An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

C-reactive protein: a critical update

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C-reactive protein: a critical update

Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318921 · Cited by 3,436

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

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Serum amyloid A, the major vertebrate acute‐phase reactant

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Immunoregulatory functions of surfactant proteins

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PENTRAXINS AT THE CROSSROADS BETWEEN INNATE IMMUNITY, INFLAMMATION, MATRIX DEPOSITION, AND FEMALE FERTILITY

Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115756 · Cited by 842

Genetically elevated C-reactive protein and ischemic vascular disease

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Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense

Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762

Complement evasion by human pathogens

Lambris, J. D., Ricklin, D., & Geisbrecht, B. V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1824 · Cited by 720

Evolution of the lectin–complement pathway and its role in innate immunity

Fujita, T. (2002) · Nature reviews. Immunology · doi:10.1038/nri800 · Cited by 697

Human Pentraxin 3 Binds to the Complement Regulator C4b-Binding Protein

Braunschweig, A., & Józsi, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023991 · Cited by 71

The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling

Inforzato, A., Jaillon, S., Moalli, F., Barbati, E., Bonavita, E., Bottazzi, B., Mantovani, A., & Garlanda, C. (2011) · Tissue Antigens · doi:10.1111/j.1399-0039.2011.01645.x · Cited by 70

C-Reactive Protein and Coronary Heart Disease: All Said—Is Not It?

Strang, F., & Schunkert, H. (2014) · Mediators of Inflammation · doi:10.1155/2014/757123 · Cited by 72

Elevated Pentraxin 3 in bone metastatic breast cancer is correlated with osteolytic function

Choi, B., Lee, E. J., Song, D., Yoon, S. C., Chung, Y., Jang, Y., Kim, S., Song, Y., Kang, S., Yoon, S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1664 · Cited by 68

Constitutive Expression of Pentraxin 3 (PTX3) Protein by Human Amniotic Membrane Cells Leads to Formation of the Heavy Chain (HC)-Hyaluronan (HA)-PTX3 Complex

Zhang, S., Zhu, Y., Chen, S., He, H., & Tseng, S. C. G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.525287 · Cited by 69

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

Doni, A., Parente, R., Laface, I., Magrini, E. I., Cunha, C., Colombo, F., de Lacerda, J. F., Campos, A., Mapelli, S. N., Petroni, F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24021-y · Cited by 68

Role of C‐reactive protein in urological cancers: A useful biomarker for predicting outcomes

Saito, K., & Kihara, K. (2012) · International Journal of Urology · doi:10.1111/j.1442-2042.2012.03121.x · Cited by 67

Serum Inflammatory Mediators as Markers of Human Lyme Disease Activity

Soloski, M. J., Crowder, L. A., Lahey, L. J., Wagner, C. A., Robinson, W. H., & Aucott, J. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093243 · Cited by 73

Plasma PTX3 protein levels inversely correlate with insulin secretion and obesity, whereas visceral adipose tissue PTX3 gene expression is increased in obesity

Osorio-Conles, Ó., Guitart, M., Chacón, M. R., Maymó‐Masip, E., Moreno‐Navarrete, J. M., Montori-Grau, M., Näf, S., Fernández‐Real, J. M., Vendrell, J. J., & Gómez-Foix, A. M. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00163.2011 · Cited by 67

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti‐Inflammatory M2 State

Dugo, L., Belluomo, M. G., Fanali, C., Russo, M., Cacciola, F., Maccarrone, M., & Sardanelli, A. M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6293740 · Cited by 67

Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1‐integrin

Fossati, G., Pozzi, D., Canzi, A., Mirabella, F., Valentino, S., Morini, R., Ghirardini, E., Filipello, F., Moretti, M., Gotti, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201899529 · Cited by 67

Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients

Infante, M. V., Allavena, P., Garlanda, C., Nebuloni, M., Morenghi, E., Rahal, D., Roncalli, M. G., Cavuto, S., Pesce, S., Monari, M., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29822 · Cited by 65

The “sweet” side of a long pentraxin: how glycosylation affects PTX3 functions in innate immunity and inflammation

Inforzato, A., Reading, P. C., Barbati, E., Bottazzi, B., Garlanda, C., & Mantovani, A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00407 · Cited by 65

Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors

Clos, T. W. D., & Mold, C. (2010) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32834253c7 · Cited by 65

Pentraxin 3: A promising therapeutic target for autoimmune diseases

Wu, Q., Cao, F., Tao, J., Li, X., Zheng, S. G., & Pan, H. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102584 · Cited by 65

Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps

Daigo, K., & Hamakubo, T. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00378 · Cited by 64

Atypical Hemolytic Uremic Syndrome-Associated Variants and Autoantibodies Impair Binding of Factor H and Factor H-Related Protein 1 to Pentraxin 3

Kopp, A., Strobel, S., Tortajada, A., de Córdoba, S. R., Sánchez‐Corral, P., Prohászka, Z., López‐Trascasa, M., & Józsi, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200357 · Cited by 63

Cloaking Silica Nanoparticles with Functional Protein Coatings for Reduced Complement Activation and Cellular Uptake

Park, J. H., Jackman, J. A., Ferhan, A. R., Belling, J. N., Mokrzecka, N., Weiss, P. S., & Cho, N. (2020) · ACS Nano · doi:10.1021/acsnano.0c05097 · Cited by 63

The long pentraxin PTX 3: A prototypical sensor of tissue injury and a regulator of homeostasis

Erreni, M., Manfredi, A. A., Garlanda, C., Mantovani, A., & Rovere, P. Q. (2017) · Immunological Reviews · doi:10.1111/imr.12570 · Cited by 61

PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition

Garlanda, C., Jaillon, S., Doni, A., Bottazzi, B., & Mantovani, A. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.11.002 · Cited by 60

Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?

Foo, S., Reading, P. C., Jaillon, S., Mantovani, A., & Mahalingam, S. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.09.006 · Cited by 60

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

Sánchez‐Corral, P., Pouw, R. B., López‐Trascasa, M., & Józsi, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01607 · Cited by 58

Role of Mesenchymal Stem Cells and Their Paracrine Mediators in Macrophage Polarization: An Approach to Reduce Inflammation in Osteoarthritis

Kuppa, S. S., Kim, H. K., Kang, J. Y., Lee, S. C., & Seon, J. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113016 · Cited by 64

Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels

Barbati, E., Specchia, C., Villella, M., Rossi, M. L., Barlera, S., Bottazzi, B., Crociati, L., d’Arienzo, C., Fanelli, R., Garlanda, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053030 · Cited by 59

Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice

Han, B., Ma, X., Zhang, J., Zhang, Y., Bai, X., Hwang, D. M., Keshavjee, S. H., Levy, G. A., McGilvray, I. D., & Liu, M. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.92 · Cited by 58

The Proteomic Profile of Circulating Pentraxin 3 (PTX3) Complex in Sepsis Demonstrates the Interaction with Azurocidin 1 and Other Components of Neutrophil Extracellular Traps

Daigo, K., Yamaguchi, N., Kawamura, T., Matsubara, K., Jiang, S., Ohashi, R., Sudou, Y., Kodama, T., Naito, M., Inoue, K., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.015073 · Cited by 58

The Influence of Pentraxin 3 on the Ovarian Function and Its Impact on Fertility

Camaioni, A., Klinger, F. G., Campagnolo, L., & Salustri, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02808 · Cited by 57

Pentraxins in Humoral Innate Immunity

Inforzato, A., Bottazzi, B., Garlanda, C., Valentino, S., & Mantovani, A. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_1 · Cited by 56

Inverse Relationship between the Inflammatory Marker Pentraxin-3, Fat Body Mass, and Abdominal Obesity in End-Stage Renal Disease

Miyamoto, T., Qureshi, A. R., Heimbürger, O., Barany, P. F., Carrero, K., Sjöberg, B., Lindholm, B., Stenvinkel, P., & Carrero, J. J. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02320311 · Cited by 56

Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer

Rubino, M., Kunderfranco, P., Basso, G., Greco, C. M., Pasqualini, F., Serio, S., Roncalli, M. G., Laghi, L., Mantovani, A., Papait, R., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1333215 · Cited by 57

Nutrients, Bioactive Compounds and Bioactivity: The Health Benefits of Sweet Cherries (Prunus avium L.)

Gonçalves, A. C., Bento, C., Silva, B. M., Simões, M. V., & Silva, L. R. (2017) · Current Nutrition & Food Science · doi:10.2174/1573401313666170925154707 · Cited by 59

Types of acute phase reactants and their importance in vaccination (Review)

Khalil, R., & Al-Humadi, N. H. (2020) · Biomedical Reports · doi:10.3892/br.2020.1276 · Cited by 56

PTX3 Binds MD-2 and Promotes TRIF-Dependent Immune Protection in Aspergillosis

Bozza, S., Campo, S., Arseni, B., Inforzato, A., Lindstedt, R., Bottazzi, B., Mantovani, A., Moretti, S., Oikonomou, V., Santis, R. D., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400814 · Cited by 54

C-Reactive Protein Directly Suppresses Th1 Cell Differentiation and Alleviates Experimental Autoimmune Encephalomyelitis

Zhang, L., Liu, S., Wright, T. T., Shen, Z.-Y., Li, H., Zhu, W., Potempa, L. A., Ji, S., Szalai, A. J., & Wu, Y. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402909 · Cited by 54

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation

Csincsi, Á. I., Szabó, Z., Bánlaki, Z., Uzonyi, B., Cserhalmi, M., Kárpáti, É., Tortajada, A., Caesar, J. J. E., Prohászka, Z., Jokiranta, T. S., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600483 · Cited by 54

Cuminaldehyde as a Lipoxygenase Inhibitor: In Vitro and In Silico Validation

Tomy, M. J., Dileep, K. V., Prasanth, S., Preethidan, D. S., Abdulhameed, S., Sadasivan, C., & Haridas, M. (2014) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-014-1066-0 · Cited by 52

Combatting infectious diseases; nanotechnology as a platform for rational vaccine design

van Riet, E., Ainai, A., Suzuki, T., Kersten, G. F. A., & Hasegawa, H. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.011 · Cited by 53

Innate immunity, hemostasis and matrix remodeling: PTX3 as a link

Doni, A., Garlanda, C., & Mantovani, A. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.012 · Cited by 54

Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”: Napoli, December 3rd–6th 2014

Ascierto, P. A., Atkins, M. B., Bifulco, C. B., Botti, G., Cochran, A. J., Davies, M. A., Demaria, S., Dummer, R., Ferrone, S., Formenti, S. C., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0736-1 · Cited by 53

The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair

Grčević, D., Sironi, M., Valentino, S., Deban, L., Cvija, H., Inforzato, A., Kovačić, N., Katavić, V., Kelava, T., Kalajzić, I., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00417 · Cited by 52

Mannose-Binding Lectin Is Expressed After Clinical and Experimental Traumatic Brain Injury and Its Deletion Is Protective*

Longhi, L. G., Orsini, F., Blasio, D. D., Fumagalli, S., Ortolano, F., Locatelli, M., Stocchetti, N., & Simoni, M. G. D. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000399 · Cited by 51

Plasma Pentraxin 3 is a More Potent Predictor of Endothelial Dysfunction than High-Sensitive C-Reactive Protein

Yasunaga, T., Ikeda, S., Koga, S., Nakata, T., Yoshida, T., Masuda, N., Kohno, S., & Maemura, K. (2014) · International Heart Journal · doi:10.1536/ihj.13-253 · Cited by 49

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

Daigo, K., Nakakido, M., Ohashi, R., Fukuda, R., Matsubara, K., Minami, T., Yamaguchi, N., Inoue, K., Jiang, S., Naito, M., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005522 · Cited by 53

Reg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut

Qi, H., Wei, J., Gao, Y., Yang, Y., Li, Y., Zhu, H., Su, L., Su, L., Zhang, Y., & Yang, R. (2020) · Communications Biology · doi:10.1038/s42003-020-01219-2 · Cited by 49

Hospital Mortality of Patients with Severe Traumatic Brain Injury is Associated with Serum PTX3 Levels

Gullo, J. D. S., Bertotti, M. M., Silva, C. C. P., Schwarzbold, M. L., Díaz, A. P., Soares, F. M. S., Freitas, F. C., Nunes, J. C., Pinheiro, J. T., Morato, E. F., et al. (2010) · Neurocritical Care · doi:10.1007/s12028-010-9462-y · Cited by 47

Pentraxin 3 Inhibits Acute Renal Injury-Induced Interstitial Fibrosis Through Suppression of IL-6/Stat3 Pathway

Xiao, Y.-F., Yang, N., Zhang, Q., Wang, Y., Yang, S., & Liu, Z. (2014) · Inflammation · doi:10.1007/s10753-014-9921-2 · Cited by 47

Circulating Inflammatory Mediators as Potential Prognostic Markers of Human Colorectal Cancer

Caro, G. D., Carvello, M., Pesce, S., Erreni, M., Marchesi, F., Todoric, J., Sacchi, M. M., Montorsi, M., Allavena, P., & Spinelli, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148186 · Cited by 47

Surface topography and hydrophilicity regulate macrophage phenotype in milled microfluidic systems

Kosoff, D., Yu, J., Suresh, V., Beebe, D. J., & Lang, J. M. (2018) · Lab on a Chip · doi:10.1039/c8lc00431e · Cited by 48

Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury

Tang, Y., Yang, X., Shu, H., Yuan, Y. L., Pan, S., Xu, J., & Shang, Y. (2021) · Hereditas · doi:10.1186/s41065-021-00176-y · Cited by 47

Chimeric calicivirus-like particles elicit specific immune responses in pigs

Crisci, E., Fraile, L. J., Moreno, N., Blanco, E., Cabezón, R., Costa, C., Mussá, T., Baratelli, M., Martínez-Orellana, P., Ganges, L., et al. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.069 · Cited by 46

The role of platelets in the pathogenesis of systemic sclerosis

Ramirez, G. A., Franchini, S., Rovere, P. Q., Sabbadini, M. G., Manfredi, A. A., & Maugeri, N. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00160 · Cited by 46

Exenatide improves ovarian and endometrial injury and preserves ovarian reserve in streptozocin induced diabetic rats

Artunc-Ulkumen, B., Pala, H. G., Pala, E. E., Yavasoglu, A., Yigitturk, G., & Erbas, O. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2014.975686 · Cited by 45

Complement activation in cancer: Effects on tumor-associated myeloid cells and immunosuppression

Magrini, E. I., Minute, L., Dambra, M., & Garlanda, C. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101642 · Cited by 47

Belimumab or anifrolumab for systemic lupus erythematosus? A risk-benefit assessment

Kirou, K. A., Dall’Era, M., Aranow, C. B., & Anders, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.980079 · Cited by 48

CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection

Wang, T., & Sun, L. (2015) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.10.002 · Cited by 45

Lack of the Long Pentraxin PTX3 Promotes Autoimmune Lung Disease but not Glomerulonephritis in Murine Systemic Lupus Erythematosus

Lech, M., Römmele, C., Kulkarni, O. P., Susanti, H. E., Migliorini, A., Garlanda, C., Mantovani, A., & Anders, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020118 · Cited by 45

The Long Pentraxin PTX3 Promotes Fibrocyte Differentiation

Pilling, D., Cox, N., Vakil, V., Verbeek, J. S., & Gomer, R. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119709 · Cited by 44

Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis

Gori, A. M., Giusti, B., Piccardi, B., Nencini, P., Palumbo, V., Nesi, M., Nucera, A., Pracucci, G., Tonelli, P., Innocenti, E., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17695572 · Cited by 49

Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands

Pilling, D., Galvis-Carvajal, E., Karhadkar, T. R., Cox, N., & Gomer, R. H. (2017) · BMC Immunology · doi:10.1186/s12865-017-0214-z · Cited by 44

The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis

Kobayashi, H., Yamashita, Y., Iwase, A., Yoshikawa, Y., Yasui, H., Kawai, Y., Uchida, K., Uno, N., Akatsuka, S., Takahashi, T., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.04.047 · Cited by 44

Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice

Kovács, R. Á., Vadászi, H., Bulyáki, É., Török, G., Tóth, V., Mátyás, D., Kun, J., Hunyadi-Gulyás, É., Fedor, F. Z., Csincsi, Á., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599771 · Cited by 43

Redox State of Pentraxin 3 as a Novel Biomarker for Resolution of Inflammation and Survival in Sepsis

Cuello, F., Shankar‐Hari, M., Mayr, U., Yin, X., Marshall, M. J., Suna, G., Willeit, P., Langley, S. R., Jayawardhana, T., Zeller, T., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.039446 · Cited by 43

Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury

Blasio, D. D., Fumagalli, S., Longhi, L. G., Orsini, F., Palmioli, A., Stravalaci, M., Vegliante, G., Zanier, E. R., Bernardi, A., Gobbi, M., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16647397 · Cited by 43

The Protective Effect against Extracellular Histones Afforded by Long-Pentraxin PTX3 as a Regulator of NETs

Daigo, K., Takamatsu, Y., & Hamakubo, T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00344 · Cited by 43

Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis

Hung, T., Tsai, J., Lin, S., Lee, C.-H., Hsieh, Y., & Chang, H. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000453159 · Cited by 43

Role of C-reactive protein as a biomarker for renal cell carcinoma

Saito, K., & Kihara, K. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.192 · Cited by 41

The Secretome Derived From Mesenchymal Stromal Cells Cultured in a Xeno-Free Medium Promotes Human Cartilage Recovery in vitro

Palamà, M. E. F., Shaw, G., Carluccio, S., Reverberi, D., Sercia, L., Persano, L., Pisignano, D., Cortese, K., Fp, B., Murphy, J. M., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00090 · Cited by 41

The innate immune system in transplantation

Oberbarnscheidt, M. H., Zecher, D., & Lakkis, F. G. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.06.006 · Cited by 41

Goodpasture Antigen-binding Protein/Ceramide Transporter Binds to Human Serum Amyloid P-Component and Is Present in Brain Amyloid Plaques

Mencarelli, C., Bode, G. H., Losen, M. H., Kulharia, M., Molenaar, P. C., Veerhuis, R., Steinbusch, H. W. M., Baets, M. H. D., Nicolaes, G. A. F., & Martínez‐Martínez, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.299545 · Cited by 40

Biology of Human Pentraxin 3 (PTX3) in Acute and Chronic Kidney Disease

Speeckaert, M. M., Speeckaert, R., Carrero, J. J., Vanholder, R. C., & Delanghe, J. (2013) · Journal of Clinical Immunology · doi:10.1007/s10875-013-9879-0 · Cited by 40

Hyaluronan interactions with innate immunity in lung biology

Tighe, R. M., & Garantziotis, S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.027 · Cited by 40

Genome-wide association analysis on host resistance against the rotten body disease in a naturally infected population of large yellow croaker Larimichthys crocea

Zhang, Z. X., Wang, Z. Y., Fang, M., Ye, K., Tang, X., & Zhang, D. L. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737615 · Cited by 40

Modulation of Voltage-Dependent and Inward Rectifier Potassium Channels by 15-Epi-Lipoxin-A4 in Activated Murine Macrophages: Implications in Innate Immunity

Moreno, C., Prieto, P., Macías, Á., Pimentel-Santillana, M., de la Cruz, A., Través, P. G., Boscá, L., & Valenzuela, C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300235 · Cited by 40

C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation

Li, H.-Y., Tang, Z.-M., Wang, Z., Lv, J.-M., Liu, X.-L., Liang, Y.-L., Cheng, B., Gao, N., Ji, S.-R., & Wu, Y. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.09.003 · Cited by 39

Pentraxin 3 (PTX3) plasma levels and carotid intima media thickness progression in the general population

Baragetti, A., Knoflach, M., Cuccovillo, I., Grigore, L., Casula, M., Garlaschelli, K., Mantovani, A., Wick, G., Kiechl, S. J., Willeit, J., et al. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.10.030 · Cited by 39

Predicting atrial fibrillation recurrence with circulating inflammatory markers in patients in sinus rhythm at high risk for atrial fibrillation: data from the GISSI atrial fibrillation trial

Masson, S., Aleksova, A., Favero, C., Staszewsky, L. I., Bernardinangeli, M., Belvito, C., Cioffi, G., Sinagra, G., Mazzone, C., Bertocchi, F., et al. (2010) · Heart · doi:10.1136/hrt.2009.191460 · Cited by 39

Levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis

Tekeoğlu, İ., Harman, H., Sağ, S., Altındiş, M., Kamanlı, A., & Nas, K. (2016) · Cytokine · doi:10.1016/j.cyto.2016.04.009 · Cited by 39

Serum Visfatin, Fetuin‐A, and Pentraxin 3 Levels in Patients With Psoriasis and Their Relation to Disease Severity

Okan, G., Baki, A. M., Yorulmaz, E., Doğru‐Abbasoğlu, S., & Vural, P. (2015) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21850 · Cited by 39

An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation

Ma, Y. J., Lee, B. L., & Garred, P. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.51 · Cited by 38

Detection of Anti-Pentraxin-3 Autoantibodies in ANCA-Associated Vasculitis

Simon, A., Subra, J., Guilpain, P., Jeannin, P., Pignon, P., Blanchard, S., Garo, E., Jaillon, S., Chevailler, A., Rénier, G., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147091 · Cited by 38

Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation

Foo, S., Chen, W., Taylor, A., Sheng, K., Yu, X., Teng, T., Reading, P. C., Blanchard, H., Garlanda, C., Mantovani, A., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004649 · Cited by 37

Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces

Smole, U., Kratzer, B., & Pickl, W. F. (2020) · European Journal of Immunology · doi:10.1002/eji.201847811 · Cited by 37

Genomic features of humoral immunity support tolerance model in Egyptian rousette bats

Larson, P. A., Bartlett, M. L., Garcia, K. Y., Chitty, J. A., Balkema‐Buschmann, A., Towner, J. S., Kugelman, J. R., Palacios, G. F., & Sánchez-Lockhart, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109140 · Cited by 37

Long Pentraxin PTX3 Exacerbates Pressure Overload–Induced Left Ventricular Dysfunction

Suzuki, S., Shishido, T., Funayama, A., Netsu, S., Ishino, M., Kitahara, T., Sasaki, T., Katoh, S., Otaki, Y., Watanabe, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053133 · Cited by 37

C-Reactive Protein: The Most Familiar Stranger

Ji, S., Zhang, S.-H., Chang, Y., Li, H., Wang, M., Lv, J., Zhu, L., Tang, P. M., & Wu, Y. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200831 · Cited by 36

Inflammatory biomarkers to predict the prognosis of acute bacterial and viral infections

de Nooijer, A., Pickkers, P., Netea, M. G., & Kox, M. (2023) · Journal of Critical Care · doi:10.1016/j.jcrc.2023.154360 · Cited by 35

New and Emerging Biomarkers in Left Ventricular Systolic Dysfunction—Insight into Dilated Cardiomyopathy

Gopal, D. M., & Sam, F. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9462-3 · Cited by 35

Plasma Pentraxin 3 Differentiates Nonalcoholic Steatohepatitis (NASH) from Non-NASH

Boğa, S., Köksal, A. R., Alkım, H., Ozguven, M. B. Y., Bayram, M., Ergün, M., Şışman, G., Neijmann, S. T., & Alkım, C. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0046 · Cited by 35

C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques

Pilely, K., Fumagalli, S., Rosbjerg, A., Genster, N., Skjoedt, M., Perego, C., Ferrante, A. M. R., Simoni, M. G. D., & Garred, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01040 · Cited by 35

Effect of combined exercise training on pentraxins and pro- inflammatory cytokines in people with multiple sclerosis as a function of disability status

Faramarzi, M., Banitalebi, E., Raisi, Z., Samieyan, M., saberi, Z., Ghahfarrokhi, M. M., Negaresh, R., & Motl, R. W. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155196 · Cited by 35

Innate Humoral Defense Factors

Hajishengallis, G., & Russell, M. W. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00015-x · Cited by 39

Recognition of Neisseria meningitidis by the Long Pentraxin PTX3 and Its Role as an Endogenous Adjuvant

Bottazzi, B., Santini, L., Savino, S., Giuliani, M. M., Dı́ez, A. I. D., Mancuso, G., Beninati, C., Sironi, M., Valentino, S., Deban, L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120807 · Cited by 36

Regular Wine Consumption in Chronic Heart Failure

Cosmi, F., Giulio, P. D., Masson, S., Finzi, A., Marfisi, R. M., Cosmi, D., Scarano, M., Tognoni, G., Maggioni, A. P., Porcu, M., et al. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.002091 · Cited by 34

Pseudomonas aeruginosa GroEL Stimulates Production of PTX3 by Activating the NF-κB Pathway and Simultaneously Downregulating MicroRNA-9

Shin, H., Jeon, J., Lee, J., Jin, S., & Ha, U. (2016) · Infection and Immunity · doi:10.1128/iai.00935-16 · Cited by 34

Wandering pathways in the regulation of innate immunity and inflammation

Mantovani, A. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.10.007 · Cited by 34

Pentraxin 3: A promising therapeutic target for cardiovascular diseases

Ye, X., Wang, Z., Lei, W., Shen, M., Tang, J., Xu, X., Yang, Y., & Zhang, H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102163 · Cited by 33

Inactivation of pentraxin 3 suppresses M2-like macrophage activity and immunosuppression in colon cancer

Chen, F., Wu, Y.-L., Cheng, C., Hsiao, Y., Chi, J.-Y., Hung, L., Chang, C., Lai, M., & Wang, J. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-023-00991-7 · Cited by 34

A Single Amino Acid Substitution in the Hemagglutinin of H3N2 Subtype Influenza A Viruses Is Associated with Resistance to the Long Pentraxin PTX3 and Enhanced Virulence in Mice

Job, E. R., Bottazzi, B., Short, K. R., Deng, Y., Mantovani, A., Brööks, A. G., & Reading, P. C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301814 · Cited by 33

Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule

Vijayaraj, P., Minasyan, A., Durra, A., Karumbayaram, S., Mehrabi, M., Aros, C. J., Ahadome, S. D., Shia, D. W., Chung, K., Sandlin, J. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.019 · Cited by 34

Amelioration of Lupus Nephritis by Serum Amyloid P Component Gene Therapy with Distinct Mechanisms Varied from Different Stage of the Disease

Zhang, W., Wu, J. C., Qiao, B., Xu, W., & Xiong, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022659 · Cited by 32

Pentraxins in innate immunity: lessons from PTX3

Deban, L., Jaillon, S., Garlanda, C., Bottazzi, B., & Mantovani, A. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1018-0 · Cited by 159

Interplay between Myeloid Cells and Humoral Innate Immunity

Jaillon, S., Bonavita, E., Garlanda, C., & Mantovani, A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0051-2016 · Cited by 3

Pentraxins in Humoral Innate Immunity

Inforzato, A., Bottazzi, B., Garlanda, C., Valentino, S., & Mantovani, A. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_1 · Cited by 56

The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity

Bottazzi, B., Garlanda, C., Cotena, A., Moalli, F., Jaillon, S., Deban, L., & Mantovani, A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00719.x · Cited by 188

PTX3 as a paradigm for the interaction of pentraxins with the Complement system

Inforzato, A., Doni, A., Barajon, I., Leone, R., Garlanda, C., Bottazzi, B., & Mantovani, A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.05.002 · Cited by 91