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Cited by 145Exercise and Physiological ResponsesPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running

McAnulty, Lisa S., Nieman, David C., Dumke, Charles L., Shooter, Lesli A., Henson, Dru A., Utter, Alan C., Milne, Ginger, McAnulty, Steven R.·2011·Applied Physiology, Nutrition, and Metabolism
DOI 10.1139/h11-120
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Abstract

Blueberries are rich in antioxidants known as anthocyanins, which may exhibit significant health benefits. Strenous exercise is known to acutely generate oxidative stress and an inflammatory state, and serves as an on-demand model to test antioxidant and anti-inflammatory compounds. The purpose of this study was to examine whether 250 g of blueberries per day for 6 weeks and 375 g given 1 h prior to 2.5 h of running at ∼72% maximal oxygen consumption counters oxidative stress, inflammation, and immune changes. Twenty-five well-trained subjects were recruited and randomized into blueberry (BB) (N = 13) or control (CON) (N = 12) groups. Blood, muscle, and urine samples were obtained pre-exercise and immediately postexercise, and blood and urine 1 h postexercise. Blood was examined for F 2-isoprostanes for oxidative stress, cortisol, cytokines, homocysteine, leukocytes, T-cell function, natural killer (NK), and lymphocyte cell counts for inflammation and immune system activation, and ferric reducing ability of plasma for antioxidant capacity. Muscle biopsies were examined for glycogen and NFkB expression to evaluate stress and inflammation. Urine was tested for modification of DNA (8-OHDG) and RNA (5-OHMU) as markers of nucleic acid oxidation. A 2 (treatment) × 3 (time) repeated measures ANOVA was used for statistical analysis. Increases in F 2-isoprostanes and 5-OHMU were significantly less in BB and plasma IL-10 and NK cell counts were significantly greater in BB vs. CON. Changes in all other markers did not differ. This study indicates that daily blueberry consumption for 6 weeks increases NK cell counts, and acute ingestion reduces oxidative stress and increases anti-inflammatory cytokines.

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Crossref · 10.1139/h11-120

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Research works printed but not linked: 2

  1. Horn P., 2007, Exerc. Immunol. Rev., 13, 100
  2. Hou D.X., 2003, Int. J. Oncol., 23, 705

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Metadata

Authors
McAnulty, L. S., Nieman, D. C., Dumke, C. L., Shooter, L. A., Henson, D. A., Utter, A. C., Milne, G., & McAnulty, S. R.
Affiliations
  • Appalachian State University (US)
  • University of Montana (US)
  • Vanderbilt University (US)
ORCID
Venue
Applied Physiology, Nutrition, and Metabolism
Publisher
Canadian Science Publishing
Published
2011-12
Volume
36
Issue
6
Pages
976-984
ISSN
  • 1715-5312 (ISSN-L)
  • 1715-5320
DOI
10.1139/h11-120
OpenAlex
W1998388034
Cited by
145
References
37
Citations by year
2026: 7 · 2025: 7 · 2024: 10 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 10 · 2019: 13 · 2018: 9 · 2017: 5 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 8 · 2012: 2
FWCI
6.48
Type
journal article
Language
en
Open access
closed
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations
  • Applied Physiology, Nutrition, and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
natural killer cells, oxidative stress, exercise-induced inflammation, running, anthocyanins, antioxidants, F2-isoprostanes, 8-hydroxy-2'-deoxyguanosine, IL-10, cytokines, NF-κB, muscle glycogen, ferric reducing ability, well-trained athletes
MeSH terms
Adolescent, Adult, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Fruit, Humans, Killer Cells, Natural, Myositis, Physical Endurance, Running, Thymidine, Biomarkers, Exercise, Interleukin-10, Oxidative Stress, Lymphocyte Count, F2-Isoprostanes, Blueberry Plants, Young Adult, Athletes

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