Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle
Open accessAbstract
It is well known that resistance exercise increases muscle protein synthesis and muscle strength. However, little is known about the effect of resistance exercise on mitochondrial dynamics, which is coupled with mitochondrial function. In skeletal muscle, mitochondria exist as dynamic networks that are continuously remodeling through fusion and fission. The purpose of this study was to investigate the effect of acute and chronic resistance exercise, which induces muscle hypertrophy, on the expression of proteins related to mitochondrial dynamics in rat skeletal muscle. Resistance exercise consisted of maximum isometric contraction, which was induced by percutaneous electrical stimulation of the gastrocnemius muscle. Our results revealed no change in levels of proteins that regulate mitochondrial fission (Fis1 and Drp1) or fusion (Opa1, Mfn1, and Mfn2) over the 24-h period following acute resistance exercise. Phosphorylation of Drp1 at Ser616 was increased immediately after exercise (P < 0.01). Four weeks of resistance training (3 times/week) increased Mfn1 (P < 0.01), Mfn2 (P < 0.05), and Opa1 (P < 0.01) protein levels without altering mitochondrial oxidative phosphorylation proteins. These observations suggest that resistance exercise has little effect on mitochondrial biogenesis but alters the expression of proteins involved in mitochondrial fusion and fission, which may contribute to mitochondrial quality control and improved mitochondrial function.
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In rat skeletal muscle, there was no change in mitochondrial protein levels involved in fission or fusion over 24 h after acute resistance exercise, while four weeks of electrical stimulation-induced resistance training increased Mfn1, Mfn2, and Opa1 protein levels.
“In rat skeletal muscle, there was no change in mitochondrial protein levels involved in mitochondrial fission or fusion over the 24 h after acute resistance exercise, while four weeks of electrical stimulation-induced resistance training (every other day, 12 sessions) increased Mfn1, Mfn2, and Opa1 protein levels [63].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [63]
Studies in rodents show increased abundance of autophagy proteins including Drp1, Bcl-2, and Bnip3 after exercise.
“Studies in rodents have shown an increased abundance of autophagy proteins including Drp1 and Bcl-2 and 19 kDa interacting protein-3 (Bnip3) after exercise (60, 65, 71, 78).”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [71]
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- Authors
- Kitaoka, Y., Ogasawara, R., Tamura, Y., Fujita, S., & Hatta, H.
- Affiliations
- The University of Tokyo (JP)
- Ritsumeikan University (JP)
- Venue
- Applied Physiology Nutrition and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2015-11
- Volume
- 40
- Issue
- 11
- Pages
- 1137-1142
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W1886603574
- Cited by
- 54
- References
- 40
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Applied Physiology Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (acceptedVersion)
- Funders
- Japan Society for the Promotion of Science (26750304, 26702028)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- resistance training, electrical stimulation, mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, skeletal muscle, Drp1 phosphorylation, Mfn1, mitofusin 2, OPA1, Fis1, muscle hypertrophy, mitochondrial quality control, mitochondrial biogenesis, gastrocnemius
- MeSH terms
- Animals, Electric Stimulation, Energy Metabolism, Isometric Contraction, Membrane Proteins, Mitochondria, Muscle, Phosphorylation, Time Factors, Rats, Sprague-Dawley, Muscle, Skeletal, GTP Phosphohydrolases, Mitochondrial Proteins, Dynamins, Resistance Training, Mitochondrial Dynamics
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