Parkinson’s disease: genetics and pathogenesis

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240

Parkinson's Disease

Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium

McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914

α-Synuclein Locus Triplication Causes Parkinson's Disease

Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,777

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,087

Genome-wide association studies for common diseases and complex traits

Hirschhorn, J. N., & Daly, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1521 · Cited by 2,923

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,854

The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737

Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Paisán‐Ruiz, C., Jain, S., Evans, E. W., Gilks, W. P., Simón, J., van der Brug, M., de Munaín, A. L., Aparicio, S. F., Gil, A. M., Khan, N. L., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.023 · Cited by 2,453

Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders

Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174

A Drosophila model of Parkinson's disease

Feany, M. Β., & Bender, W. W. (2000) · Nature · doi:10.1038/35006074 · Cited by 2,156

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

Sidransky, E., Nalls, M. A., Aasly, J. O., Aharon-Peretz, J., Annesi, G., Barbosa, E. R., Bar-Shira, A., Berg, D., Bras, J., Brice, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901281 · Cited by 2,135

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Baker, M., Mackenzie, I. R., Pickering-Brown, S. M., Gass, J., Rademakers, R., Lindholm, C., Snowden, J., Adamson, J., Sadovnick, A. D., Rollinson, S., et al. (2006) · Nature · doi:10.1038/nature05016 · Cited by 2,058

α-synuclein locus duplication as a cause of familial Parkinson's disease

Chartier-Harlin, M.-C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17103-1 · Cited by 2,029

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

Bull, P. C., Thomas, G. R., Rommens, J. M., Forbes, J., & Cox, D. W. (1993) · Nature Genetics · doi:10.1038/ng1293-327 · Cited by 1,939

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

Chaudhuri, К. R., & Schapira, A. H. V. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70068-7 · Cited by 1,818

Incidence of Parkinson's Disease: Variation by Age, Gender, and Race/Ethnicity

Eeden, S. K. V. D. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg068 · Cited by 1,805

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Masliah, E., Rockenstein, E. M., Veinbergs, I., Mallory, M. E., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., & Mucke, L. (2000) · Science · doi:10.1126/science.287.5456.1265 · Cited by 1,779

Genome-wide association study reveals genetic risk underlying Parkinson's disease

Simón-Sánchez, J., Schulte, C., Bras, J. M., Sharma, M., Gibbs, J. R., Berg, D., Paisan-Ruiz, C., Lichtner, P., Scholz, S. W., Hernandez, D. G., et al. (2009) · Nature Genetics · doi:10.1038/ng.487 · Cited by 1,751

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

Conway, K. A., Harper, J. D., & Lansbury, P. T. (1998) · Nature Medicine · doi:10.1038/3311 · Cited by 1,520

6-Hydroxy-dopamine induced degeneration of central monoamine neurons.

Ungerstedt, U. (1968) · European Journal of Pharmacology · doi:10.1016/0014-2999(68)90164-7 · Cited by 1,516

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Cruts, M., Gijselinck, I., van der Zee, J., Engelborghs, S., Wils, H., Pirici, D., Rademakers, R., Vandenberghe, R., Dermaut, B., Martin, J.-J., et al. (2006) · Nature · doi:10.1038/nature05017 · Cited by 1,512

Association between Early-Onset Parkinson's Disease and Mutations in theParkinGene

Lücking, C. B., Dürr, A., Bonifati, V., Vaughan, J. R., Michele, G. D., Gasser, T., Harhangi, B. S., Meco, G., Denèfle, P., Wood, N. W., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005253422103 · Cited by 1,489

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A., & Ghetti, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7737 · Cited by 1,474

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

Healy, D. G., Falchi, M., O'Sullivan, S. S., Bonifati, V., Durr, A., Bressman, S., Brice, A., Aasly, J., Zabetian, C. P., Goldwurm, S., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70117-0 · Cited by 1,425

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

Satake, W., Nakabayashi, Y., Mizuta, I., Hirota, Y., Ito, C., Kubo, M., Kawaguchi, T., Tsunoda, T., Watanabe, M., Takeda, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.485 · Cited by 1,338

Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00682-7 · Cited by 1,266

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

West, A. B., Moore, D. J., Biskup, S., Bugayenko, A., Smith, W. W., Ross, C. A., Dawson, V. L., & Dawson, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507360102 · Cited by 1,228

Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

Auluck, P. K., Chan, H. Y. E., Trojanowski, J. Q., Lee, V. M.-Y., & Bonini, N. M. (2002) · Science · doi:10.1126/science.1067389 · Cited by 1,227

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Canet-Aviles, R., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A., & Cookson, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402959101 · Cited by 1,115

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2

Pulst, S.-M., Nechiporuk, A. V., Nechiporuk, T., Gispert, S., Chen, X., Lopes‐Cendes, Í., Pearlman, S., Starkman, S., Díaz, G. O., Lunkes, A., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-269 · Cited by 1,113

Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease

Shimura, H., Schlossmacher, M. G., Hattori, N., Frosch, M. P., Trockenbacher, A., Schneider, R., Mizuno, Y., Kosik, K. S., & Selkoe, D. J. (2001) · Science · doi:10.1126/science.1060627 · Cited by 1,053

Sydney multicenter study of Parkinson's disease: Non‐L‐dopa–responsive problems dominate at 15 years

Hely, M. A., Morris, J. G. L., Reid, W. G. J., & Trafficante, R. (2005) · Movement Disorders · doi:10.1002/mds.20324 · Cited by 1,050

Description of Parkinson's Disease as a Clinical Syndrome

Fahn, S. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07458.x · Cited by 979

Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria

Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972

The PINK1/Parkin pathway regulates mitochondrial morphology

Poole, A. C., Thomas, R. E., Andrews, L. A., McBride, H. M., Whitworth, A. J., & Pallanck, L. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709336105 · Cited by 885

Parkinson Disease in Twins

Tanner, C. M., Ottman, R., Goldman, S. M., Ellenberg, J., Chan, P., Mayeux, R. P., & Langston, J. W. (1999) · JAMA · doi:10.1001/jama.281.4.341 · Cited by 876

Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms

Rodríguez‐Oroz, M., Jahanshahi, M., Krack, P., Litvan, I., Macías, R. J., Bézard, E., & Obeso, J. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70293-5 · Cited by 866

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A., & Price, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132197599 · Cited by 824

A meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease

Hernán, M. A., Takkouche, B., Caamaño‐Isorna, F., & Gestal‐Otero, J. J. (2002) · Annals of Neurology · doi:10.1002/ana.10277 · Cited by 818 · cited 1×

Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

Outeiro, T. F., & Lindquist, S. L. (2003) · Science · doi:10.1126/science.1090439 · Cited by 811

A common LRRK2 mutation in idiopathic Parkinson's disease

Gilks, W. P., Abou-Sleiman, P. M., Gandhi, S., Jain, S., Singleton, A., Lees, A. J., Shaw, K., Bhatia, K. P., Bonifati, V., Quinn, N. P., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17830-1 · Cited by 774

Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

Ichinose, H., Ohye, T., Takahashi, E.-I., Seki, N., Hori, T.-A., Segawa, M., Nomura, Y., Endo, K., Tanaka, H., Tsuji, S., et al. (1994) · Nature Genetics · doi:10.1038/ng1194-236 · Cited by 770

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

Zhou, B., Westaway, S. K., Levinson, B., Johnson, M., Gitschier, J. M., & Hayflick, S. J. (2001) · Nature Genetics · doi:10.1038/ng572 · Cited by 756

Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation

Serpell, L. C., Berriman, J. A., Jakes, R., Goedert, M., & Crowther, R. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4897 · Cited by 755

Comparison of kindreds with parkinsonism and α‐synuclein genomic multiplications

Farrer, M. J., Kachergus, J. M., Forno, L. S., Lincoln, S., Wang, D., Hulihan, M., Maraganore, D. M., Gwinn, K. A., Wszołek, Z. K., Dickson, D. W., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10846 · Cited by 711

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

Deng, H., Dodson, M. W., Huang, H., & Guo, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803998105 · Cited by 707

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson’s disease

Neumann, J., Bras, J., Deas, E., O'Sullivan, S. S., Parkkinen, L., Lachmann, R. H., Li, A., Holton, J., Guerreiro, R., Paudel, R., et al. (2009) · Brain · doi:10.1093/brain/awp044 · Cited by 696

LRRK2 G2019S as a Cause of Parkinson's Disease in Ashkenazi Jews

Ozelius, L. J., Senthil, G., Saunders-Pullman, R. J., Ohmann, E. L., Deligtisch, A., Tagliati, M., Hunt, A. L., Klein, C., Henick, B. S., Hailpern, S. M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmc055509 · Cited by 681

Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System

Kirik, D., Rosenblad, C., Burger, C., Lundberg, C., Johansen, T. E., Muzyczka, N., Mandel, R. J., & Björklund, A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02780.2002 · Cited by 649

α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

Chen, L., & Feany, M. Β. (2005) · Nature Neuroscience · doi:10.1038/nn1443 · Cited by 634

The parkinson's complex: Parkinsonism is just the tip of the iceberg

Langston, J. W. (2006) · Annals of Neurology · doi:10.1002/ana.20834 · Cited by 608

Mutations in the Glucocerebrosidase Gene and Parkinson's Disease in Ashkenazi Jews

Aharon-Peretz, J., Rosenbaum, H., & Gershoni-Baruch, R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033277 · Cited by 597

The Familial Parkinsonism Gene LRRK2 Regulates Neurite Process Morphology

MacLeod, D., Dowman, J., Hammond, R., Leete, T., Inoue, K., & Abeliovich, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.008 · Cited by 561

Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European Populations

Kachergus, J. M., Mata, I. F., Hulihan, M., Taylor, J. P., Lincoln, S., Aasly, J. O., Gibson, J. M., Ross, O. A., Lynch, T., Wiley, J. C., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429256 · Cited by 549

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

Yang, Y., Ouyang, Y., Yang, L., Beal, M. F., McQuibban, G. A., Vogel, H. S., & Lu, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711845105 · Cited by 549

Invited Article: Nervous system pathology in sporadic Parkinson disease

Braak, H., & Tredici, K. D. (2008) · Neurology · doi:10.1212/01.wnl.0000312279.49272.9f · Cited by 548

PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron

Morgan, N. V., Westaway, S. K., Morton, J. E. V., Gregory, A., Gissen, P., Sonek, S., Cangül, H., Coryell, J. C., Canham, N. L. E., Nardocci, N., et al. (2006) · Nature Genetics · doi:10.1038/ng1826 · Cited by 532

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

Lin, X. Z., Parisiadou, L., Gu, X., Wang, L., Shim, H., Sun, L., Xie, C., Long, C.-X., Yang, W.-J., Ding, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.006 · Cited by 532

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

Di Fonzo, A., Rohé, C. F., Ferreira, J., Chien, H. F., Vacca, L., Stocchi, F., Guedes, L., Fabrizio, E., Manfredi, M., Vanacore, N., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17829-5 · Cited by 531

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

Biskup, S., Moore, D. J., Celsi, F., Higashi, S., West, A. B., Andrabi, S. A., Kurkinen, K. M. A., Yu, S., Savitt, J. M., Waldvogel, H. J., et al. (2006) · Annals of Neurology · doi:10.1002/ana.21019 · Cited by 530

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

Maraganore, D. M. (2006) · JAMA · doi:10.1001/jama.296.6.661 · Cited by 518

High-Resolution Whole-Genome Association Study of Parkinson Disease

Maraganore, D. M., de Andrade, M., Lesnick, T. G., Strain, K. J., Farrer, M. J., Rocca, W. A., Pant, P. V. K., Frazer, K. A., Cox, D., & Ballinger, D. G. (2005) · The American Journal of Human Genetics · doi:10.1086/496902 · Cited by 505

Lewy bodies and parkinsonism in families with parkin mutations

Farrer, M. J., Chan, P., Chen, R., Tan, L. C. S., Lincoln, S., Hernandez, D. G., Forno, L. S., Gwinn, K. A., Petrucelli, L., Hussey, J., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1132 · Cited by 483

α-synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

Lo Bianco, C., Ridet, J.-L., Schneider, B. L., Déglon, N., & Aebischer, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152339799 · Cited by 482

Genome‐Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease

Edwards, T. L., Scott, W. K., Almonte, C., Burt, A., Powell, E. H., Beecham, G. W., Wang, L., Zuchner, S. L., Konidari, I., Wang, G., et al. (2010) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2009.00560.x · Cited by 471

A susceptibility locus for Parkinson's disease maps to chromosome 2p13

Gasser, T., Müller‐Myhsok, B., Wszołek, Z. K., Oehlmann, R., Calne, D. B., Bonifati, V., Bereznai, B., Fabrizio, E., Vieregge, P., & Horstmann, R. D. (1998) · Nature Genetics · doi:10.1038/ng0398-262 · Cited by 462

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

Nichols, W. C., Pankratz, N., Hernandez, D., Paisán-Ruíz, C., Jain, S., Halter, C. A., Michaels, V. E., Reed, T., Rudolph, A., Shults, C. W., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17828-3 · Cited by 457

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

Pankratz, N., Wilk, J. B., Latourelle, J. C., DeStefano, A. L., Halter, C. A., Pugh, E., Doheny, K. F., Gusella, J. F., Nichols, W. C., Foroud, T., et al. (2008) · Human Genetics · doi:10.1007/s00439-008-0582-9 · Cited by 445

Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease models

Karpinar, D. P., Balija, M. B. G., Kügler, S., Opazo, F., Rezaei‐Ghaleh, N., Wender, N., Kim, H., Taschenberger, G., Falkenburger, B. H., Heise, H., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.257 · Cited by 432

Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

Willingham, S., Outeiro, T. F., DeVit, M. J., Lindquist, S. L., & Muchowski, P. J. (2003) · Science · doi:10.1126/science.1090389 · Cited by 422

Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease

Kirik, D., Annett, L. E., Bürger, C., Muzyczka, N., Mandel, R. J., & Björklund, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536383100 · Cited by 416

Occurrence of Parkinson's syndrome in type 1 Gaucher disease

Neudorfer, O., Giladi, N., Elstein, D., Abrahamov, A., Turezkite, T., Aghai, E., Reches, A., Bembi, B., & Zimran, A. (1996) · QJM · doi:10.1093/qjmed/89.9.691 · Cited by 412

The progression of pathology in longitudinally followed patients with Parkinson’s disease

Halliday, G. M., Hely, M. A., Reid, W. G. J., & Morris, J. G. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0344-8 · Cited by 410

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α‐synuclein

Lakso, M., Vartiainen, S., Moilanen, A., Sirviö, J., Thomas, J. H., Nass, R., Blakely, R., & Wong, G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01809.x · Cited by 403

β-Synuclein Inhibits α-Synuclein Aggregation

Hashimoto, M., Rockenstein, E., Mante, M., Mallory, M., & Masliah, E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00462-7 · Cited by 398

Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication

Fuchs, J., Nilsson, C., Kachergus, J. M., Munz, M., Larsson, E., Schüle, B., Langston, J. W., Middleton, F. A., Ross, O. A., Hulihan, M., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000254458.17630.c5 · Cited by 397

Glucocerebrosidase mutations in subjects with parkinsonism

Lwin, A. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.11.004 · Cited by 375

Parkinsonism among Gaucher disease carriers

Göker-Alpan, Ö., Schiffmann, R., LaMarca, M. E., Nussbaum, R. L., McInerney-Leo, A. M., & Sidransky, E. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024455 · Cited by 373

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q

Mori, H., Kondo, T., Yokochi, M., Matsumine, H., Nakagawa-Hattori, Y., Miyake, T., Suda, K., & Mizuno, Y. (1998) · Neurology · doi:10.1212/wnl.51.3.890 · Cited by 370

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

Dickson, D. W., Fujishiro, H., DelleDonne, A., Menke, J., Ahmed, Z., Klos, K. J., Josephs, K. A., Frigerio, R., Burnett, M., Parisi, J. E., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0345-7 · Cited by 364

Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset

Gan‐Or, Z., Giladi, N., Rozovski, U., Shifrin, C., Rosner, S., Gurevich, T., Bar‐Shira, A., & Orr‐Urtreger, A. (2008) · Neurology · doi:10.1212/01.wnl.0000304039.11891.29 · Cited by 363

Parkin disease: a phenotypic study of a large case series

Khan, N. L., Graham, E., Critchley, P., Schrag, A. E., Wood, N. W., Lees, A. J., Bhatia, K. P., & Quinn, N. P. (2003) · Brain · doi:10.1093/brain/awg142 · Cited by 352

Early-onset parkinsonism associated with PINK1 mutations

Bonifati, V., Rohé, C. F., Breedveld, G. J., Fabrizio, E., Mari, M. D., Tassorelli, C., Tavella, A., Marconi, R., Nicholl, D. J., Chien, H. F., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000167546.39375.82 · Cited by 338

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson's disease

Bianco, C. L., Schneider, B. L., Bauer, M., Sajadi, A., Brice, A., Iwatsubo, T., & Aebischer, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405313101 · Cited by 329

A meta-analysis of Parkinson's disease and exposure to pesticides.

Priyadarshi, A., Khuder, S., Schaub, E. A., & Shrivastava, S. (2000) · PubMed · Cited by 319

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

Khan, N. L., Jain, S., Lynch, J. M., Pavese, N., Abou‐Sleiman, P. M., Holton, J. L., Healy, D. G., Gilks, W. P., Sweeney, M. G., Ganguly, M., et al. (2005) · Brain · doi:10.1093/brain/awh667 · Cited by 317

Deciphering the role of heterozygous mutations in genes associated with parkinsonism

Klein, C., Lohmann-Hedrich, K., Rogaeva, E. A., Schlossmacher, M. G., & Lang, A. E. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70174-6 · Cited by 309

Calcium, ageing, and neuronal vulnerability in Parkinson's disease

Surmeier, D. J. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70246-6 · Cited by 303

Aggregated α-Synuclein Mediates Dopaminergic Neurotoxicity In Vivo

Periquet, M., Fulga, T. A., Myllykangas, L., Schlossmacher, M. G., & Feany, M. Β. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0285-07.2007 · Cited by 299

Parkin mutations are frequent in patients with isolated early‐onset parkinsonism

Periquet, M., Latouche, M., Lohmann, E., Rawal, N., Michele, G. D., Ricard, S., Teive, H. A. G., Fraix, V., Vidailhet, M., Nicholl, D. J., et al. (2003) · Brain · doi:10.1093/brain/awg136 · Cited by 296

Increased susceptibility to sporadic Parkinson's disease by a certain combined ?-synuclein/apolipoprotein E genotype

Krüger, R., Vieira-Saecker, A. M. M., Kuhn, W., Berg, D., M�ller, T., K�hnl, N., Fuchs, G., Storch, A., Hungs, M., Woitalla, D., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 281

Familial Aggregation of Parkinson's Disease in Iceland

Sveinbjörnsdóttir, S., Hicks, A. A., Jónsson, T., Pétursson, H., Guðmundsson, G., Frigge, M. L., Kong, A., Gulcher, J. R., & Stefánsson, K. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012143432404 · Cited by 277

Absence of nigral degeneration in aged parkin/DJ‐1/PINK1 triple knockout mice

Kitada, T., Tong, Y., Gautier, C., & Shen, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06350.x · Cited by 271

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family

Funayama, M., Hasegawa, K., Ohta, E., Kawashima, N., Komiyama, M., Kowa, H., Tsuji, S., & Obata, F. (2005) · Annals of Neurology · doi:10.1002/ana.20484 · Cited by 270

Lrrk2 and Lewy body disease

Ross, O. A., Toft, M., Whittle, A. J., Johnson, J. L., Papapetropoulos, S., Mash, D. C., Litvan, I., Gordon, M. F., Wszołek, Z. K., Farrer, M. J., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20731 · Cited by 268

Autosomal dominant parkinsonism associated with variable synuclein and tau pathology

Wszolek, Z. K., Pfeiffer, R. F., Tsuboi, Y., Uitti, R. J., McComb, R. D., Stoessl, A. J., Strongosky, A. J., Zimprich, A. A., Müller‐Myhsok, B., Farrer, M. J., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000125015.06989.db · Cited by 266

A susceptibility gene for late‐onset idiopathic Parkinson's disease

Hicks, A. A., Pétursson, H., Jónsson, T., Stefánsson, H., Johannsdottir, H., Sainz, J., Frigge, M. L., Kong, A., Gulcher, J. R., Stefánsson, K., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10324 · Cited by 265

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts

Myers, A., Pittman, A. M., Zhao, A. S., Rohrer, K., Kaleem, M. A., Marlowe, L., Lees, A. J., Leung, D. G., McKeith, I. G., Perry, R. H., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.018 · Cited by 263

Genome-wide Linkage Analysis of a Parkinsonian-Pyramidal Syndrome Pedigree by 500 K SNP Arrays

Shojaee, S., Sina, F., Banihosseini, S. S., Kazemi, M., Kalhor, R., Shahidi, G. A., Fakhrai-Rad, H., Ronaghi, M., & Elahi, E. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.05.005 · Cited by 257

Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease

Clark, L. N., Ross, B., Wang, Y., Mejia‐Santana, H., Harris, J. M., Louis, E. D., Cote, L. J., Andrews, H., Fahn, S., Waters, C., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000276989.17578.02 · Cited by 253

Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations

van de Warrenburg, B. P. C., Lammens, M. M. Y., Lücking, C. B., Denèfle, P., Wesseling, P., Booij, J., Praamstra, P., Quinn, N. P., Brice, A., & Horstink, M. W. I. M. (2001) · Neurology · doi:10.1212/wnl.56.4.555 · Cited by 253

Patterns and stages of α-synucleinopathy

ZACCAI, J. H., Brayne, C., McKeith, I. G., Matthews, F. E., & Ince, P. G. (2008) · Neurology · doi:10.1212/01.wnl.0000306697.48738.b6 · Cited by 249

Molecular mechanisms of α-synuclein neurodegeneration

Waxman, E. A., & Giasson, B. I. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.013 · Cited by 247

A critical evaluation of current staging of α-synuclein pathology in Lewy body disorders

Jellinger, K. A. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.07.006 · Cited by 247

Lewy body Parkinson's disease in a large pedigree with 77Parkin mutation carriers

Pramstaller, P. P., Schlossmacher, M. G., Jacques, T. S., Scaravilli, F., Eskelson, C., Pepivani, I., Hedrich, K., Adel, S., McNeal, M. G., Hilker, R., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20587 · Cited by 244

Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial Parkinsonism associated with mutations in the Parkin gene

Hilker, R., Klein, C., Ghaemi, M., Kis, B., Strotmann, T., Ozelius, L. J., Lenz, O., Vieregge, P., Herholz, K., Heiss, W., et al. (2001) · Annals of Neurology · doi:10.1002/ana.74 · Cited by 244

Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system

Chiba‐Falek, O. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.26.3101 · Cited by 241

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson’s disease risk in Taiwan

Fonzo, A. D., Chou, Y. W., Lu, C.-S., van Doeselaar, M., Simons, E. J., Rohé, C. F., Chang, H., Chen, R., Weng, Y.-H., Vanacore, N., et al. (2006) · Neurogenetics · doi:10.1007/s10048-006-0041-5 · Cited by 229

Tyrosine and serine phosphorylation of α-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

Chen, L., Periquet, M., Wang, X., Negro, A., McLean, P. J., Hyman, B. T., & Feany, M. Β. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39088 · Cited by 224

G2019S LRRK2 mutation in French and North African families with Parkinson's disease

Lesage, S., Ibáñez, P., Lohmann, E., Pollak, P., Tison, F., Tazir, M., Leutenegger, A., Guimaraes, J., Bonnet, A., Agid, Y., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20636 · Cited by 217

The genetics of Parkinson's syndromes: a critical review

Hardy, J., Lewis, P. A., Révész, T., Lees, A. J., & Paisán‐Ruiz, C. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.03.008 · Cited by 216

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents

Chen, S., Grigsby, C. L., Law, C. S., Ni, X.-P., Nekrep, N., Olsen, K., Humphreys, M. H., & Gardner, D. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35314 · Cited by 214

Dopaminergic Cell Loss Induced by Human A30P α -Synuclein Gene Transfer to the Rat Substantia Nigra

Klein, R. L., King, M. A., Hamby, M. E., & Meyer, E. M. (2002) · Human Gene Therapy · doi:10.1089/10430340252837206 · Cited by 212

α‐Synuclein promoter confers susceptibility to Parkinson's disease

Pals, P., Lincoln, S., Manning, J. R., Heckman, M. G., Skipper, L. M., Hulihan, M., den Broeck, M. V., Pooter, T. D., Cras, P. P., Crook, J. E., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20268 · Cited by 211

Paralysis agitans. I. Pathologische Anatomie

Lewy, F. (1912) · Medical Entomology and Zoology · Cited by 208

Gaucher Disease and Parkinsonism: A Phenotypic and Genotypic Characterization

Tayebi, N., Callahan, M., Madike, V., Stubblefield, B. K., Orviský, E., Krasnewich, D. M., Fillano, J. J., & Sidransky, E. (2001) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3201 · Cited by 205

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Ross, O. A., Wu, Y., Lee, M., Funayama, M., Chen, M., Soto, A. I., Mata, I. F., Lee‐Chen, G., Chen, C., Tang, M., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21405 · Cited by 195

The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson’s disease and originates from a common ancestor

Goldwurm, S., Fonzo, A. D., Simons, E. J., Rohé, C. F., Zini, M., Canesi, M., Tesei, S., Zecchinelli, A., Antonini, A., Mariani, C. B., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.035568 · Cited by 195

Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

Bianco, C. L., Shorter, J., Régulier, E., Lashuel, H. A., Iwatsubo, T., Lindquist, S. L., & Aebischer, P. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35781 · Cited by 193

Survival Study of Parkinson Disease in Olmsted County, Minnesota

Elbaz, A., Bower, J. H., Peterson, B. J., Maraganore, D. M., McDonnell, S. K., Ahlskog, J. E., Schaid, D. J., & Rocca, W. A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.1.91 · Cited by 190

Substantia nigra tangles are related to gait impairment in older persons

Schneider, J. A., Li, J., Li, Y., Wilson, R. S., Kordower, J. H., & Bennett, D. A. (2005) · Annals of Neurology · doi:10.1002/ana.20723 · Cited by 185

Handbuch der Neurologie.

(1911) · JAMA · doi:10.1001/jama.1911.02560030051032 · Cited by 175

A heterozygous effect for PINK1 mutations in Parkinson's disease?

Abou‐Sleiman, P. M., Muqit, M. M. K., McDonald, N. Q., Yang, Y. X., Gandhi, S., Healy, D. G., Harvey, K., Harvey, R. J., Deas, E., Bhatia, K. P., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20960 · Cited by 171

Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease

Zabetian, C. P., Hutter, C. M., Factor, S. A., Nutt, J. G., Higgins, D. S., Griffith, A., Roberts, J. W., Leis, B. C., Kay, D. M., Yearout, D., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21157 · Cited by 165

Mendelian forms of Parkinson's disease

Gasser, T. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.12.007 · Cited by 165

Significant Linkage of Parkinson Disease to Chromosome 2q36-37

Pankratz, N., Nichols, W. C., Uniacke, S. K., Halter, C. A., Rudolph, A., Shults, C. W., Conneally, P. M., & Foroud, T. (2003) · The American Journal of Human Genetics · doi:10.1086/374383 · Cited by 161

Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families

Pankratz, N. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg270 · Cited by 151

A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

Zabetian, C. P., Samii, A., Mosley, A. D., Roberts, J. W., Leis, B. C., Yearout, D., Raskind, W. H., & Griffith, A. (2005) · Neurology · doi:10.1212/01.wnl.0000172630.22804.73 · Cited by 150

The prodromal phase of sporadic Parkinson's disease: Does it exist and if so how long is it?

Hawkes, C. H. (2008) · Movement Disorders · doi:10.1002/mds.22242 · Cited by 144

Haplotype-specific expression of exon 10 at the human MAPT locus

Caffrey, T. M., Joachim, C. L., Paracchini, S., Esiri, M. M., & Wade‐Martins, R. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl429 · Cited by 135

Expanding the clinical phenotype of SNCA duplication carriers

Nishioka, K., Ross, O. A., Ishii, K., Kachergus, J. M., Ishiwata, K., Kitagawa, M., Kono, S., Obi, T., Mizoguchi, K., Inoue, Y., et al. (2009) · Movement Disorders · doi:10.1002/mds.22682 · Cited by 135

Parkin variants in North American Parkinson's disease: Cases and controls

Lincoln, S., Maraganore, D. M., Lesnick, T. G., Bounds, R., de Andrade, M., Bower, J. H., Hardy, J., & Farrer, M. J. (2003) · Movement Disorders · doi:10.1002/mds.10601 · Cited by 131

Imaging neurodegeneration in Parkinson's disease

Pavese, N., & Brooks, D. J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.003 · Cited by 130

Tau gene and Parkinson's disease: a case-control study and meta-analysis

Healy, D. G. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.026203 · Cited by 125

Leucine-Rich Repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population

Funayama, M., Li, Y., Tomiyama, H., Yoshino, H., Imamichi, Y., Yamamoto, M., Murata, M., Toda, T., Mizuno, Y., & Hattori, N. (2007) · Neuroreport · doi:10.1097/wnr.0b013e32801254b6 · Cited by 124

Neuropathology and Neurodegeneration in Rodent Brain Induced by Lentiviral Vectormediated Overexpression of α‐Synuclein

Lauwers, E., Debyser, Z., Dorpe, J. V., Strooper, B. D., Nuttin, B., & Baekelandt, V. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00035.x · Cited by 123

Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease

Khan, N. L., Katzenschlager, R., Watt, H., Bhatia, K. P., Wood, N. W., Quinn, N. P., & Lees, A. J. (2004) · Neurology · doi:10.1212/01.wnl.0000118281.66802.81 · Cited by 120

Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients

Kay, D. M., Moran, D., Moses, L., Poorkaj, P., Zabetian, C. P., Nutt, J. G., Factor, S. A., Yu, C., Montimurro, J. S., Keefe, R. G., et al. (2006) · Annals of Neurology · doi:10.1002/ana.21039 · Cited by 116

Pathological overlap in cases of parkinsonism associated with neurofibrillary tangles

Geddes, J. F., Hughes, A. J., Lees, A. J., & Daniel, S. E. (1993) · Brain · doi:10.1093/brain/116.1.281 · Cited by 115

Return of the cycad hypothesis – does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health?

Ince, P. G., & Codd, G. A. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00686.x · Cited by 110

Untangling the tau gene association with neurodegenerative disorders

Pittman, A. M., Fung, H., & de Silva, R. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl190 · Cited by 110

Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease

Biskup, S., & West, A. B. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.015 · Cited by 108

Familial aggregation of early‐ and late‐onset Parkinson's disease

Marder, K. S., Levy, G., Louis, E. D., Mejia‐Santana, H., COTE, L. J., Andrews, H., Harris, J. M., Waters, C., Ford, B., Frucht, S. J., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10711 · Cited by 104

Functional association of the parkin gene promoter with idiopathic Parkinson's disease

West, A. B. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.22.2787 · Cited by 102

G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort

Brás, J., Guerreiro, R. J., Ribeiro, M. H., Januário, C., Morgadinho, A., Oliveira, C. R., Cunha, L., Hardy, J., & Singleton, A. (2005) · Movement Disorders · doi:10.1002/mds.20682 · Cited by 99

Inclusion Body Formation and Neurodegeneration Are Parkin Independent in a Mouse Model of α-Synucleinopathy

von Coelln, R., Thomas, B., Andrabi, S. A., Lim, K. L., Savitt, J. M., Saffary, R., Stirling, W. L. H., Bruno, K. J., Hess, E. J., Lee, M. K., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0414-06.2006 · Cited by 92

Clinical features of parkinsonian patients with the α‐synuclein (G209A) mutation

Bostantjopoulou, S., Katsarou, Z., Papadimitriou, A., Veletza, V., Hatzigeorgiou, G., & Lees, A. J. (2001) · Movement Disorders · doi:10.1002/mds.1221 · Cited by 85

Meta-Analysis in Genome-Wide Association Datasets: Strategies and Application in Parkinson Disease

Εvangelou, Ε., Maraganore, D. M., & Ioannidis, J. P. A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000196 · Cited by 83

The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism

DePaolo, J., Göker-Alpan, Ö., Samaddar, T., Lopez, G. J., & Sidransky, E. (2009) · Movement Disorders · doi:10.1002/mds.22538 · Cited by 79

Escaping Parkinson's disease: A neurologically healthy octogenarian with the LRRK2 G2019S mutation

Kay, D. M., Kramer, P., Higgins, D. S., Zabetian, C. P., & Payami, H. (2005) · Movement Disorders · doi:10.1002/mds.20618 · Cited by 76

Hereditary parkinsonism: Parkinson disease look‐alikes—An algorithm for clinicians to “PARK” genes and beyond

Klein, C., Schneider, S. A., & Lang, A. E. (2009) · Movement Disorders · doi:10.1002/mds.22675 · Cited by 73

Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease

Mellick, G. D., Maraganore, D. M., & Silburn, P. A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.078 · Cited by 66

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Oliveira, S. A., Scott, W. K., NANCE, M. A., Watts, R. L., Hubble, J. P., Koller, W. C., Lyons, K. E., Pahwa, R., Stern, M. B., Hiner, B. C., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.975 · Cited by 61

Common variants of LRRK2 are not associated with sporadic Parkinson's disease

Biskup, S., Mueller, J. C., Sharma, M., Lichtner, P., Zimprich, A. A., Berg, D., Wüllner, U., Illig, T., Meitinger, T., & Gasser, T. (2005) · Annals of Neurology · doi:10.1002/ana.20664 · Cited by 56

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Fung, H., Xiromerisiou, G., Gibbs, J. R., Wu, Y., Eerola, J., Gourbali, V., Hellström, O., Chen, C. M., Duckworth, J., Papadimitriou, A., et al. (2006) · Neurodegenerative Diseases · doi:10.1159/000097301 · Cited by 42

Glucocerebrosidase mutations are not found in association with LRRK2 G2019S in subjects with parkinsonism

Eblan, M. J., Scholz, S. W., Stubblefield, B. K., Gutti, U., Göker-Alpan, Ö., Hruska, K. S., Singleton, A., & Sidransky, E. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.032 · Cited by 16

Review: Recent progress in frontotemporal lobar degeneration

Pickering-Brown, S. M. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01045.x · Cited by 13

Familial Aggregation of Parkinson's Disease

de la Fuente‐Fernández, R., & Db, C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441512 · Cited by 9

Inflammasomes: mechanism of action, role in disease, and therapeutics

Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340

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Hyman, A. A., Weber, C. A., & Jülicher, F. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013325 · Cited by 3,155

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Chang, D., Nalls, M. A., Hallgrímsdóttir, I. B., Hunkapiller, J., van der Brug, M., Cai, F., International Parkinson's Disease Genomics Consortium, 23andMe Research Team, Kerchner, G. A., Ayalon, G., et al. (2017) · Nature Genetics · doi:10.1038/ng.3955 · Cited by 1,112

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Filipović, M. R., Živanović, J., Álvarez, B., & Banerjee, R. V. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,059

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Genç, Ş., Zadeoğluları, Z., Fuss, S. H., & Genç, K. (2012) · Journal of Toxicology · doi:10.1155/2012/782462 · Cited by 756

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Ye, H., Robak, L. A., Yu, M., Cykowski, M. D., & Shulman, J. M. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-034145 · Cited by 503

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Thomas, B. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2697 · Cited by 76

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Zhang, P.-L., Chen, Y., Zhang, C.-H., Wang, Y., & Fernández-Fúnez, P. (2017) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2017-105047 · Cited by 93

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Pirooznia, S. K., Rosenthal, L. S., Dawson, V. L., & Dawson, T. M. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000189 · Cited by 36

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Litvan, I., Halliday, G. M., Hallett, M., Goetz, C. G., Rocca, W. A., Duyckaerts, C. J., Ben‐Shlomo, Y., Dickson, D. W., Lang, A. E., Chesselet, M., et al. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3180415e42 · Cited by 122