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The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting
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Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
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“STAT3 also plays major roles in immature DC development and function”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Merad et al., 2013
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Metadata
- Authors
- Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A.
- Affiliations
- Department of Oncological Sciences,
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2013-03-21
- Volume
- 31
- Issue
- 1
- Pages
- 563-604
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- PMC
- PMC3853342
- OpenAlex
- W2168028214
- Cited by
- 2,309
- References
- 302
- Citations by year
- 2026: 78 · 2025: 106 · 2024: 150 · 2023: 157 · 2022: 187 · 2021: 209 · 2020: 232 · 2019: 225 · 2018: 209 · 2017: 192 · 2016: 187 · 2015: 172 · 2014: 150 · 2013: 54
- FWCI
- 16.37
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA173861)
- National Institute of Allergy and Infectious Diseases (U01AI095611)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- dendritic cells, dendritic cell lineage, hematopoietic lineage, dendritic cell differentiation, dendritic cell subsets, steady-state immunity, inflammation, adaptive immune response
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Dendritic Cells, Humans, Inflammation, Lymphoid Tissue, Inflammation Mediators, Cell Lineage
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