The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

The regulation of IL-10 production by immune cells

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Innate lymphoid cells — a proposal for uniform nomenclature

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Mediator and cohesin connect gene expression and chromatin architecture

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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

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Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

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Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

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An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

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Innate IL-17-producing cells: the sentinels of the immune system

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

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Th17 cells in human disease

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Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor

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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

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The PAS Superfamily: Sensors of Environmental and Developmental Signals

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Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

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Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

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IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines

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Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.

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The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

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Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

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Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

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Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1

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Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles

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Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

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AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

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The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

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The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

Nguyen, L. P., & Bradfield, C. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 718

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

Nguyen, N. T., Kimura, A., Nakahama, T., Chinen, I., Masuda, K., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014465107 · Cited by 705

Loss of teratogenic response to 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) in mice lacking the Ah (dioxin) receptor

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Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology

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Identification of a novel mechanism of regulation of Ah (dioxin) receptor functionPreprint

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Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

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The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

Grenert, J. P., Sullivan, W. P., Fadden, P., Haystead, T., Clark, J., Mimnaugh, E. G., Krutzsch, H. C., Ochel, H.-J., Schulte, T. W., Sausville, E. A., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23843 · Cited by 568

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

Kimura, A., Naka, T., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804231105 · Cited by 561

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

Veldhoen, M., Hirota, K., Christensen, J. R., O’Garra, A., & Stockinger, B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081438 · Cited by 548

Transcriptional Regulation of NF-E2 p45-related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway

Miao, W., Hu, L., Scrivens, P. J., & Batist, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412081200 · Cited by 541

Association of the Ah receptor with the 90-kDa heat shock protein.

Perdew, G. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68314-0 · Cited by 517

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

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Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

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Diversity of murine gamma genes and expression in fetal and adult T lymphocytes

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Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

Qiu, J., Guo, X., Chen, Z. E., He, L., Sonnenberg, G. F., Artis, D., Fu, Y., & Zhou, L. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.002 · Cited by 431

Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo*

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Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

Kimura, A., Naka, T., Nakahama, T., Chinen, I., Masuda, K., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090560 · Cited by 426

Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity

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Diversity, rearrangement, and expression of murine T cell gamma genes

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Hepatitis B Virus X-Associated Protein 2 Is a Subunit of the Unliganded Aryl Hydrocarbon Receptor Core Complex and Exhibits Transcriptional Enhancer Activity

Meyer, B., Pray-Grant, M. G., Heuvel, J. P. V., & Perdew, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.978 · Cited by 390

Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice

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Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis

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The Multitasking Organ: Recent Insights into Skin Immune Function

Meglio, P. D., Perera, G. K., & Nestle, F. O. (2011) · Immunity · doi:10.1016/j.immuni.2011.12.003 · Cited by 370

A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals

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p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cellsPreprint

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Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.

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NRF2 Modulates Aryl Hydrocarbon Receptor Signaling: Influence on Adipogenesis

Shin, S., Wakabayashi, N., Misra, V., Biswal, S., Lee, G., Agoston, E., Yamamoto, M., & Kensler, T. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00915-07 · Cited by 355

Lesions of Aryl-hydrocarbon Receptor–deficient Mice

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Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries

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Ah receptor: Dioxin-mediated toxic responses as hints to deregulated physiologic functions

Bock, K. W., & Köhle, C. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.01.017 · Cited by 340

Recent advances in IL-22 biology

Zenewicz, L. A., & Flavell, R. A. (2011) · International Immunology · doi:10.1093/intimm/dxr001 · Cited by 340

Identification of Functional Domains of the Aryl Hydrocarbon Receptor

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RelB, a New Partner of Aryl Hydrocarbon Receptor-Mediated Transcription

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Aryl Hydrocarbon Receptor Imported into the Nucleus following Ligand Binding Is Rapidly Degraded via the Cytosplasmic Proteasome following Nuclear Export

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Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

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Analysis of the four alleles of the murine aryl hydrocarbon receptor

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Evidence That the Co-chaperone p23 Regulates Ligand Responsiveness of the Dioxin (Aryl Hydrocarbon) Receptor

Kazlauskas, A., Poellinger, L., & Pongratz, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13519 · Cited by 302

Estrogen Receptors in Immunity and Autoimmunity

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The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans

Wincent, E., Amini, N., Luecke-Johansson, S., Glatt, H. R., Bergman, J., Crescenzi, C., Rannug, A., & Rannug, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808321200 · Cited by 288

Novel Compound 2-Methyl-2H-pyrazole-3-carboxylic Acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) Prevents 2,3,7,8-TCDD-Induced Toxicity by Antagonizing the Aryl Hydrocarbon Receptor

Kim, S., Henry, E. C., Kim, D., Kim, Y., Shin, K. J., Han, M. S., Lee, T. G., Kang, J., Gasiewicz, T. A., Ryu, S. H., et al. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.021832 · Cited by 287

Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family

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Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

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The Aromatic Hydrocarbon Receptor Modulates the Hepa 1c1c7 Cell Cycle and Differentiated State Independently of Dioxin

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Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

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An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI

Okey, A. B. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm096 · Cited by 264

A ligand for the aryl hydrocarbon receptor isolated from lung

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Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues

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Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity.

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Constitutive Activation of the Aromatic Hydrocarbon Receptor

Chang, C., & Puga, A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.525 · Cited by 245

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

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Characterization of the AhR−hsp90−XAP2 Core Complex and the Role of the Immunophilin-Related Protein XAP2 in AhR Stabilization

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Recruitment of the NCoA/SRC-1/p160 Family of Transcriptional Coactivators by the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Complex

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Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor

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Recent advances in understanding the mechanisms of TCDD immunotoxicity

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The hsp90 Chaperone Complex Regulates Intracellular Localization of the Dioxin Receptor

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Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences

Sun, Y., Boverhof, D. R., Burgoon, L. D., Fielden, M. R., & Zacharewski, T. R. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh782 · Cited by 201

Structure and Expression of the Ah Receptor Repressor Gene

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Role of the aryl hydrocarbon receptor in cell cycle regulation

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External influences on the immune system via activation of the aryl hydrocarbon receptor

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Epidermal T Cells and Wound Healing

Havran, W. L., & Jameson, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902733 · Cited by 187

The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems

McMillan, B. J., & Bradfield, C. A. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.037259 · Cited by 183

The Immunophilin-like Protein XAP2 Regulates Ubiquitination and Subcellular Localization of the Dioxin Receptor

Kazlauskas, A., Poellinger, L., & Pongratz, I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007765200 · Cited by 177

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