Cited by 111Cardiovascular Function and Risk FactorsCardiac Fibrosis and RemodelingCardiomyopathy and Myosin Studies

Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes

Severson, David L·2004·Canadian Journal of Physiology and Pharmacology

Abstract

Diabetic cardiomyopathy is defined as ventricular dysfunction of the diabetic heart in the absence of coronary artery disease. With the use of both in vivo and ex vivo techniques to assess cardiac phenotype, reduced contractile performance can be observed in experiments with mouse models of both type 1 (insulin-deficient) and type 2 (insulin-resistant) diabetes. Both systolic dysfunction (reduced left ventricular pressures and decreased cardiac output) and diastolic dysfunction (impaired relaxation) is observed in diabetic hearts, along with enhanced susceptibility to ischemic injury. Metabolism is also altered in diabetic mouse hearts: glucose utilization is reduced and fatty acid utilization is increased. The use of geneticallyengineered mice has provided a powerful experimental approach to test mechanisms that may be responsible for the deleterious effects of diabetes on cardiac function.Key words: cardiac function, cardiac metabolism, cardiac phenotype.

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Registry

Crossref · 10.1139/y04-065

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108 of 108 references verified0 citation errors · 0 not checkable

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  • Diabetes is associated with shifts in myocardial substrate utilization characterized by an increase in FA utilization and a decrease in glucose utilization.

    “It has long been known that diabetes is associated with shifts in myocardial substrate utilization characterized by an increase in FA utilization and a decrease in glucose utilization (37, 315).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [315]

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Authors
Severson, D. L.
Affiliations
University of Calgary (CA)
Corresponding author
Severson, David L
Venue
Canadian Journal of Physiology and Pharmacology
Published
2004-10-01
Volume
82
Issue
10
Pages
813-823
ISSN
  • 0008-4212 (ISSN-L)
  • 1205-7541
OpenAlex
W2107447005
Cited by
111
References
107
Citations by year
2025: 1 · 2023: 2 · 2022: 7 · 2021: 3 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 11 · 2012: 4
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Locations
  • Canadian Journal of Physiology and Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords
diabetic cardiomyopathy, type 1 diabetes, type 2 diabetes, mouse model, ventricular dysfunction, systolic dysfunction, diastolic dysfunction, myocardial ischemic injury, myocardial metabolism, glucose utilization, fatty acid utilization, genetically modified mice
MeSH terms
Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Disease Models, Animal, Humans, Cardiomyopathies, Mice

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