease · doi:10.14336/ad.2020.0520 · Cited by 126 · see citing works
COVID-19 and cognitive impairment: neuroinvasive and blood‒brain barrier dysfunction
Chen, Y., Yang, W., Chen, F., & Cui, L. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02579-8 · Cited by 124 · see citing works
Zakeri, A., Jadhav, A. P., Sullenger, B. A., & Nimjee, S. M. (2020) · Journal of NeuroInterventional Surgery · doi:10.1136/neurintsurg-2020-016794 · Cited by 121 · see citing works
Post-COVID 19 neurological syndrome: Implications for sequelae’s treatment
Camargo-Martínez, W., Lozada-Martínez, I. D., Escobar-Collazos, A., Navarro-Coronado, A., Moscote‐Salazar, L. R., Pacheco-Hernández, A., Janjua, T. M., & Bosque‐Varela, P. (2021) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2021.04.001 · Cited by 128 · see citing works
Neurological involvement of coronavirus disease 2019: a systematic review
Ghannam, M., Alshaer, Q., Al-Chalabi, M., Zakarna, L., Robertson, J., & Manousakis, G. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09990-2 · Cited by 119 · see citing works
SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings
Williams, P. C. M., Howard‐Jones, A. R., Hsu, P. S., Palasanthiran, P., Gray, P. E., McMullan, B. J., Britton, P. N., & Bartlett, A. W. (2020) · Pathology · doi:10.1016/j.pathol.2020.08.001 · Cited by 121 · see citing works
Siow, I., Lee, K. S., Zhang, J. J. Y., Saffari, S. E., Ng, A., & Young, B. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105549 · Cited by 116 · see citing works
Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review
Tu, T. M., Goh, C., Tan, Y. K., Leow, A. S., Pang, Y., Chien, J. M.-F., Shafi, H., Chan, B., Hui, A. C.-F., Koh, J. S., et al. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105379 · Cited by 115 · see citing works
Rehabilitation setting during and after Covid-19: An overview on recommendations
Agostini, F., Mangone, M., Ruiu, P., Paolucci, T., Santilli, V., & Bernetti, A. (2020) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-2776 · Cited by 117 · see citing works
Histopathological findings and clinicopathologic correlation in COVID-19: a systematic review
Caramaschi, S., Kapp, M., Miller, S., Eisenberg, R., Johnson, J. E., Epperly, G., Maiorana, A., Silvestri, G., & Giannico, G. A. (2021) · Modern Pathology · doi:10.1038/s41379-021-00814-w · Cited by 111 · see citing works
Moro, E., Priori, A., Beghi, E., Helbok, R., Campiglio, L., Bassetti, C. L., Bianchi, E., Maia, L. F., Öztürk, Ş., Cavallieri, F., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14407 · Cited by 111 · see citing works
Pathogenesis, Clinical Manifestations and Complications of COVID-19
Kordzadeh-Kermani, E., Khalili, H., & Karimzadeh, I. (2020) · Future Microbiology · doi:10.2217/fmb-2020-0110 · Cited by 116 · see citing works
Coronavirus Disease 2019–Associated Coagulopathy
Lippi, G., Sanchis‐Gomar, F., Favaloro, E. J., Lavie, C. J., & Henry, B. M. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.10.031 · Cited by 110 · see citing works
The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19
Basile, M. S., Cavalli, E., McCubrey, J. A., Hernández‐Bello, J., Muñóz-Valle, J. F., Fagone, P., & Nicoletti, F. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.11.002 · Cited by 112 · see citing works
Guerrero, J. I., Barragán, L. A., Martínez, J. D., Montoya, J. P., Peña, A., Sobrino, F. E., Tovar-Spinoza, Z. S., & Ghotme, K. A. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-06185-6 · Cited by 110 · see citing works
COVID-19 and cerebrovascular diseases: a comprehensive overview
Tsivgoulis, G. K., Palaiodimou, L., Zand, R., Lioutas, V., Krogias, C., Katsanos, A. H., Shoamanesh, A., Sharma, V. K., Shahjouei, S., Baracchini, C., et al. (2020) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286420978004 · Cited by 112 · see citing works
Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study
Shahjouei, S., Naderi, S., Li, J., Khan, A., Chaudhary, D. P., Farahmand, G., Male, S., Griessenauer, C. J., Sabra, M., Mondello, S., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102939 · Cited by 106 · see citing works
Rheumatic manifestations of COVID-19: a systematic review and meta-analysis
Ciaffi, J., Melicòni, R., Ruscitti, P., Berardicurti, O., Giacomelli, R., & Ursini, F. (2020) · BMC Rheumatology · doi:10.1186/s41927-020-00165-0 · Cited by 106 · see citing works
Neurological features of COVID-19 and their treatment: a review
Orsucci, D., Ienco, E. C., Nocita, G., Napolitano, A., & Vista, M. (2020) · Drugs in Context · doi:10.7573/dic.2020-5-1 · Cited by 103 · see citing works
Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series
Reddy, S. T., Garg, T., Shah, C., Nascimento, F. A., Imran, R., Kan, P. T. M., Bowry, R., Gonzales, N. R., Barreto, A. D., Kumar, A., et al. (2020) · Case Reports in Neurology · doi:10.1159/000508958 · Cited by 106 · see citing works
Stem cell therapy for COVID‐19, ARDS and pulmonary fibrosis
Li, Z., Niu, S., Guo, B., Gao, T., Wang, L., Wang, Y., Wang, L., Tan, Y., Wu, J., & Hao, J. (2020) · Cell Proliferation · doi:10.1111/cpr.12939 · Cited by 105 · see citing works
COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications
Yamamoto, V., Bolanos, J. F., Fiallos, J., Strand, S. E., Morris, K., Shahrokhinia, S., Cushing, T. R., Hopp, L., Tiwari, A., Hariri, R., et al. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200831 · Cited by 100 · see citing works
Pediatric Ischemic Stroke: An Infrequent Complication of SARS‐CoV ‐2
Beslow, L. A., Linds, A. B., Fox, C. K., Kossorotoff, M., Zambrano, Y. C. Z., Hernández, M., Hassanein, S. M. A., Byrne, S., Lim, M. J., Maduaka, N., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25991 · Cited by 99 · see citing works
Acute and Post-Acute Neurological Complications of COVID-19
Al-Ramadan, A., Rabab’h, O., Shah, J., & Gharaibeh, A. (2021) · Neurology International · doi:10.3390/neurolint13010010 · Cited by 97 · see citing works
Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
Burks, S. M., Rosas-Hernandez, H., Alejandro Ramirez-Lee, M., Cuevas, E., & Talpos, J. C. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.031 · Cited by 97 · see citing works
Vonck, K. E. J., Garrez, I., Herdt, V. D., Hemelsoet, D., Laureys, G., Raedt, R., & Boon, P. (2020) · European Journal of Neurology · doi:10.1111/ene.14329 · Cited by 98 · see citing works
Janardhan, V., Janardhan, V., & Kalousek, V. (2020) · Journal of Neuroimaging · doi:10.1111/jon.12770 · Cited by 95 · see citing works
Characteristics and outcomes of COVID-19 associated stroke: a UK multicentre case-control study
Perry, R. J., Smith, C. J., Roffe, C., Simister, R. J., Narayanamoorthi, S., Marigold, R., Willmot, M. R., Dixit, A. K., Hassan, A., Quinn, T. J., et al. (2020) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-324927 · Cited by 96 · see citing works
Self-citationMore on COVID‐19 coagulopathy in Caucasian patients
Fogarty, H., Townsend, L., Cheallaigh, C. N., Bergin, C. J., Martín‐Loeches, I., Browne, P., Bacon, C. L., Gaule, R., Gillett, A., Byrne, M., et al. (2020) · British Journal of Haematology · doi:10.1111/bjh.16791 · Cited by 96 · see citing works
Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men
Tu, T. M., Seet, C. Y. H., Koh, J. S., Tham, C. H., Chiew, H. J., Angon, J., Chua, C. Y. K., Hui, A. C.-F., Tan, S. S. Y., Vasoo, S. S., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.7498 · Cited by 95 · see citing works
COVID‑19 and ischemic stroke: Mechanisms of hypercoagulability (Review)
Zhang, S., Zhang, J., Wang, C., Chen, X., Zhao, X., Jing, H., Liu, H., Li, Z., Wang, L., & Shi, J. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4854 · Cited by 99 · see citing works
Kubota, T., & Kuroda, N. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.106349 · Cited by 92 · see citing works
COVID-19 and thrombotic microangiopathies
Tiwari, N. R., Phatak, S. B., Sharma, V. R., & Agarwal, S. K. (2021) · Thrombosis Research · doi:10.1016/j.thromres.2021.04.012 · Cited by 92 · see citing works
Neuropathologic findings of patients with COVID-19: a systematic review
Pajo, A. T., Espiritu, A. I., Apor, A. D. A. O., & Jamora, R. D. G. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05068-7 · Cited by 91 · see citing works
Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study
Fan, S., Xiao, M., Han, F., Xia, P., Bai, X., Chen, H., Zhang, H., Ding, X., Zhao, H., Zhao, J., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00806 · Cited by 90 · see citing works
Acute Cerebrovascular Events With COVID-19 Infection
Dhamoon, M. S., Thaler, A. I., Gururangan, K., Kohli, A., Sisniega, D. C., Wheelwright, D., Mensching, C., Fifi, J. T., Fara, M. G., Jetté, N., et al. (2020) · Stroke · doi:10.1161/strokeaha.120.031668 · Cited by 87 · see citing works
COVID-19: Neurological Considerations in Neonates and Children
Stafstrom, C. E., & Jantzie, L. L. (2020) · Children · doi:10.3390/children7090133 · Cited by 90 · see citing works
The Spectrum of Neuroimaging Findings on CT and MRI in Adults With COVID-19
Moonis, G., Filippi, C. G., Kirsch, C., Mohan, S., Stein, E. G., Hirsch, J. A., & Mahajan, A. K. (2020) · American Journal of Roentgenology · doi:10.2214/ajr.20.24839 · Cited by 87 · see citing works
Gulko, E., Oleksk, M. L., Gomes, W. A., Ali, S., Mehta, H. B., Overby, P. J., Al‐Mufti, F., & Rozenstein, A. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6805 · Cited by 87 · see citing works
Wang, Z., Yang, Y., Liang, X., Gao, B., Liu, M., Li, W., Chen, Z., & Wang, Z. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.571996 · Cited by 87 · see citing works
Cavalli, E., Bramanti, A., Ciurleo, R., Tchorbanov, A. I., Giordano, A., Fagone, P., Belizna, C. C., Bramanti, P., Shoenfeld, Y., & Nicoletti, F. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4659 · Cited by 85 · see citing works
Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis
Yamakawa, M., Kuno, T., Mikami, T., Takagi, H., & Gronseth, G. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105288 · Cited by 83 · see citing works
Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke
Xie, X., Wang, L., Dong, S., Ge, S., & Zhu, T. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.380869 · Cited by 85 · see citing works
Ning, Q., Wu, D., Wang, X., Xi, D., Chen, T., Chen, G., Wang, H., Lü, H., Wang, M., Zhu, L., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00907-1 · Cited by 82 · see citing works
Neurology of COVID-19 in Singapore
Koh, J. S., Silva, D. A. D., Quek, A. M. L., Chiew, H. J., Tu, T. M., Seet, C. Y. H., Hoe, R. H. M., Saini, M., Hui, A. C.-F., Angon, J., et al. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117118 · Cited by 80 · see citing works
Self-citationNeuropathological findings in two patients with fatal COVID‐19
Jensen, M. P., Quesne, J. P. C. L., Officer‐Jones, L., Teodòsio, A., Thaventhiran, J. E. D., Ficken, C., Goddard, M. J., Smith, C., Menon, D. K., & Allinson, K. S. J. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12662 · Cited by 79 · see citing works
- Authors
- Beyrouti, R., Adams, M. E., Benjamin, L., Cohen, H., Farmer, S. F., Goh, Y. Y., Humphries, F., Jäger, H. R., Losseff, N. A., Perry, R. J., Shah, S., Simister, R. J., Turner, D., Chandratheva, A., & Werring, D. J.
- Affiliations
- University College London Hospitals NHS Foundation Trust (GB)
- University of Liverpool (GB)
- University College London (GB)
- Corresponding author
- Werring, David J
- ORCID
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2020-04-30
- Volume
- 91
- Issue
- 8
- Pages
- 889-891
- ISSN
- 0022-3050 (ISSN-L)
- 1468-330X
- PMC
- PMC7231545
- OpenAlex
- W3022807497
- Cited by
- 711
- References
- 5
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 32 · 2023: 40 · 2022: 117 · 2021: 253 · 2020: 250 · 2012: 1
- FWCI
- 71.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- COVID-19 pandemic, SARS-CoV-2, ischemic stroke, large vessel occlusion, D-dimer, coagulopathy, venous thrombosis, anticoagulation failure, neurological complications of COVID-19, stroke features
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Aged, 80 and over, Brain Ischemia, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Coronavirus Infections, Stroke, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
