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Regulatory T Cells in Cancer
Open accessAbstract
The immune system has evolved complex effector mechanisms to protect the host against a diversity of pathogenic organisms and regulatory adaptations that can curtail pathological sequelae of inflammatory events, prevent autoimmunity, and assist in tissue repair. Cancers, by virtue of their local manifestations of tissue dysfunction and destruction, inflammation, and genomic instability, can evoke these protective mechanisms, which support the progression of tumors and prevent their immune eradication. Central to these processes is a subset of CD4+T cells, known as regulatory T (Treg) cells, that express the X chromosome–linked transcription factor FOXP3. In addition to their critical role in controlling autoimmunity and suppressing inflammatory responses in diverse biological settings, Treg cells are ubiquitously present in the tumor microenvironment where they promote tumor development and progression by dampening antitumor immune responses. Furthermore, Treg cells can directly support the survival of transformed cells through the elaboration of growth factors and interacting with accessory cells in tumors such as fibroblasts and endothelial cells. Current insights into the biology of tumor-associated Treg cells have opened up opportunities for their selective targeting in cancer, with the goal of alleviating their suppression of antitumor immune responses while maintaining overall immune homeostasis.
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“Regulatory T (Treg) cells maintain immune homeostasis and prevent autoimmunity.”
From Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer (2025) · cites this paper as [41]
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Metadata
- Authors
- Plitas, G., & Rudensky, A. Y.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Annual Review of Cancer Biology
- Publisher
- Annual Reviews
- Published
- 2020-03-09
- Volume
- 4
- Issue
- 1
- Pages
- 459-477
- ISSN
- 2472-3428 (ISSN-L)
- OpenAlex
- W3011819632
- Cited by
- 148
- References
- 153
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 29 · 2023: 21 · 2022: 27 · 2021: 23 · 2020: 7
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Annual Review of Cancer Biology (publishedVersion, cc-by)
- Funders
- Memorial Sloan-Kettering Cancer Center (CA008748, P30 CA008748, Support Grant P30 CA008748)
- National Institutes of Health (CA008748, AI034206)
- Ludwig Center at Harvard (P30 CA008748, AI034206)
- National Cancer Institute (P30CA008748)
- National Institute of Allergy and Infectious Diseases (R37AI034206)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- regulatory T cells, Foxp3, tumor microenvironment, tumor immunosuppression, CD4+ T cells, tumor progression, tumor-associated Treg cells, tumor-infiltrating lymphocytes, cancer-associated fibroblasts, tumor angiogenesis, immune homeostasis
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