Cited by 1,472Heat shock proteins researchGenetics, Aging, and Longevity in Model OrganismsUbiquitin and proteasome pathways

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The Biology of Proteostasis in Aging and Disease

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Labbadia, Johnathan, Morimoto, Richard I·2015·Annual Review of Biochemistry

DOI 10.1146/annurev-biochem-060614-033955PMC PMC4539002

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Abstract

Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is characterized by the appearance of nonnative protein aggregates in various tissues. Protein aggregation is routinely suppressed by the proteostasis network (PN), a collection of macromolecular machines that operate in diverse ways to maintain proteome integrity across subcellular compartments and between tissues to ensure a healthy life span. Here, we review the composition, function, and organizational properties of the PN in the context of individual cells and entire organisms and discuss the mechanisms by which disruption of the PN, and related stress response pathways, contributes to the initiation and progression of disease. We explore emerging evidence that disease susceptibility arises from early changes in the composition and activity of the PN and propose that a more complete understanding of the temporal and spatial properties of the PN will enhance our ability to develop effective treatments for protein conformational diseases.

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Authors: Labbadia, J., & Morimoto, R. I.
Affiliations: Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208;
Northwestern University (US)
Corresponding author: Morimoto, Richard I
ORCID: Morimoto, Richard I
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2015-06-02
Volume: 84
Issue: 1
Pages: 435-464
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev-biochem-060614-033955
PMC: PMC4539002
OpenAlex: W2152231829
Cited by: 1,472
References: 182
Citations by year: 2026: 142 · 2025: 127 · 2024: 150 · 2023: 152 · 2022: 140 · 2021: 148 · 2020: 143 · 2019: 139 · 2018: 136 · 2017: 106 · 2016: 69 · 2015: 19
FWCI: 10.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Ellison Medical Foundation
National Institutes of Health (5p50mh094267-05)
National Institute on Aging (R37AG026647, R01AG026647)
National Institute of Mental Health (P50-MH094267)
National Institute of General Medical Sciences (P50GM081892, R01GM038109, R37GM038109)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: proteostasis, proteostasis network, aging, protein aggregation, stress response pathways, protein conformational diseases, disease susceptibility, lifespan
MeSH terms: Aging, Animals, Humans, Proteins, Neurodegenerative Diseases, Metabolic Networks and Pathways, Proteolysis, Endoplasmic Reticulum Stress

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