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Cited by 99Advanced Fluorescence Microscopy TechniquesNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Fluorescence Imaging of Neural Activity, Neurochemical Dynamics, and Drug-Specific Receptor Conformation with Genetically Encoded Sensors

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Dong, Chunyang, Zheng, Yu, Long-Iyer, Kiran, Wright, Emily C., Li, Yulong, Tian, Lin·2022·Annual Review of Neuroscience
DOI 10.1146/annurev-neuro-110520-031137PMC PMC9940643
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Abstract

Recent advances in fluorescence imaging permit large-scale recording of neural activity and dynamics of neurochemical release with unprecedented resolution in behaving animals. Calcium imaging with highly optimized genetically encoded indicators provides a mesoscopic view of neural activity from genetically defined populations at cellular and subcellular resolutions. Rigorously improved voltage sensors and microscopy allow for robust spike imaging of populational neurons in various brain regions. In addition, recent protein engineering efforts in the past few years have led to the development of sensors for neurotransmitters and neuromodulators. Here, we discuss the development and applications of these genetically encoded fluorescent indicators in reporting neural activity in response to various behaviors in different biological systems as well as in drug discovery. We also report a simple model to guide sensor selection and optimization.

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Research works printed but not linked: 100

  1. 10.1126/science.aav6416 · DOI
  2. 10.3389/fnmol.2013.00002 · DOI
  3. 10.1016/j.cobme.2019.09.008 · DOI
  4. 10.1073/pnas.96.20.11241 · DOI
  5. Borden PM, Zhang P, Shivange AV, Marvin JS, Cichon J, et al. 2020. A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies. bioRxiv 2020.02.07.939504. https://doi.org/10.1101/2020.02.07.939504 · DOI
  6. 10.1007/978-1-62703-601-6_23 · DOI
  7. 10.1038/s41593-018-0211-4 · DOI
  8. 10.1038/s41586-020-3008-z · DOI · Paper page
  9. 10.1016/j.neuron.2020.05.005 · DOI
  10. 10.1016/j.celrep.2021.109465 · DOI
  11. Dalangin R, Drobizhev M, Molina RS, Aggarwal A, Patel R, et al. 2020. Far-red fluorescent genetically encoded calcium ion indicators. bioRxiv 2020.11.12.380089. https://doi.org/10.1101/2020.11.12.380089 · DOI
  12. 10.7554/eLife.12727 · DOI
  13. 10.1038/s41592-019-0435-6 · DOI
  14. Dong A, He K, Dudok B, Farrell JS, Guan W, et al. 2021. A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo. Nat. Biotechnol. In press · DOI
  15. 10.1016/j.cell.2021.03.043 · DOI · Paper page
  16. 10.1074/jbc.M103049200 · DOI
  17. 10.1016/j.chembiol.2020.02.004 · DOI
  18. 10.1016/j.neuron.2021.05.026 · DOI
  19. 10.1016/j.neuron.2019.02.037 · DOI · Paper page
  20. 10.1126/science.aab0810 · DOI · Paper page
  21. 10.1016/j.neuron.2012.02.011 · DOI
  22. 10.3389/fnins.2021.644313 · DOI
  23. 10.1016/j.cell.2014.05.017 · DOI · Paper page
  24. 10.1038/nrd.2017.178 · DOI
  25. 10.1073/pnas.1720648115 · DOI
  26. 10.1039/C7RA11347A · DOI
  27. 10.1016/j.cell.2019.04.007 · DOI
  28. 10.1016/j.neuron.2012.06.040 · DOI
  29. 10.1038/s41592-020-0953-2 · DOI · Paper page
  30. 10.1038/nbt.4184 · DOI
  31. 10.1016/j.celrep.2021.109284 · DOI
  32. 10.1124/jpet.105.100172 · DOI
  33. 10.5625/lar.2018.34.4.147 · DOI
  34. 10.1016/j.cell.2019.05.022 · DOI · Paper page
  35. 10.1038/s41583-019-0231-4 · DOI
  36. Kovacs GL., 2004, EJIFCC, 15, 107
  37. 10.1038/nmeth.1782 · DOI
  38. 10.1038/sj.gt.3301905 · DOI
  39. 10.1126/sciadv.abb7438 · DOI
  40. 10.1016/j.yhbeh.2006.06.028 · DOI · Paper page
  41. 10.1038/s41467-019-08441-5 · DOI
  42. 10.1038/nmeth.1243 · DOI · Paper page
  43. 10.1038/nmeth.2333 · DOI
  44. 10.1038/s41592-018-0171-3 · DOI
  45. 10.1038/s41592-019-0471-2 · DOI
  46. 10.1021/acs.analchem.9b00447 · DOI
  47. 10.1038/42264 · DOI
  48. 10.1038/s41586-019-1235-y · DOI
  49. 10.1002/0471142301.ns0705s52 · DOI
  50. 10.1038/nature03352 · DOI · Paper page
  51. 10.1016/j.conb.2014.05.003 · DOI
  52. 10.1073/pnas.051636098 · DOI
  53. 10.1073/pnas.0400417101 · DOI · Paper page
  54. 10.1038/84397 · DOI
  55. 10.1038/s41434-020-0169-1 · DOI · Paper page
  56. 10.1038/s41589-020-0535-8 · DOI
  57. 10.1016/j.cbpa.2020.07.006 · DOI
  58. 10.1016/j.chembiol.2006.03.007 · DOI
  59. 10.3389/fncel.2019.00052 · DOI
  60. 10.1126/science.aat4422 · DOI
  61. 10.1038/s41592-020-0936-3 · DOI
  62. 10.1126/science.abb0556 · DOI
  63. 10.1038/s41589-018-0004-9 · DOI
  64. 10.1371/journal.pbio.3000965 · DOI
  65. 10.1038/s41592-018-0294-6 · DOI
  66. 10.1111/j.1365-2958.1996.tb02484.x · DOI
  67. 10.1016/j.brainres.2007.01.125 · DOI
  68. 10.1016/j.neuron.2020.09.036 · DOI · Paper page
  69. 10.1016/j.celrep.2015.10.050 · DOI
  70. 10.7554/eLife.16178 · DOI
  71. 10.1146/annurev-biochem-060614-034411 · DOI
  72. 10.1038/s41587-020-0710-1 · DOI
  73. 10.1186/s12915-018-0480-0 · DOI
  74. 10.1085/jgp.201812201 · DOI
  75. 10.1016/j.tips.2012.03.007 · DOI
  76. 10.1038/nrd.2017.229 · DOI
  77. 10.1038/nn.3709 · DOI
  78. 10.1016/j.cell.2018.06.042 · DOI · Paper page
  79. 10.1038/s41592-020-00981-9 · DOI
  80. 10.1073/pnas.1516579113 · DOI
  81. Tai F, 2001, Acta Theriol. Sin., 21, 50
  82. Tai F, 2001, Acta Zool. Sin., 47, 260
  83. 10.1038/s41586-018-0636-7 · DOI
  84. 10.1038/nmeth.1398 · DOI · Paper page
  85. 10.2174/138161209789824803 · DOI
  86. 10.1016/j.cell.2020.11.040 · DOI
  87. 10.1016/j.cell.2019.11.004 · DOI
  88. 10.1038/s41593-021-00823-7 · DOI · Paper page
  89. 10.1016/j.conb.2018.03.010 · DOI · Paper page
  90. 10.1038/s41589-018-0207-0 · DOI
  91. 10.1016/j.brainres.2013.04.042 · DOI
  92. 10.1016/j.molmed.2010.11.004 · DOI
  93. 10.1111/ejn.14628 · DOI · Paper page
  94. 10.1021/acschembio.7b01085 · DOI
  95. 10.1016/j.cell.2016.05.031 · DOI
  96. 10.14348/molcells.2015.0263 · DOI
  97. 10.1002/cpns.56 · DOI
  98. 10.1101/2021.11.08.467793 · DOI
  99. 10.1126/science.1208592 · DOI
  100. 10.1016/j.conb.2015.04.001 · DOI

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Metadata

Authors
Dong, C., Zheng, Y., Long-Iyer, K., Wright, E. C., Li, Y., & Tian, L.
Affiliations
  • University of California, Davis (US)
  • Peking University (CN)
Corresponding author
  • Li, Yulong
  • Tian, Lin
ORCID
Venue
Annual Review of Neuroscience
Publisher
Annual Reviews
Published
2022-07-08
Volume
45
Issue
1
Pages
273-294
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
DOI
10.1146/annurev-neuro-110520-031137
PMC
PMC9940643
OpenAlex
W4220839458
Cited by
99
References
11
Citations by year
2026: 19 · 2025: 29 · 2024: 26 · 2023: 20 · 2022: 5
FWCI
3.08
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (1uf1mh128336-01)
  • National Science Fund for Distinguished Young Scholars
  • National Institute of Mental Health (R01MH101214, UF1 MH128336, T32MH112507)
  • National Eye Institute (R21EY031858)
  • National Institute of Neurological Disorders and Stroke (U01NS120820, U01NS113295, R01NS129888)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
genetically encoded fluorescent indicators, calcium imaging, neural recording, voltage sensor, drug discovery, behaving animals
MeSH terms
Animals, Brain, Neurons, Receptors, Drug, Neurotransmitter Agents, Optical Imaging

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