Berberine on the prevention and management of cardiometabolic disease: clinical applications and mechanisms of action

Prevalence of Diagnosed Atrial Fibrillation in Adults: National Implications for Rhythm Management and Stroke Prevention: the AnTicoagulation and Risk Factors In Atrial Fibrillation (ATRIA) Study

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Global Public Health Burden of Heart Failure

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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

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Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

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AMPK: a key regulator of energy balance in the single cell and the whole organism

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Role of gut microbiota in atherosclerosis

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Biological properties and clinical applications of berberine

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Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension

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Berberine activates thermogenesis in white and brown adipose tissue

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Position paper Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

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Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats

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Research progress on berberine with a special focus on its oral bioavailability

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Transforming berberine into its intestine-absorbable form by the gut microbiota

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The Role of Nutraceuticals in Statin Intolerant Patients

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Berberine: Therapeutic Potential of an Alkaloid Found in Several Medicinal Plants

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The consequences of disrupting cardiac inwardly rectifying K+ current (IK1) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes

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Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe−/− mice

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Berberine decreases PCSK9 expression in HepG2 cells

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The involvement of P-glycoprotein in berberine absorption

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Nano strategies for berberine delivery, a natural alkaloid of Berberis

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Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE−/− Mice

Wu, M., Yang, S., Wang, S., Cao, Y., Zhao, R., Li, X., Xing, Y., & Liu, L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00223 · Cited by 201 · see citing works

Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

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Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition

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Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats

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Inhibition of PCSK9 Transcription by Berberine Involves Down-regulation of Hepatic HNF1α Protein Expression through the Ubiquitin-Proteasome Degradation Pathway

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Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction

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Berberine as a potential autophagy modulator

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Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2

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Cardiovascular effects of berberine in patients with severe congestive heart failure

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Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

Wu, Y., Zhang, L., Wu, Z., Shan, T.-T., & Xiong, C. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2150394 · Cited by 121 · see citing works

Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy

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Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

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Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds

Li, M., Shu, X., Xu, H., Zhang, C., Yang, L., Zhang, L. R., & Ji, G. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0987-5 · Cited by 114 · see citing works

Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans

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Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure

Abudureyimu, M., Yu, W., Cao, R. Y., Zhang, Y., Liu, H., & Zheng, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.565751 · Cited by 108 · see citing works

Displacement of Bilirubin from Albumin by Berberine

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Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention

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Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine

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A nutraceutical approach (Armolipid Plus) to reduce total and LDL cholesterol in individuals with mild to moderate dyslipidemia: Review of the clinical evidence

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Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling

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Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats

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Introduction to the metabolic syndrome

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Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation

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Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC

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Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1–Smad signalling

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Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway

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Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate

Zhang, Y., Cui, Y., Gao, L., & Jiang, H.-L. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.04.074 · Cited by 83 · see citing works

Berberine treatment prevents cardiac dysfunction and remodeling through activation of 5′-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cells

Chang, W., Zhang, M., Meng, Z., Yu, Y., Fan, Y., Hatch, G. M., & Chen, L. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.043 · Cited by 79 · see citing works

Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux

Hang, W., He, B., Chen, J., Xia, L., Wen, B., Liang, T., Wang, X., Zhang, Q., Wu, Y., Chen, Q., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01121 · Cited by 76 · see citing works

Target acquired: Selective autophagy in cardiometabolic disease

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8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models

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Antifibrotic cardioprotection of berberine via downregulating myocardial IGF-1 receptor-regulated MMP-2/MMP-9 expression in diabetic rats

Li, G., Xing, W., Zhang, M., Geng, F., Yang, H., Zhang, H., Zhang, X., Li, J., Dong, L., & Gao, F. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00093.2018 · Cited by 70 · see citing works

Herbal medicine for epilepsy seizures in Asia, Africa and Latin America: A systematic review

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Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4

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Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

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Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice

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Berberine Pretreatment Confers Cardioprotection Against Ischemia–Reperfusion Injury in a Rat Model of Type 2 Diabetes

Chang, W., Li, K., Guan, F., Yao, F., Yu, Y., Zhang, M., Hatch, G. M., & Chen, L. (2016) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248415627873 · Cited by 66 · see citing works

Non-coding RNAs and Berberine: A new mechanism of its anti-diabetic activities

Chang, W. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.055 · Cited by 66 · see citing works

Berberine mitigates high glucose-potentiated platelet aggregation and apoptosis by modulating aldose reductase and NADPH oxidase activity

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Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats

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Renoprotective effects of berberine as adjuvant therapy for hypertensive patients with type 2 diabetes mellitus: Evaluation via biochemical markers and color Doppler ultrasonography

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The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1

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Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein efflux

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Effects of berberine on glucose-lipid metabolism, inflammatory factors and insulin resistance in patients with metabolic syndrome

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Berberine elicits anti‐arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model

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Improving drug safety: From adverse drug reaction knowledge discovery to clinical implementation

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Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors to Reduce Cardiovascular Inflammation and Outcomes

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Efficacy and safety of berberine alone or combined with statins for the treatment of hyperlipidemia: A systematic review and meta-analysis of randomized controlled clinical trials

Zhang, L.-S., Zhang, J.-H., Feng, R., Jin, X.-Y., Yang, F.-W., Ji, Z.-C., Zhao, M.-Y., Zhang, M.-Y., Zhang, B.-L., & Li, X.-M. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500393 · Cited by 50 · see citing works

Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols, and Berberine) in Patients with Low-Moderate Risk Hypercholesterolemia: A Double-Blind, Placebo-Controlled Study

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Anticipating drug side effects by comparative pharmacology

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Berberine activates peroxisome proliferator‐activated receptor gamma to increase atherosclerotic plaque stability in Apoe−/− mice with hyperhomocysteinemia

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The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins

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The enhancement of cardiac toxicity by concomitant administration of berberine and macrolides

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Incidence Rate of Adverse Drug Reactions During Long-Term Follow-Up of Patients Newly Treated with Amiodarone

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Berberine reduced blood pressure and improved vasodilation in diabetic rats

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Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu

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P66Shc-SIRT1 Regulation of Oxidative Stress Protects Against Cardio-cerebral Vascular Disease

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Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation

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Myocardial hypertrophy is improved with berberine treatment via long non-coding RNA MIAT-mediated autophagy

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Inhibitory effects of berberine on ATP-sensitive K+ channels in cardiac myocytes

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CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity

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Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats

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Increased Bioavailable Berberine Protects Against Myocardial Ischemia Reperfusion Injury Through Attenuation of NFκB and JNK Signaling Pathways

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Berberine induces hERG channel deficiency through trafficking inhibition

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Effect of berberine on acetylcholine-induced atrial fibrillation in rabbit.

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