The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running
Abstract
Blueberries are rich in antioxidants known as anthocyanins, which may exhibit significant health benefits. Strenous exercise is known to acutely generate oxidative stress and an inflammatory state, and serves as an on-demand model to test antioxidant and anti-inflammatory compounds. The purpose of this study was to examine whether 250 g of blueberries per day for 6 weeks and 375 g given 1 h prior to 2.5 h of running at ∼72% maximal oxygen consumption counters oxidative stress, inflammation, and immune changes. Twenty-five well-trained subjects were recruited and randomized into blueberry (BB) (N = 13) or control (CON) (N = 12) groups. Blood, muscle, and urine samples were obtained pre-exercise and immediately postexercise, and blood and urine 1 h postexercise. Blood was examined for F 2-isoprostanes for oxidative stress, cortisol, cytokines, homocysteine, leukocytes, T-cell function, natural killer (NK), and lymphocyte cell counts for inflammation and immune system activation, and ferric reducing ability of plasma for antioxidant capacity. Muscle biopsies were examined for glycogen and NFkB expression to evaluate stress and inflammation. Urine was tested for modification of DNA (8-OHDG) and RNA (5-OHMU) as markers of nucleic acid oxidation. A 2 (treatment) × 3 (time) repeated measures ANOVA was used for statistical analysis. Increases in F 2-isoprostanes and 5-OHMU were significantly less in BB and plasma IL-10 and NK cell counts were significantly greater in BB vs. CON. Changes in all other markers did not differ. This study indicates that daily blueberry consumption for 6 weeks increases NK cell counts, and acute ingestion reduces oxidative stress and increases anti-inflammatory cytokines.
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“Several other studies have reported that dietary antioxidants do not affect the typical changes in lymphocyte function induced by acute exercise, but many of these studies have examined non-specific aspects of cell-mediated immunity (McAnulty et al. 2011; Petersen et al. 2001).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as McAnulty et al. 2011
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Cites
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- Horn P., 2007, Exerc. Immunol. Rev., 13, 100
- Hou D.X., 2003, Int. J. Oncol., 23, 705
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The isoprostanes—25 years later
Milne, G. L., Dai, Q., & Roberts, L. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.007 · Cited by 335
Self-citationFruit Polyphenols: A Review of Anti-inflammatory Effects in Humans
Joseph, S. V., Edirisinghe, I., & Burton‐Freeman, B. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.767221 · Cited by 296
Immunomodulatory Effects of Dietary Polyphenols
Shakoor, H. I., Feehan, J., Apostolopoulos, V., Platat, C., Dhaheri, A. S. A., Ali, H. I., Ismail, L. C., Bosevski, M., & Stojanovska, L. (2021) · Nutrients · doi:10.3390/nu13030728 · Cited by 268
Hosseini, B., Berthon, B. S., Saedisomeolia, A., Starkey, M. R., Collison, A., Wark, P. A. B., & Wood, L. G. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy082 · Cited by 252
Pap, N., Fidelis, M., Azevedo, L. C., do Carmo, M. A. V., Wang, D., Mocan, A., Pereira, E. P. R., Xavier-Santos, D., Sant’Ana, A. S., Yang, B., et al. (2021) · Current Opinion in Food Science · doi:10.1016/j.cofs.2021.06.003 · Cited by 259
Metadata
- Authors
- McAnulty, L. S., Nieman, D. C., Dumke, C. L., Shooter, L. A., Henson, D. A., Utter, A. C., Milne, G., & McAnulty, S. R.
- Affiliations
- Appalachian State University (US)
- University of Montana (US)
- Vanderbilt University (US)
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2011-12
- Volume
- 36
- Issue
- 6
- Pages
- 976-984
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W1998388034
- Cited by
- 145
- References
- 37
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 10 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 10 · 2019: 13 · 2018: 9 · 2017: 5 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 8 · 2012: 2
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Physiology, Nutrition, and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- natural killer cells, oxidative stress, exercise-induced inflammation, running, anthocyanins, antioxidants, F2-isoprostanes, 8-hydroxy-2'-deoxyguanosine, IL-10, cytokines, NF-κB, muscle glycogen, ferric reducing ability, well-trained athletes
- MeSH terms
- Adolescent, Adult, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Fruit, Humans, Killer Cells, Natural, Myositis, Physical Endurance, Running, Thymidine, Biomarkers, Exercise, Interleukin-10, Oxidative Stress, Lymphocyte Count, F2-Isoprostanes, Blueberry Plants, Young Adult, Athletes
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