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Pentatricopeptide Repeat Proteins in Plants
Open accessAbstract
Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants, with more than 400 members in most species. Over the past decade, much has been learned about the molecular functions of these proteins, where they act in the cell, and what physiological roles they play during plant growth and development. A typical PPR protein is targeted to mitochondria or chloroplasts, binds one or several organellar transcripts, and influences their expression by altering RNA sequence, turnover, processing, or translation. Their combined action has profound effects on organelle biogenesis and function and, consequently, on photosynthesis, respiration, plant development, and environmental responses. Recent breakthroughs in understanding how PPR proteins recognize RNA sequences through modular base-specific contacts will help match proteins to potential binding sites and provide a pathway toward designing synthetic RNA-binding proteins aimed at desired targets.
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Citations
Cited by
Organization and regulation of mitochondrial protein synthesis
Ott, M., Amunts, A., & Brown, A. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014334 · Cited by 282
Colas des Francs-Small, C., Falcon de Longevialle, A., Li, Y., Lowe, E., Tanz, S. K., Smith, C., Bevan, M. W., & Small, I. (2014) · PLANT PHYSIOLOGY · doi:10.1104/pp.114.244616 · Cited by 81
Self-citationQiu, T., Zhao, X., Feng, H., Qi, L., Yang, J., Peng, Y., & Zhao, W. (2021) · Plant Biotechnology Journal · doi:10.1111/pbi.13659 · Cited by 82
Lee, K., Han, J. H., Park, Y., Colas des Francs‐Small, C., Small, I., & Kang, H. (2017) · New Phytologist · doi:10.1111/nph.14528 · Cited by 72
Self-citationEvidence of Natural Selection Acting on a Polymorphic Hybrid Incompatibility Locus in Mimulus
Sweigart, A. L., & Flagel, L. E. (2015) · Genetics · doi:10.1534/genetics.114.171819 · Cited by 35
Wang, Y., Yan, J., Zhang, Q., Ma, X., Zhang, J., Su, M., Wang, X., & Huang, Y. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx127 · Cited by 34
Seshadri, S. R., Banarjee, C., Barros, M. H., & Fontanesi, F. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa424 · Cited by 30
“PPR motifs are degenerate 35 amino acid repeats, which mediate RNA-binding; although in a small number of cases, they have also been shown to bind to DNA or proteins (41).”
BackgroundHillen, H. S., Markov, D. A., Wojtas, I. D., Hofmann, K. B., Lidschreiber, M., Cowan, A. T., Jones, J. L., Temiakov, D., Cramer, P., & Anikin, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009329118 · Cited by 21
Huynh, S. D., Melonek, J., Colas des Francs‐Small, C., Bond, C. S., & Small, I. (2023) · New Phytologist · doi:10.1111/nph.19166 · Cited by 17
Self-citationNguyen, T.-T., Best, C., Shevtsov, S., Zmudjak, M., Quadrado, M., Mizrahi, R., Zer, H., Mireau, H., & Ostersetzer-Biran, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052670 · Cited by 11
Schizosaccharomyces pombe Ppr10 is required for mitochondrial translation
Liu, Z., Li, Y., Xie, W., & Huang, Y. (2020) · FEMS Microbiology Letters · doi:10.1093/femsle/fnaa170 · Cited by 10
Schizosaccharomyces pombe Ppr10 and mpa1 together mediate mitochondrial translational initiation
Luo, Y., Wang, Y., & Huang, Y. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100869 · Cited by 10
Metadata
- Authors
- Barkan, A., & Small, I.
- Venue
- Annual Review of Plant Biology
- Publisher
- Annual Reviews
- Published
- 2014-04-29
- Volume
- 65
- Issue
- 1
- Pages
- 415-442
- ISSN
- 1543-5008 (ISSN-L)
- 1545-2123
- OpenAlex
- W2169861297
- Cited by
- 1,031
- References
- 0
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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