Effects of an acute bout of resistance exercise on fiber-type specific GLUT4 and IGF-1R expression
Abstract
The effects of resistance exercise on fiber-type-specific expression of insulin-like growth factor I receptor (IGF-1R) and glucose transporter 4 (GLUT4) was determined in 6 healthy males. The expression of both genes increased in Type I fibers (p < 0.05), but only GLUT4 increased (p < 0.05) in Type II fibers. These data demonstrates that an acute bout of resistance exercise can up-regulate mechanisms of glucose uptake in slow and fast-twitch fibers, but the IGF signaling axis may not be as effective in fast-twitch fibers.
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Resistance exercise increases expression of GLUT-4 in type II fibers and enhances intracellular insulin sensitivity.
“Additionally, resistance exercise has been shown to increase the expression of GLUT-4 in type II fibers and enhance intracellular insulin sensitivity (84–87).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [86]
Resistance exercise specifically promotes hypertrophy in type II muscle fibers, while not significantly affecting type I fibers.
“Resistance exercise has been found to specifically promote hypertrophy in type II muscle fibers, while not significantly affecting type I fibers.”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [86]
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- Authors
- Gallagher, P. M., Touchberry, C. D., Teson, K., McCabe, E., Tehel, M., & Wacker, M. J.
- Affiliations
- University of Kansas (US)
- University of Missouri–Kansas City (US)
- Venue
- Applied Physiology Nutrition and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2013-05
- Volume
- 38
- Issue
- 5
- Pages
- 581-586
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W1974464485
- Cited by
- 17
- References
- 52
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Physiology Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- resistance training, GLUT4, IGF-1 receptor, skeletal muscle fiber types, type I muscle fibers, type II fibers, glucose uptake, IGF signaling, gene expression, acute exercise
- MeSH terms
- Dietary Fiber, Humans, Insulin-Like Growth Factor I, Signal Transduction, Exercise, Muscle Fibers, Fast-Twitch, Glucose Transporter Type 4
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