Cited by 2,309Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

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The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

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Merad, Miriam, Sathe, Priyanka, Helft, Julie, Miller, Jennifer, Mortha, Arthur·2013·Annual Review of Immunology

DOI 10.1146/annurev-immunol-020711-074950PMC PMC3853342

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Abstract

Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.

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Authors: Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A.
Affiliations: Department of Oncological Sciences,
ORCID: Helft, Julie
Mortha, Arthur
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2013-03-21
Volume: 31
Issue: 1
Pages: 563-604
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-020711-074950
PMC: PMC3853342
OpenAlex: W2168028214
Cited by: 2,309
References: 302
Citations by year: 2026: 78 · 2025: 106 · 2024: 150 · 2023: 157 · 2022: 187 · 2021: 209 · 2020: 232 · 2019: 225 · 2018: 209 · 2017: 192 · 2016: 187 · 2015: 172 · 2014: 150 · 2013: 54
FWCI: 16.37
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA173861)
National Institute of Allergy and Infectious Diseases (U01AI095611)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: dendritic cells, dendritic cell lineage, hematopoietic lineage, dendritic cell differentiation, dendritic cell subsets, steady-state immunity, inflammation, adaptive immune response
MeSH terms: Animals, Cell Differentiation, Cell Movement, Dendritic Cells, Humans, Inflammation, Lymphoid Tissue, Inflammation Mediators, Cell Lineage

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The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

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