Cited by 1,196Mitochondrial Function and PathologyAutophagy in Disease and TherapyCell death mechanisms and regulation

The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

Chan, David C.·2012·Annual Review of Genetics

Open this paper in CoChat — free account

Abstract

Mitochondria are dynamic organelles that continually undergo fusion and fission. These opposing processes work in concert to maintain the shape, size, and number of mitochondria and their physiological function. Some of the major molecules mediating mitochondrial fusion and fission in mammals have been discovered, but the underlying molecular mechanisms are only partially unraveled. In particular, the cast of characters involved in mitochondrial fission needs to be clarified. By enabling content mixing between mitochondria, fusion and fission serve to maintain a homogeneous and healthy mitochondrial population. Mitochondrial dynamics has been linked to multiple mitochondrial functions, including mitochondrial DNA stability, respiratory capacity, apoptosis, response to cellular stress, and mitophagy. Because of these important functions, mitochondrial fusion and fission are essential in mammals, and even mild defects in mitochondrial dynamics are associated with disease. A better understanding of these processes likely will ultimately lead to improvements in human health.

Integrity signals

Registry

Crossref · 10.1146/annurev-genet-110410-132529

Cites

141 of 141 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026
Mechanisms of mitophagy
Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
Self-citation
Mitochondria and cell death: outer membrane permeabilization and beyond
Tait, S. W. G., & Green, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2952 · Cited by 2,593
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442
ER Tubules Mark Sites of Mitochondrial Division
Friedman, J. R., Lackner, L. L., West, M., DiBenedetto, J. R., Nunnari, J., & Voeltz, G. K. (2011) · Science · doi:10.1126/science.1207385 · Cited by 2,072
Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938
The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis
Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L., & Youle, R. J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00055-7 · Cited by 1,755
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735

Show all 141 references

Sorted by citations

Items 701–800 of 997

Escalating Bi-Directional Feedback Loops between Proinflammatory Microglia and Mitochondria in Ageing and Post-Diagnosis of Parkinson’s Disease
Ravenhill, S. M., Evans, A. H., & Crewther, S. G. (2023) · Antioxidants · doi:10.3390/antiox12051117 · Cited by 22
Effect of myonuclear number and mitochondrial fusion on Drosophila indirect flight muscle organization and size
Rai, M., & Nongthomba, U. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.06.021 · Cited by 19
“(Optic atrophy1) are required for outer and inner mitochondrial membrane fusion, respectively [25].”
Background
Mitochondrial fission promotes radiation-induced increase in intracellular Ca2+ level leading to mitotic catastrophe in mouse breast cancer EMT6 cells
Bo, T., Yamamori, T., Yamamoto, K., Fujimoto, M., Yasui, H., & Inanami, O. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.027 · Cited by 20
“It is known that mitochondrial fission closely relates to apoptosis induction [2].”
Background
PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proliferation
Liu, X., Yan, Q., Liu, X., Wei, W., Zou, L., Zhao, F., Zeng, S., Yi, L., Ding, H., Zhao, M., et al. (2024) · Journal of Virology · doi:10.1128/jvi.01751-23 · Cited by 19
“Mitochondria are central to cellular metabolism (23) and undergo continuous processes such as division, fusion, and phagocytosis to promote mitochondrial quality control (24).”
Background
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation
Song, Z., Cui, Y., Xin, L., Xiao, R., Feng, J., Li, C., Yin, Z., Wang, H., Li, Q., Wang, M., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.01.013 · Cited by 22
How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
Devrim-Lanpir, A., Hill, L., & Knechtle, B. (2021) · Antioxidants · doi:10.3390/antiox10020153 · Cited by 20
“It is dynamically regulated by processes of fusion, fusion and mitophagy [22].”
Background
Inhibition of DRP1 Impedes Zygotic Genome Activation and Preimplantation Development in Mice
Li, Y., Mei, N., Cheng, G., Yang, J., & Zhou, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.788512 · Cited by 20
“…ROS, DRP1 INTRODUCTION Mitochondria are dynamic organelles in the process of division and fusion and play crucial roles in many physiological functions, such as energy production, metabolites synthesis, calcium signaling, cell proliferation and death (Chan, 2012; Nunnari and Suomalainen, 2012).”
Background
Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation
Dang, X., Walton, E. K., Zabłocka, B., Baloh, R. H., Shy, M. E., & Dorn, G. W. (2022) · Cells · doi:10.3390/cells11061053 · Cited by 19
“of outer membrane tethering and fusion, whereas OPA1 is the effector of subsequent inner membrane fusion [2].”
Background
Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients
Bordoni, M., Pansarasa, O., Scarian, E., Cristofani, R., Leone, R., Fantini, V., Garofalo, M., Diamanti, L., Bernuzzi, S., Gagliardi, S., et al. (2022) · Cells · doi:10.3390/cells11081272 · Cited by 19
“Generally, in healthy conditions, the mitochondrial network is regulated by the interplay between Dynamin-related protein 1 (DRP1) and Fission 1 (FIS1) that promote fission, while Mitofusin 1 and 2 (MFN1, MFN2), and Optic atrophy 1 (OPA1) promote fusion [13].”
Background
Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network
Prochownik, E. V. (2022) · Cells · doi:10.3390/cells11243974 · Cited by 17
PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling
Cao, Y., Zhang, Y., Gerile, W., Guo, Y., Wu, L., Wu, L., Song, K., Lü, W., & Yu, J. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00597-z · Cited by 19
“Excessive fission and deficient fusion in mitochondria during sepsis result in the accumulation of mitochondrial fragmentation, which induces the production of ROS and permeabilizes the outer membrane, damaging mitochondrial function (Chan 2012).”
Background
Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer
Hasani, S., Young, L. E. A., Nort, W. V., Banerjee, M., Rivas, D. R., Kim, J., Xiong, X., Sun, R. C., Gentry, M. S., Sesaki, H., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06202-3 · Cited by 19
Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome
Zhang, J., Lv, W., Zhang, G., Zeng, M., Cao, W., Su, J., Cao, K. J., & Liu, J. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0339 · Cited by 22
“Mitofusin-1/2 (MFN1/2) and optic atrophy 1 (OPA1) mediate fusion, and dynamin-1 like protein (DRP1) promotes ﬁssion (Chan, 2012).”
The mediating role of inflammaging between mitochondrial dysfunction and sarcopenia in aging: a review.
Xu, X., & Wen, Z. (2023) · PubMed Central · Cited by 21
Photobleaching and phototoxicity of mitochondria in live cell fluorescent super-resolution microscopy
Lee, C.-H., Wallace, D. C., & Burke, P. J. (2024) · Mitochondrial Communications · doi:10.1016/j.mitoco.2024.03.001 · Cited by 18
“9,10 Since mitochondria fission/fusion has important physiological and clinical consequences, 11–13 the morphology of mitochondria under stress and toxic stimulus is an important topic in metabolism and cell biology, linked to a myriad of clinical pathologies.”
Background
Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer's disease: A focused review
Arjmand, S., Ilaghi, M., Sisakht, A. K., Guldager, M. B., Wegener, G., Landau, A. M., & GJEDDE, A. H. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14035 · Cited by 23
“30 Accordingly, mitochondrial fission generates two daughter mitochondria from the division of a single mitochondrion, whereas mitochondrial fusion is the merging of two mitochondria to create a single, larger mitochondrion.”
Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells
Lages, Y., Nascimento, J. M., Lemos, G. G. M., Galina, A., Castilho, L. R., & Rehen, S. K. (2015) · PeerJ · doi:10.7717/peerj.1486 · Cited by 21
“10.1007/s00280-006-0224-7 503 Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, and 504 Chandran S. 2011.”
Influential
1α,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells
Ryan, Z. C., Craig, T. A., Wang, X., Delmotte, P. F., Salisbury, J. L., Lanza, I. R., Sieck, G. C., & Kumar, R. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.092 · Cited by 19
“mediator of mitochondrial fission [34,39,40] and the reduced expression of mRNAs for the mitochondrial fusion mediators, OPA1 and MFN2 [35,41,42] might account for the increase in mitochondrial fragmentation.”
Background
Mitochondrial quality control and neurodegenerative diseases
Gao, F., & Zhang, J. (2018) · Neuronal Signaling · doi:10.1042/ns20180062 · Cited by 19
Phenylephrine Attenuated Sepsis-Induced Cardiac Inflammation and Mitochondrial Injury Through an Effect on the PI3K/Akt Signaling Pathway
Li, H., Li, K.-Y., Xing, Y., Tang, X., Yang, D., Dai, X., Lu, D., & Wang, H. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000651 · Cited by 19
Evaluation of mitochondria in oocytes following γ-irradiation
Wang, Q., Stringer, J. M., Liu, J., & Hutt, K. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-56423-w · Cited by 19
Impaired Metabolic Flexibility in the Osteoarthritis Process: A Study on Transmitochondrial Cybrids
Dalmao‐Fernández, A., Lund, J., Hermida‐Gómez, T., Vázquez-Mosquera, M. E., Rego‐Pérez, I., Blanco, F. J., & Fernández-Moreno, M. (2020) · Cells · doi:10.3390/cells9040809 · Cited by 19
“Mitochondrial dynamics are altered by different metabolic status in the cell and this is controlled by fission and fusion processes [50].”
Background
Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies
Genovese, I., Vezzani, B., Danese, A., Modesti, L., Vitto, V. A. M., Corazzi, V., Pelucchi, S., Pinton, P., & Giorgi, C. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102308 · Cited by 21
Mitochondrial Dynamics in the Drosophila Ovary Regulates Germ Stem Cell Number, Cell Fate, and Female Fertility
Garcez, M., Branco‐Santos, J., Gracio, P. C., & Homem, C. C. F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.596819 · Cited by 19
“Furthermore, mitochondria fusion is also known to be crucial for mitochondria quality control (Chan, 2012), allowing mixing of mitochondrial content to dilute damages, so our findings could reflect an accumulation of damaged mitochondria due to reduced fusion events, culminating in GSCs loss.”
BackgroundInfluential
Cdk8 Kinase Module: A Mediator of Life and Death Decisions in Times of Stress
Friedson, B., & Cooper, K. F. (2021) · Microorganisms · doi:10.3390/microorganisms9102152 · Cited by 19
Dynamic properties of mitochondria during human corticogenesis
Baum, T., & Gama, V. (2021) · Development · doi:10.1242/dev.194183 · Cited by 20
Enhancing the photostability of red fluorescent proteins through FRET with Si-rhodamine for dynamic super-resolution fluorescence imaging
Zhou, X., Miao, L., Zhou, W., Chen, Y., Ruan, Y., Wang, X., Wang, G., Bao, P., Qiao, Q., & Xu, Z. (2025) · Chemical Science · doi:10.1039/d5sc02442k · Cited by 18
A catalytic domain variant of mitofusin requiring a wildtype paralog for function uncouples mitochondrial outer-membrane tethering and fusion
Engelhart, E. A., & Hoppins, S. C. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006347 · Cited by 19
Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila
Katti, P., Rai, M., Srivastava, S., D’Silva, P., & Nongthomba, U. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112486 · Cited by 18
Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity
Dang, X., Williams, S. B., Devanathan, S., Franco, A., Fu, L., Bernstein, P. R., Walters, D., & Dorn, G. W. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00163 · Cited by 18
“The lead compound of this chemical series (2) demonstrated in vivo engagement of neuronal mitochondria after intravenous administration; its daily intramuscular administration reversed neuromuscular degeneration in a mouse model of CMT2A (17).”
Background
A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease
Chen, H., Chen, F., Jiang, Y., Zhang, L., Hu, G., Sun, F., Zhang, M., Ji, Y., Chen, Y., Che, G., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.881239 · Cited by 19
“DRP1 GTPase and its receptors (FIS1, MFF, MID49, and MiD51/MIEF1) are the most broadly investigated fission regulators network in recent years (Chan, 2012).”
Background
The Interplay between Dysregulated Metabolism and Epigenetics in Cancer
Bassal, M. A. (2023) · Biomolecules · doi:10.3390/biom13060944 · Cited by 19
Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy
Ueda, H., Tran, Q. T. H., Tran, L., Higasa, K., Ikeda, Y., Kondo, N., Hashiyada, M., Sato, C., Sato, Y., Ashida, A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38588-7 · Cited by 18
Mitophagy plays a “double-edged sword” role in the radiosensitivity of cancer cells
Wang, Q., & Liu, C. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05515-2 · Cited by 20
“Mitochondrial homeostasis is particularly important for ROS level and maintained by an intricate balance between fission, fusion, mitochondrial biogenesis, and mitophagy (Chan 2012; Hoitzing et al. 2015).”
Background
Parvalbumin alters mitochondrial dynamics and affects cell morphology
Janickova, L., Henzi, T., Safiulina, D., Kaasik, A., & Schwaller, B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2921-x · Cited by 18
Idh2 Deficiency Exacerbates Acrolein‐Induced Lung Injury through Mitochondrial Redox Environment Deterioration
Park, J. H., Ku, H. J., Lee, J. H., & Park, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1595103 · Cited by 18
“Additionally, these are also the main targets of ROS and oxidative stressinduced damage, as observed in various pathological states [16, 17].”
Background
Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity
Pereira, L. C., Miranda, L. F. C., Franco‐Bernardes, M. F., Tasso, M. J., Duarte, F. V., Varela, A. T. I., Rolo, A. P., Palmeira, C. M., & Dorta, D. J. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.06.021 · Cited by 18
“Furthermore, mitochondria undergo remodeling through fusion and fission, and this balance controls their structure and number [6].”
Background
A Molecular Perspective on Mitochondrial Membrane Fusion: From the Key Players to Oligomerization and Tethering of Mitofusin
Vecchis, D. D., Brandner, A. F., Baaden, M., Cohen, M. M., & Taly, A. (2019) · The Journal of Membrane Biology · doi:10.1007/s00232-019-00089-y · Cited by 20
Inhibition of 37/67kDa Laminin-1 Receptor Restores APP Maturation and Reduces Amyloid-β in Human Skin Fibroblasts from Familial Alzheimer’s Disease
Bhattacharya, A., Izzo, A., Mollo, N., Napolitano, F., Limone, A., Margheri, F., Mocali, A., Minopoli, G., Bianco, A. L., Maggio, F. D., et al. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040232 · Cited by 17
“Because the mitochondrial function is linked to the organization of the mitochondrial network [29], we examined the mitochondrial morphology by using the Mitotracker Red CMXRos prob (Figure 4).”
Method
Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1)
Wu, W., Chai, Q., & Zhang, Z. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108968 · Cited by 17
The Present and Future of Mitochondrial-Based Therapeutics for Eye Disease
Ji, M. H., Kreymerman, A., Belle, K. C., Ghiam, B. K., Muscat, S. P., Mahajan, V. B., Enns, G. M., Mercola, M. A., & Wood, E. H. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.8.4 · Cited by 18
Early triggers of moderately high‐fat diet‐induced kidney damage
Sánchez‐Navarro, A., Martínez-Rojas, M. A., Bohn, R. I. C., Pérez‐Villalva, R., Zambrano, E., Castro-Rodríguez, D. C., & Bobadilla, N. A. (2021) · Physiological Reports · doi:10.14814/phy2.14937 · Cited by 20
“…found that Drp1 protein levels, that is a member of the GTPase family, and controls the final step in mitochondrial fission (CorreaRotter & Gamba, 1997), was significantly elevated in the MHFD group, while Mfn1/2, a basic component of the mitochondrial fusion machinery did not change (Chan, 2012).”
BackgroundInfluential
Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer
Jiang, H.-Y., Chen, Y.-L., Xu, X.-X., Li, C., Chen, Y., Li, D.-P., Zeng, X.-Q., & Gao, H. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.770 · Cited by 15
Hydroxytyrosol Attenuates High-Fat-Diet-Induced Oxidative Stress, Apoptosis and Inflammation of Blunt Snout Bream (Megalobrama amblycephala) through Its Regulation of Mitochondrial Homeostasis
Dong, Y., Xia, T., Yu, M., Wang, L., Song, K., Zhang, C., & Lu, K. (2022) · Fishes · doi:10.3390/fishes7020078 · Cited by 19
“PGC-1α/β: Peroxisome proliferators activated receptor γ coactivator-1 α/β; TFAM: Mitochondrial transcription factor A; NRF-1: Nuclear respiratory factor 1; IL-6: interleukin 6; p38 MAPK: p38 mitogen-activated protein kinase; CCR2: C-C motif chemokine receptor 2; CD68: CD68 molecule; SIRT-1: sirtuin 1; Bax: apoptosis r…”
BackgroundInfluential
Isoquinolines alkaloids and cancer metabolism: Pathways and targets to novel chemotherapy
Mello, A. L. D. N., & Zancan, P. (2022) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14043 · Cited by 18
“The proposed mechanism of action is related to mitochondrial fission process and involves dynamin- like 1 protein (DNM1L), a protein that is translocated from the cytosol to mitochondria leading to mitochondrial fission (Chan, 2012).”
Background
Resolvin D1 attenuates sepsis induced acute kidney injury targeting mitochondria and NF-κB signaling pathway
Wang, L., Li, J., Liao, R., Li, Y., Jiang, L., Zhang, Z., Geng, J., Fu, P., Su, B., & Zhao, Y. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12269 · Cited by 20
“Several studies have shown that the mitochondrion is a highly dynamic organelle [4, 37].”
Background
Naringenin, a flavanone constituent from Sea buckthorn pulp extract, prevents ultraviolet (UV)-B radiation-induced skin damage via alleviation of impaired mitochondrial dynamics mediated inflammation in human dermal fibroblasts and Balb/c mice models
Archoo, S., Bhat, A. M., Gorke, S., Wani, I. A., Sidiqui, A., Ahmed, Z., & Sheikh, T. A. (2024) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2024.112944 · Cited by 17
Mitochondrial destabilization in tendinopathy and potential therapeutic strategies
Cheng, L., Zheng, Q., Qiu, K., Ker, D. F. E., Chen, X., & Yin, Z. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.09.003 · Cited by 18
“The delicate interplay between fission and fusion acts as a fundamental mechanism for regulating mitochondrial structure and function, thereby ensuring cellular homeostasis [89].”
Background
Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease
Simcox, E. M., Reeve, A. K., & Turnbull, D. M. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130189 · Cited by 18
Monitoring the Effects of Pharmacological Reagents on Mitochondrial Morphology
Fu, D., & Lippincott‐Schwartz, J. (2018) · Current Protocols in Cell Biology · doi:10.1002/cpcb.45 · Cited by 17
“Mitochondrial fusion and fission are tightly regulated by a group of specific proteins (Chan, 2012; Youle & van der Bliek, 2012).”
Background
Thyroid hormone treatment alleviates the impairments of neurogenesis, mitochondrial biogenesis and memory performance induced by methamphetamine
Tamijani, S. M. S., Beirami, E., Ahmadiani, A., & Dargahi, L. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.05.003 · Cited by 18
Hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion–fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress
Ren, S., Rehman, Z. U., Shi, M., Yang, B., Liu, P., Yin, Y., Qu, Y., Meng, C., Yang, Z., Gao, X., et al. (2019) · Veterinary Research · doi:10.1186/s13567-019-0654-y · Cited by 18
Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma
Coazzoli, M., Napoli, A., Roux-Biejat, P., Palma, C. D., Moscheni, C., Catalani, E., Zecchini, S., Conte, V., Giovarelli, M., Caccia, S., et al. (2020) · Cells · doi:10.3390/cells9040848 · Cited by 17
“In mammalian cells, the primary players in mitochondrial morphology are mitofusin1 and mitofusin2 (Mfn1, Mfn2), and optic atrophy 1 (OPA1), which are essential for outer and inner mitochondrial membrane fusion, respectively, and dynamin-related protein 1 (Drp1), which is essential for the process of fission [14,15,19,…”
Background
Age-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression
Nivison, M. P., Ericson, N. G., Green, V. M., Bielas, J. H., Campbell, J. S., & Horner, P. J. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.07.001 · Cited by 19
“Deficits in mitochondrial fusion impede mitochondrial repair and function (Chan, 2006a, 2006b, 2012; Chen et al., 2011; Cho et al., 2010).”
Background
Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology
Wang, Y., Xu, C., Ma, L., Mou, Y., Zhang, B., Zhou, S., Tian, Y., Trinh, J., Zhang, X., & Li, X.-J. (2019) · Life Science Alliance · doi:10.26508/lsa.201800268 · Cited by 17
“Role of Z-FA-FMK on mitochondrial dynamics and motor neuron loss in SMA Mitochondria are highly dynamic and constantly undergo ﬁ ssion and fusion to maintain normal shape and function (Chan, 2012; Otera et al, 2013; van der Bliek et al, 2013; Wagener, 2016).”
Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts
Zanfardino, P., Longo, G., Amati, A., Morani, F., Picardi, E., Girolamo, F., Pafundi, M., Cox, S. N., Manzari, C., Tullo, A., et al. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac201 · Cited by 16
Effects of Redox Homeostasis and Mitochondrial Damage on Alzheimer’s Disease
Wu, Y., & Hsieh, H. (2023) · Antioxidants · doi:10.3390/antiox12101816 · Cited by 16
“The process of mitochondrial dynamics is tightly regulated by mitochondrial fusion and fission events [50].”
Impaired mitophagosome–lysosome fusion mediates olanzapine‐induced aging
Chen, X., Wang, Z., Zheng, P., Dongol, A., Xie, Y., Ge, X., Zheng, M., Dang, X., Seyhan, Z. B., Nagaratnam, N., et al. (2023) · Aging Cell · doi:10.1111/acel.14003 · Cited by 18
“The hyperfragmen-tation of the mitochondrial network emerges with aging and is negatively regulated by fusion-related proteins and positively regulated by fission-related proteins (Chan, 2012 ; Jiang et al., 2015 ; Sharma et al., 2019 ).”
Background
Imaging of Mitochondrial Dynamics in Motor and Sensory Axons of Living Mice
Bolea, I., Gan, W., Manfredi, G., & Magrané, J. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801415-8.00006-0 · Cited by 15
Isolation of functional mitochondria by inertial microfluidics – a new method to sort intracellular organelles from a small scale biological sample
Tesauro, C., Ferrando, B., Ma, X., Jepsen, M. L., Ivarsen, A. K. R., Frøhlich, R. F., Stevnsner, T., Knudsen, B. R., & Ho, Y. (2017) · RSC Advances · doi:10.1039/c7ra03384b · Cited by 16
Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1
Ciarlo, L., Vona, R., Manganelli, V., Gambardella, L., Raggi, C., Marconi, M., Malorni, W., Sorice, M., Garofalo, T., & Matarrese, P. (2018) · Oncotarget · doi:10.18632/oncotarget.24792 · Cited by 16
“Mitochondria are a highly responsive network of organelles in constant balance between two states: a set of individual spherical organelle or an elaborate network of interconnected elements [1].”
Background
The C3HC type zinc-finger protein (ZFC3) interacting with Lon/MAP1 is important for mitochondrial gene regulation, infection hypha development and longevity of Magnaporthe oryzae
Liu, S., Wei, Y., & Zhang, S. (2020) · BMC Microbiology · doi:10.1186/s12866-020-1711-4 · Cited by 16
Players in Mitochondrial Dynamics and Female Reproduction
Zou, W., Ji, D., Zhang, Z., Yang, L., & Cao, Y. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.717328 · Cited by 18
“Mitochondrial fission leads to the removal of aberrant mitochondria while under stress and undergoing apoptosis and the assignment of mitochondria into daughter cells (Twig et al., 2008) (Chan, 2012).”
Background
In vitro exposure to very low-level laser modifies expression level of extracellular matrix protein RNAs and mitochondria dynamics in mouse embryonic fibroblasts
Giuliani, A., Lorenzini, L., Alessandri, M., Torricella, R., Baldassarro, V. A., Giardino, L., & Calzà, L. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0593-8 · Cited by 16
“The coordination between fusion and fission contributes to the response of mammalian cells to stress, and mitochondrial bioenergetics seems to be strongly dependent on mitochondrial morphology [37].”
Background
Dynamic organization of intracellular organelle networks
Li, W., Zhang, S., & Yang, G. (2020) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1505 · Cited by 15
Estrogen deprivation aggravates cardiometabolic dysfunction in obese-insulin resistant rats through the impairment of cardiac mitochondrial dynamics
Minta, W., Palee, S., Mantor, D., Sutham, W., Jaiwongkam, T., Kerdphoo, S., Pratchayasakul, W., Kumfu, S., Chattipakorn, S. C., & Chattipakorn, N. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.006 · Cited by 16
“Mitochondria play an important role in the control of cell survival, especially in the heart (Chan, 2012).”
Influential
Physiological Functions of Mitochondrial Reactive Oxygen Species
Choi, T. G., & Kim, S. S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88386 · Cited by 22
“physically interact to mechanistically mediate OMM and IMM fusion, respectively [29, 57, 58].”
Background
Mitochondria in aneurysms and dissections of the human ascending aorta
Gutierrez, P. S., Marques-Piubelli, M. L., Naal, K. G., Dias, R. R., & Borges, L. D. F. (2020) · Cardiovascular Pathology · doi:10.1016/j.carpath.2020.107207 · Cited by 15
MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
Miao, J., Chen, W., Wang, P., Zhang, X., Wang, L., Wang, S., & Wang, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413507 · Cited by 15
“These two opposing processes work in concert to maintain the shape, size, and number of mitochondria and their physiological functions [6].”
Background
Triplication of HSA21 on alterations in structure and function of mitochondria
Ganguly, B. B., & Kadam, N. N. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.05.007 · Cited by 16
Alterations of mitochondrial dynamics allow retrograde propagation of locally initiated axonal insults
Lassus, B., Magnifico, S., Pignon, S., Belenguer, P., Miquel, M., & Peyrin, J. (2016) · Scientific Reports · doi:10.1038/srep32777 · Cited by 16
Elongated mitochondrial constrictions and fission in muscle fatigue
Lavorato, M., Loro, E., Debattisti, V., Khurana, T. S., & Franzini‐Armstrong, C. (2018) · Journal of Cell Science · doi:10.1242/jcs.221028 · Cited by 15
“…after cell division, also occur continually in interphase cells and are of primary importance in maintaining mitochondrial size and shape as well as, indirectly, cellular homeostasis and general heath of the organism (Chen and Chan, 2010; Westermann, 2010; Chan, 2012; Rana et al., 2017).”
Background
Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues
Lizama, B. N., Palubinsky, A. M., & McLaughlin, B. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.08.013 · Cited by 14
“Each neuron must generate, repair, and replace hundreds to thousands of biologically active mitochondria in order to supply sufficient ATP and calcium buffering capacity to ensure cell viability (Chan, 2012; Chang and Reynolds, 2006; Erecinska and Silver, 1989; Golpich et al., 2017).”
Multiplexed quantitative evaluation on mitochondrial toxicity of tris (2,3-dibromopropyl) phosphate in hepatocyte
Ma, X., Lu, D., Liu, Y., Le, Y., Chen, H., Li, X., & Wang, C. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112425 · Cited by 14
Directly Reprogrammed Human Neurons to Understand Age‐Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration
Gudenschwager, C., Chavez, I., Cárdenas, C., & González-Billault, C. E. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5586052 · Cited by 12
“In neurons, abnormal mitochondrial dynamics are associated with impaired function [44, 45] and contribute to the development of NDDs [46, 47].”
Background
Characterisation of cold-induced mitochondrial fission in porcine aortic endothelial cells
Quiring, L., Walter, B., Lohaus, N., Schwan, D., Rech, A., Dlugos, A. M., & Rauen, U. (2022) · Molecular Medicine · doi:10.1186/s10020-021-00430-z · Cited by 13
“2007), for quality control (Chan 2012; Twig et al.”
Background
High-fat diet exacerbates 1-Bromopropane-induced loss of dopaminergic neurons in the substantia nigra of mice through mitochondrial damage associated necroptotic pathway
Song, M., Qiang, Y., Wang, S., Shan, S., Zhang, L., Liu, C., Song, F., & Zhao, X. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116280 · Cited by 14
Hematopoietic stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division
Filippi, M. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.01.006 · Cited by 15
Dysbindin-1 regulates mitochondrial fission and gamma oscillations
Zhao, J. W., Zhu, H., Duan, K., Petralia, R. S., Wang, Y., Gu, Q., Panja, D., & Li, Z. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01038-9 · Cited by 13
The Role of Mitonuclear Incompatibility in Bipolar Disorder Susceptibility and Resilience Against Environmental Stressors
Gonzalez, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.636294 · Cited by 19
“Anterograde signaling can modulate bioenergetics based on cellular demands via mitochondrial fusion/fission to regulate mitochondrial copy number, morphology, mitophagy, and movement (Chen and Chan, 2009; Chan, 2012; Quiros et al., 2016).”
Background
Engineered aluminum nanoparticle induces mitochondrial deformation and is predicated on cell phenotype
Lujan, H., Mulenos, M. R., Carrasco, D., Zechmann, B., Hussain, S. M., & Sayes, C. M. (2021) · Nanotoxicology · doi:10.1080/17435390.2021.2011974 · Cited by 13
Reactive nitrogen species as therapeutic targets for autophagy/mitophagy modulation to relieve neurodegeneration in multiple sclerosis: Potential application for drug discovery
Li, W., Wu, M., Li, Y., & Shen, J. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.07.032 · Cited by 16
High‐throughput detection and quantification of mitochondrial fusion through imaging flow cytometry
Nascimento, A., Lannigan, J. A., & Kashatus, D. F. (2016) · Cytometry Part A · doi:10.1002/cyto.a.22891 · Cited by 14
“These functions of mitochondria are profoundly influenced by mitochondrial morphology (4), which is characterized by continuous cycles of fusion and fission (5).”
Background
Mitochondrial Dynamics: Shaping Metabolic Adaptation
Cantó, C. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.004 · Cited by 15
Mgm1 is required for maintenance of mitochondrial function and virulence in Candida albicans
Liang, C., Zhang, B., Cui, L., Lǐ, J., Yu, Q., & Li, M. (2018) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2018.09.006 · Cited by 14
RETRACTED: Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations
Huang, N., Lin, C., Lin, Y., Huang, C., Chiou, C., Lee, Y., Lee, S.-Y., Huang, H., & Yang, Y.-C. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.11.016 · Cited by 14
Retracted
Molecular pathways of mitochondrial outer membrane protein degradation
Zheng, J., Li, L., & Jiang, H. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190275 · Cited by 13
Teriflunomide preserves peripheral nerve mitochondria from oxidative stress-mediated alterations
Malla, B., Cotten, S., Ulshöfer, R., Paul, F., Hauser, A. E., Niesner, R. A., Bros, H., & Infante‐Duarte, C. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320944773 · Cited by 16
Perspective – ultrastructural analyses reflect the effects of sleep and sleep loss on neuronal cell biology
Wang, L., & Aton, S. J. (2022) · SLEEP · doi:10.1093/sleep/zsac047 · Cited by 13
“While both fission and fusion can be adaptive cellular responses to mitochondrial stress, it is important to note that both are also an essential feature of apoptosis [44, 45].”
Legionella and mitochondria, an intriguing relationship
García-Rodríguez, F. J., Buchrieser, C., & Escoll, P. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.10.001 · Cited by 12
Unwinding the role of Wnt signaling cascade and molecular triggers of motor neuron degeneration in amyotrophic lateral sclerosis (ALS)
Soumya, B. S., Shreenidhi, V. P., Agarwal, A., Gandhirajan, R. K., Dharmarajan, A., & Warrier, S. R. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110807 · Cited by 14
Mechanism of Mitochondrial Kinetic Imbalance and Nrf2 Signaling Pathway-Mediated Oxidative Stress in Nickel and/or Chromium-Induced Kidney Injury in Mice
Du, J., Li, Z., Cao, X., Qi, Q., Wang, L., Liu, P., Chen, Y., Hu, G., Guo, X., & Gao, X. (2024) · Antioxidants · doi:10.3390/antiox13080980 · Cited by 13
The role of mitochondrial fusion and fission in the process of cardiac oxidative stress.
Yu, F., Abdelwahid, E., Xu, T., Hu, L., Wang, M., Li, Y., Mogharbel, B. F., de Carvalho, K. A. T., Guarita-Souza, L. C., An, Y., et al. (2020) · PubMed · doi:10.14670/hh-18-191 · Cited by 14
Mitochondrial Fusion Potentially Regulates a Metabolic Change in Tibetan Chicken Embryonic Brain During Hypoxia
Tang, Q., Ding, C., Xu, Q., Bai, Y., Qiao, X., Wang, K., & Fang, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.585166 · Cited by 14
“Having observed a higher mitochondrial quality in TBCs than DLCs under hypoxia, we sought to determine whether it is related to mitochondrial fusion which is regulated by MFN1, MFN2, and OPA1.”
BackgroundInfluential
Mitochondrial dynamics in neurodegeneration: from cell death to energetic states
Khacho, M., & Slack, R. S. (2015) · AIMS molecular science · doi:10.3934/molsci.2015.2.161 · Cited by 13
“The equilibrium of fission and fusion events not only dictates the structural morphology of mitochondria, but also regulates metabolism [10-12].”
Background
In vitro and in vivo assays for mitochondrial fission and fusion
Hoppins, S. C., Lackner, L. L., Lee, J. E., & Mears, J. A. (2019) · Methods in cell biology · doi:10.1016/bs.mcb.2019.11.010 · Cited by 13
“Dnm1/Drp1 (yeast/mammals) was identified as the sole mitochondrial fission DRP, whereas two fusion DRPs, Fzo1/Mfn1 (and Mfn2) and Mgm1/OPA1 (yeast/mammals) were discovered to drive fusion of the outer and inner mitochondrial membranes (OMM and IMM), respectively (Chan, 2012; Hoppins et al., 2007).”
Background
BAX regulates dendritic spine development via mitochondrial fusion
Gu, Q., Duan, K., Petralia, R. S., Wang, Y., & Li, Z. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.06.002 · Cited by 13
“The balance between fusion and fission is essential for the homeostasis and quality control of mitochondria (Chan, 2012).”
Background
Microsporidia Promote Host Mitochondrial Fragmentation by Modulating DRP1 Phosphorylation
Luo, J. G., Xu, J., Xie, C., Zhao, Z., Guo, J., Wen, Y., Li, T., & Zhou, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147746 · Cited by 12
“The human protein DRP1, which is a large GTPase of the dynamin family, is a critical player in the process of mitochondrial fission [33].”
Background
Mitochondrial dynamics in vascular remodeling and target-organ damage
Zhu, T., Hu, Q., Yuan, Y., Yao, H., Zhang, J., & Qi, J. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1067732 · Cited by 12
Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria
Xu, W. Q., & Li, X. (2023) · Molecules · doi:10.3390/molecules28114432 · Cited by 11

Authors: Chan, D. C.
Affiliations: California Institute of Technology (US)
Corresponding author: Chan, David C.
ORCID: Chan, David C.
Venue: Annual Review of Genetics
Publisher: Annual Reviews
Published: 2012-12-15
Volume: 46
Issue: 1
Pages: 265-287
ISSN: 0066-4197 (ISSN-L)
1545-2948
DOI: 10.1146/annurev-genet-110410-132529
OpenAlex: W2157334943
Cited by: 1,196
References: 141
Citations by year: 2026: 56 · 2025: 45 · 2024: 73 · 2023: 97 · 2022: 94 · 2021: 109 · 2020: 110 · 2019: 102 · 2018: 96 · 2017: 93 · 2016: 89 · 2015: 100 · 2014: 76 · 2013: 53 · 2012: 2
FWCI: 3.80
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Genetics (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of General Medical Sciences (R01GM062967, GM083121, GM062967, R01GM083121)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: mitochondrial fusion, mitochondrial fission, mitochondrial dynamics, mitochondrial morphology, mitochondrial DNA stability, respiratory capacity, apoptosis, cellular stress response, mitophagy, mitochondrial disease
MeSH terms: Animals, DNA, Mitochondrial, Humans, Membrane Proteins, Mitochondria, Mitosis, Mutation, Apoptosis, GTP Phosphohydrolases, Mitochondrial Diseases, Dynamins, Mitochondrial Membranes, Mice, Mitochondrial Size, Mitochondrial Turnover

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks