The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Effects of steroid therapy on inflammatory cell subtypes in asthma
Open accessAbstract
RATIONALE Airway inflammation in asthma is heterogeneous with different phenotypes. The inflammatory cell phenotype is modified by corticosteroids and smoking. Steroid therapy is beneficial in eosinophilic asthma (EA), but evidence is conflicting regarding non-eosinophilic asthma (NEA). OBJECTIVES To assess the inflammatory cell phenotypes in asthma after eliminating potentially confounding effects; to compare steroid response in EA versus NEA; and to investigate changes in sputum cells with inhaled corticosteroid (ICS). METHODS Subjects undertook ICS withdrawal until loss of control or 28 days. Those with airway hyper-responsiveness (AHR) took inhaled fluticasone 1000 microg daily for 28+ days. Cut-off points were > or = or <2% for sputum eosinophils and > or = or <61% for neutrophils. RESULTS After steroid withdrawal (n=94), 67% of subjects were eosinophilic, 31% paucigranulocytic and 2% mixed; there were no neutrophilic subjects. With ICS (n=88), 39% were eosinophilic, 46% paucigranulocytic, 3% mixed and 5% neutrophilic. Sputum neutrophils increased from 19.3% to 27.7% (p=0.024). The treatment response was greater in EA for symptoms (p<0.001), quality of life (p=0.012), AHR (p=0.036) and exhaled nitric oxide (p=0.007). Lesser but significant changes occurred in NEA (ie, paucigranulocytic asthma). Exhaled nitric oxide was the best predictor of steroid response in NEA for AHR (area under the curve 0.810), with an optimum cut-off point of 33 ppb. CONCLUSIONS After eliminating the effects of ICS and smoking, a neutrophilic phenotype could be identified in patients with moderate stable asthma. ICS use led to phenotype misclassification. Steroid responsiveness was greater in EA, but the absence of eosinophilia did not indicate the absence of a steroid response. In NEA this was best predicted by baseline exhaled nitric oxide.
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Development and validation of a questionnaire to measure asthma control
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Self-citationLung Function Testing: Selectionof reference Values and Interpretative Strategies
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Mast-Cell Infiltration of Airway Smooth Muscle in Asthma
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Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults
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Cited by
Dweik, R. A., Boggs, P. B., Erzurum, S. C., Irvin, C. G., Leigh, M. W., Lundberg, J. O., Olin, A.-C., Plummer, A. L., & Taylor, D. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.9120-11st · Cited by 2,539
Self-citationPeriostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
Jia, G., Erickson, R. W., Choy, D. F., Mosesova, S., Wu, L. C., Solberg, O. D., Shikotra, A., Carter, R., Audusseau, S., Hamid, Q., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.06.025 · Cited by 615
Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis
Moore, W. C., Hastie, A. T., Li, X., Li, H., Busse, W. W., Jarjour, N. N., Wenzel, S. E., Peters, S. P., Meyers, D. A., & Bleecker, E. R. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.011 · Cited by 600
Role of Probiotics in Human Gut Microbiome-Associated Diseases
Kim, S.-K., Guevarra, R. B., Kim, Y.-T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J.-H. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1906.06064 · Cited by 519
Szefler, S. J., Wenzel, S., Brown, R., Erzurum, S. C., Fahy, J. V., Hamilton, R. G., Hunt, J. F., Kita, H., Liu, A. H., Panettieri, R. A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.979 · Cited by 395
Metadata
- Authors
- Cowan, D. C., Cowan, J. O., Palmay, R., Williamson, A., & Taylor, D. R.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2009-12-08
- Volume
- 65
- Issue
- 5
- Pages
- 384-390
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2138563820
- Cited by
- 310
- References
- 52
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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