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Cited by 252Nutritional Studies and DietPhytochemicals and Antioxidant ActivitiesExercise and Physiological Responses

Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: a systematic literature review and meta-analysis.

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Hosseini, Banafshe, Berthon, Bronwyn S, Saedisomeolia, Ahmad, Starkey, Malcolm R, Collison, Adam, Wark, Peter A B, Wood, Lisa G·2018·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/nqy082
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Abstract

Background Inflammation is associated with an increased risk of a range of chronic diseases. A diet high in fruit and vegetables may help to reduce inflammation, as fruit and vegetables are rich sources of antioxidants and other biologically active substances, which may improve immune function.Objective To summarize the evidence, we executed a systematic review and meta-analysis examining the effects of fruit and/or vegetable intake on inflammatory biomarkers and immune cells in humans with different diseases and conditions.Design Electronic databases including PubMed, Cochrane, CINAHL, and EMBASE were systematically searched up to March 2018.Results Eighty-three studies were included. Of these, 71 (86%) were clinical trials, and 12 were observational studies (n = 10 cross-sectional and n = 2 cohort). Amongst the observational research, n = 10 studies found an inverse association between intakes of fruit or vegetables and inflammatory biomarkers. Similarly, the majority of the intervention studies (68%, n = 48) reported beneficial effects of fruit or vegetable intake on ≥1 biomarker of systemic or airway inflammation. A meta-analysis of included studies showed that fruit or vegetable intake decreased circulating levels of C-reactive protein and tumor necrosis factor-α (P < 0.05) and increased the γδ-T cell population (P < 0.05).Conclusions In conclusion, this review suggests that higher intakes of fruit and vegetables lead to both a reduction in proinflammatory mediators and an enhanced immune cell profile.

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  • Various components in fruits and vegetables (fiber, folate, vitamins, non-nutrient phytochemicals such as carotenoids and flavonoids) have a profound impact on the immune system and may potentially affect clinical outcomes of ICI therapy.

    “Various components included in fruits and vegetables, i.e., fiber, folate, vitamins, and non-nutrient phytochemicals, such as carotenoids and flavonoids, which have a profound impact on the immune system, may potentially also affect the clinical outcomes of ICI therapy [71].”

    From A Clinical Outcome of the Anti-PD-1 Therapy of Melanoma in Polish Patients Is Mediated by Population-Specific Gut Microbiome Composition (2022) · cites this paper as [71]

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Cited by

Sorted by citations

Authors
Hosseini, B., Berthon, B. S., Saedisomeolia, A., Starkey, M. R., Collison, A., Wark, P. A. B., & Wood, L. G.
Affiliations
  • Hunter Medical Research Institute (AU)
  • Western Sydney University (AU)
Corresponding author
Wood, Lisa G
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2018-07
Volume
108
Issue
1
Pages
136-155
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/nqy082
OpenAlex
W2809593089
Cited by
252
References
10
Citations by year
2026: 30 · 2025: 33 · 2024: 33 · 2023: 48 · 2022: 39 · 2021: 35 · 2020: 19 · 2019: 12 · 2018: 3
FWCI
3.14
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
fruit and vegetable intake, dietary antioxidants, inflammation, inflammatory markers, C-reactive protein, TNF-α, γδ T cells, immune cell subsets, airway inflammation, chronic disease risk
MeSH terms
Diet, Feeding Behavior, Fruit, Humans, Inflammation, Vegetables, Biomarkers

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