Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes
Abstract
Diabetic cardiomyopathy is defined as ventricular dysfunction of the diabetic heart in the absence of coronary artery disease. With the use of both in vivo and ex vivo techniques to assess cardiac phenotype, reduced contractile performance can be observed in experiments with mouse models of both type 1 (insulin-deficient) and type 2 (insulin-resistant) diabetes. Both systolic dysfunction (reduced left ventricular pressures and decreased cardiac output) and diastolic dysfunction (impaired relaxation) is observed in diabetic hearts, along with enhanced susceptibility to ischemic injury. Metabolism is also altered in diabetic mouse hearts: glucose utilization is reduced and fatty acid utilization is increased. The use of geneticallyengineered mice has provided a powerful experimental approach to test mechanisms that may be responsible for the deleterious effects of diabetes on cardiac function.Key words: cardiac function, cardiac metabolism, cardiac phenotype.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Diabetes is associated with shifts in myocardial substrate utilization characterized by an increase in FA utilization and a decrease in glucose utilization.
“It has long been known that diabetes is associated with shifts in myocardial substrate utilization characterized by an increase in FA utilization and a decrease in glucose utilization (37, 315).”
From Cardiac remodeling in obesity (2008) · cites this paper as [315]
Cites
Haffner, S. M., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390404 · Cited by 7,000 · see citing works
Grundy, S. M., Benjamin, I. J., Burke, G. L., Chait, A., Eckel, R. H., Howard, B. V., Mitch, W., Smith, S. C., & Sowers, J. R. (1999) · Circulation · doi:10.1161/01.cir.100.10.1134 · Cited by 2,698 · see citing works
Lipotoxicity: when tissues overeat
Schaffer, J. E. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00008 · Cited by 914 · see citing works
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A. D., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14080 · Cited by 887 · see citing works
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214080 · Cited by 765 · see citing works
A novel mouse model of lipotoxic cardiomyopathy
Chiu, H.-C., Kovács, A., Ford, D. A., Hsu, F., Garcia, R. A., Herrero, P., Saffitz, J. E., & Schaffer, J. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10947 · Cited by 762 · see citing works
Inoguchi, T., Battan, R., Handler, E., Sportsman, J. R., Heath, W., & King, G. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.11059 · Cited by 739 · see citing works
Evidence for Cardiomyopathy in Familial Diabetes Mellitus
Regan, T. J., Lyons, M. M., Ahmed, S. S., Levinson, G. E., Oldewurtel, H. A., Ahmad, M., & Haider, B. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108843 · Cited by 728 · see citing works
Effect of Vanadate on Elevated Blood Glucose and Depressed Cardiac Performance of Diabetic Rats
Heyliger, C. E., Tahiliani, A. G., & McNeill, J. H. (1985) · Science · doi:10.1126/science.3156405 · Cited by 717 · see citing works
New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes
Saltiel, A. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00239-2 · Cited by 684 · see citing works
Nuclear Receptors and the Control of Metabolism
Francis, G. A., Fayard, E., Picard, F., & Auwerx, J. H. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142528 · Cited by 632 · see citing works
Adaptation and Maladaptation of the Heart in Diabetes: Part I
Taegtmeyer, H., McNulty, P. H., & Young, M. E. (2002) · Circulation · doi:10.1161/01.cir.0000012466.50373.e8 · Cited by 517 · see citing works
Finck, B. N., Han, X., Courtois, M., Aimond, F., Nerbonne, J. M., Kovacs, A., Gross, R. W., & Kelly, D. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336724100 · Cited by 501 · see citing works
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
Green, K., Brand, M. D., & Murphy, M. P. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s110 · Cited by 490 · see citing works
Regulation of energy substrate metabolism in the diabetic heart
Stanley, W. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00047-3 · Cited by 480 · see citing works
Adaptation and Maladaptation of the Heart in Diabetes: Part II
Young, M. E., McNulty, P. H., & Taegtmeyer, H. (2002) · Circulation · doi:10.1161/01.cir.0000012467.61045.87 · Cited by 465 · see citing works
Molecular basis of functional voltage‐gated K + channel diversity in the mammalian myocardium
Nerbonne, J. M. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00285.x · Cited by 453 · see citing works
Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
Belke, D. D., Larsen, T. S., Gibbs, E. M., & Severson, D. L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1104 · Cited by 401 · see citing works
Self-citationYagyu, H., Chen, G., Yokoyama, M., Hirata, K., Augustus, A. S., Kako, Y., Seo, T., Hu, Y., Lutz, E. P., Merkel, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16751 · Cited by 394 · see citing works
Kajstura, J., Fiordaliso, F., Andreoli, A. M., Li, B., Chimenti, S., Medow, M. S., Limana, F., Nadal‐Ginard, B., Leri, A., & Anversa, P. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1414 · Cited by 384 · see citing works
Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy
Wakasaki, H., Koya, D., Schöen, F. J., Jirousek, M. R., Ways, D. K., Hoit, B. D., Walsh, R. A., & King, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9320 · Cited by 379 · see citing works
Belke, D. D., Bétuing, S., Tuttle, M. J., Graveleau, C., Young, M. E., Pham, M., Zhang, D., Cooksey, R. C., McClain, D. A., Litwin, S. E., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13946 · Cited by 377 · see citing works
Self-citationEchocardiographic assessment of cardiac function in conscious and anesthetized mice
Yang, X.-P., Liu, Y.-H., Rhaleb, N., Kurihara, N., Kim, H. E., & Carretero, O. A. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.5.h1967 · Cited by 365 · see citing works
Diabetes-Obesity Syndromes in Mice
Coleman, D. L. (1982) · Diabetes · doi:10.2337/diab.31.1.s1 · Cited by 354 · see citing works
Impact of anesthesia on cardiac function during echocardiography in mice
Roth, D. M., Swaney, J. S., Dalton, N. D., Gilpin, E. A., & ROSS, J. R. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00845.2001 · Cited by 351 · see citing works
Barouch, L. A., Berkowitz, D. E., Harrison, R. W., O’Donnell, C. P., & Hare, J. M. (2003) · Circulation · doi:10.1161/01.cir.0000083716.82622.fd · Cited by 341 · see citing works
Belke, D. D., Betuing, S., Tuttle, M. J., Graveleau, C., Young, M. E., Pham, M., Zhang, D., Cooksey, R. C., McClain, D. A., Litwin, S. E., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213946 · Cited by 330 · see citing works
Self-citationTomlinson, K., Gardiner, S. M., Hebden, R. A., & Bennett, T. M. (1992) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00059-6 · Cited by 321 · see citing works
Pacher, P., Liaudet, L., Soriano, F. G., Mabley, J. G., Szabó, É., & Szabó, C. (2002) · Diabetes · doi:10.2337/diabetes.51.2.514 · Cited by 281 · see citing works
Aasum, E., Hafstad, A. D., Severson, D. L., & Larsen, T. S. (2003) · Diabetes · doi:10.2337/diabetes.52.2.434 · Cited by 280 · see citing works
Self-citationThe Molecular Genetics of Rodent Single Gene Obesities
Leibel, R. L., Chung, W. K., & Chua, S. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.31937 · Cited by 277 · see citing works
Lee, C. D., Folsom, A. R., Pankow, J. S., & Brancati, F. L. (2004) · Circulation · doi:10.1161/01.cir.0000116389.61864.de · Cited by 276 · see citing works
Semeniuk, L. M., Kryski, A. J., & Severson, D. L. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00088.2002 · Cited by 266 · see citing works
Self-citationTrost, S. U., Belke, D. D., Bluhm, W. F., Meyer, M., Swanson, E., & DILLMANN, W. H. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1166 · Cited by 262 · see citing works
Defective intracellular Ca2+ signaling contributes to cardiomyopathy in Type 1 diabetic rats
Choi, K. M., Zhong, Y., Hoit, B. D., Grupp, I. L., Hahn, H. S., Dilly, K. W., Guatimosim, S., Lederer, W. J., & Matlib, M. A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00313.2002 · Cited by 251 · see citing works
Mouse models of insulin resistance
Hribal, M. L., Oriente, F., & Accili, D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00561.2001 · Cited by 251 · see citing works
Mouse Models of Insulin Resistance
Nandi, A. A., KITAMURA, Y., Kahn, C. R., & Accili, D. (2004) · Physiological Reviews · doi:10.1152/physrev.00032.2003 · Cited by 247 · see citing works
Bowman, J. C., Steinberg, S. F., Jiang, T., Geenen, D. L., Fishman, G. I., & Buttrick, P. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119755 · Cited by 229 · see citing works
Gibbs, E. M., Stock, J. L., McCoid, S. C., Stukenbrok, H., Pessin, J. E., Stevenson, R. W., Milici, A. J., & McNeish, J. D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117823 · Cited by 226 · see citing works
Nongenetic mouse models of non—insulin-dependent diabetes mellitus
Luo, J., Quan, J., Tsai, J., Hobensack, C. K., Sullivan, C., Hector, R., & Reaven, G. M. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90027-0 · Cited by 224 · see citing works
Studies on Streptozotocin Diabetes
Ganda, O. P., Rossini, A. A., & Like, A. A. (1976) · Diabetes · doi:10.2337/diab.25.7.595 · Cited by 224 · see citing works
Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter
Race, J. E., Makhlouf, F. N., Logue, P. J., Wilson, F. H., Dunham, P. B., & Holtzman, E. J. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.6.c1210 · Cited by 223 · see citing works
Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse
Petro, A. E., Cotter, J., Cooper, D. A., Peters, J. C., Surwit, S. J., & Surwit, R. S. (2004) · Metabolism · doi:10.1016/j.metabol.2003.11.018 · Cited by 207 · see citing works
Myocardial substrate metabolism: Implications for diabetic Cardiomyopathy
Rodrigues, B. B., Cam, M., & McNeill, J. H. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(08)80016-8 · Cited by 206 · see citing works
Cardiac Physiology in Transgenic Mice
James, J. F., Hewett, T. E., & Robbins, J. M. (1998) · Circulation Research · doi:10.1161/01.res.82.4.407 · Cited by 197 · see citing works
Jaffer, F. A., & Weissleder, R. (2004) · Circulation Research · doi:10.1161/01.res.0000119321.18573.5a · Cited by 193 · see citing works
Metabolic Abnormalities in the Diabetic Heart
Lopaschuk, G. D. (2002) · Heart Failure Reviews · doi:10.1023/a:1015328625394 · Cited by 184 · see citing works
Fein, F. S. (1990) · Diabetes Care · doi:10.2337/diacare.13.11.1169 · Cited by 181 · see citing works
Way, K. J., Isshiki, K., Suzuma, K., Yokota, T., Zvagelsky, D., Schöen, F. J., Sandusky, G. E., Pechous, P. A., Vlahos, C. J., Wakasaki, H., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2709 · Cited by 180 · see citing works
Kass, D. A., Hare, J. M., & Georgakopoulos, D. (1998) · Circulation Research · doi:10.1161/01.res.82.4.519 · Cited by 177 · see citing works
Krump, É., Sanghera, J. S., Pelech, S., Furuya, W., & Grinstein, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.937 · Cited by 174 · see citing works
The diabetic heart is more sensitive to ischemic injury
Paulson, D. J. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00018-7 · Cited by 170 · see citing works
Yang, Z., Berr, S. S., Gilson, W. D., Toufektsian, M.-C., & French, B. A. (2004) · Circulation · doi:10.1161/01.cir.0000118495.88442.32 · Cited by 167 · see citing works
Cardiac consequences of diabetes mellitus
SHEHADEH, A. A., & Regan, T. J. (1995) · Clinical Cardiology · doi:10.1002/clc.4960180604 · Cited by 164 · see citing works
Diabetes and Cardiovascular Disease
Resnick, H. E., & Howard, B. V. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.103904 · Cited by 162 · see citing works
Effects of glucose intolerance on myocardial function and collagen-linked glycation.
Avendaño, G., Agarwal, R., Bashey, R. I., Lyons, M. M., Soni, B. J., Jyothirmayi, G. N., & Regan, T. J. (1999) · Diabetes · doi:10.2337/diabetes.48.7.1443 · Cited by 158 · see citing works
Aasum, E., Belke, D. D., Severson, D. L., Riemersma, R. A., Cooper, M., Andreassen, M., & Larsen, T. S. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00226.2001 · Cited by 154 · see citing works
Self-citationNielsen, L. B., Bartels, E. D., & Bollano, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203458200 · Cited by 146 · see citing works
The effect of chronic alloxan- and streptozotocin-induced diabetes on isolated rat heart performance
Vadlamudi, R. V. S. V., Rodgers, R. L., & McNeill, J. H. (1982) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y82-127 · Cited by 140 · see citing works
Feuvray, D. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00037-0 · Cited by 135 · see citing works
Glucose and fatty acid metabolism in the isolated working mouse heart
Belke, D. D., Larsen, T. S., Lopaschuk, G. D., & Severson, D. L. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.4.r1210 · Cited by 130 · see citing works
Self-citationHayden, J. M., & Reaven, P. D. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200010000-00010 · Cited by 121 · see citing works
Viewpoint: Are Studies in Genetically Altered Mice Out of Control?
Sigmund, C. D. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1425 · Cited by 120 · see citing works
C-NMR: a simple yet comprehensive method for analysis of intermediary metabolism
Jeffrey, F. M. H., Rajagopal, A., Malloy, C. R., & Sherry, A. D. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90004-f · Cited by 115 · see citing works
Comparison of Two Murine Models of Familial Hypertrophic Cardiomyopathy
McConnell, B. K., Fatkin, D., Semsarian, C., Jones, K. A., Georgakopoulos, D., Maguire, C. T., Healey, M. J., Mudd, J. O., Moskowitz, I. P. G., Conner, D. A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.4.383 · Cited by 115 · see citing works
Primary myocardial disease in the diabetic mouse. An ultrastructural study.
Giacomelli, F., & Wiener, J. (1979) · PubMed · Cited by 114 · see citing works
Physiological assessment of complex cardiac phenotypes in genetically engineered mice
Christensen, G., Wang, Y., & Chien, K. R. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.272.6.h2513 · Cited by 103 · see citing works
Analysis of organ physiology in transgenic mice
Rao, S. I., & Verkman, A. S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.1.c1 · Cited by 99 · see citing works
Lopaschuk, G. D., Katz, S., & McNeill, J. H. (1983) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y83-068 · Cited by 94 · see citing works
Apolipoprotein B Production Reduces Lipotoxic Cardiomyopathy
Yokoyama, M., Yagyu, H., Hu, Y., Seo, T., Hirata, K., Homma, S., & Goldberg, I. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311995200 · Cited by 94 · see citing works
Mouse isolated perfused heart: Characteristics and cautions
Sutherland, F., Shattock, M. J., Baker, K. E., & Hearse, D. J. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03925.x · Cited by 94 · see citing works
Carley, A. N., Semeniuk, L. M., Shimoni, Y., Aasum, E., Larsen, T. S., Berger, J. P., & Severson, D. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00329.2003 · Cited by 94 · see citing works
Self-citationDu, X. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00187-5 · Cited by 93 · see citing works
Jackson, C. V., McGrath, G. M., Tahiliani, A. G., Vadlamudi, R. V. S. V., & McNeill, J. H. (1985) · Diabetes · doi:10.2337/diab.34.9.876 · Cited by 93 · see citing works
Marfella, R., Di Filippo, C., Esposito, K., Nappo, F., Piegari, E., Cuzzocrea, S., Berrino, L., Rossi, F., Giugliano, D., & D’Amico, M. (2004) · Diabetes · doi:10.2337/diabetes.53.2.454 · Cited by 92 · see citing works
Yu, Z., Tibbits, G. F., & McNeill, J. H. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.5.h2082 · Cited by 88 · see citing works
Liu, G., Iden, J., Kovithavongs, K., Gulamhusein, R., Duff, H. J., & Kavanagh, K. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.054064 · Cited by 84 · see citing works
New Approaches to Phenotypic Analysis in Adult Mice
Hoit, B. D. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1294 · Cited by 82 · see citing works
Leiter, E. H. (2002) · Diabetologia · doi:10.1007/s00125-001-0743-z · Cited by 76 · see citing works
Suárez, J., Belke, D. D., Gloss, B. R., Dieterle, T., McDonough, P. M., Kim, Y., Brunton, L. L., & DILLMANN, W. H. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00245.2003 · Cited by 71 · see citing works
Khairallah, M., Labarthe, F., Bouchard, B., Danialou, G., Petrof, B. J., & Rosiers, C. D. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00942.2003 · Cited by 67 · see citing works
The isolated working mouse heart: methodological considerations
Larsen, T. S., Belke, D. D., Sas, R., Giles, W. R., Severson, D. L., Lopaschuk, G. D., & Tyberg, J. V. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050870 · Cited by 67 · see citing works
Self-citationAlterations in collagen cross-linking impair myocardial contractility in the mouse heart.
Capasso, J. M., Robinson, T. F., & Anversa, P. (1989) · Circulation Research · doi:10.1161/01.res.65.6.1657 · Cited by 65 · see citing works
Genetic engineering in mice: impact on insulin signalling and action
Lamothe, B., Baudry, A., Desbois, P., Lamotte, L., Bucchini, D., MEYTS, P. D., & Joshi, R. L. (1998) · Biochemical Journal · doi:10.1042/bj3350193 · Cited by 57 · see citing works
Cittadini, A., Mantzoros, C. S., Hampton, T. G., Travers, K. E., Katz, S. E., Morgan, J. P., Flier, J. S., & Douglas, P. S. (1999) · Circulation · doi:10.1161/01.cir.100.21.2177 · Cited by 57 · see citing works
p38 MAP kinase-mediated negative inotropic effect of HIV gp120 on cardiac myocytes
Kan, H. J., Xie, Z., & Finkel, M. S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00059.2003 · Cited by 56 · see citing works
Effect of experimental diabetes on isolated rat heart responsiveness to isoproterenol
Vadlamudi, R. V. S. V., & McNeill, J. H. (1984) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y84-020 · Cited by 55 · see citing works
Chylomicron and palmitate metabolism by perfused hearts from diabetic mice
Neitzel, A., Carley, A. N., & Severson, D. L. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2002 · Cited by 47 · see citing works
Self-citationRodrigues, B. B. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00045-x · Cited by 45 · see citing works
Naumova, A. V., Weiss, R. G., & Chacko, V. P. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00474.2003 · Cited by 37 · see citing works
Cardiovascular nuclear magnetic resonance: basic and clinical applications
Forder, J. R., & Pohost, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18868 · Cited by 32 · see citing works
An improved isolated, left ventricular ejecting, murine heart model
Windt, L. J. D., Willems, J., Reneman, R. S., Vusse, G. J., Arts, T. G. J., & van Bilsen, M. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050767 · Cited by 30 · see citing works
Effect of experimental diabetes on rat cardiac cAMP, phosphorylase, and inotropy
Vadlamudi, R. V. S. V., & McNeill, J. H. (1983) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1983.244.6.h844 · Cited by 29 · see citing works
Cardiovascular nuclear magnetic resonance: basic and clinical applications
Forder, J. R., & Pohost, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318868 · Cited by 25 · see citing works
Hoit, B. D., & Walsh, R. A. (1997) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(97)00003-0 · Cited by 21 · see citing works
Simoni, R., Hill, R. L., & Vaughan, M. M. (2002) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)35800-4 · Cited by 18 · see citing works
Saito, K., Nishi, S., 鹿島, 友., & Tanaka, H. (1984) · The American Journal of Cardiology · doi:10.1016/0002-9149(84)90446-6 · Cited by 18 · see citing works
Molecular genetic analysis of diabetes in mice
GANNON, M. A. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02453-2 · Cited by 18 · see citing works
Alpha 1-adrenoceptor-mediated phosphoinositide breakdown and inotropic responses in diabetic hearts
Xiang, H., & McNeill, J. H. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.260.2.h557 · Cited by 18 · see citing works
Wenzel, S., Soltanpour, G., & Schlüter, K. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1476-5 · Cited by 12 · see citing works
Protocols for Hemodynamic Assessment of Transgenic Mice In Vivo
Georgakopoulos, D., & Kass, D. A. (2003) · Humana Press eBooks · doi:10.1385/1-59259-350-x:233 · Cited by 11 · see citing works
Diabetes and Cardiac Dysfunction
Severson, D. L., Aasum, E., Belke, D. D., Larsen, T. S., Semeniuk, L., & Shimoni, Y. (2003) · Progress in experimental cardiology · doi:10.1007/978-1-4419-9232-1_29 · Cited by 7 · see citing works
Self-citationSutherland, F., Baker, K. E., Shattock, M. J., & Hearse, D. J. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03926.x · Cited by 6 · see citing works
Mechanisms in the pathogenesis of diabetic cardiomyopathy
Jain, M., Liao, R., Miller, T. A., LeBrasseur, N. K., & Sawyer, D. B. (2003) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200308000-00004 · Cited by 5 · see citing works
Hei, Y.-J., Diamond, J., & McNeill, J. H. (1992) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(92)90242-c · Cited by 5 · see citing works
Regulation of Cardiac Function in Diabetes
Netticadan, T., Rastogi, S., Chohan, P. K., Goyal, R. K., & Dhalla, N. S. (2003) · Progress in experimental cardiology · doi:10.1007/978-1-4419-9232-1_28 · Cited by 3 · see citing works
Tappia, P. S., Mengi, S. A., & Dhalla, N. S. (2003) · Progress in experimental cardiology · doi:10.1007/978-1-4419-9232-1_27 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works
Diabetic Cardiomyopathy Revisited
Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543 · see citing works
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Mitochondrial Energetics in the Heart in Obesity-Related Diabetes
Boudina, S., Sena, S., Theobald, H., Sheng, X., Wright, J. J., Hu, X. X., Aziz, S., Johnson, J. I., Bugger, H., Zaha, V. G., et al. (2007) · Diabetes · doi:10.2337/db07-0481 · Cited by 586 · see citing works
Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
An, D., & Rodrigues, B. B. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00278.2006 · Cited by 443 · see citing works
Anderson, E. J., Kypson, A. P., Rodriguez, E., Anderson, C. A., Lehr, E. J., & Neufer, P. D. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.031 · Cited by 440 · see citing works
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy
Knapp, M., Tu, X., & Wu, R. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0042-6 · Cited by 329 · see citing works
Rodent models of diabetic cardiomyopathy
Bugger, H., & Abel, E. D. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001941 · Cited by 284 · see citing works
Diagnostic approaches for diabetic cardiomyopathy
Lorenzo-Almorós, A., Tuñón, J., Orejas, M., Cortés, M., Egido, J., & Lorenzo, Ó. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0506-x · Cited by 262 · see citing works
Fatty acid metabolism is enhanced in type 2 diabetic hearts
Carley, A. N., & Severson, D. L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.03.005 · Cited by 232 · see citing works
Self-citationMa, S., Feng, J. H., Zhang, R., Chen, J., Han, D. H., Li, X., Yang, B. Y., Li, X., Fan, M., Li, C., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4602715 · Cited by 202 · see citing works
Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding
Wright, J. J., Kim, J., Buchanan, J., Boudina, S., Sena, S., Bakirtzi, K., Ilkun, O. L., Theobald, H. A., Cooksey, R. C., Kandror, K. V., et al. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp017 · Cited by 174 · see citing works
Hollander, J. M., Thapa, D., & Shepherd, D. L. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00747.2013 · Cited by 171 · see citing works
Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations
Dabkowski, E. R., Williamson, C. L., Bukowski, V. C., Chapman, R. S., Leonard, S. S., Peer, C. J., Callery, P. S., & Hollander, J. M. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00467.2008 · Cited by 161 · see citing works
Taking Diabetes to Heart—Deregulation of Myocardial Lipid Metabolism in Diabetic Cardiomyopathy
Bayeva, M., Sawicki, K. T., & Ardehali, H. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000433 · Cited by 156 · see citing works
The Role of ERK1/2 in the Development of Diabetic Cardiomyopathy
Xu, Z., Sun, J., Tong, Q., Lin, Q., Qian, L.-B., Park, Y., & Zheng, Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122001 · Cited by 129 · see citing works
Lebeche, D., Davidoff, A. J., & Hajjar, R. J. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1347 · Cited by 122 · see citing works
An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart
Fang, X., Palanivel, R., Cresser, J., Schram, K., Ganguly, R., Thong, F. S. L., Tuinei, J., Xu, A., Abel, E. D., & Sweeney, G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00086.2010 · Cited by 117 · see citing works
Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes
Steinbusch, L. K. M., Schwenk, R. W., Ouwens, D. M., Diamant, M., Glatz, J. F. C., & Luiken, J. J. F. P. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0690-x · Cited by 95 · see citing works
Pulinilkunnil, T., Kienesberger, P. C., Nagendran, J., Waller, T. J., Young, M. E., Kershaw, E. E., Korbutt, G. S., Haemmerle, G., Zechner, R., & Dyck, J. R. B. (2013) · Diabetes · doi:10.2337/db12-0927 · Cited by 93 · see citing works
Alterations in energy metabolism in cardiomyopathies
Taha, M., & Lopaschuk, G. D. (2007) · Annals of Medicine · doi:10.1080/07853890701618305 · Cited by 91 · see citing works
Cardiac lipoprotein lipase: Metabolic basis for diabetic heart disease
Pulinilkunnil, T., & Rodrigues, B. B. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.09.017 · Cited by 92 · see citing works
Oxidative Stress as a Mechanism of Added Sugar-Induced Cardiovascular Disease
Dhar, I., & Prasad, K. (2014) · International Journal of Angiology · doi:10.1055/s-0034-1387169 · Cited by 90 · see citing works
Gong, D.-J., Wang, L., Yang, Y., Zhang, J., & Liu, X. (2019) · Renal Failure · doi:10.1080/0886022x.2019.1643737 · Cited by 83 · see citing works
Fatty Acids and Insulin Modulate Myocardial Substrate Metabolism in Humans With Type 1 Diabetes
Peterson, L. R., Herrero, P., McGill, J. B., Schechtman, K. B., Kisrieva-Ware, Z., Lesniak, D., & Gropler, R. J. (2007) · Diabetes · doi:10.2337/db07-1199 · Cited by 79 · see citing works
Diabetic Cardiomyopathy: An Immunometabolic Perspective
Mishra, P. K., Ying, W., Nandi, S. S., Bandyopadhyay, G. K., Patel, K. P., & Mahata, S. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00072 · Cited by 73 · see citing works
Diabetic Cardiomyopathy: Impact of Biological Sex on Disease Development and Molecular Signatures
Toedebusch, R. G., Belenchia, A. M., & Pulakat, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00453 · Cited by 62 · see citing works
Paula-Gomes, S., Gonçalves, D. A. P., Baviera, A. M., Zanon, N., Navegantes, L. C. C., & Kettelhut, Í. D. C. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1347209 · Cited by 58 · see citing works
Steinbusch, L. K. M., Luiken, J. J. F. P., Vlasblom, R., Chabowski, A., Hoebers, N., Coumans, W. A., Vroegrijk, I. O. C. M., Voshol, P. J., Ouwens, D. M., Glatz, J. F. C., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00106.2011 · Cited by 57 · see citing works
Zhang, Y., Yuan, D., Yao, W., Zhu, Q., Liu, Y., Huang, F., Feng, J., Chen, X., Huang, Y., Chi, X., et al. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3919627 · Cited by 55 · see citing works
Aziz, M. T. A., El-Ibrashy, I. N., Mikhailidis, D. P., Rezq, A. M., Wassef, M. A. A., Fouad, H. H., Ahmed, H. H., Sabry, D., Shawky, H. M., & Hussein, R. E. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-13 · Cited by 54 · see citing works
The cardio-protective signaling and mechanisms of adiponectin.
Nanayakkara, G., Kariharan, T., Wang, L., Zhong, J., & Amin, R. (2012) · PubMed Central · Cited by 51 · see citing works
Oakes, N. D., Thalén, P., Aasum, E., Edgley, A. J., Larsen, T. S., Furler, S. M., Ljung, B., & Severson, D. L. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00233.2005 · Cited by 51 · see citing works
Self-citationEvidence for a Causal Role of Oxidative Stress in the Myocardial Complications of Insulin Resistance
Ritchie, R. H. (2009) · Heart Lung and Circulation · doi:10.1016/j.hlc.2008.11.003 · Cited by 49 · see citing works
Loganathan, R., Bilgen, M., Al‐Hafez, B., Zhero, S. V., Alenezy, M. D., & Smirnova, I. V. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00521.2006 · Cited by 48 · see citing works
Li, H., Xu, C.-Q., Li, Q.-F., Gao, X.-X., Sugano, E., Tomita, H., Yang, L.-M., & Shi, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091958 · Cited by 40 · see citing works
Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases
Andreadou, I., Efentakis, P., Frenis, K., Daiber, A., & Schulz, R. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00885-5 · Cited by 46 · see citing works
Lipoprotein lipase mediated fatty acid delivery and its impact in diabetic cardiomyopathy
Kim, M. S., Wang, Y., & Rodrigues, B. B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.001 · Cited by 46 · see citing works
Loganathan, R., Bilgen, M., Al‐Hafez, B., Alenezy, M. D., & Smirnova, I. V. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-7 · Cited by 45 · see citing works
Evaluation of the cardiolipin biosynthetic pathway and its interactions in the diabetic heart
Croston, T. L., Shepherd, D. L., Thapa, D., Nichols, C. E., Lewis, S. E., Dabkowski, E. R., Jagannathan, R., Baseler, W. A., & Hollander, J. M. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.07.005 · Cited by 45 · see citing works
Hu, J., Klein, J., Du, J., & Wang, X.-N. H. (2008) · Endocrinology · doi:10.1210/en.2008-0132 · Cited by 51 · see citing works
Ichikawa, R., Daimon, M., Miyazaki, T., Kawata, T., Miyazaki, S., Maruyama, M., Chiang, S.-J., Suzuki, H., Ito, C., Sato, F., et al. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-38 · Cited by 42 · see citing works
Lipoprotein Lipase and Its Delivery of Fatty Acids to the Heart
Shang, R., & Rodrigues, B. B. (2021) · Biomolecules · doi:10.3390/biom11071016 · Cited by 38 · see citing works
Belke, D. D., & Severson, D. L. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-068-7_4 · Cited by 38 · see citing works
Self-citationSharma, V. K., Mustafa, S., Patel, N., Wambolt, R. B., Allard, M. F., & McNeill, J. H. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.037 · Cited by 38 · see citing works
Proteasome biology and therapeutics in cardiac diseases
Shukla, S. K., & Rafiq, K. (2018) · Translational research · doi:10.1016/j.trsl.2018.09.003 · Cited by 38 · see citing works
Mouse Models for Studies of Cardiovascular Complications of Type 1 Diabetes
Shen, X., & Bornfeldt, K. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1394.004 · Cited by 37 · see citing works
Sato, S., Suzuki, J., Hirose, M., Yamada, M., Zenimaru, Y., Nakaya, T., Ichikawa, M., Imagawa, M., Takahashi, S., Ikuyama, S., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00227.2019 · Cited by 36 · see citing works
Diabetic cardiomyopathy: Where are we 40 years later?
Sharma, V. S., McNeill, J. H., & Verma, S. (2006) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(06)70914-x · Cited by 36 · see citing works
Wang, X., West, J. A., Murray, A. J., & Griffin, J. L. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00128 · Cited by 33 · see citing works
Shearer, J., Ross, K. D., Hughey, C. C., Johnsen, V. L., Hittel, D. S., & Severson, D. L. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00525.2010 · Cited by 32 · see citing works
Self-citationTao, S., Yang, D., Zhang, L., Yu, L., Wang, Z., Li, L., Zhang, J., Yao, R., Huang, L. S., & Shao, M. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.891428 · Cited by 30 · see citing works
Ceylan‐Isik, A. F., LaCour, K. H., & Ren, J. T. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04331.x · Cited by 30 · see citing works
Bigford, G. E., Bracchi-Ricard, V. C., Keane, R. W., Nash, M. S., & Bethea, J. R. (2013) · ASN NEURO · doi:10.1042/an20130021 · Cited by 29 · see citing works
Ceylan‐Isik, A. F., LaCour, K. H., & Ren, J. T. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01273.2005 · Cited by 28 · see citing works
Shimoni, Y., Chen, K., Emmett, T., & Kargacin, G. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.114 · Cited by 27 · see citing works
Kanda, S., Nakashima, R., Takahashi, K., Tanaka, J., Ogawa, J., Ogata, T., Yachi, M., Araki, K., & Ohsumi, J. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.09084fp · Cited by 27 · see citing works
Ding, H., Howarth, A. G., Pannirselvam, M., Anderson, T. J., Severson, D. L., Wiehler, W. B., Triggle, C. R., & Tuana, B. S. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00037.2005 · Cited by 26 · see citing works
Self-citationKorkmaz‐Icöz, S., Lehner, A., Li, S., Vater, A., Radovits, T., Brune, M., Ruppert, M., Sun, X., Brlecic, P., Zorn, M., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00956.2015 · Cited by 26 · see citing works
Herrero, P., McGill, J. B., Lesniak, D., Dence, C. S., Scott, S. W., Kisrieva-Ware, Z., & Gropler, R. J. (2008) · Journal of Nuclear Cardiology · doi:10.1007/bf03007360 · Cited by 26 · see citing works
Hybrid docking-QSAR studies of DPP-IV inhibition activities of a series of aminomethyl-piperidones
Amini, Z., Fatemi, M. H., & Gharaghani, S. (2016) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2016.08.003 · Cited by 24 · see citing works
Korkmaz‐Icöz, S., Lehner, A., Li, S., Vater, A., Radovits, T., Hegedűs, P., Ruppert, M., Brlecic, P., Zorn, M., Karck, M., et al. (2015) · Journal of Diabetes Research · doi:10.1155/2015/396414 · Cited by 22 · see citing works
Sharma, V. S., Sharma, A., Saran, V., Bernatchez, P. N., Allard, M. F., & McNeill, J. H. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.01.044 · Cited by 22 · see citing works
Heinonen, S. E., Merentie, M., Hedman, M., Mäkinen, P. I., Loponen, E., Kholová, I., Bosch, F., Laakso, M., & Ylä‐Herttuala, S. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-59 · Cited by 21 · see citing works
Cioffi, G., Faggiano, P. M., Lucci, D., Lenarda, A. D., Mureddu, G. F., Tarantini, L., Verdecchia, P., Comaschi, M., Giorda, C. B., Velussi, M., et al. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834acc6d · Cited by 19 · see citing works
Shearer, J., Fueger, P. T., Wang, Z., Bracy, D. P., Wasserman, D. H., & Rottman, J. N. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.07.003 · Cited by 18 · see citing works
Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy
Kain, V., & Halade, G. V. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00031 · Cited by 18 · see citing works
Chen, X., Li, Y., Yuan, X., Yuan, W., Li, C., Zeng, Y., Lian, Y., Qiu, X., Qin, Y. H., Zhang, G., et al. (2022) · Diabetes · doi:10.2337/db21-0506 · Cited by 17 · see citing works
Wen, S., Velmurugan, B. K., Day, C. H., Shen, C.-Y., Chun, L.-C., Tsai, Y., Lin, Y., Chen, R., Kuo, C., & Huang, C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26007 · Cited by 16 · see citing works
Wölkart, G., Stessel, H., Saad, Z., Kirchengast, M., & Brünner, F. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706772 · Cited by 16 · see citing works
Is there a link between glucose levels and heart failure? An update
Schainberg, A., Ribeiro‐Oliveira, A., & Ribeiro, J. M. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000500010 · Cited by 14 · see citing works
El‐Sayyad, H. I., Al-Haggar, M. S., El-Ghawet, H. A., & Bakr, I. H. (2012) · Nutrition · doi:10.1016/j.nut.2011.12.013 · Cited by 12 · see citing works
Wenzel, S., Soltanpour, G., & Schlüter, K. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1476-5 · Cited by 12 · see citing works
Myocardial metabolism of triacylglycerol‐rich lipoproteins in type 2 diabetes
Niu, Y., & Evans, R. D. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173542 · Cited by 11 · see citing works
Granieri, M. C., Rocca, C., Bartolo, A. D., Nettore, I. C., Rago, V., Romeo, N., Ceramella, J., Mariconda, A., Macchia, P. E., Ungaro, P., et al. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043492 · Cited by 10 · see citing works
Chen, X., & Ding, H. (2011) · Experimental Diabetes Research · doi:10.1155/2011/421982 · Cited by 10 · see citing works
Niu, Y.-G., & Evans, R. D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90260.2008 · Cited by 10 · see citing works
Saran, V., Sharma, V. S., Wambolt, R. B., Yuen, V. G., Allard, M. F., & McNeill, J. H. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0078 · Cited by 9 · see citing works
Shushakova, N., Park, J. K., Menne, J., & Fliser, D. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02165.x · Cited by 9 · see citing works
Ma, P., Yao, L., Lin, X., Gu, T., Rong, X., Batey, R. G., Yamahara, J., Wang, J., & Li, Y. (2016) · PubMed Central · Cited by 8 · see citing works
Kang, S., Majid, A., Hammoudi, N., & Lebeche, D. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118617 · Cited by 7 · see citing works
Targeting the ubiquitin proteasome system in diabetic cardiomyopathy
Bozi, L. H. M., & Campos, J. C. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.06.009 · Cited by 7 · see citing works
Das, P. N., Kumar, A., Bairagi, N., & Chatterjee, S. (2017) · Molecular BioSystems · doi:10.1039/c7mb00264e · Cited by 7 · see citing works
Studying the role of random translocation of GLUT4 in cardiomyocytes on calcium oscillations
Halder, S., Das, P. N., Ghosh, S., Bairagi, N., & Chatterjee, S. (2023) · Applied Mathematical Modelling · doi:10.1016/j.apm.2023.10.006 · Cited by 4 · see citing works
Kara, L., Abbou, A., Grari, R., Regagba, D., & Benmansour, M. (2018) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2018.07.198 · Cited by 4 · see citing works
Apoptotic cell death in heart failure associated with diabetes
Bhuvaneshwari, P., & Riswana, N. (2019) · International Journal of Clinicopathological Correlation · doi:10.4103/ijcpc.ijcpc_1_19 · Cited by 4 · see citing works
Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset
Lee, C. S., Zhai, Y., & Rodrigues, B. B. (2022) · Engineering · doi:10.1016/j.eng.2022.06.013 · Cited by 3 · see citing works
Gropler, R. J., & Malloy, C. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-61401-4_11 · Cited by 3 · see citing works
Diet-induced insulin resistance altered cardiac GLUT4 and FATP/CD36 expression in rats
Afolabi, O. A., Alabi, B. A., & Oluranti, O. I. (2022) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-022-00312-1 · Cited by 3 · see citing works
Systolic Dysfunction of the Heart in Type 1 Diabetes Mellitus
Lakomkin, V. L., Abramov, A. A., Lukoshkova, E. V., Просвирнин, А. В., & Kapelko, V. I. (2021) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-021-05321-1 · Cited by 3 · see citing works
Non-antigen processing immunoproteasomes in diabetic hearts?
Dewey, S., & Gomes, A. V. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.03.024 · Cited by 2 · see citing works
Sun, J., Xu, J., Liu, Y., Xu, X., Zhang, S., Hao, Y., Lin, Y., Han, Y., Li, F., & Yuan, H. S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1022861 · Cited by 2 · see citing works
Diabetes-Associated Cardiomyopathy and Cell Therapy
Hochhauser, E., Morozov, M., & Arad, M. (2013) · CRC Press eBooks · doi:10.1201/b14663-16 · Cited by 1 · see citing works
CALPASTATIN OVER-EXPRESSION REDUCES CARDIAC FIBROSIS IN A MURINE MODEL OF TYPE 2 DIABETES
Singh, M. K. (2011) · Scholarship@Western (Western University) · Cited by 1 · see citing works
New Insights on Cardiomyopathy [Working Title]
Said, S. M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100931 · Cited by 1 · see citing works
Cardiac Dysfunction and Metabolism: Unravelling the Molecular Cross-Talk
Sharma, V. S., & McNeill, J. H. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7130-2_9 · Cited by 1 · see citing works
Dynamic O-GlcNAcylation of Nucleocytoplasmic Proteins
Hart, G. W., & Sakabe, K. (2007) · Elsevier eBooks · doi:10.1016/b978-044451967-2/00088-x · Cited by 1 · see citing works
CD36: a target to restore cardiac function in type 2 diabetes
Steinbusch, L. K. M. (2011) · doi:10.26481/dis.20111013ls
The Diabetic Heart: Examination of the Inner Mitochondrial Membrane
Croston, T. L. (2013) · doi:10.33915/etd.4958
- Authors
- Severson, D. L.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Severson, David L
- Venue
- Canadian Journal of Physiology and Pharmacology
- Publisher
- Canadian Science Publishing
- Published
- 2004-10-01
- Volume
- 82
- Issue
- 10
- Pages
- 813-823
- ISSN
- 0008-4212 (ISSN-L)
- 1205-7541
- OpenAlex
- W2107447005
- Cited by
- 111
- References
- 107
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 7 · 2021: 3 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 11 · 2012: 4
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Physiology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- diabetic cardiomyopathy, type 1 diabetes, type 2 diabetes, mouse model, ventricular dysfunction, systolic dysfunction, diastolic dysfunction, myocardial ischemic injury, myocardial metabolism, glucose utilization, fatty acid utilization, genetically modified mice
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Disease Models, Animal, Humans, Cardiomyopathies, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review