Parkinson’s disease: genetics and pathogenesis

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240

Parkinson's Disease

Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium

McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914

α-Synuclein Locus Triplication Causes Parkinson's Disease

Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836

Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease

Xu, J., Minobe, E., & Kameyama, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.867385 · Cited by 20

Modelling Parkinson's Disease in C. elegans : Strengths and Limitations

Ma, L., Li, X., Liu, C., Yan, W., Ma, J., Petersen, R. B., Peng, A., & Huang, K. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220915103502 · Cited by 20

Piperine improves levodopa availability in the 6‐OHDA ‐lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase

Hu, X., Yu, L., Li, Y., Li, X., Zhao, Y., Xiong, L., Ai, J., Chen, Q., Wang, X., Chen, X., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14383 · Cited by 22

Involvement of regulated cell deaths in aging and age-related pathologies

Torre, L. D., Beato, A., Capone, V., Carannante, D., Verrilli, G., Favale, G., Gaudio, N. D., Megchelenbrink, W., Benedetti, R., Altucci, L., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102251 · Cited by 20

The role of α-synuclein in neurodegeneration — An update

Jellinger, K. A. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0013-1 · Cited by 19

An Inflection Point in Gene Discovery Efforts for Neurodegenerative Diseases

Jager, P. L. D., & Bennett, D. A. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.275 · Cited by 19

Performance evaluation of combined feature selection and classification methods in diagnosing parkinson disease based on voice feature

Wibawa, M. S., Nugroho, H. A., & Setiawan, N. A. (2015) · International Conference on Science in Information Technology · doi:10.1109/icsitech.2015.7407790 · Cited by 20

Identifying a Comprehensive ceRNA Network to Reveal Novel Targets for the Pathogenesis of Parkinson's Disease

Zhang, X., Feng, S., Fan, Y., Luo, Y., Jin, L., & Li, S. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00810 · Cited by 19

Modulation of ARTS and XIAP by Parkin Is Associated with Carnosic Acid Protects SH-SY5Y Cells against 6-Hydroxydopamine-Induced Apoptosis

Fu, R., Huang, L.-C., Lin, C., & Tsai, C.-W. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0443-4 · Cited by 19

Adverse Outcome Pathway on Inhibition of the mitochondrial complex I of nigro-striatal neurons leading to parkinsonian motor deficits

Bal‐Price, A., Leist, M., Schildknecht, S., Monnet‐Tschudi, F., Paini, A., & Terron, A. (2018) · OECD series on adverse outcome pathways · doi:10.1787/b46c3c00-en · Cited by 22

Neurotrophe Naturstoffe – ihre Chemie und Biologie

Xu, J., Lacoske, M. H., & Theodorakis, E. A. (2013) · Angewandte Chemie · doi:10.1002/ange.201302268 · Cited by 18

δ-Opioid Receptor Activation Attenuates Hypoxia/MPP+-Induced Downregulation of PINK1: a Novel Mechanism of Neuroprotection Against Parkinsonian Injury

Xu, Y., Zhi, F., Peng, Y., Shao, N., Khiati, D., Balboni, G., Yang, Y., & Xia, Y. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1043-7 · Cited by 18

Conformational change of organic cofactor PLP is essential for catalysis in PLP-dependent enzymes

Ngo, H.-P.-T., Nguyen, D. Q., Park, H., Park, Y. S., Kwak, K., Kim, T., Lee, J. H., Cho, K. S., & Kang, L. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.9.090 · Cited by 18

Traffic-related air pollution, road traffic noise, and Parkinson’s disease: Evaluations in two Dutch cohort studies

Lomme, J., Reedijk, M., Peters, S., Downward, G. S., Stefanopoulou, M., Vermeulen, R. C. H., & Huss, A. (2023) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000272 · Cited by 18

Stemming the Hype: What Can We Learn from iPSC Models of Parkinson's Disease and How Can We Learn It?

Jacobs, B. M. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-130268 · Cited by 18

Novel Dimer Compounds That Bind α-Synuclein Can Rescue Cell Growth in a Yeast Model Overexpressing α-Synuclein. A Possible Prevention Strategy for Parkinson’s Disease

Kakish, J., Allen, K. J. H., Harkness, T. A. A., Krol, E. S., & Lee, J. S. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00209 · Cited by 18

Gait Influence Diagrams in Parkinson’s Disease

Ren, P., Karahan, E., Chen, C., Luo, R., Geng, Y., Bosch‐Bayard, J., Bringas-Vega, M. L., Yao, D., Kendrick, K. M., & Valdes-Sosa, P. A. (2016) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2016.2622285 · Cited by 18

Parkinson’s disease research: adopting a more human perspective to accelerate advances

Marshall, L. J., & Willett, C. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.09.010 · Cited by 19

Binding mechanism of naringenin with monoamine oxidase – B enzyme: QM/MM and molecular dynamics perspective

Hunday, G., Sivanandam, M., Kandasamy, S., & Kumaradhas, P. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06684 · Cited by 18

Reading Comprehension in Parkinson's Disease

Murray, L. L., & Rutledge, S. (2014) · American Journal of Speech-Language Pathology · doi:10.1044/2014_ajslp-13-0087 · Cited by 18

Evolutionary development of neural systems in vertebrates and beyond

O’Connell, L. A. (2013) · Journal of Neurogenetics · doi:10.3109/01677063.2013.789511 · Cited by 17

Lipid‐induced polymorphic amyloid fibril formation by α‐synuclein

Singh, B., Morris, R. J., Kunath, T., MacPhee, C. E., & Horrocks, M. H. (2023) · Protein Science · doi:10.1002/pro.4736 · Cited by 15

Regulatory SVA retrotransposons and classical HLA genotyped-transcripts associated with Parkinson’s disease

Kulski, J. K., Suzuki, S., Shiina, T., Pfaff, A. L., & Kõks, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1349030 · Cited by 18

Progression and recovery of Parkinsonism in a chronic progressive MPTP-induction model in the marmoset without persistent molecular and cellular damage

Franke, S. K., van Kesteren, R. E., Wubben, J. A. M., Hofman, S., Paliukhovich, I., van der Schors, R. C., van Nierop, P., Smit, A. B., & Philippens, I. H. C. H. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.065 · Cited by 18

Cross-species Transcriptomic Comparison of In Vitro and In Vivo Mammalian Neural Cells

LoVerso, P. R., Wachter, C. M., & Cui, F. (2015) · Bioinformatics and Biology Insights · doi:10.4137/bbi.s33124 · Cited by 17

Potential neuroprotective effect of androst‐5‐ene‐3β, 17β‐diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model

Salama, R. M., Tadros, M. G., Schaalan, M. F., Bahaa, N., Abdel-Tawab, A. M., & Khalifa, A. E. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26412 · Cited by 17

The impact of chronic exposure to air pollution over oxidative stress parameters and brain histology

Bernardi, R., Zanchi, A. C., Damaceno‐Rodrigues, N. R., Veras, M. M., Saldiva, P. H. N., Barros, H. M. T., & Rhoden, C. R. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14023-0 · Cited by 17

Resource Allocation Schemes For Target Localization In Distributed Multiple Radar Architectures

Godrich, H., Petropulu, A. P., & Poor, H. V. (2010) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.42016 · Cited by 17

A cyclodextrin-based approach for selective detection of catecholamine hormone mixtures

Yang, J., Kim, H. T., & Kim, H. (2014) · Micro and Nano Systems Letters · doi:10.1186/s40486-014-0001-z · Cited by 17

Effects of inspiratory muscle training on respiratory muscle strength, lung function, functional capacity and cardiac autonomic function in Parkinson's disease: Randomized controlled clinical trial protocol

Ferro, A. M., Basso-Vanelli, R. P., de Mello, R. L. M., Garcia-Araújo, A. S., Mendes, R. G., Costa, D., & Gianlorenço, A. C. (2019) · Physiotherapy Research International · doi:10.1002/pri.1777 · Cited by 16

Sex Differences in Cerebral Blood Flow and Serum Inflammatory Cytokines and Their Relationships in Mild Traumatic Brain Injury

Zhao, P., Zhu, P., Zhang, D., Yin, B., Wang, Y., Hussein, N. M., Yan, Z., Liu, X., & Bai, G. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.755152 · Cited by 19

Identification of Cuproptosis Clusters and Integrative Analyses in Parkinson’s Disease

Zhang, M., Meng, W., Liu, C., Wang, H., Li, R., Wang, Q., Gao, Y., Zhou, S., Du, T., Yuan, T., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13071015 · Cited by 16

Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Salem, H. A., Abu‐Elfotuh, K., Alzahrani, S., Rizk, N. I., Ali, H. S., Elsherbiny, N. M., Aljohani, A. A., Hamdan, A. M., Panneerselvam, C., Abdou, N. S., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102420 · Cited by 17

Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson’s disease

Ay, M., Charli, A., Langley, M. R., Jang, A.-Y., Padhi, P., Jin, H., Anantharam, V., Kalyanaraman, B., Kanthasamy, A., & Kanthasamy, A. G. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1356703 · Cited by 15

Gene-based vaccines and immunotherapeutic strategies against neurodegenerative diseases: Potential utility and limitations

Kudrna, J. J., & Ugen, K. E. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1065364 · Cited by 16

Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32

Pavlou, M. A. S., Colombo, N., Fuertes-Álvarez, S., Nicklas, S., González-Cano, L., Marín, M. C., Gonçalves, J. M., & Schwamborn, J. C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9989-9 · Cited by 16

Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model

Liu, Y., Jin, W., Deng, Z., Wang, J., & Zhang, Q. (2020) · Marine Drugs · doi:10.3390/md18090438 · Cited by 16

Neuroprotective Potential of Hesperidin as Therapeutic Agent in the Treatment of Brain Disorders: Preclinical Evidence-based Review

Bansal, K., Singh, V., Singh, S., & Mishra, S. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230320144722 · Cited by 16

Novel and functional ABCB1 gene variant in sporadic Parkinson’s disease

Li, Y., Li, Y., Pang, S., Huang, W., Zhang, A., Hawley, R. G., & Yan, B. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.02.025 · Cited by 16

Novel Inhibitors of Human DOPA Decarboxylase Extracted fromEuonymus glabraRoxb.

Ren, J., Zhang, Y., Jin, H., Yu, J. Q., Zhou, Y., Wu, F., & Zhang, W. (2014) · ACS Chemical Biology · doi:10.1021/cb500009r · Cited by 16

Phenome-based gene discovery provides information about Parkinson’s disease drug targets

Chen, Y., & Xu, R. (2016) · BMC Genomics · doi:10.1186/s12864-016-2820-1 · Cited by 16

Disturbed expression of autophagy genes in blood of Parkinson’s disease patients

Haddad, S. E., Serrano, A., Moal, F., Normand, T., Robin, C., Charpentier, S., Valéry, A., Brulé, F., Auzou, P., Mollet, L., et al. (2020) · Gene · doi:10.1016/j.gene.2020.144454 · Cited by 16

Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders

Song, L., Li, H., Yang, W., Yin, H., Wang, J., Guo, M., & Yang, Z. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116576 · Cited by 15

A Dual GLP-1/GIP Receptor Agonist Is More Effective than Liraglutide in the A53T Mouse Model of Parkinson’s Disease

Zhang, Z., Shi, M., Li, Z., Ling, Y., Zhai, L., Yuan, Y., Ma, H., Li, H., Li, Z., Zhang, Z., et al. (2023) · Parkinson s Disease · doi:10.1155/2023/7427136 · Cited by 16

Machine learning for predicting cognitive decline within five years in Parkinson’s disease: Comparing cognitive assessment scales with DAT SPECT and clinical biomarkers

Gorji, A., & Jouzdani, A. F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304355 · Cited by 19

Molecular basis of Parkinsons’s disease linked to LRRK2 mutations

Пчелина, С. Н., Emelyanov, A., & Usenko, T. S. (2014) · Molecular Biology · doi:10.1134/s0026893314010117 · Cited by 15

A Systems Model of Parkinson's Disease Using Biochemical Systems Theory

Sasidharakurup, H., Melethadathil, N., Nair, B. G., & Diwakar, S. (2017) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2017.0056 · Cited by 15

Changes in the Serum Urate Level Can Predict the Development of Parkinsonism in the 6-Hydroxydopamine Animal Model

Sarukhani, M. R., Haghdoost-Yazdi, H., & Khandan-Chelarci, G. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2522-y · Cited by 15

Unexpected BrdU inhibition on astrocyte-to-neuron conversion

Chen, G., Li, W., Wang, T., Liao, J.-C., Wang, X., Wang, Q., Wan, K.-Y., Yang, Y.-Y., He, Q., & Zhang, J. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.325747 · Cited by 15

Applying bioinformatics to proteomics: Is machine learning the answer to biomarker discovery for PD and MSA?

Mattison, H. A., Stewart, T., & Zhang, J. (2012) · Movement Disorders · doi:10.1002/mds.25189 · Cited by 15

Nrf2 Deficiency Exacerbates Parkinson’s Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells

Lu, R., Zhou, X., Zhang, L., 张明阳, & Yang, X. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s478683 · Cited by 15

Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose

Li, J., Li, S., Zhang, L., Ouyang, L., & Liu, B. (2015) · Oncotarget · doi:10.18632/oncotarget.5803 · Cited by 14

Moderate intensity aerobic exercise alleviates motor deficits in 6-OHDA lesioned rats and reduces serum levels of biomarkers of Parkinson's disease severity without recovery of striatal dopamine or tyrosine hydroxylase

Kasanga, E. A., Soto, I., Centner, A., McManus, R., Shifflet, M. K., Navarrete, W., Han, Y., Lisk, J. P., Ehrhardt, T., Wheeler, K., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114875 · Cited by 14

Ferulic acid mitigated rotenone toxicity -Evoked Parkinson in rat model by featuring apoptosis, oxidative stress, and neuroinflammation signaling

Youssef, O. M., Lashine, N. H., El-Nablaway, M., Elyamany, M. I., Youssef, M. M., & Arida, D. A. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102614 · Cited by 14

Dual Function of Phosphoubiquitin in E3 Activation of Parkin

Walinda, E., Morimoto, D., Sugase, K., & Shirakawa, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.728600 · Cited by 14

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

Workman, C. D., Fietsam, A. C., & Rudroff, T. (2020) · Brain Sciences · doi:10.3390/brainsci10070467 · Cited by 14

Drosophila Skp1 Homologue SkpA Plays a Neuroprotective Role in Adult Brain

Dabool, L., Hakim‐Mishnaevski, K., Juravlev, L., Flint-Brodsly, N., Mandel, S. A., & Kurant, E. (2020) · iScience · doi:10.1016/j.isci.2020.101375 · Cited by 14

Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo

Sarkar, S., Bardai, F. H., Olsen, A. L., Lohr, K. M., Zhang, Y., & Feany, M. Β. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00454-3 · Cited by 13

A Data-Driven Biophysical Computational Model of Parkinson’s Disease Based on Marmoset Monkeys

Ranieri, C. M., Pimentel, J. M., Romano, M. R., Elias, L. A., Romero, R. A. F., Lones, M. A., de Araújo, M. F. P., Vargas, P. A., & Moioli, R. C. (2021) · IEEE Access · doi:10.1109/access.2021.3108682 · Cited by 14

Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells

Bearoff, F. M., Dhavale, D. D., Kotzbauer, P. T., & Kortagere, S. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.12.006 · Cited by 15

Chemically-induced oxidative stress increases the vulnerability of PC12 cells to rotenone-induced toxicity

de Groot, M. W. G. D. M., & Westerink, R. H. S. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.02.008 · Cited by 14

Targeting GTPases in Parkinson’s disease: comparison to the historic path of kinase drug discovery and perspectives

Hong, L., & Sklar, L. A. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00052 · Cited by 14

Effects of pramipexole treatment on the α-synuclein content in serum exosomes of Parkinson's disease patients

Luo, H.-T., Zhang, J.-P., & Miao, F. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3471 · Cited by 14

Therapeutic implications of circadian clocks in neurodegenerative diseases

Chang, Y. C., & Kim, J. Y. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24572 · Cited by 15

The Remote Assessment of Parkinsonism Supporting the Ongoing Development of Interventions in Gaucher Disease

Higgins, A., Toffoli, M., Mullin, S., Lee, C., Koletsi, S., Avenali, M., Blandini, F., & Schapira, A. H. V. (2021) · Neurodegenerative Disease Management · doi:10.2217/nmt-2021-0032 · Cited by 13

Interferon Gamma Potentiates the Injury Caused by MPP(+) on SH-SY5Y Cells, Which is Attenuated by the Nitric Oxide Synthases Inhibition

Titze-de-Almeida, S. S., Lustosa, C., Horst, C. H., Bel, E. A. D., & Titze‐de‐Almeida, R. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1449-1 · Cited by 14

Parkinson's Disease

Jellinger, K. A. (2011) · Wiley eBooks · doi:10.1002/9781444341256.ch21 · Cited by 14

Therapeutic Effect of Human Adipocyte-derived Stem Cell-derived Exosomes on a Transgenic Mouse Model of Parkinson’s Disease

Chan, L., Hsu, W., Chen, K., Wang, W., Hung, Y.-C., & Hong, C. (2023) · In Vivo · doi:10.21873/invivo.13300 · Cited by 15

Mitochondrial Dysfunction in Dopaminergic Neurons Derived from Patients with LRRK2- and SNCA-Associated Genetic Forms of Parkinson’s Disease

Vetchinova, A. S., Рафаилевна, К. М., Ivanov, M. V., Kutukova, K. A., Mudzhiri, N. M., Frumkina, L. E., Васильевич, Б. А., Sukhorukov, V. S., & Illarioshkin, S. N. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45100529 · Cited by 16

Research Progress on the Relationship between Parkinson's Disease and REM Sleep Behavior Disorder

Zhou, Y., Liu, X., & Xu, B. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2309166 · Cited by 13

Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response

Guerra-Moreno, Á., & Hanna, J. W. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.726398 · Cited by 13

Animal Models of Autosomal Recessive Parkinsonism

Bastioli, G., Regoni, M., Cazzaniga, F. A., Luca, C. M. G. D., Bistaffa, E., Zanetti, L., Moda, F., Valtorta, F., & Sassone, J. (2021) · Biomedicines · doi:10.3390/biomedicines9070812 · Cited by 13

Association between two α-2-macroglobulin gene polymorphisms and Parkinson's disease: a meta-analysis

Guo, X., Tang, P., Li, X., Li, C., Zhang, X., & Li, R. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2014.996641 · Cited by 13

Translational Research in Neurology

Honig, L. S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.2883 · Cited by 13

Modeling Neurological Disorders by Human Induced Pluripotent Stem Cells

Kunkanjanawan, T., Noisa, P., & Parnpai, R. (2011) · BioMed Research International · doi:10.1155/2011/350131 · Cited by 14

CpG demethylation in the neurotoxicity of 1-methyl-4-phenylpyridinium might mediate transcriptional up-regulation of α-synuclein in SH-SY5Y cells

Yang, J., Yang, Z., Wang, X., Sun, M., Wang, Y., & Wang, X. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.08.023 · Cited by 13

Recent Advances in Drug Repurposing for Parkinson’s Disease

Chen, X., Gumina, G., & Virga, K. G. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180719144850 · Cited by 13

Association of the Polygenic Risk Score with the Incidence Risk of Parkinson’s Disease and Cerebrospinal Fluid α-Synuclein in a Chinese Cohort

Li, W., Fan, D., Shen, Y., Zhou, F., Chen, Y., Wang, Y., Yang, H., Mei, J., Li, L., Xu, Z.-Q., et al. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00066-2 · Cited by 13

Micro/nanoparticle-enabled ultrasound therapy of brain diseases

Qiu, L., Zhu, Z., Liang, J., Qiao, X., Xu, H., Xiang, H., Ding, H., & Chen, Y. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215531 · Cited by 12

Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes

Bitar, S., Baumann, T., Weber, C., Abusaada, M., Rojas-Charry, L., Ziegler, P., Schettgen, T., Randerath, I. E., Venkataramani, V., Michalke, B., et al. (2024) · eLife · doi:10.7554/elife.97027 · Cited by 13

Selective dopamine detection using aptamer-functionalized glassy carbon electrodes

Walsh, R., Ho, U. K., Wang, X. L., & DeRosa, M. C. (2015) · Canadian Journal of Chemistry · doi:10.1139/cjc-2014-0444 · Cited by 12

Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease

Geldenhuys, W. J., Kochi, A., Lin, L., Sutariya, V. B., Dluzen, D. E., der Schyf, C. J. V., & Lim, M. H. (2014) · ChemBioChem · doi:10.1002/cbic.201300770 · Cited by 12

Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced mouse model of Parkinson's disease

Tonouchi, A., Nagai, J., Togashi, K., Goshima, Y., & Ohshima, T. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13617 · Cited by 12

The association between frailty and Parkinson’s disease in the ReSPOnD trial

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Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson’s Disease

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Proteome-Wide Discovery of Cortical Proteins That May Provide Motor Resilience to Offset the Negative Effects of Pathologies in Older Adults

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Association of rs1801582 and rs1801334 PARK2 Polymorphisms with risk of Parkinson's disease: A case-control study in South India and Meta-Analysis

Veerabathiran, R., Alphonsa, T., Akram Husain, R. S., Ahmed, S. S. S. J., Subramaniyan, K., & Kumar, S. S. (2016) · Meta Gene · doi:10.1016/j.mgene.2016.09.007 · Cited by 12

Sostenibilidad y turismo en los paisajes culturales de la industrialización

Abad, C. J. P. (2017) · Arbor · doi:10.3989/arbor.2017.785n3006 · Cited by 12

Parkinsonian GM2 synthase knockout mice lacking mature gangliosides develop urinary dysfunction and neurogenic bladder

Gil-Tommee, C., Vidal-Martínez, G., Reyes, C. A., Vargas‐Medrano, J., Herrera, G. V., Martin, S. M., Chaparro, S. A., & Perez, R. G. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.10.014 · Cited by 12

Self-assembly of Amphiphilic Diblock Copolymers Induced by Liquid-Liquid Phase Separation

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Relationship and factor structure in multisystem neurodegeneration in Parkinson's disease

Hattori, T., Orimo, S., Hallett, M., Wu, T., Inaba, A., Azuma, R., & Mizusawa, H. (2014) · Acta Neurologica Scandinavica · doi:10.1111/ane.12273 · Cited by 12

Do Tardive Dyskinesia and l-Dopa Induced Dyskinesia Share Common Genetic Risk Factors? An Exploratory Study

Greenbaum, L., Goldwurm, S., Zozulinsky, P., Lifschytz, T., Cohen, O. S., Yahalom, G., Cilia, R., Tesei, S., Asselta, R., Inzelberg, R., et al. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0020-x · Cited by 12

Retrograde trafficking of VMAT2 and its role in protein stability in non-neuronal cells

Qiuzi, W., Xu, H., Wang, W., Chang, F., Jiang, Y., & Yongjian, L. (2016) · Journal of Biomedical Research · doi:10.7555/jbr.30.20160061 · Cited by 12

Mapping the experiences and needs of deep brain stimulation for people with Parkinson’s disease and their family members

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The prominin-like Gene Expressed in a Subset of Dopaminergic Neurons Regulates Locomotion in Drosophila

Ryu, T. H., Subramanian, M., Yeom, E., & Yu, K. (2022) · Molecules and Cells · doi:10.14348/molcells.2022.0006 · Cited by 11

Design and synthesis of benzo[d]thiazol-2-yl-methyl-4-(substituted)-piperazine-1-carbothioamide as novel neuronal nitric oxide inhibitors and evaluation of their neuroprotecting effect in 6-OHDA-induced unilateral lesioned rat model of Parkinson's disease

Agrawal, S., Kumari, R., Sophronea, T., Kumari, N., & Luthra, P. M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113838 · Cited by 11

Aging and the Inflammasomes

Marín‐Aguilar, F., Ruı́z-Cabello, J., & Cordero, M. D. (2018) · Experientia supplementum · doi:10.1007/978-3-319-89390-7_13 · Cited by 12

Evidence From Parkinson's Disease That the Superior Colliculus Couples Action and Perception

Pretegiani, E., Vanegas‐Arroyave, N., FitzGibbon, E. J., Hallett, M., & Optican, L. M. (2019) · Movement Disorders · doi:10.1002/mds.27861 · Cited by 11

Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson’s Disease Influence Sporadic Forms?

Lanore, A., Lesage, S., Mariani, L., Menon, P. J., Ravassard, P., Cheval, H., Corti, O., Brice, A., & Corvol, J. (2022) · Genes · doi:10.3390/genes13030479 · Cited by 11

Mixed Neuropathologies, Neural Motor Resilience and Target Discovery for Therapies of Late-Life Motor Impairment

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Genetics and Pathogenesis of Parkinson's Syndrome

Ye, H., Robak, L. A., Yu, M., Cykowski, M. D., & Shulman, J. M. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-034145 · Cited by 503

Parkinson's Disease: From Molecular Pathways in Disease to Therapeutic Approaches

Thomas, B. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2697 · Cited by 76

Genetics of Parkinson’s disease and related disorders

Zhang, P.-L., Chen, Y., Zhang, C.-H., Wang, Y., & Fernández-Fúnez, P. (2017) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2017-105047 · Cited by 93

Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection

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The Etiopathogenesis of Parkinson Disease and Suggestions for Future Research. Part I

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