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Cited by 50Physical Activity and HealthCardiovascular and exercise physiologyDementia and Cognitive Impairment Research

A Systematic Review of the Impact of Physical Exercise-Induced Increased Resting Cerebral Blood Flow on Cognitive Functions

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Renke, Maria B., Marcinkowska, Anna B., Kujach, Sylwester, Winklewski, Paweł J.·2022·Frontiers in Aging Neuroscience
DOI 10.3389/fnagi.2022.803332PMC PMC8882971
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Abstract

Brain perfusion declines with aging. Physical exercise represents a low-cost accessible form of intervention to increase cerebral blood flow; however, it remains unclear if exercise-induced amelioration of brain perfusion has any impact on cognition. We aimed to provide a state-of-the art review on this subject. A comprehensive search of the PubMed (MEDLINE) database was performed. On the basis of the inclusion and exclusion criteria, 14 studies were included in the analysis. Eleven of the studies conducted well-controlled exercise programs that lasted 12–19 weeks for 10–40 participants and two studies were conducted in much larger groups of subjects for more than 5 years, but the exercise loads were indirectly measured, and three of them were focused on acute exercise. Literature review does not show a direct link between exercise-induced augmentation of brain perfusion and better cognitive functioning. However, in none of the reviewed studies was such an association the primary study endpoint. Carefully designed clinical studies with focus on cognitive and perfusion variables are needed to provide a response to the question whether exercise-induced cerebral perfusion augmentation is of clinical importance.

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  • Dose-response for both moderate-to-vigorous physical activity and vigorous physical activity are positively associated with grade point average, with stronger effects observed for vigorous physical activity.

    “Dose-response for both MVPA and VPA were positively associated with GPA, with stronger effects observed for VPA (Alfaro-Chaverri et al., 2025; Donnelly et al., 2016; Renke et al., 2022; Singh et al., 2025).”

    From Physical activity and academic performance in adolescents: a systematic review of intensity, frequency, and mediating factors (2026) · cites this paper as Renke et al., 2022

    The Introduction discusses how exercise intensity affects cerebral blood flow, and the Results report cognitive outcomes, chiefly in older adults. Searches for GPA, academic performance, and a dose-response comparison of moderate-to-vigorous and vigorous activity found no passage addressing the claimed association with GPA. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Renke, M. B., Marcinkowska, A. B., Kujach, S., & Winklewski, P. J.
Affiliations
  • Gdańsk University of Technology (PL)
  • Gdańsk Medical University (PL)
  • Gdansk University of Physical Education and Sport (PL)
Corresponding author
Renke, Maria B.
ORCID
Venue
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Published
2022-02-14
Volume
14
Pages
803332-803332
ISSN
1663-4365 (ISSN-L)
DOI
10.3389/fnagi.2022.803332
PMC
PMC8882971
OpenAlex
W4213017074
Cited by
50
References
18
Citations by year
2026: 18 · 2025: 14 · 2024: 6 · 2023: 9 · 2022: 3
FWCI
1.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Aging Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Narodowe Centrum Badań i Rozwoju (POWR.03.05.00-00-z082/18)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
physical activity, resting cerebral blood flow, cerebral perfusion, cognitive function, aging, acute exercise, exercise intervention, cognitive aging

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