The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
microRNA: A Master Regulator of Cellular Processes for Bioengineering Systems
Abstract
microRNAs (miRNAs) are small RNAs 18 to 24 nucleotides in length that serve the pivotal function of regulating gene expression. Instead of being translated into proteins, the mature single-stranded miRNA binds to messenger RNAs (mRNAs) to interfere with the translational process. It is estimated that whereas only 1% of the genomic transcripts in mammalian cells encode miRNA, nearly one-third of the encoded genes are regulated by miRNA. Various bioinformatics databases, tools, and algorithms have been developed to predict the sequences of miRNAs and their target genes. In combination with the in silico approaches in systems biology, experimental studies on miRNA provide a new bioengineering approach for understanding the mechanism of fine-tuning gene regulation. This review aims to provide state-of-the-art information on this important mechanism of gene regulation for researchers working in biomedical engineering and related fields. Particular emphases are placed on summarizing the current tools and strategies for miRNA study from a bioengineering perspective and the possible applications of miRNAs (such as antagomirs and miRNA sponges) in biomedical engineering research.
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Cites
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Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Silencing of microRNAs in vivo with ‘antagomirs’
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Cited by
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Self-citationRyoo, S.-R., Lee, J., Yeo, J., Na, H.-K., Kim, Y.-K., Jang, H., Lee, J. H., Han, S. W., Lee, Y., Kim, V. N., et al. (2013) · ACS Nano · doi:10.1021/nn401183s · Cited by 309
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Self-citationEpigenetic regulation: A new frontier for biomedical engineers
Chen, Z., Li, S., Subramaniam, S., Shyy, J. Y.-J., & Chien, S. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044720 · Cited by 163
Self-citationMeyer, U. A., Zanger, U. M., & Schwab, M. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100502 · Cited by 157
Metadata
- Authors
- Sun, W., Julie Li, Y.-S., Huang, H.-D., Shyy, J. Y.-J., & Chien, S.
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2010-07-01
- Volume
- 12
- Issue
- 1
- Pages
- 1-27
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2166144761
- Cited by
- 236
- References
- 20
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
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