Regulatory T Cells in Cancer

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

Robert, C., Thomas, L., Bondarenko, I., O'Day, S., Weber, J., Garbe, C., Lebbe, C., Baurain, J.-F., Testori, A., Grob, J.-J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1104621 · Cited by 4,496

How regulatory T cells work

Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463

N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses

Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,315

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

Iwai, Y., Ishida, M., Tanaka, Y., Okazaki, T., Honjo, T., & Minato, N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192461099 · Cited by 3,261

The Immunobiology of Cancer Immunosurveillance and Immunoediting

Dunn, G. P., Old, L. J., & Schreiber, R. D. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.017 · Cited by 3,192

CTLA-4 Control over Foxp3 + Regulatory T Cell Function

Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866

An essential role for Scurfin in CD4+CD25+ T regulatory cells

Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D. J., Usheva, A., Erat, A., Chen, J., Enjyoji, K., Linden, J. M., Oukka, M., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062512 · Cited by 2,613

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

Nagarsheth, N., Wicha, M. S., & Zou, W. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.49 · Cited by 2,251

Regulatory T cells, tumour immunity and immunotherapy

Zou, W. (2006) · Nature reviews. Immunology · doi:10.1038/nri1806 · Cited by 2,135

Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation

Anderson, A. C., Joller, N., & Kuchroo, V. K. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.001 · Cited by 2,096

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Azizi, E., Carr, A. J., Plitas, G., Cornish, A. E., Konopacki, C., Prabhakaran, S., Nainys, J., Wu, K., Kiseliovas, V., Setty, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.060 · Cited by 1,976

Inhibitory effect of tumor cell-derived lactic acid on human T cells

Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S., et al. (2007) · Blood · doi:10.1182/blood-2006-07-035972 · Cited by 1,946

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J., Buist, N. R. M., Levy‐Lahad, E., Mazzella, M., Goulet, O., Perroni, L., et al. (2001) · Nature Genetics · doi:10.1038/83707 · Cited by 1,916

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

Qureshi, O. S., Zheng, Y., Nakamura, K., Attridge, K., Manzotti, C., Schmidt, E. M., Baker, J., Jeffery, L. E., Kaur, S., Briggs, Z., et al. (2011) · Science · doi:10.1126/science.1202947 · Cited by 1,860

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

Kim, J. M., Rasmussen, J. P., & Rudensky, A. Y. (2006) · Nature Immunology · doi:10.1038/ni1428 · Cited by 1,827

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Fontenot, J. D., Rasmussen, J. P., Gavin, M. A., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1263 · Cited by 1,819

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Hui, E., Cheung, J., Zhu, J., Su, X., Taylor, M. J., Wallweber, H. A., Sasmal, D. K., Huang, J., Kim, J. M., Mellman, I., et al. (2017) · Science · doi:10.1126/science.aaf1292 · Cited by 1,689

The multifaceted roles of fatty acid synthesis in cancer

Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

Shimizu, J., Yamazaki, S., & Sakaguchi, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5211 · Cited by 1,491

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

Kalliolias, G. D., & Ivashkiv, L. B. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.169 · Cited by 1,453

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

Angelin, A., Gil‐de‐Gómez, L., Dahiya, S., Jiao, J., Guo, L., Levine, M. H., Wang, Z., Quinn, W. J., Kopinski, P. K., Wang, L., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.018 · Cited by 1,304

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

Pandiyan, P., Zheng, L., Ishihara, S., Reed, J., & Lenardo, M. J. (2007) · Nature Immunology · doi:10.1038/ni1536 · Cited by 1,277

Metabolic Instruction of Immunity

Buck, M. D., Sowell, R., Kaech, S. M., & Pearce, E. L. (2017) · Cell · doi:10.1016/j.cell.2017.04.004 · Cited by 1,270

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

Walker, M., Kasprowicz, D. J., Gersuk, V. H., Bénard, A., Landeghen, M. V., Buckner, J. H., & Ziegler, S. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19441 · Cited by 1,242

Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Setoguchi, R., Hori, S., Takahashi, T., & Sakaguchi, S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041982 · Cited by 1,234

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Zheng, Y., Josefowicz, S. Z., Chaudhry, A., Peng, X. P., Forbush, K. A., & Rudensky, A. Y. (2010) · Nature · doi:10.1038/nature08750 · Cited by 1,170

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

Cao, X., Cai, S. F., Fehniger, T. A., Song, J., Collins, L. I., Piwnica-Worms, D. R., & Ley, T. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.014 · Cited by 1,117

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

Munn, D. H., & Mellor, A. L. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.002 · Cited by 1,081

The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

Fallarino, F., Grohmann, U., You, S., McGrath, B. C., Cavener, D. R., Vacca, C., Orabona, C., Bianchi, R., Belladonna, M. L., Volpi, C., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6752 · Cited by 1,078

Systemic effects of local radiotherapy

Formenti, S. C., & Demaria, S. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70082-8 · Cited by 1,063

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

Grossman, W. J., Verbsky, J. W., Barchet, W., Colonna, M., Atkinson, J. P., & Ley, T. J. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.002 · Cited by 1,021

Mechanisms of suppression by suppressor T cells

von Boehmer, H. (2005) · Nature Immunology · doi:10.1038/ni1180 · Cited by 1,015

A Distinct Function of Regulatory T Cells in Tissue Protection

Arpaia, N., Green, J. A., Moltedo, B., Arvey, A., Hemmers, S., Yuan, S., Treuting, P. M., & Rudensky, A. Y. (2015) · Cell · doi:10.1016/j.cell.2015.08.021 · Cited by 991

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

Peggs, K. S., Quezada, S. A., Chambers, C. A., Korman, A. J., & Allison, J. P. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082492 · Cited by 967

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

Chatila, T. A., Blaeser, F., Ho, N. Y., Lederman, H. M., Voulgaropoulos, C., Helms, C., & Bowcock, A. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11679 · Cited by 937

An essential role for the IL-2 receptor in Treg cell function

Chinen, T., Kannan, A., Levine, A. G., Fan, X., Klein, U., Zheng, Y., Gasteiger, G., Feng, Y., Fontenot, J. D., & Rudensky, A. Y. (2016) · Nature Immunology · doi:10.1038/ni.3540 · Cited by 934

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

Formenti, S. C., Rudqvist, N.-P., Golden, E., Cooper, B., Wennerberg, E., Lhuillier, C., Vanpouille-Box, C., Friedman, K., Ferrari de Andrade, L., Wucherpfennig, K. W., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0232-2 · Cited by 928

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

Berod, L., Friedrich, C., Nandan, A., Freitag, J., Hagemann, S., Harmrolfs, K., Sandouk, A., Hesse, C., Castro, C. N., Bähre, H., et al. (2014) · Nature Medicine · doi:10.1038/nm.3704 · Cited by 927

Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

Lutsiak, M. E. C., Semnani, R. T., De Pascalis, R., Kashmiri, S. V. S., Schlom, J., & Sabzevari, H. (2005) · Blood · doi:10.1182/blood-2004-06-2410 · Cited by 903

Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients

Fu, J., Xu, D., Liu, Z., Shi, M., Zhao, P., Fu, B., Zhang, Z., Yang, H., Zhang, H., Zhou, C., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.102 · Cited by 897

CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

Ghiringhelli, F., Larmonier, N., Schmitt, E., Parcellier, A., Cathelin, D., Garrido, C., Chauffert, B., Solary, É., Bonnotte, B., & Martin, F. (2004) · European Journal of Immunology · doi:10.1002/eji.200324181 · Cited by 878

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

Saito, T., Nishikawa, H., Wada, H., Nagano, Y., Sugiyama, D., Atarashi, K., Maeda, Y., Hamaguchi, M., Ohkura, N., Sato, E., et al. (2016) · Nature Medicine · doi:10.1038/nm.4086 · Cited by 871

Regulatory T cells and Foxp3

Rudensky, A. Y. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01018.x · Cited by 839

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

Ma, C., Kesarwala, A. H., Eggert, T., Medina-Echeverz, J., Kleiner, D. E., Jin, P., Stroncek, D. F., Terabe, M., Kapoor, V., ElGindi, M., et al. (2016) · Nature · doi:10.1038/nature16969 · Cited by 766 · cited 1×

Immunity, inflammation and cancer: a leading role for adenosine

Antonioli, L., Blandizzi, C., Pacher, P., & Haskó, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3613 · Cited by 765

Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor

Maj, T., Wang, W., Crespo, J., Zhang, H., Wang, W., Wei, S., Zhao, L., Vatan, L., Shao, I., Szeliga, W., et al. (2017) · Nature Immunology · doi:10.1038/ni.3868 · Cited by 733

The secret ally: immunostimulation by anticancer drugs

Galluzzi, L., Senovilla, L., Zitvogel, L., & Kroemer, G. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3626 · Cited by 708

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

Plitas, G., Konopacki, C., Wu, K., Bos, P. D., Morrow, M., Putintseva, E. V., Chudakov, D. M., & Rudensky, A. Y. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.032 · Cited by 695

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

De Simone, M., Arrigoni, A., Rossetti, G., Gruarin, P., Ranzani, V., Politano, C., Bonnal, R. J. P., Provasi, E., Sarnicola, M. L., Panzeri, I., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.021 · Cited by 687

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

Tan, W., Zhang, W., Strasner, A., Grivennikov, S. I., Cheng, J. Q., Hoffman, R. M., & Karin, M. (2011) · Nature · doi:10.1038/nature09707 · Cited by 658

Pivotal Phase III Trial of Two Dose Levels of Denileukin Diftitox for the Treatment of Cutaneous T-Cell Lymphoma

Olsen, E. A., Duvic, M. A., Frankel, A. E., Kim, Y. H., Martin, A., Vonderheid, E. C., Jegasothy, B. V., Wood, G. S., Gordon, M., HEALD, P. W., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.2.376 · Cited by 610

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

González‐Suárez, E., Jacob, A. P., Jones, J. C., Miller, R. E., Roudier-Meyer, M. P., Erwert, R. D., Pinkas, J., Branstetter, D., & Dougall, W. C. (2010) · Nature · doi:10.1038/nature09495 · Cited by 606

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

Ng, W., Duggan, P. J., Ponchel, F., Matarese, G., Lombardi, G., Edwards, A. D., Isaacs, J. D., & Lechler, R. I. (2001) · Blood · doi:10.1182/blood.v98.9.2736 · Cited by 606

Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients

Romano, E., Kusio-Kobialka, M., Foukas, P. G., Baumgaertner, P., Meyer, C., Ballabeni, P., Michielin, O., Weide, B., Romero, P., & Speiser, D. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417320112 · Cited by 601

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

Nishizuka, Y., & Sakakura, T. (1969) · Science · doi:10.1126/science.166.3906.753 · Cited by 592

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

Arce Vargas, F., Furness, A. J. S., Litchfield, K., Joshi, K., Rosenthal, R., Ghorani, E., Solomon, I., Lesko, M. H., Ruef, N., Roddie, C., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.02.010 · Cited by 592

Control of Regulatory T Cell Lineage Commitment and Maintenance

Josefowicz, S. Z., & Rudensky, A. Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.009 · Cited by 584

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

Sawant, D. V., Yano, H., Chikina, M. D., Zhang, Q., Liao, M., Liu, C., Callahan, D. J., Sun, Z., Sun, T., Tabib, T., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0346-9 · Cited by 569

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

Liang, B., Workman, C., Lee, J., Chew, C., Dale, B. M., Colonna, L., Flores, M., Li, N., Schweighoffer, E., Greenberg, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5916 · Cited by 566

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

Martens, A., Wistuba-Hamprecht, K., Foppen, M. G., Yuan, J., Postow, M. A., Wong, P., Romano, E., Khammari, A., Dreno, B., Capone, M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2412 · Cited by 541 · cited 1×

Continuous requirement for the TCR in regulatory T cell function

Levine, A. G., Arvey, A. J., Jin, W., & Rudensky, A. Y. (2014) · Nature Immunology · doi:10.1038/ni.3004 · Cited by 536

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

Klysz, D., Tai, X., Robert, P. A., Craveiro, M., Cretenet, G., Oburoglu, L., Mongellaz, C., Floess, S., Fritz, V., Matias, M. I., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aab2610 · Cited by 522

OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients

Curti, B. D., Kovacsovics-Bankowski, M., Morris, N. P., Walker, E., Chisholm, L., Floyd, K., Walker, J. M., Gonzalez, I. L., Meeuwsen, T., Fox, B. A., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4174 · Cited by 503

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

Baban, B., Chandler, P., Sharma, M. D., Pihkala, J. P. S., Koni, P. A., Munn, D. H., & Mellor, A. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900986 · Cited by 494

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

Sage, P. T., Francisco, L. M., Carman, C. V., & Sharpe, A. H. (2012) · Nature Immunology · doi:10.1038/ni.2496 · Cited by 484

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells

Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., Shimizu, J., Nomura, T., Chiba, T., & Sakaguchi, S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050940 · Cited by 465

Tumor infiltrating Foxp3+ regulatory T‐cells are associated with recurrence in pathologic stage I NSCLC patients

Petersen, R. P., Campa, M. J., Sperlazza, J. R., Conlon, D. H., Joshi, M.-B., Harpole, D. H., & Patz, E. F. (2006) · Cancer · doi:10.1002/cncr.22282 · Cited by 446

Fatty acid metabolism in the regulation of T cell function

Lochner, M., Berod, L., & Sparwasser, T. D. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.005 · Cited by 427

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

Feng, Y., Arvey, A., Chinen, T., van der Veeken, J., Gasteiger, G., & Rudensky, A. Y. (2014) · Cell · doi:10.1016/j.cell.2014.07.031 · Cited by 422

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

Piconese, S., Valzasina, B., & Colombo, M. P. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071341 · Cited by 415

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Vargas, F. A., Furness, A. J. S., Solomon, I., Joshi, K., Mekkaoui, L., Lesko, M. H., Miranda, E., Dahan, R., Georgiou, A., Śledzińska, A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.013 · Cited by 415

Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy

Colombo, M. P., & Piconese, S. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2250 · Cited by 414

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25− into CD25+ T regulatory cells

Curti, A., Pandolfi, S., Valzasina, B., Aluigi, M., Isidori, A., Ferri, E., Salvestrini, V., Bonanno, G., Rutella, S., Durelli, I., et al. (2006) · Blood · doi:10.1182/blood-2006-07-036863 · Cited by 409

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

Sharma, M. D., Hou, D., Liu, Y., Koni, P. A., Metz, R. A., Chandler, P., Mellor, A. L., He, Y., & Munn, D. H. (2009) · Blood · doi:10.1182/blood-2008-12-195354 · Cited by 406

Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

Godin-Ethier, J., Hanafi, L., Piccirillo, C. A., & Lapointe, R. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1331 · Cited by 398

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors

Marabelle, A., Kohrt, H. E. K., Sagiv-Barfi, I., Ajami, B., Axtell, R. C., Zhou, G., Rajapaksa, R., Green, M. R., Torchia, J. A., Brody, J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64859 · Cited by 393

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

Klotz, L., Burgdorf, S., Dani, I., Saijo, K., Floßdorf, J., Hucke, S., Alferink, J., Novak, N., Beyer, M., Mayer, G., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082771 · Cited by 363

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

Pacella, I., Procaccini, C., Focaccetti, C., Miacci, S., Timperi, E., Faicchia, D., Severa, M., Rizzo, F., Coccia, E. M., Bonacina, F., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720113115 · Cited by 352

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

Rech, A. J., Mick, R., Martin, S., Recio, A., Aqui, N. A., Powell, D. J., Colligon, T. A., Trosko, J. A., Leinbach, L. I., Pletcher, C. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003330 · Cited by 344

Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes

Röllinghoff, M., Starzinski‐Powitz, A., Pfizenmaier, K., & Wagner, H. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.2.455 · Cited by 335

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

McHugh, R. S., & Shevach, E. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.5979 · Cited by 319

Immune Monitoring of the Circulation and the Tumor Microenvironment in Patients with Regionally Advanced Melanoma Receiving Neoadjuvant Ipilimumab

Tarhini, A. A., Edington, H. D. J., Butterfield, L. H., Lin, Y., Shuai, Y., Tawbi, H. A., Sander, C., Yin, Y., Holtzman, M. P., Johnson, J. T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087705 · Cited by 316

Rationale for anti-OX40 cancer immunotherapy

Aspeslagh, S., Postel-Vinay, S. C., Rusakiewicz, S., Soria, J., Zitvogel, L., & Marabelle, A. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.08.021 · Cited by 316

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

Bos, P. D., Plitas, G., Rudra, D., Lee, S. Y., & Rudensky, A. Y. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130762 · Cited by 305

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

Mahmud, S. A., Manlove, L. S., Schmitz, H. M., Xing, Y., Wang, Y., Owen, D. L., Schenkel, J. M., Boomer, J. S., Green, J. M., Yagita∥, H., et al. (2014) · Nature Immunology · doi:10.1038/ni.2849 · Cited by 282

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

Cohen, A. D., Schaer, D., Liu, C., Li, Y., Hirschhorn-Cymerman, D., Kim, S. C., Diab, A. K., Rizzuto, G. A., Duan, F., Perales, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010436 · Cited by 266

Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells

Li, H., Hong, S., Qian, J., Zheng, Y., Yang, J., & Yi, Q. (2010) · Blood · doi:10.1182/blood-2009-11-255026 · Cited by 248

IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells

Gasteiger, G., Hemmers, S., Firth, M. A., Floc’h, A. L., Huse, M., Sun, J. C.-Y., & Rudensky, A. Y. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122462 · Cited by 246

Depletion of CD4+CD25+ human regulatory T cells in vivo: Kinetics of Treg depletion and alterations in immune functions in vivo and in vitro

Mahnke, K., Schönfeld, K., Fondel, S., Ring, S., Karakhanova, S., Wiedemeyer, K., Bedke, T., Johnson, T., Storn, V., Schallenberg, S., et al. (2007) · International Journal of Cancer · doi:10.1002/ijc.22617 · Cited by 245

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

Jacobs, J. F. M., Punt, C. J. A., Lesterhuis, W. J., Sutmuller, R. P. M., Brouwer, H., Scharenborg, N. M., Klasen, I. S., Hilbrands, L. B., Figdor, C. G., de Vries, I. J. M., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1757 · Cited by 243

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

Kurose, K., Ohue, Y., Wada, H., Iida, S., Ishida, T., Kojima, T., Doi, T., Suzuki, S., Isobe, M., Funakoshi, T., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0357 · Cited by 239

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

Araujo, L., Khim, P., Mkhikian, H., Mortales, C., & Demetriou, M. (2017) · eLife · doi:10.7554/elife.21330 · Cited by 234

Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment

Muroyama, Y., Nirschl, T. R., Kochel, C. M., Bujanda, Z. A. L., Theodros, D., Mao, W., Carrera-Haro, M. A., Ghasemzadeh, A., Marciscano, A. E. E., Velarde, E., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0040 · Cited by 230

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

Bour‐Jordan, H., & Bluestone, J. A. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00775.x · Cited by 229

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity

Howie, D., Cobbold, S. P., Adams, E., ten Bokum, A., Necula, A. S., Zhang, W., Huang, H., Roberts, D. J., Thomas, B. C., Hester, S., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.89160 · Cited by 225

A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti–PD-(L)1 and Anti–CTLA-4 in Preclinical Models

Willingham, S. B., Ho, P. Y., Hotson, A. N., Hill, C. M., Piccione, E. C., Hsieh, J. Y., Liu, L., Buggy, J. J., McCaffery, I., & Miller, R. A. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0056 · Cited by 225

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

Liu, X., Mo, W., Ye, J., Li, L., Zhang, Y., Hsueh, E. C., Hoft, D. F., & Peng, G. (2018) · Nature Communications · doi:10.1038/s41467-017-02689-5 · Cited by 224

IMA901, a multipeptide cancer vaccine, plus sunitinib versus sunitinib alone, as first-line therapy for advanced or metastatic renal cell carcinoma (IMPRINT): a multicentre, open-label, randomised, controlled, phase 3 trial

Rini, B. I., Stenzl, A., Zdrojowy, R., Коган, М. И., Shkolnik, M. I., Oudard, S. M., Weikert, S., Sergio Bracarda, A., Crabb, S. J., Bedke, J., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30408-9 · Cited by 221

Natural Regulatory T Cells and De Novo-Induced Regulatory T Cells Contribute Independently to Tumor-Specific Tolerance

Zhou, G., & Levitsky, H. I. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2155 · Cited by 220

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Paterson, A. M., Lovitch, S. B., Sage, P. T., Juneja, V. R., Lee, Y., Trombley, J. D., Arancibia-Cárcamo, C. V., Sobel, R. A., Rudensky, A. Y., Kuchroo, V. K., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141030 · Cited by 220

Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice

Chensue, S. W., Lukacs, N. W., Yang, T., Shang, X., Frait, K. A., Kunkel, S. L., Kung, T. T., Wiekowski, M., Hedrick, J. A., Cook, D. N., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.5.573 · Cited by 214

Tumor-infiltrating human CD4 + regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity

Ahmadzadeh, M., Pasetto, A., Jia, L., Deniger, D. C., Stevanović, S., Robbins, P. F., & Rosenberg, S. A. (2019) · Science Immunology · doi:10.1126/sciimmunol.aao4310 · Cited by 207

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody

Ha, D., Tanaka, A., Kibayashi, T., Tanemura, A., Sugiyama, D., Wing, J. B., Lim, E. L., Teng, K. W. W., Adeegbe, D., Newell, E. W., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812186116 · Cited by 205

Higher intratumoral infiltrated Foxp3+ Treg numbers and Foxp3+/CD8+ ratio are associated with adverse prognosis in resectable gastric cancer

Shen, Z., Zhou, S., Wang, Y., Li, R., Zhong, C., Liang, C., & Sun, Y. (2010) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-010-0816-9 · Cited by 201

A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens

Péré, H., Montier, Y., Bayry, J., Quintin‐Colonna, F., Merillon, N., Dransart, E., Badoual, C., Gey, A., Ravel, P., Marcheteau, E., et al. (2011) · Blood · doi:10.1182/blood-2011-01-329656 · Cited by 185

Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma

Vence, L. M., Palucka, K., Fay, J. W., Ito, T., Liu, Y., Banchereau, J., & Ueno, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710557105 · Cited by 184

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated T regs

Torrey, H., Butterworth, J., Mera, T., Okubo, Y., Wang, L., Baum, D., DEFUSCO, A. A., Plager, S., Warden, S., Huang, D., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aaf8608 · Cited by 184

The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment

Sharma, M. D., Shinde, R. S., McGaha, T. L., Huang, L., Holmgaard, R., Wolchok, J. D., Mautino, M. R., Celis, E., Sharpe, A. H., Francisco, L., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500845 · Cited by 178

Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells

Kim, I.-K., Kim, B.-S., Koh, C.-H., Seok, J.-W., Park, J.-S., Shin, K.-S., Bae, E.-A., Lee, G.-E., Jeon, H., Cho, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3922 · Cited by 167

Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis

Shrimali, R. K., Ahmad, S., Verma, V., Zeng, P., Ananth, S., Gaur, P., Gittelman, R. M., Yusko, E. C., Sanders, C. M., Robins, H. S., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0292 · Cited by 161

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Chopra, M., Biehl, M., Steinfatt, T., Brandl, A., Kums, J., Amich, J., Vaeth, M., Kuen, J., Holtappels, R., Podlech, J., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151563 · Cited by 161

Stromal PD-L1–Positive Regulatory T cells and PD-1–Positive CD8-Positive T cells Define the Response of Different Subsets of Non–Small Cell Lung Cancer to PD-1/PD-L1 Blockade Immunotherapy

Wu, S.-P., Liao, R.-Q., Tu, H., Wang, W., Dong, Z., Huang, S., Guo, W., Gou, L.-Y., Sun, H., Zhang, Q., et al. (2017) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2017.11.132 · Cited by 154

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types

Magnuson, A. M., Kiner, E., Ergün, A., Park, J. S., Asinovski, N., Ortiz-Lopez, A., Kilcoyne, A., Paoluzzi-Tomada, E., Weissleder, R., Mathis, D. J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810580115 · Cited by 151

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer

Ren, L., Yu, Y., Wang, L., Zhu, Z., Lu, R., & Yao, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.12409 · Cited by 149

Modulation of GITR for cancer immunotherapy

Schaer, D., Murphy, J. T., & Wolchok, J. D. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.12.011 · Cited by 142

Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer

Villarreal, D. O., L'Huillier, A., Armington, S., Mottershead, C., Filippova, E. V., Coder, B., Petit, R. G., & Princiotta, M. F. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1119 · Cited by 142

Pathogenesis of the Post-Neonatal Thymectomy Wasting Syndrome

McIntire, K. R., SELL, S., & MILLER, J. F. A. P. (1964) · Nature · doi:10.1038/204151a0 · Cited by 131

Adipocyte–Tumor Cell Metabolic Crosstalk in Breast Cancer

Hoy, A. J., Balaban, S., & Saunders, D. N. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.02.009 · Cited by 130

Early Detection of Tumor Cells by Innate Immune Cells Leads to Treg Recruitment through CCL22 Production by Tumor Cells

Faget, J., Biota, C., Bachelot, T., Gobert, M., Treilleux, I., Goutagny, N., Durand, I., Léon-Goddard, S., Blay, J. Y., Caux, C., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0573 · Cited by 129

Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy

Mahne, A. E., Mauze, S., Joyce-Shaikh, B., Xia, J., Bowman, E. P., Beebe, A. M., Cua, D. J., & JAIN, R. K. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0797 · Cited by 127

In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination

Bayry, J., Tchilian, E. Z., Davies, M. N., Forbes, E. K., Draper, S. J., Kaveri, S. V., Hill, A. V. S., Kazatchkine, M. D., Beverley, P. C. L., Flower, D. R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803453105 · Cited by 126

Roles of the RANKL–RANK axis in antitumour immunity — implications for therapy

Ahern, E. S., Smyth, M. J., Dougall, W. C., & Teng, M. W. L. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0095-y · Cited by 115

Cyclophosphamide Promotes Chronic Inflammation–Dependent Immunosuppression and Prevents Antitumor Response in Melanoma

Sevko, A., Sade-Feldman, M., Kanterman, J., Michels, T., Falk, C. S., Umansky, L., Ramacher, M., Kato, M., Schadendorf, D., Baniyash, M., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.444 · Cited by 111

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

Onda, M., Kobayashi, K., & Pastan, I. H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820388116 · Cited by 111

The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer

Ward, S., Li, K. K., Hepburn, E. A., Weston, C. J., Curbishley, S. M., Reynolds, G. M., Hejmadi, R. K., Bicknell, R., Eksteen, B., Ismail, T., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.572 · Cited by 100

Full restoration of peripheral Foxp3 + regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras

Komatsu, N., & Hori, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702004104 · Cited by 95

Human regulatory T cells lack the cyclophosphamide‐extruding transporter ABCB 1 and are more susceptible to cyclophosphamide‐induced apoptosis

Dimeloe, S., Frick, C., Fischer, M., Gubser, P. M., Razik, L., Bantug, G. R., Ravon, M., Langenkamp, A., & Hess, C. (2014) · European Journal of Immunology · doi:10.1002/eji.201444879 · Cited by 89

Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice

Ahern, E. S., Harjunpää, H., Barkauskas, D. S., Allen, S. M., Takeda, K., Yagita∥, H., Wyld, D., Dougall, W. C., Teng, M. W. L., & Smyth, M. J. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0606 · Cited by 87

Free fatty acid release from human breast cancer tissue inhibits cytotoxic T-lymphocyte-mediated killing

Kleinfeld, A. M., & Okada, C. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500151-jlr200 · Cited by 79

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma

Cheung, L. S., Fu, J. L., Kumar, P., Kumar, A., Urbanowski, M. E., Ihms, E. A., Parveen, S., Bullen, C. K., Patrick, G. J., Harrison, R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815087116 · Cited by 72

Radiotherapy Effects on Anti-Tumor Immunity: Implications for Cancer Treatment

Demaria, S., & Formenti, S. C. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00128 · Cited by 69

Effect of Modified Vaccinia Ankara–5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer

Scurr, M. J., Pembroke, T., Bloom, A. C., Roberts, D. J., Thomson, A., Smart, K., Bridgeman, H. M., Adams, R., Brewster, A. E., Jones, R., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2017.2579 · Cited by 68

Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

Davies, M. N., Bayry, J., Tchilian, E. Z., Vani, J., Shaila, M. S., Forbes, E. K., Draper, S. J., Beverley, P. C. L., Tough, D. F., & Flower, D. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008084 · Cited by 59

Preliminary results of a phase I/IIa study of BMS-986156 (glucocorticoid-induced tumor necrosis factor receptor–related gene [GITR] agonist), alone and in combination with nivolumab in pts with advanced solid tumors.

Siu, L. L., Steeghs, N., Meniawy, T. M., Joerger, M., Spratlin, J. L., Rottey, S., Nagrial, A. M., Cooper, A. J., Meier, R., Guan, X., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.35.15_suppl.104 · Cited by 55

Suppression of T regs by anti‐glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon‐α gene therapy for pancreatic cancer

Aida, K., Miyakawa, R., Suzuki, K. A. O., Narumi, K., Udagawa, T., Yamamoto, Y., Chikaraishi, T., Yoshida, T., & Aoki, K. (2013) · Cancer Science · doi:10.1111/cas.12332 · Cited by 53

A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist

Leyland, R., Watkins, A., Mulgrew, K. A., Holoweckyj, N., Bamber, L., Tigue, N. J., Offer, E., Andrews, J. L., Li, Y., Mullins, S., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2000 · Cited by 52

RANK-mediated signaling network and cancer metastasis

Chu, G. C., & Chung, L. W. K. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9488-7 · Cited by 50

A nonimmune function of T cells in promoting lung tumor progression

Green, J. A., Arpaia, N., Schizas, M., Dobrin, A., & Rudensky, A. Y. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170356 · Cited by 45

Anti–CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers—Letter

Ferrara, R., Susini, S., & Marabelle, A. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3740 · Cited by 29

Anti‐ CD 25 monoclonal antibody Fc variants differentially impact regulatory T cells and immune homeostasis

Huss, D. J., Pellerin, A., Collette, B., Kannan, A., Peng, L., Datta, A., Wipke, B. T., & Fontenot, J. D. (2016) · Immunology · doi:10.1111/imm.12609 · Cited by 23

Cancer Vaccination Reprograms Regulatory T Cells into Helper CD4 T Cells to Promote Antitumor CD8 T-Cell Responses

Chai, J. (2011) · Immunotherapy · doi:10.2217/imt.11.22 · Cited by 3

The tumor microenvironment

Anderson, N. M., & Simon, M. C. (2020) · Current Biology · doi:10.1016/j.cub.2020.06.081 · Cited by 2,718

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

Blass, E., & Ott, P. A. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00460-2 · Cited by 1,042

CD8+ T cells in the cancer-immunity cycle

Giles, J. R., Globig, A.-M., Kaech, S. M., & Wherry, E. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.005 · Cited by 507

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

Reticker-Flynn, N. E., Zhang, W., Belk, J. A., Basto, P. A., Escalante, N. K., Pilarowski, G. O. W., Bejnood, A., Martins, M. M., Kenkel, J. A., Linde, I. L., et al. (2022) · Cell · doi:10.1016/j.cell.2022.04.019 · Cited by 399

Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer

Becker, W. R., Nevins, S. A., Chen, D. C., Chiu, R., Horning, A. M., Guha, T. K., Laquindanum, R., Mills, M. A., Chaı̈b, H., Ladabaum, U., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01088-x · Cited by 333

Tumor resident regulatory T cells

Glasner, A., & Plitas, G. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101476 · Cited by 47

Two Faces of Regulatory T Cells: From Immune Defense to Tumoral Progression

Medeiros, S. S. D. E., Souza, L., de Souza, W. M., Mayeiro, M. G. C., & Degasperi, G. R. (2020) · Annual Research & Review in Biology · doi:10.9734/arrb/2020/v35i1230317

Regulatory T cells: A target in anticancer immunotherapy.

Enokida, T., & Nishikawa, H. (2017) · PubMed · Cited by 1

Regulatory T Cells in Tumor Microenvironment: Therapeutic Approaches and Clinical Implications

Sureka, N., & Zaheer, S. (2025) · Cell Biology International · doi:10.1002/cbin.70031 · Cited by 13

Advancement in the Research on Regulatory T Cells and Tumor

Ding, Y. (2011) · Journal of International Obstetrics and Gynecology