Cited by 597Biomarkers in Disease MechanismsImmune Response and InflammationComplement system in diseases

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An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

Bottazzi, Barbara, Doni, Andrea, Garlanda, Cecilia, Mantovani, Alberto·2010·Annual Review of Immunology

DOI 10.1146/annurev-immunol-030409-101305

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Abstract

The innate immune system consists of a cellular and a humoral arm. Pentraxins (e.g., the short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the humoral arm of innate immunity which also includes complement components, collectins, and ficolins. In response to microorganisms and tissue damage, neutrophils, macrophages, and dendritic cells are major sources of fluid-phase pattern-recognition molecules (PRMs) belonging to different molecular classes. Humoral PRMs in turn interact with and regulate cellular effectors. Effector mechanisms of the humoral innate immune system include activation and regulation of the complement cascade; agglutination and neutralization; facilitation of recognition via cellular receptors (opsonization); and regulation of inflammation. Thus, the humoral arm of innate immunity is an integrated system consisting of different molecules and sharing functional outputs with antibodies.

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Authors: Bottazzi, B., Doni, A., Garlanda, C., & Mantovani, A.
Affiliations: IRCCS Humanitas Research Hospital (IT)
Laboratory for Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano (Milano) 20089, Italy;, ,
University of Milan (IT)
ORCID: Bottazzi, Barbara
Doni, Andrea
Mantovani, Alberto
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2010-03-01
Volume: 28
Issue: 1
Pages: 157-183
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-030409-101305
OpenAlex: W2160125610
Cited by: 592
References: 133
Citations by year: 2026: 11 · 2025: 27 · 2024: 34 · 2023: 32 · 2022: 44 · 2021: 42 · 2020: 40 · 2019: 35 · 2018: 28 · 2017: 36 · 2016: 48 · 2015: 38 · 2014: 45 · 2013: 45 · 2012: 30
FWCI: 2.28
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Keywords: pentraxins, C-reactive protein, pentraxin 3, pattern recognition molecules, complement system, collectins, ficolins, opsonization, agglutination, neutralization, inflammation regulation, immunoglobulins, neutrophils, macrophages, dendritic cells
MeSH terms: Animals, Antibodies, C-Reactive Protein, Humans, Immunity, Innate, Ligands, Immunity, Humoral

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An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

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