Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

The blood-brain barrier: Bottleneck in brain drug development

Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246

Blood–brain barrier delivery

Pardridge, W. M. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2006.10.013 · Cited by 1,191

Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway

Qian, Z., Li, H., Sun, H., & Ho, K. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.4.561 · Cited by 1,035

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

Uchida, Y., Ohtsuki, S., Katsukura, Y., Ikeda, C., Suzuki, T., Kamiie, J., & Terasaki, T. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07208.x · Cited by 881

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

Yu, Y. J., Zhang, Y., Kenrick, M., Hoyte, K., Luk, W., Lu, Y., Atwal, J., Elliott, J. M., Prabhu, S., Watts, R. J., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002230 · Cited by 794

The blood–brain barrier in health and disease

Daneman, R. (2012) · Annals of Neurology · doi:10.1002/ana.23648 · Cited by 794

CNS Delivery Via Adsorptive Transcytosis

Hervé, F., Ghinea, N., & Scherrmann, J.-M. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9055-2 · Cited by 676

Targeting central nervous system pathologies with nanomedicines

Mizrahy, S., Gutkin, A., Decuzzi, P., & Peer, D. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1533556 · Cited by 22

Deletion of Protocadherin Gamma C3 Induces Phenotypic and Functional Changes in Brain Microvascular Endothelial Cells In Vitro

Gabbert, L., Dilling, C., Meybohm, P., & Burek, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.590144 · Cited by 21

Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development

Liu, T., Lü, L., Cheng, C., He, B., & Jiang, T. (2022) · Nano Research · doi:10.1007/s12274-022-4385-4 · Cited by 20

A hydrogel model of the human blood-brain barrier using differentiated stem cells

Singh, N. R., Gromnicova, R., Brachner, A., Kraev, I., Romero, I. A., Neuhaus, W., & Male, D. K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283954 · Cited by 20

Brain-targeting redox-sensitive micelles for codelivery of TMZ and β-lapachone for glioblastoma therapy

Dai, Y., Min, Y., Lu, Z., Cheng, L., Ni, H., Yang, Y., & Zhou, W. (2024) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2024.102772 · Cited by 20

Progress and perspectives on nanoplatforms for drug delivery to the brain

Xu, Y., Wei, L., & Wang, H. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101636 · Cited by 20

Single domain antibody-based vectors in the delivery of biologics across the blood–brain barrier: a review

Gao, Y., Zhu, J., & Lu, H. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00873-7 · Cited by 19

A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood–Brain Barrier Crossing Therapeutic Strategies

Chim, S. M., Howell, K., Kokkosis, A. G., Zambrowicz, B., Karalis, K. P., & Pavlopoulos, E. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16101314 · Cited by 22

Nanomedicine for targeting brain Neurodegeneration: Critical barriers and circadian rhythm Considerations

Pineiro‐Alonso, L., Rubio-Prego, I., Lobyntseva, A., González‐Freire, E., Langer, R., & Alonso, M. J. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115606 · Cited by 22

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Pauwels, M. J., Xie, J., Ceroi, A., Balusu, S., Castelein, J., Wonterghem, E. V., Imschoot, G. V., Ward, A., Menheniott, T. R., Gustafsson, O., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121830 · Cited by 19

Recent Advancements in Nanocarrier-assisted Brain Delivery of Phytochemicals Against Neurological Diseases

Mishra, K., Rana, R., Tripathi, S., Siddiqui, S., Yadav, P. K., Yadav, P. N., & Chourasia, M. K. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03955-3 · Cited by 18

Emerging trends in virus and virus-like particle gene therapy delivery to the brain

Mandalawatta, H. P. P., Rajendra, K. C., Fairfax, K. A., & Hewitt, A. W. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102280 · Cited by 18

Time-sequenced drug delivery approaches towards effective chemotherapeutic treatment of glioma

Li, M., Luo, Z. Y., Xia, Z., Shen, X., & Cai, K. (2017) · Materials Horizons · doi:10.1039/c7mh00342k · Cited by 19

Transferrin functionalized poloxamer-chitosan nanoparticles of metformin: physicochemical characterization, in-vitro, and Ex-vivo studies

Birajdar, S. V., Mazahir, F., & Yadav, A. K. (2023) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2023.2282990 · Cited by 17

The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro

Tóth, A. E., Siupka, P., Augustine, T. J. P., Venø, S. T., Thomsen, L. B., Moos, T., Lohi, H., Madsen, P., Lykke‐Hartmann, K., & Nielsen, M. S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0988-x · Cited by 18

The Tumor-Derived Exosomes Enhanced Bevacizumab across the Blood–Brain Barrier for Antiangiogenesis Therapy against Glioblastoma

Chu, L., Sun, Y., Tang, X., Duan, X., Zhao, Y., Xia, H., Xu, L., Zhang, P., Sun, K., Yang, G., et al. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c01227 · Cited by 19

Alzheimer’s Disease, Brain Injury, and C.N.S. Nanotherapy in Humans: Sonoporation Augmenting Drug Targeting

D'Arrigo, J. S. (2017) · Medical Sciences · doi:10.3390/medsci5040029 · Cited by 15

Nanotargeting of Drug(s) for Delaying Dementia: Relevance of Covid-19 Impact on Dementia

D'Arrigo, J. S. (2020) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317520976761 · Cited by 16

Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy

Najem, H., Khasraw, M., & Heimberger, A. B. (2021) · Cells · doi:10.3390/cells10082032 · Cited by 17

Drug delivery to the brain

Khosa, A., Saha, R. N., & Singhvi, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816505-8.00005-9 · Cited by 16

Molecular fMRI of neurochemical signaling

Wei, H., Frey, A. M., & Jasanoff, A. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109372 · Cited by 15

Generation of KS-487 as a novel LRP1-binding cyclic peptide with higher affinity, higher stability and BBB permeability

Sakamoto, K. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101367 · Cited by 15

Regulation of pathological blood-brain barrier for intracranial enhanced drug delivery and anti-glioblastoma therapeutics

Wang, K., Zhang, F., WEN, C., HUANG, Z., ZHANG, Y., HU, Z., HU, F., & Wen, L. (2021) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2022.025696 · Cited by 14

Photooxidative inhibition and decomposition of β-amyloid in Alzheimer's by nano-assemblies of transferrin and indocyanine green

Hou, T., Shao, X., Ding, M., Mei, K., Wang, X., Guan, P., & Hu, X. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124432 · Cited by 15

Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease

Leitao, A. D. G., Ahammad, R. U., Spencer, B. J., Wu, C., Masliah, E., & Rissman, R. A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106285 · Cited by 16

Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array

Manuel, T. J., Sigona, M. K., Phipps, M. A., Kusunose, J., Luo, H., Yang, P., Newton, A. T., Gore, J. C., Grissom, W. A., Chen, L. M., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.015 · Cited by 16

Unlocking therapeutic potential of siRNA-based drug delivery system for treatment of Alzheimer's disease

Jain, S., Bhushan, B., Mishra, A. K., & Singh, R. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106413 · Cited by 17

Treating brain diseases using systemic parenterally-administered protein therapeutics: Dysfunction of the brain barriers and potential strategies

Zaghmi, A., Drouin‐Ouellet, J., Brambilla, D., & Gauthier, M. A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120461 · Cited by 17

Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer’s Disease Treatment

Séguy, L., Guyon, L., Maurel, M., Verdié, P., Davis, A., Corvaisier, S., Lisowski, V., Dallemagne, P., Groo, A., & Malzert‐Fréon, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101626 · Cited by 16

Towards a translational physiologically-based pharmacokinetic (PBPK) model for receptor-mediated transcytosis of anti-transferrin receptor monoclonal antibodies in the central nervous system

Chang, H.-Y., Wu, S., Chowdhury, E. A., & Shah, D. K. (2022) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-021-09800-w · Cited by 16

The development of biological therapies for neurological diseases: moving on from previous failures

Qosa, H., & Volpe, D. A. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1437142 · Cited by 15

Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases

García, F., & Heiman, M. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00799-z · Cited by 14

Lactoferrin Nanoparticle-Vanadium Complex: A Promising High-Efficiency Agent against Glioblastoma by Triggering Autophagy and Ferroptosis

Gai, S., Yan, Q., Li, S., Zhong, X., Qin, Y., & Jiang, M. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02696 · Cited by 14

Receptor-mediated transportation through BBB

Zhang, Z., & Zhan, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814001-7.00005-6 · Cited by 14

Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads

Aguiar, S. I., Dias, J., Manuel, A. M., Russo, R. L., Góis, P. M. P., Aires‐da‐Silva, F., & Gonçalves, J. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.03.002 · Cited by 14

Fine-tuning bispecific therapeutics

Lim, S. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107582 · Cited by 14

Development of the blood–brain barrier

Gastfriend, B. D., & Daneman, R. (2026) · Development · doi:10.1242/dev.205134 · Cited by 17

Nanomedicine-Driven Therapeutic Interventions of Autophagy and Stem Cells in The Management of Alzheimer’s Disease

Alhodieb, F. S., Rahman, M. A., Barkat, M. A., Alanezi, A. A., Barkat, H. A., Hadi, H. A., Harwansh, R. K., & Mittal, V. (2023) · Nanomedicine · doi:10.2217/nnm-2022-0108 · Cited by 13

Recent Advances in Delivery of Peptide and Protein Therapeutics to the Brain

Arora, S., Bajaj, T., Kumar, J., Goyal, M., Singh, A., & Singh, C. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001690 · Cited by 13

The anterior chamber of the eye technology and its anatomical, optical, and immunological bases

Yang, S.-N., Shi, Y., & Berggren, P. (2024) · Physiological Reviews · doi:10.1152/physrev.00024.2023 · Cited by 13

Characterizing emerging companies in computational drug development

Markey, C., Croset, S., Woolley-Meza, O., Buldun, C. M., Koch, C. P., Koller, D., & Reker, D. (2024) · Nature Computational Science · doi:10.1038/s43588-024-00594-8 · Cited by 13

Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona‐Assisted DNA Cubes

Kim, K., Kang, J. H., Thai, H. B. D., Back, J. H., Mao, C., Lee, J. E., Ko, Y. T., & Ahn, D. (2024) · Small Methods · doi:10.1002/smtd.202400902 · Cited by 13

Cachexia: Pathophysiology and Ghrelin Liposomes for Nose-to-Brain Delivery

de Barros, C. T., Rios, A. C., Alves, T., Batain, F., Crescencio, K., Lopes, L. J., Zielińska, A., Severino, P. B., Mazzola, P. G., Souto, E. B., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175974 · Cited by 15

Comparison of polypeptides that bind the transferrin receptor for targeting gold nanocarriers

McQuaid, C., Halsey, A. M., Dubois, M., Romero, I. A., & Male, D. K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252341 · Cited by 15

New Perspectives of Gene Therapy on Polyglutamine Spinocerebellar Ataxias: From Molecular Targets to Novel Nanovectors

Borbolla‐Jiménez, F. V., Prado-Audelo, M. L. D., Cisneros, B., Caballero-Florán, I. H., Leyva‐Gómez, G., & Magaña, J. J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071018 · Cited by 13

Recent progress in nanomedicines for imaging and therapy of brain tumors

Hasan, I., Roy, S., Guo, B., Du, S., Tao, W., & Chang, C. (2022) · Biomaterials Science · doi:10.1039/d2bm01572b · Cited by 13

Energetics of ligand-receptor binding affinity on endothelial cells: An in vitro model

Fotticchia, I., Guarnieri, D., Fotticchia, T., Falanga, A. P., Vecchione, R., Giancola, C., & Netti, P. A. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.04.018 · Cited by 13

Dementia and neurodegenerative disorder: An introduction

Birajdar, S. V., Mulchandani, M., Mazahir, F., & Yadav, A. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824331-2.00007-8 · Cited by 14

Targeted miRNA Delivery in Epilepsy: Mechanisms, Advances, and Therapeutic Potential

Shyam, M., Bm, O., Srirangan, P., Nivedita, N., & Prince, S. E. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10436-z · Cited by 13

Natural polymeric nanocarriers in malignant glioma drug delivery and targeting

Gao, Y., Wang, R., Zhao, L., & Liu, A. (2021) · Journal of drug targeting · doi:10.1080/1061186x.2021.1904250 · Cited by 12

Review of Current Strategies for Delivering Alzheimer's Disease Drugs Across the Blood-Brain Barrier

Wong, K. H., Riaz, M. K., Xie, Y., Zhang, X., Liu, Q., Chen, H., Bian, Z., Chen, X., Lü, A., & Yang, Z. (2022) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20106 · Cited by 12

Efficacy of Polymer-Based Nanomedicine for the Treatment of Brain Cancer

Naki, T., & Aderibigbe, B. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051048 · Cited by 14

Harnessing the Activity of the Fungal Metalloprotease, Mpr1, To Promote Crossing of Nanocarriers through the Blood–Brain Barrier

Aaron, P. A., & Gelli, A. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00348 · Cited by 12

Surface-modified polycaprolactone nanoparticles for the brain-targeted delivery of nevirapine

Lahkar, S., & Das, M. K. (2020) · Journal of Nanoparticle Research · doi:10.1007/s11051-020-04831-9 · Cited by 12

Applications of Nanoparticles in Alzheimer’s Disease

Liu, Y., & Shen, Y. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230098 · Cited by 12

Promoting Drug Delivery to the Brain by Modulating the Transcytosis Process across the Blood–Brain Barrier

Zhang, L., Mao, Z., Li, W., Chi, S., Cheng, H., Wang, Z., Wang, C., & Liu, Z. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c02767 · Cited by 12

Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device

Hudecz, D., McCloskey, M. C., Vergo, S. B., Christensen, S., McGrath, J. L., & Nielsen, M. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065624 · Cited by 12

A dual-targeting peptide for glioblastoma screened by phage display peptide library biopanning combined with affinity-adaptability analysis

Li, X., Pu, X., Wang, X., Wang, J., Liao, X., Huang, Z., & Yin, G. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123306 · Cited by 12

Nanostructure self-assembly for direct nose-to-brain drug delivery

Chaud, M. V., Rios, A. C., dos Santos, C. A., de Barros, C. T., de Souza, J. F., & Alves, T. F. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817998-7.00019-7 · Cited by 11

Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo

Kucharz, K., Kutuzov, N. P., Zhukov, O., Janiurek, M. M., & Lauritzen, M. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03266-2 · Cited by 12

The development of biomarkers to reduce attrition rate in drug discovery focused on oncology and central nervous system

Safavi, M., Sabourian, R., & Abdollahi, M. R. (2016) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2016.1217196 · Cited by 11

Improving drug delivery to the brain: the prodrug approach

Huttunen, K. M. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2355180 · Cited by 10

Nano-biohybrids with cell-penetrating peptides: A molecular trojans for glioblastoma precision medicine

Phatale, V., Khairnar, P., Shukla, S., Puri, N., Sahane, P., & Srivastava, S. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126077 · Cited by 11

Generation of a Human Conditionally Immortalized Cell-based Multicellular Spheroidal Blood-Brain Barrier Model for Permeability Evaluation of Macromolecules

Isogai, R., Morio, H., Okamoto, A., Kitamura, K., & Furihata, T. (2022) · BIO-PROTOCOL · doi:10.21769/bioprotoc.4465 · Cited by 10

Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Holst, M. R., de Wit, N. M., Ozgür, B., Brachner, A., Hyldig, K., Appelt‐Menzel, A., Sleven, H., Cader, M. Z., de Vries, H. E., Neuhaus, W., et al. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00480-x · Cited by 12

Evaluation of Cell‐Penetrating Peptides Using Microfluidic In Vitro 3D Brain Endothelial Barrier

Chung, B., Kim, J., Nam, J., Kim, H., Jeong, Y., Liu, H., Cho, Y., Kim, Y. H., Oh, H. J., & Chung, S. H. (2020) · Macromolecular Bioscience · doi:10.1002/mabi.201900425 · Cited by 11

A blood-brain barrier crossing peptide

Li, X., Zhang, Y., Wang, Y., Chen, Y., Xu, T., Wang, L., Gao, J., & Yang, Z. (2023) · Science China Materials · doi:10.1007/s40843-022-2484-1 · Cited by 9

The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Kurtyka, M., Wessely, F., Bau, S. S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., et al. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151406 · Cited by 12

Microfluidic in vitro brain endothelial monolayer model to evaluate cell-penetrating peptides

Chung, B., Kim, J., Liu, H.-W., Nam, J., Kim, H., Oh, H. J., Kim, Y. H., & Chung, S. H. (2019) · Micro and Nano Systems Letters · doi:10.1186/s40486-019-0092-7 · Cited by 9

Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier

Bao, Y., & Lu, W. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2193390 · Cited by 10

CmPn/CmP Signaling Networks in the Maintenance of the Blood Vessel Barrier

Gnanasekaran, R., Aickareth, J., Hawwar, M., Sanchez, N., Croft, J., & Zhang, J. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13050751 · Cited by 9

Molecular Trojan Horses for treating lysosomal storage diseases

Leal, A. F., İnci, O. K., Seyrantepe, V., Rintz, E., Çelik, B., Ago, Y., León, D., Súarez, D. A., Alméciga-Díaz, C. J., & Tomatsu, S. (2023) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2023.107648 · Cited by 9

Aptamer-Based Delivery of Genes and Drugs Across the Blood–Brain Barrier

Yang, L., Yin, Y., Liu, X., & Guo, B. (2026) · Pharmaceuticals · doi:10.3390/ph19010164 · Cited by 8

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood–brain barrier shuttle scFv8D3

de la Rosa, A., Metzendorf, N. G., Morrison, J. I., Faresjö, R., Rofo, F., Petrovic, A., O’Callaghan, P., Syvänen, S., & Hultqvist, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-25965-x · Cited by 7

A yeast display immunoprecipitation screen for targeted discovery of antibodies against membrane protein complexes

Lajoie, J. M., Cho, Y. K., Frost, D. C., Bremner, S. B., Li, L., & Shusta, E. V. (2019) · Protein Engineering Design and Selection · doi:10.1093/protein/gzz035 · Cited by 7

Promoting transcellular traversal of the blood–brain barrier by simultaneously improving cellular uptake and accelerating lysosomal escape

Zhang, L., Li, W., Xu, Z., Mao, Z., Yang, M., Wang, C., & Liu, Z. (2025) · Nanoscale · doi:10.1039/d4nr05134c · Cited by 7

Antibody Engineering for Receptor-Mediated Transcytosis Across the Blood–Brain Barrier

Guo, K., Cao, D., Marchese-Thomas, L. P., & Dong, Y. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00379 · Cited by 7

Brain delivery of a neurotrophic peptide derived from secreted amyloid precursor protein APPsα as a therapeutic strategy for Alzheimer's disease

Rehra, L., Erdinger, S., Wagner, L., Baltissen, D., Just, J., König, L., Mühlberg, E., Eisenzapf, T., Kilian, L., Banićević, M., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114374 · Cited by 7

Next Generation of Brain Cancer Nanomedicines to Overcome the Blood–Brain Barrier (BBB): Insights on Transcytosis, Perivascular Tumor Growth, and BBB Models

Bor, G., & Hosta‐Rigau, L. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300161 · Cited by 9

Drug Design for Alzheimer’s Disease: Biologics vs. Small Molecules

Weaver, D. F. (2023) · Current Alzheimer Research · doi:10.2174/0115672050301583240307114452 · Cited by 7

Systematic Reversal of Drug Resistance in Cancer

Zhu, S., Wang, X., & Jiang, H. (2024) · Targets · doi:10.3390/targets2030015 · Cited by 7

Liposomes: Production Methods and Application in Alzheimer’s Disease

Naziris, N., & Demetzos, C. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-78787-5_48 · Cited by 7

Functional validation of the simplified in vitro 3D Co-culture based BBB model

Kim, W., Kim, J., Lee, S., Kim, H., Jung, H., Joo, K. M., & Nam, D. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.07.107 · Cited by 7

Recent Advances of Nanotechnology in Brain Targeting

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Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part I: receptor-mediated nose-to-brain delivery approaches for glioblastoma

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