The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Plasmacytoid Dendritic Cells: Recent Progress and Open Questions
Open accessAbstract
Plasmacytoid dendritic cells (pDCs) are specialized in rapid and massive secretion of type I interferon (IFN-α/β) in response to foreign nucleic acids. Combined with their antigen presentation capacity, this powerful functionality enables pDCs to orchestrate innate and adaptive immune responses. pDCs combine features of both lymphocytes and classical dendritic cells and display unique molecular adaptations to nucleic acid sensing and IFN production. In the decade since the identification of the pDC as a distinct immune cell type, our understanding of its molecular underpinnings and role in immunity has progressed rapidly. Here we review select aspects of pDC biology including cell fate establishment and plasticity, specific molecular mechanisms of pDC function, and the role of pDCs in T cell responses, antiviral immunity, and autoimmune diseases. Important unresolved questions remain in these areas, promising exciting times in pDC research for years to come.
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Cites
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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
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Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Type I interferons in anticancer immunity
Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M. J., & Kroemer, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3845 · Cited by 1,305
Development and Function of Dendritic Cell Subsets
Mildner, A., & Jung, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.016 · Cited by 767
Mining the Human Gut Microbiota for Immunomodulatory Organisms
Geva-Zatorsky, N., Sefik, E., Kua, L., Pasman, L., Tan, T. G., Ortiz-Lopez, A., Yanortsang, T. B., Yang, L., Jupp, R., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.01.022 · Cited by 762
Metadata
- Authors
- Reizis, B., Bunin, A., Ghosh, H. S., Lewis, K. L., & Sisirak, V.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2011-04-23
- Volume
- 29
- Issue
- 1
- Pages
- 163-183
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2117053011
- Cited by
- 619
- References
- 9
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Reizis, B., Bunin, A., Ghosh, H. S., Lewis, K. L., & Sisirak, V. (2011). Plasmacytoid Dendritic Cells: Recent Progress and Open Questions. Annual Review of Immunology. https://doi.org/10.1146/annurev-immunol-031210-101345
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